• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Saskatchewan Methadone Guidelines
Saskatchewan Methadone Guidelines

... a) Arrange screening for medical complications associated with drug use (e.g. liver function tests, Hep B, Hep C, HIV, TB) including informed consent and pre- and post-test counselling procedures b) Identify factors that put the individual at further risk for harm (e.g., unsafe sexual practices, emo ...
Oculocardiac reflex as a predictive sign of postoperative nausea and
Oculocardiac reflex as a predictive sign of postoperative nausea and

... 95% CI 0.8 to 12.7). Table 2 shows this relation between OCR and PONV in our group of patients. Twenty four patients required atropine treatment to reverse intraoperative bradycardia, of which 3 (12.5%) developed PONV. Fifty two patients did not need intraoperative atropine to treat OCR, of which 3 ...
ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF SEDIMENTAL EXTRACT OF TINOSPORA CORDIFOLIA Research Article
ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF SEDIMENTAL EXTRACT OF TINOSPORA CORDIFOLIA Research Article

... To study the Type 2 diabetes mediated obesity and their resurrection with SETc using preclinical evaluation. A study kept for OGTT, RBGT with SETc in normal and diabetic animals and the resulting time and dose dependant reduction in BGC were recorded in vivo. The effect of test drug among the glucon ...
Cholinergic Urticaria
Cholinergic Urticaria

... Allergy to foods is rare,but a food diary may be helpful (time may vary from few second to 24 hr).  Only a CBCdiff ,ESR (SLE,UV,MG), screening test for thyroid autoAB(%14)may be worthwhile.  If angioedema is a major component, screening test for C1 sterase inhibitor deficiency ,should be performe ...
Plavix - Products - Bristol
Plavix - Products - Bristol

... Thienopyridines, including Plavix, increase the risk of bleeding. Thienopyridines inhibit platelet aggregation for the lifetime of the platelet (7-10 days). Because the half-life of clopidogrel’s active metabolite is short, it may be possible to restore hemostasis by administering exogenous platelet ...
presentation source
presentation source

... needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes re ...
SELECTIVE SEROTONIN REUPTAKE INHIBITORS
SELECTIVE SEROTONIN REUPTAKE INHIBITORS

... suggest that fluvoxamin could be a potential drug for the treatment of delirium in older adults due to sigma-1 receptor agonist activity although they emphasise that a randomized double-blind, placebo-controlled study is necessary to confirm this hypothesis. Pre-existing changes in pharmacokinetics ...
Reimbursement Support Request Form
Reimbursement Support Request Form

... called peginterferon alfa-2a to treat chronic (lasting a long time) hepatitis C infection (CHC) in people 5 years and older whose livers still work normally, and who have not been treated before with a medicine called an interferon alpha. This combination is also used to treat CHC patients coinfecte ...
study on factors affecting the efficiency of marker
study on factors affecting the efficiency of marker

... different background selection methods:The genetic responses for two background traits under different background selection methods was given in figure 6: during backcross phase, the genetic responses for two background traits show slowly increase by degrees trend with the increase of backcross gene ...
Rapanofal Package Insert
Rapanofal Package Insert

... administration (administration should take 60 to 90 seconds). The doses for induction and maintenance vary depending upon species and preanesthetics. The duration of anesthesia varies depending upon species, dose, and preanesthetics. In dogs, the duration of anesthesia following the recommended indu ...
National Prescribing Indicators 2015–2016
National Prescribing Indicators 2015–2016

... is recommended that all patients are reviewed and stepped down from treatment doses where appropriate8,9. Although PPIs are generally well tolerated, there is emerging evidence that some serious adverse effects may be linked with long-term PPI use. These include fractures of the hip, wrist and spine ...
Extract from Clinical Evaluation Report: Ruxolitinib
Extract from Clinical Evaluation Report: Ruxolitinib

... erythropoiesis stimulating agents, androgens and prednisone. None of these are approved in Australia for the treatment of MF. Other drugs, including busulfan, melphalan, and 2chlorodeoxyadenosine, have been used to treat patients refractory to HU, but have had minimal clinical effect.1, 2. Other the ...
Professional Competencies for Canadian Pharmacy Technicians at
Professional Competencies for Canadian Pharmacy Technicians at

... The demands on the health care system and the changes in the delivery of health care require effective use of human resources, individually and in teams, to provide patientcentred, outcomes- focused care and to optimize the safe and effective preparation, distribution, and use of medications. Pharma ...
effect of cytochrome p450 2d6 and 3a enzyme inhibition on
effect of cytochrome p450 2d6 and 3a enzyme inhibition on

... years ago (Kalso 2005, Olkkola and Hagelberg 2009). After the introduction of immediate- and extended-release oral oxycodone into the market in the 1990s, the global use of oxycodone has increased rapidly (Coluzzi and Mattia 2005, Leong et al. 2009, Hamunen et al. 2009). These new oxycodone preparat ...
RM-0106.02
RM-0106.02

... Hydrochloride Capsules are administered to a nursing woman. Because of the potential for adverse events, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Safety and effectiveness in pediatric ...
Bleomycin
Bleomycin

... reaction, similar to anaphylaxis clinically, has been reported. The reaction may be immediate or delayed for several hours, and usually occurs after the first or second dose (see WARNINGS). It consists of hypotension, mental confusion, fever, chills, and wheezing. Treatment is symptomatic including ...
Etanercept level ELISA
Etanercept level ELISA

... then removed by washing. Subsequently, a biotinylated anti-drug antibody is added. This antibody binds to the Etanercept/TNF/anti-TNF complex present in the microtiter well. Excess biotinylated antibody is removed by washing, followed by addition of horseradish peroxidase (HRP) conjugated streptavid ...
Antihistamines  in  the  treatment  of  asthma J . B
Antihistamines in the treatment of asthma J . B

... show that antihistamines result in significant protection, but in some studies the effect, although significant, is very small and does not appear to be clinically relevant. Moreover, in such situations, calcium antagonists and a-blockers were found to be effective in the laboratory but had little o ...
ASPIRIN 75 mg, WHICH FORMULATION?
ASPIRIN 75 mg, WHICH FORMULATION?

... mucosa from local irritation although duodenal damage can still occur.4 Results from several endoscopic studies in healthy volunteers support this hypothesis, gastric erosion6-10 and micro-bleeding6-8 being less in those who used the enteric-coated preparation. It is known that these lesions are not ...
MAGMA manual (version 1.05)
MAGMA manual (version 1.05)

... reference build, it is crucial to make sure that the SNP locations you are using as input are based on the same human genome build as the gene locations. Gene locations for protein-coding genes (using Entrez gene IDs) are provided on the MAGMA website for builds 36 (hg18), 37 (hg19) and 38. For the ...
View eBook - Absorption Systems
View eBook - Absorption Systems

... Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enzymes and some transporters. Therefore, reliance on probe substrates and inhibitors can potentially lead to false negatives. In recognition of this, the n ...
Study protocol
Study protocol

... hypertension is similar to that of angiotensin converting enzyme inhibitors [3,4]. However, those two drug categories also have potential differences because of different mechanisms of action. The anigiotensin converting enzyme inhibitors may have actions that are not related to inhibition of the re ...
Piracetam (NootropilIV)
Piracetam (NootropilIV)

... When parenteral administration is needed (e.g. swallowing difficulties, unconsciousness) piracetam can be administered intravenously at the same recommended daily dose. • The solution for injection will be administered intravenously over several minutes. • The solution for infusion will be administe ...
DRUG NAME: Cytarabine
DRUG NAME: Cytarabine

... 500 mg (25 mL) single use vials at a concentration of 20 mg/mL and in 1000 mg (10 mL) and 2000 mg (20 mL) single use vials at a concentration of 100 mg/mL. Store at room temperature. Protect from light.33 Hospira Healthcare Corporation supplies cytarabine as a sterile solution without preservative i ...
Heroin and cocaine co-use in a group of injection drug users in
Heroin and cocaine co-use in a group of injection drug users in

... polydrug use, because a large proportion of drug users regularly consume more than one substance. The concomitant use of opioid drugs and cocaine is one type of polydrug use that has been documented in diverse subgroups of the drug-using population. The prevalence of cocaine use in untreated heroin- ...
< 1 ... 84 85 86 87 88 89 90 91 92 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report