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wet granulation
wet granulation

... aqueous solution. Thus, the most effective disintegrating agents in most tablet systems are those with the highest wa-ter uptake property. In general, the more hydrophilic, the better disinte- ...
Table 3 - HAL Descartes
Table 3 - HAL Descartes

... screen for SOX10 gene deletions. Briefly, the 3 coding exons of the SOX10 gene, exon 4 of POLR2F and 4 regions located 5’ of SOX10 were amplified in two multiplex reactions. The beginning of exon 3 and the middle of the exon 5 coding sequences are not covered by the amplicons, however a deletion res ...
Antiviral Agents, Topical Therapeutic Class Review (TCR) September 20, 2012
Antiviral Agents, Topical Therapeutic Class Review (TCR) September 20, 2012

... manufacturers. Search strategy included the use of all drugs in this class. Randomized, controlled trials studying agents within this class for the FDA-approved indications are considered the most relevant in this category. Studies included for analysis in the review were published in English, perfo ...


... bone marrow suppression ( Amberkar, C. E., et al., 2000 ). AA is a rare, dose independent , irreversible, idiosyncratic, manifestationof CAP which in most cases is seen years after the treatment ( Younis, A.A. ,1989 (b)) and is fatal ( Turton, A. A., 2002 ) risk of developing AA after CAP administra ...
Medications and Alcohol Craving - Assisted Recovery Centers of
Medications and Alcohol Craving - Assisted Recovery Centers of

... Three of the four medications approved in the United States or Europe for treating alcoholism are reported to reduce craving; these include naltrexone (ReVia™), acamprosate, and tiapride. The remaining medication, disulfiram (Antabuse®), may also possess some anticraving activity. Additional medicat ...
Convergent Evolution in the Genetic Basis of Müllerian Mimicry in
Convergent Evolution in the Genetic Basis of Müllerian Mimicry in

... analyze sequence chromatograms. Genetic markers and linkage map assembly: As crossing over between sister chromatids does not occur during oogenesis in Lepidoptera, all markers on the same chromosome inherited from the mother are in complete linkage. Three H. melpomene F2 broods (44, 48, and 52) seg ...
Single Nucleotide Polymorphism (SNP) of the Endothelial Nitric
Single Nucleotide Polymorphism (SNP) of the Endothelial Nitric

... predicted (not shown) by Hardy-Weinberg equilibrium (Table 1). Additive and dominant effects of the eNOS (T) allele were significantly higher in the patients with idiopathic asthenozoospermia than in the controls, as shown in Table 1. Comparisons between the asthenozoospermic and control groups rega ...
Convergent Evolution in the Genetic Basis of Müllerian
Convergent Evolution in the Genetic Basis of Müllerian

... analyze sequence chromatograms. Genetic markers and linkage map assembly: As crossing over between sister chromatids does not occur during oogenesis in Lepidoptera, all markers on the same chromosome inherited from the mother are in complete linkage. Three H. melpomene F2 broods (44, 48, and 52) seg ...
[FDA Approved Labeling for Zoloft® for the Treatment of Social... Attachment to FDA Approval Letter for NDA 19-839/S-045]
[FDA Approved Labeling for Zoloft® for the Treatment of Social... Attachment to FDA Approval Letter for NDA 19-839/S-045]

... mean reduction of approximately 7 points on the CYBOCS total score which was significantly greater than the 3 point reduction for placebo patients. Analyses for age and gender effects on outcome did not suggest any differential responsiveness on the basis of age or sex. In a longer-term study, patie ...
ACPA Resource Guide  2013 Edition Chronic Pain Medication & Treatment
ACPA Resource Guide 2013 Edition Chronic Pain Medication & Treatment

... Unfortunately, however hopeful the individual may be and however well-meaning the treatment may be, the reality is that there are risks associated with almost any treatment for chronic pain. The best approach is for people with pain to ask questions about the benefits and risks or side effects when ...
Prevention Guide - Safe Handling of Hazardous Drugs
Prevention Guide - Safe Handling of Hazardous Drugs

... NOTE: The information contained in this document is not exhaustive and in no way represents a legal interpretation of the laws and regulations. Your sectorbased association, the ASSTSAS, in no way guarantees that occupational accidents or diseases and the hazards related thereto will be eliminated t ...
View Prescribing Details
View Prescribing Details

Introduction to Anabolic Steroids
Introduction to Anabolic Steroids

... Generally speaking, the hypothesis that a drug acts by only one mode of action can be tested by examining the dose/response curve. If an effect is dependent only upon the activity of a receptor, then the log response should follow a sigmoidal function (an S shaped curve). The graph would be nearly ...
CFTR Mutations in Congenital Absence of Vas Deferens
CFTR Mutations in Congenital Absence of Vas Deferens

... explained by another genetic factor, namely the polymorphic TGm locus in front of the Tn locus (11). Different alleles can be found depending on the number of TG repeats found at this locus. The higher number of TG repeats, the less efficient exon 9 splicing will occur (Fig 2). The 5T polymorphism c ...
Antibiotic Drug Delivery Systems for the Intracellular
Antibiotic Drug Delivery Systems for the Intracellular

... otic to the market and the limited lifetime of antibiotics, the design of drug delivery sys‐ tems to enable the targeting of antibiotics inside the cells, to improve their activity in different intracellular niches at different pH and oxygen concentrations, and to achieve a reduced dosage and freque ...
Leaflet PACKAGE LEAFLET: INFORMATION FOR THE
Leaflet PACKAGE LEAFLET: INFORMATION FOR THE

... with volatile halogenous anaesthetics, imipraminic antidepressants, serotoninergicnoradrenergic antidepressants, guanethidine and related products. It is recommended to take precautions for patients receiving an association of ephedrine and MAOI, and also with reserpine, methyldopa or theophylline d ...
Effects of ciclesonide and fluticasone on cortisol secretion in patients with
Effects of ciclesonide and fluticasone on cortisol secretion in patients with

... All statistical analyses were carried out with SAS (release 9.1; SAS Institute Inc., Cary, NC, USA). Serum cortisol mesor, urine cortisol variables, bone formation markers, log-transformed PC20 and lung variables were analysed by means of an ANCOVA or ANOVA [26] with treatment, period, sequence, pat ...
simvastatin tablets usp - Lupin Pharmaceuticals, Inc.
simvastatin tablets usp - Lupin Pharmaceuticals, Inc.

... 7 days had no effect on plasma AUC (and Cmax) of either total HMG-CoA reductase inhibitory activity or fenofibric acid; there was a modest reduction (approximately 35%) of simvastatin acid which was not considered clinically significant (see WARNINGS, Myopathy/Rhabdomyolysis and PRECAUTIONS, Drug In ...
Methadone-Drug Interactions
Methadone-Drug Interactions

... multidrug regimens – called “polypharmacy” – for acute or chronic disease, which can result in clinically important drug interactions. While multiple drugs often are necessary for treating complex or resistant conditions, side effects of the drugs themselves may induce disease symptoms rather than a ...
Restless Legs Syndrome
Restless Legs Syndrome

... • The genetic contribution of BTBD9 to RLS approximates that of the ApoE4 allele association to Alzheimer’s disease. • The results are extremely credible – the gene variants and their effect sizes are similar in 5 different populations in which RLS was diagnosed by 3 different groups. ...
Vol 1   Pg 2 EXECUTIVE SUMMARY
Vol 1 Pg 2 EXECUTIVE SUMMARY

... answer questions about dose, intentionality, causality, or the nature of trends in cases of serious adverse events with OTC and prescription products. ...
Calculation of allele frequencies of breeding
Calculation of allele frequencies of breeding

... the same eye color, hair color, or body build as you? Variation is easy for us to see in humans, but variations exist in all organisms. To us, all mosquitoes look the same, but upon closer observation, we can see many variations in the population of mosquitoes. These variations arise from random mut ...
Substance Abuse
Substance Abuse

... Purcell DW, Parsons JT, Halkitis PN, Mizuno Y, Woods WJ. Substance use and sexual transmission risk behavior of HIV-positive men who have sex with men. J Subst Abuse. 2001;13:185-200. Stall R, Paul JP, Greenwood G et al. Alcohol use, drug use and alcohol-related problems among men who have sex with ...
The Challenges of Methamphetamine
The Challenges of Methamphetamine

... Purcell DW, Parsons JT, Halkitis PN, Mizuno Y, Woods WJ. Substance use and sexual transmission risk behavior of HIV-positive men who have sex with men. J Subst Abuse. 2001;13:185-200. Stall R, Paul JP, Greenwood G et al. Alcohol use, drug use and alcohol-related problems among men who have sex with ...
Infusion reactions associated with use of biologic
Infusion reactions associated with use of biologic

... Biologic medicines, such as monoclonal antibodies are gaining popularity for prevention and treatment of diseases. Due to their binding specificity for the molecular target of interest, or other biochemical pathways in human system, they provide benefits of lowering the unwanted systemic effects wit ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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