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Genome-Wide Identification of Allelic Expression in Hypertensive
Genome-Wide Identification of Allelic Expression in Hypertensive

... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
BREVIBLOC [Injection esmolol hydrochloride]
BREVIBLOC [Injection esmolol hydrochloride]

... congestive heart failure. Inhibition with beta-blockade always carries the potential hazard of further depressing myocardial contractility and may precipitate or worsen cardiac failure. Therefore, special caution should be exercised when administering BREVIBLOC Injection / BREVIBLOC PREMIXED Injecti ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION

... that may include other measures (psychological, educational, social) for patients with this syndrome. Drug treatment may not be indicated for all patients with this syndrome. Stimulants are not intended for use in the patient who exhibits symptoms secondary to environmental factors and/or other prim ...
Ketofol for bone marrow aspiration and lumbar puncture in Children
Ketofol for bone marrow aspiration and lumbar puncture in Children

... CO2 increased slightly after induction (24). Willman and Andolfatto published a study of 114 patients requiring procedural sedation and analgesia mainly for orthopedic procedures were given a 1:1 mixture of propofol and ketamine. Transient hypoxia occurred in 2.6% of patients, out of them one patien ...
EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis
EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

... the microsomal epoxide hydrolase gene (EPHX1), T113C and A139G, may influence susceptibility to chronic obstructive pulmonary disease (COPD) and asthma. We genotyped participants from the Copenhagen City Heart Study (n510,038) and the Copenhagen General Population Study (n537,022) for the T113C and ...
Quetiapine for insomnia: A review of the literature
Quetiapine for insomnia: A review of the literature

... quetiapine (50 or 100 mg) compared with $0.05 per tablet of hydroxyzine hydrochloride (100 mg), making quetiapine 90 times more expensive than hydroxyzine, another agent used to treat insomnia.16 A retrospective chart review of 692 soldiers treated with quetiapine at Madigan Army Medical Center in T ...
consensus statement - Academy of Medicine of Malaysia
consensus statement - Academy of Medicine of Malaysia

... Calcipotriol has also been used in combination therapy with UVB, PUVA, cyclosporin, methotrexate and retinoids in moderate and severe psoriasis. ...
The efficacy of glucosamine sulfate in osteoarthritis
The efficacy of glucosamine sulfate in osteoarthritis

... considered when claiming that purported independent trials of glucosamine sulfate also yielded null results when compared with industry-sponsored studies. These issues could be summarized for at least 3 studies. The trial by Cibere et al (22) allocated ⬎35% of patients to ⱕ1,000 mg/day glucosamine, ...
FETAL MORPHINE METABOLISM AND CLEARANCE ARE
FETAL MORPHINE METABOLISM AND CLEARANCE ARE

... Ultrasound was performed at 70 to 110 days to confirm singleton pregnancy, fetal size, and placental location. Lights were cycled (7:00 AM on, 7:00 PM off) and feeding times (8:00 AM and 4:00 PM) were constant. Animals were maintained in accordance with all National Institutes of Health, U.S. Depart ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
HIGHLIGHTS OF PRESCRIBING INFORMATION These

... diabetes, in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system (e.g., beta-blockers) [see Drug Interactions (7)], or in patients who experience recurrent hypoglycemia. Risk Factors for Hypoglycemia The risk of hypoglycemia after an injectio ...
Product Information  Zyrtec Zyrtec PI
Product Information Zyrtec Zyrtec PI

... Miscellaneous. Weight increase (see comment below), fever, oedema, chest pain, pain, rigors, dysmenorrhoea, thirst, decreased libido. Weight gain was reported as an adverse effect in 0.4% of cetirizine patients in placebo-controlled trials. In an open study of six months’ duration, the mean gain in ...
non-leukaemia related neutropenia or thrombocytopenia in the following
non-leukaemia related neutropenia or thrombocytopenia in the following

... The prescribed dose should be administered orally, with a meal and a large glass of water. Doses of 400 mg or 600 mg should be administered once daily, whereas a dose of 800 mg should be administered as 400 mg twice a day. In children, Imatinib mesylate treatment can be given as a once-daily dose or ...
as zoledronic acid monohydrate
as zoledronic acid monohydrate

... requiring oral surgery, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of ONJ. In patients who develop ONJ while on bisphosphonate therapy, surgery at the affected area may exacerbate the condition. Clinical judgment of the treating physic ...
Clenbuterol toxicity: a NSW Poisons Information Centre experience
Clenbuterol toxicity: a NSW Poisons Information Centre experience

... a descriptive US study found that clenbuterol is often taken with thyroxine, anabolic steroids and products containing caffeine and stimulants, which appears to exacerbate toxicity.14 Limitations of our descriptive study include non-standardised methods of telephone enquiry and coding which is likel ...
Pfizer Inc 235 East 42"° Street 235/24/l0A New York, NY 10017-5755
Pfizer Inc 235 East 42"° Street 235/24/l0A New York, NY 10017-5755

... Under the License Agreement, Novartis's right of reference to Pfizer's amlodipine IND and NDA "shall expire automatically upon the termination or expiration of this Agreement." Although Pfizer believes that the Agreement remains in effect through September 25, 2007 (when the pediatric exclusivity fo ...
Document
Document

... in six other pea plant characters, each represented by two traits • What Mendel called a “heritable factor” is what we now call a gene Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
Furosemide - Circulation
Furosemide - Circulation

... resulting in maximum diuretic effects of up to two thirds of the glomerular filtration rate.1' 2 Clearance data,3 4 micropuncture studies,5 6 and stop-flow analyses7 indicate sites of action in both the proximal and distal tubules, including the ascending limb of the loop of Henle. Toxicological eva ...
focusing in on adderall - Institute for Food Laws and Regulations
focusing in on adderall - Institute for Food Laws and Regulations

... for abuse, and that such abuse leads to severe psychological or physical dependence.1 Cocaine, opium, and morphine are examples of drugs that are listed in the same category.2 Today, various forms amphetamines are prescribed to 1.5 million children annually in the United States.3 This paper will foc ...
- Boehringer Ingelheim (Canada)
- Boehringer Ingelheim (Canada)

... APTIVUS capsules plus low-dose ritonavir, and from paediatric patients treated with APTIVUS capsules or tipranavir oral solution (which contains a vitamin E derivative) plus low-dose ritonavir have demonstrated that with or without the vitamin E-containing oral solution there was no effect of tipran ...
clinical practice guidelines for treatment of alcohol dependence
clinical practice guidelines for treatment of alcohol dependence

... of patients with alcohol dependence. Research on hospital and community based screening suggests that raised value of one or both of these measures, in the absence of other causes, is strongly linked to the ultimate diagnosis of alcohol dependence. Screening instruments are used in epidemiological s ...
Genome-Wide Identification of Allelic Expression in Hypertensive Rats
Genome-Wide Identification of Allelic Expression in Hypertensive Rats

... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
Genomic analysis of clinical samples with serologic ABO blood
Genomic analysis of clinical samples with serologic ABO blood

... historical blood grouping was uncomplicated (blood group O) and ABO genotyping indicated the O1vO1v genotype. A patient with non-Hodgkin lymphoma had polyagglutinable RBCs, but was shown to have the O1O1v genotype. Various medical conditions associated with ABO discrepancies. Nineteen patients with ...
EVALUATION OF ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF... NEGUNDO ON PYLORUS LIGATURE INDUCED AND ASPIRIN INDUCED ULCER IN...
EVALUATION OF ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF... NEGUNDO ON PYLORUS LIGATURE INDUCED AND ASPIRIN INDUCED ULCER IN...

... H.pylori)[3]. Flood gates of research on Helicobacter pylori actually opened up when Marshall and Warren in 1984 demonstrated the association between this organism with active chronic gastritis and peptic ulcer[4]. Long term use of NSAIDs can also cause gastric ulcer. Treatment cost is estimated mor ...
product information
product information

... RejuveNail Anti-fungal Nail Lacquer should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Use in lactation It is not known whether this drug is excreted in human milk. Since many drugs are excreted in human milk, caution should be exercised when Re ...
Drug-induced hypo- and hyperprolactinemia: mechanisms, clinical
Drug-induced hypo- and hyperprolactinemia: mechanisms, clinical

... glands, suprarenal glands and choroid plexus [13]. These receptors have a single membrane crossing, generating an extracellular domain on which the ligand binds and an intracellular one, coupling the receptors with the signaling molecules [13]. Noteworthy, the prolactin receptors interact with three ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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