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Drugs to thin your blood
Drugs to thin your blood

... If your INR is above the target range, there is an increased risk of bleeding. You should monitor for the related signs and symptoms and seek immediate medical care should they occur. • Signs of bleeding: Please refer to the section on “What are the possible side effects” If you have history of dru ...
Abuse and Diversion of Controlled Substances
Abuse and Diversion of Controlled Substances

... morphine, oxycodone, meperidine, hydromorphone and codeine preparations), sedatives/hypnotics (e.g. benzodiazepines) and stimulants (e.g. amphetamines, methylphenidate). Anecdotal evidence from family practitioners in Canada indicates that the drugs most commonly requested by name in the office sett ...
Drugs for RA
Drugs for RA

... provides cardiovascular protection. Prolonged decrease in PGI2 produces these adverse cardiovascular effects DI: CYP2C9 inhibition, so you don’t metabolize fluconazole (A trizole) and fluvastatin ...
Genetics Unit
Genetics Unit

... Augustinian monk and botanist whose experiments in breeding garden peas led to his eventual recognition as founder of the science of genetics (1822-1884) ...
FY M.Pharm Medicinal Chemistry
FY M.Pharm Medicinal Chemistry

... Study of cell penetrating peptides and fusogenic peptides and their applications in drug delivery 3. Drug Membrane interactions  Possible effects of drugs on the membranes & effect of membrane on drugs  Role of drug membrane interaction in pharmacokinetics & pharmacodynamics of drugs  Development ...
A4 Stable Angina
A4 Stable Angina

... - started when pt has regular sx or when sx causing  activity -Blockers Efficacy - 1st line tx (80 – 90% pts improved anginal sx) - the only tx shown to affect CAD mortality - cardioprotective, antiHTN effects - ideal for pts with concomitant HTN,  resting HR, supraventricular tachycardia, atrial ...
8 - Ani-Viral
8 - Ani-Viral

... Resistance usually develop Due to high rate of mutation at several code. Pheytion is liver enzyme-inducer ...
December 2012 - APhA DrugInfoLine
December 2012 - APhA DrugInfoLine

... followed by how much of the medication is in 1 mL. These modifications are being made to eliminate the need for providers to calculate the total amount of heparin medication in a product containing more than 1 mL, FDA reported, thereby reducing the risk of miscalculations that may result in medicati ...
Cough and Cold Products - OHP Preferred Drug List
Cough and Cold Products - OHP Preferred Drug List

... serious and potentially life­threatening side effects can occur from such use, according to a January 2008 FDA public  health advisory (1) . The FDA is still reviewing cough/cold medication use in 2­11 yr olds and will announce those  recommendations soon.This advisory comes on the heels of the FDA’ ...
Lecture : Contents : Treatment of Urinary Tract Infection
Lecture : Contents : Treatment of Urinary Tract Infection

...  A)hypersensitivity B) G6PD deficiency o Megaloblastic anemia due to TMP.  Drug interactions o Displace bilirubin- if severe – kernicterus ( jaundice) < severe elevation of bilirubin , it can cause damage to nerve cells. It’s not used in case of (children and pregnancy) because their enzymes are n ...
Genetic Testing
Genetic Testing

... authorization for each signature occurrence (such as access limited by password). A screening test is characterized by one or both of the following: a) The package insert indicates that the assay is for screening purposes only; and/or b) There is no pre-existing indication that the individual is at ...
Clinical Global Impressions (CGI) Scale
Clinical Global Impressions (CGI) Scale

... a patient “much worse” at week 3 when he or she was rated “much improved” at week 2). Second, the rating becomes partly a memory test with an intrinsic loss function (i.e., as time goes by, the rater’s memory of the first visit worsens). The Efficacy Index has also been criticized. Parametric statis ...
Neuroradiological, clinical and genetic characterization of new forms
Neuroradiological, clinical and genetic characterization of new forms

... mutations give rise to Aicardi-Goutières Syndrome, a paediatric onset leukodystrophy, dominant TREX1 mutations cause adult-onset Retinal Vasculopathy with Cerebral Leukodystrophy (RVCL). Further evidence for a clinical spectrum caused by mutations in the same gene is observed in carriers of dominant ...
Genetics Problems A
Genetics Problems A

... 5) Draw a Punnett square to show the offspring possible between a man heterozygous for tongue rolling and a woman who cannot roll her tongue? a) What is the genotypic ratio in this cross: ...
MS_Word ~ 184 KB
MS_Word ~ 184 KB

... ‘Medication Management Plan’ or otherwise), as part of the patient’s health care record, must be in accordance with the facility’s local protocols and procedures. Facilities must establish systems and implement local protocols for the regular review of medication orders, as appropriate in the partic ...
Migraines in a Minute (or less)
Migraines in a Minute (or less)

...  po rapid onset  po slow onset rapid --> slow  high --> low efficacy  high --> low relapse  more --> less se’s ...
Basic Heredity
Basic Heredity

... GENETICS Basic Heredity ...
Future Challenges - Thrombosis Research Institute
Future Challenges - Thrombosis Research Institute

... All anticoagulants can cause bleeding ...
Lecture #26 - Suraj @ LUMS
Lecture #26 - Suraj @ LUMS

... color, and metabolic rate are governed by the cumulative effects of many genes. • Polygenic traits are not expressed as absolute or discrete characters, as was the case with Mendel's pea plant traits. ...
Gene
Gene

... with each other and in one generation we made 1000 plants, how many tall pea plants and short pea plants should we have? ...
Over the Counter Drugs (OTC) - Tri
Over the Counter Drugs (OTC) - Tri

... Due to some of the negative side effects some first time users may not abuse DXM. ...
Pretin D Prescribing Information
Pretin D Prescribing Information

... for 2 weeks after stopping use of an MAO inhibitor. The antihypertensive effects of β adrenergic blocking agents, Methyldopa, Reserpine, and Veratrum alkaloids may be reduced by sympathomimetics. Increased ectopic pacemaker activity can occur when Pseudoephedrine is used ...
Roxb.
Roxb.

... A. Chemical Analysis :-A preliminary chemical examination of the stem bark revealed the presence of a white substance, a mixture of three coloured compounds, besides reducing sugars, oxalic acid and a phytosterol. A number of solvents were tried for the extraction of the constituents from the air dr ...
The completeness of medication histories in
The completeness of medication histories in

... [email protected] nL Received 24 May 1999, accepted 16 February 2000. ...
Insert Presentation title here
Insert Presentation title here

... Metabolic Syndrome Does Metabolic Syndrome exist or is it a sum of its risk components? ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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