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Anticoagulants
Anticoagulants

... • Fast action intravenously or by injection (not absorbed through the stomach or intestinal wall) • peak after injection 2 - 4 hr • Complex metabolism (long chains broken up) • half life 1 - 5 hr; cleared by the reticuloendothelial system and some excreted in urine. • A few Drug-drug interactions • ...
Evolution Practice Questions
Evolution Practice Questions

... have traits that are better suited to their environment are more likely to survive and reproduce than those with less desirable traits. 4. Natural selection works on an organism’s Phenotype ...
1. Basic Genetic Concepts The Nature of Inheritance (Genetics)
1. Basic Genetic Concepts The Nature of Inheritance (Genetics)

... The Nature of Inheritance (Genetics) Genetics is the study of how genes are inherited AND how they influence the physical characteristics of each individual. Genetics relates to 2 basic processes: 1) the distribution of genes into haploid gametes • i.e., by meiosis ...
7. Calculation of Doses- General considerations.ppt [相容模式]
7. Calculation of Doses- General considerations.ppt [相容模式]

... mg/day for 5 days by intravenous infusion. The usual daily dose of prednisone is 5 to 60 mg/day, depending on the condition being treated. Calculate the doses that the patient received, as a multiple of the highest usual daily dose. q ...
ULM COLLEGE OF PHARMACY Drug Information Center 318
ULM COLLEGE OF PHARMACY Drug Information Center 318

... Back to Top University of Louisiana at Monroe College of Pharmacy Drug Information Center View previous issues of the FYDI newsletter. For comments and suggestions please email [email protected]. Disclaimer: No information source can replace clinical judgment applied to a specific case. Some of the d ...
Study Guide - Mrs. Averett`s Classroom
Study Guide - Mrs. Averett`s Classroom

... A gene is a segment of DNA that tells the cell how to make a particular polypeptide. The location of a gene on a chromosome is called a locus. A gene has the same locus on both chromosomes in a pair of homologous chromosomes. In genetics, scientists often focus on a single gene or set of genes. Geno ...
1. Single gene traits
1. Single gene traits

... fruit to be either yellow (Y) or red (y). So for these tomatoes: • Inheriting one P allele makes the fruit pale regardless of any other alleles inherited. • If the tomato gets two p alleles and at least one Y allele, the fruit will be yellow. • If the tomato gets the genotype ppyy, it will be red. T ...
Epidemiology
Epidemiology

... Thailand, New Zealand and Australia ...
words - marric.us
words - marric.us

... a cell, and the model compares and contrasts the processes of mitosis and meiosis. Which is included in the model’s explanation? A. Both processes involve the formation of haploid gametes. B. Both processes produce genetically identical daughter cells. C. Mitosis has five phases, while meiosis has o ...
Research: Eyes on the Goal
Research: Eyes on the Goal

... cancer scientists and clinicians developed a personalized treatment for a patient with a hereditary form of pancreatic cancer who was not expected to live more than three months. Genetic analysis of the tumor showed that it would likely be responsive to two particular drugs, and after several cycles ...
Biotechnology: Social and Environmental Issues
Biotechnology: Social and Environmental Issues

... controversy, genetically engineered plants and microorganisms, biodiversity, bovine growth hormone, transgenic animals, genetically modified food, human genetic engineering/eugenics, cloning, DNA identification, privacy, DNA databases, and genetic discrimination; behavioral genetics; forensic DNA, t ...
Guidelines for Monitoring and Reporting Adverse Drug Reactions
Guidelines for Monitoring and Reporting Adverse Drug Reactions

... being unknown or incompletely documented previously. 12. Unexpected adverse drug reaction An adverse reaction, the nature or severity of which is not mentioned in the summary of product characteristic or market authorization, or expected from ...
Chapter 10 Test (Lessons 1,2,3) Study Guide
Chapter 10 Test (Lessons 1,2,3) Study Guide

... Polygenic inheritance is when more than one gene affects the trait. Codominance is when both alleles of a gene are expressed equally; both alleles will be present in the heterozygote. *Environmental factors can influence the way genes are expressed. *Most traits are the result of complex inheritance ...
Clinical Implications of Chirality and Stereochemistry in
Clinical Implications of Chirality and Stereochemistry in

... exists as a racemic mixture of Rand S- enantiomers. Studies have shown that the S-thalidomide ...
Full Text in PDF
Full Text in PDF

... 29, 31. Of all the cardiac cells, the M cell of the ventricular muscle is particularly sensitive to the drugs that increase the action potential duration10. Most of the arrhythmia caused by the clinical drugs is as a result of the interplay of three factors as –blockage of ionic channels, genetic pr ...
presentation_6-18-2012-21-37-54
presentation_6-18-2012-21-37-54

... comparison of different treatments adjusted according to the results of their direct comparison with a common control, so that the strength of the randomized trials is preserved. Empirical evidence indicates that results of adjusted indirect comparison are usually, but not always, consistent with th ...
Chapter13
Chapter13

... were passed from generation to generation by “heritable factors” ...
Slide 1 - Atorvaacademics.com
Slide 1 - Atorvaacademics.com

... Beta-Blockers • Studies have shown that Beta Blockers are beneficial in reducing subsequent MI or recurrent Ischemia or both. • If ischemia & chest pain are ongoing early IV beta blockade can be used. • The choice of beta blocker can be made individually on the basis of the drug’s pharmacokinetics, ...
Richard Dawkins on the nature of the gene
Richard Dawkins on the nature of the gene

... We may note two things here: firstly, Dawkins’s desire to find a basic unit to which all else can be reduced; and, secondly, the fact that his ‘gene’ is physically indistinct from the rest of the world: it is characterised by what it does, not what it is. Dawkins proceeds: “The average life-expectan ...
Review questions from 2003-2014 IB exams for option D Medicine
Review questions from 2003-2014 IB exams for option D Medicine

... 5. Explain why depressants are sometimes describes as anti-depressants 6. The most widely used depressant is ethanol. Discuss the harmful effects of regularly taking large amounts of ethanol by referring to 4 specific problems 7. List 3 prescription depressants 8. One problem with many drugs is that ...
Functional Genomics and the Path from Genetic
Functional Genomics and the Path from Genetic

... Functional Genomics and the Path from Genetic Variation to Clinical Translation 2nd Annual Cross-Disciplinary Symposium on the State of Science, Technology, and Capacity at Washington University in St. Louis Sponsored by the Intellectual and Developmental Disabilities Research Center and St. Louis C ...
Clinical Meeting - Moor Park Medical Practice
Clinical Meeting - Moor Park Medical Practice

... are working collaboratively with other practices having Open Day Events, promoting self-care, healthy eating, pharmacy first. The health centre Open Day was well received so this will be repeated with other services. The practice work with Avicenna and Dr Akbar’s surgery who are all located within t ...
Demystifying FDA`s 505(b)(2) Drug Registration Process
Demystifying FDA`s 505(b)(2) Drug Registration Process

... nonclinical studies, if applicable, and starting clinical trials. This will ensure that as well as selection of the RLD, can result in sigall FDA requirements are addressed. For examnificant delays, increased costs, time and resource ple, in glaucoma compounds deployment or, intreatment, the worst c ...
Pharmacological Approaches to Stuttering
Pharmacological Approaches to Stuttering

... Combinations of medications can be fatal None of these drugs were designed for stuttering or were approved by the FDA to treat stuttering Faulty theoretical justifications Poor empirical support  Weak research designs provide weak positive ...
Name - S3 amazonaws com
Name - S3 amazonaws com

... (5) Define and distinguish between punctuated equilibrium and phyletic gradualism. punctuated equilibrium is evolution in short bursts followed by long periods of equilibrium phyletic gradualism is the slow constant genetic changes over time (5) Define and distinguish between biological and morpholo ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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