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المحاضره السابعه Liver extraction ratio: The liver extraction ratio (ER
المحاضره السابعه Liver extraction ratio: The liver extraction ratio (ER

... Significance of drug metabolism:  It is important to consider what fraction of drug is eliminated by metabolism & what fraction is eliminated by excretion.  Drugs which are highly metabolized such as (theophylline, lidocaine) demonstrate large variation in elimination half life's in various peopl ...
SNMMI Nuclear Medicine Clinical Trial Group, LLC January 2016
SNMMI Nuclear Medicine Clinical Trial Group, LLC January 2016

... The following sponsored studies are currently using NMCTG services: Movember (Australia) NMCTG is providing clinical management for two international, multicenter, academic trials in prostate cancer imaging being funded by the Movember Foundation. Both studies use the Keosys Imagys platform housed a ...
CH91 Page 1-5 - Pharmacotherapy
CH91 Page 1-5 - Pharmacotherapy

... • Determine the risk/benefit of treating the patient’s disease based on her preferences and her depression history (number and severity of depressive episodes, suicidal ideation/suicide attempts, and psychiatric admissions) and counsel the patient based on the benefit-risk ratio.2 • If the decisio ...
Dev. Date
Dev. Date

... released into the duodenum to aid the emulsification of fats. Bile can also contain drugs which have been metabolised in the liver. Changes in the genetic code which occur in a population and result in the production of enzymes, particularly cytochrome P450 enzymes, which as a result may be more or ...
inhibition of COX-1
inhibition of COX-1

... Primary prevention Active monitoring and searching for persons having risk factors with the goal to prevent formation of atherosclerosis !! Low doses of acetylsalicylic acid!! Males – accorcing to clinical studies taking aspirin din´t decrease mortlity, decreased occurrence of MI, increased cerebra ...
in the kidney - Faculty Sites
in the kidney - Faculty Sites

... Acts about 30 min. after administration Used to relieve burning, pain, urgency, frequency in UTI Reduces bladder spasms ...
Population Genetics - elysciencecenter.com
Population Genetics - elysciencecenter.com

Gregor Mendel
Gregor Mendel

... 1. Example: In pea plants, the plant’s flower can either be white or purple. White and purple are the alleles. B. Dominant Allele: The allele that determines the organism’s appearance. (Always written in capitalized italic letters. Ex: AA ) C. Recessive Allele: The allele that does not have noticeab ...
Efficacy of an Analgesic and Anti-inflammatory Ayurvedic Medicine
Efficacy of an Analgesic and Anti-inflammatory Ayurvedic Medicine

... Thus, narcotics along with other medicines known as nonstero­ idal anti-inflammatory drugs (NSAIDs) are being increasingly used. The biggest risk with NSAIDs is severe and sometimes fatal gastrointestinal bleeding, increase in stomach acid, reduce the stomach’s normal protective mucus layer, cause d ...
TIMOPTOL
TIMOPTOL

... at this time, although a fluorescein study and tonography studies indicate that the predominant action may be related to reduced aqueous formation. However, in some studies a slight increase in outflow facility was also observed. Unlike miotics, TIMOPTOL reduces intraocular pressure with little or n ...
Clinical Medication Sheet
Clinical Medication Sheet

... Aerosolized Antimicrobial Agents: Antimicrobial agents such as antibiotics have been aerosolized for the treatment of pulmonary infections. The aerosol route targets the lungs specifically, while in some cases avoiding systemic side effects (pentamidine administration). It is important to understand ...
Human Research
Human Research

... treatments are unknown. When those are unknown, including patients in randomized trials is permissible So, is there any conflict between 1, physicians revealing their honest treatment preferences and 2, offering patients a chance to participate in clinical trials? –para2, p198 Vaughn suggests that a ...
Telephone counselling for alcohol and drug issues
Telephone counselling for alcohol and drug issues

... The Classification All forms of marijuana are mind-altering. In other words, they change how the brain works. They all contain THC (delta-9tetrahydrocannabinol), the main active chemical in marijuana. They also contain more than 400 other chemicals. Marijuana's effects on the user depend on the str ...
Handout - International Pain School
Handout - International Pain School

... morphine as the onset of action is within 20-30 min and the duration is four hours. In some countries, because the shelf life of liquid morphine is limited, immediate release morphine tablets are available. For continuous control of cancer pain, these have to be given every four hours, unless there ...
Sensi Chew Insomnia Plus 60MG CBD
Sensi Chew Insomnia Plus 60MG CBD

... mostly found in the peripheral organs and cells associated with the immune system. All of the cannabinoids found in cannabis work together to provide synergistic advantages with cells from both CB1 and CB2 receptors. In addition to cannabinoids and common to all plants used for compounding remedies ...
I. A few words about Medical Genetics
I. A few words about Medical Genetics

... crossing over, mutations, and environmental and other non-genetic influences all help assure that individuals throughout history are each unique. Religions also emphasize the importance of one's spiritual aspect (soul, spirit) and spiritual environment (such as the history of past actions) as influe ...
view presentation - Pacira Pharmaceuticals, Inc.
view presentation - Pacira Pharmaceuticals, Inc.

... • Improved dosing and administration – weekly and monthly profiles to improve PK/PD • Three active partnerships for multiple products and combinations of products – subcutaneous dosing • DepoFoam® provides a novel opportunity for long acting intrathecal injection for Multiple Sclerosis, Alzheimer's, ...
Course Intro and Expectations 2017
Course Intro and Expectations 2017

... • ~7000 coding sequence changes (non-synonymous variants). • ~500 amino acid substitutions predicted to be deleterious to gene function, the vast majority are in heterozygous state. • ~75 de novo SNPs acquired per generation ~7000 Mendelian inherited diseases (CF, DMD, etc) – these are defined as ra ...
Product Information
Product Information

... in healthy and transplant patients has been reported to reduce the exposure to the active metabolite, mycophenolic acid. This is possibly due to a decrease in mycophenolate mofetil solubility at an increased gastric pH. The clinical relevance of reduced mycophenolic acid exposure on organ rejection ...
highlights - Graef Lab
highlights - Graef Lab

... major problem. Writing in Chemistry and Biology, Schiffer and colleagues propose a novel structure-based strategy for combating drug resistance, using HIV-1 protease — for which several active-site inhibitors are approved — as an example. HIV-1 protease cleaves the HIV Gag and Pol precursor proteins ...
Stilizan ®
Stilizan ®

... Higher Doses: In physically healthy adults, the initials dose is 5 mg two times a day. Dosage can be increased up to 15 mg after one week. If more elevated doses are required, it should be administrated with 5 mg augmentations with the intervals less than 3 days. After achieving satisfactory results ...
WAUSAU HOSPITAL DRUG FORMULARY 2010
WAUSAU HOSPITAL DRUG FORMULARY 2010

... Physicians may request patient-specific consultation from the clinical pharmacy services for a variety of medication-related problems, including but not limited to those listed below. Patient Medication History Interview. On request, the pharmacist will interview patient and consult other resources ...
Use and Perceived Benefits of Handheld Computer
Use and Perceived Benefits of Handheld Computer

... opportunity to participate in the study followed by a 4-week period to synchronize their HCs. The survey had 5 sections: demographic information including physician specialty and years in practice; experience with healthcare technology including other HC applications; frequency of HC clinical refere ...
(zolpidem CR) Fact Sheet - The Main Line Center for the Family
(zolpidem CR) Fact Sheet - The Main Line Center for the Family

... • Most common: drowsiness and dizziness. • Does not alter normal sleep stages. • Anecdotal: uncommonly, can cause black outs (loss of memory of activities) soon after ingested if the patient does not go right to sleep. • Classified as a Schedule IV drug, but abuse potential is likely somewhat less t ...


... treatment of IPF, 81% of physicians stated that there are patients they would never start on drug therapy; reporting of severe symptoms by the patients was the most common criterion to initiate treatment [7]. However, once severe symptoms have developed in IPF, the disease is usually in an advanced ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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