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Insert Presentation title here
Insert Presentation title here

... Metabolic Syndrome Does Metabolic Syndrome exist or is it a sum of its risk components? ...
Microevolution Evolution within a population
Microevolution Evolution within a population

... Mutation Non-random mating Natural Selection ...
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File

... • Speciation refers to the formation of a new species. • There is an enormous diversification between species that evolution alone cannot explain. • A group of similar organisms that can interbreed and produce fertile offspring in the natural environment. ...
NedGeneticsCompRecomb12 51 KB
NedGeneticsCompRecomb12 51 KB

... If W+, no other pigments are made in the body of the flower, only in throat spots. If w-, the first block is released, allowing pink, or red if D+ is there. And finally, let me introduce the concept of suppressors, addressed briefly in the chart of modified ratios we discussed. -Suppressors are not ...
SEBs in Canada
SEBs in Canada

... • Released March 5, 2010: http://www.hcsc.gc.ca/dhp-mps/brgtherap/applicdemande/guides/seb-pbu/notice-avis_sebpbu_2010-eng.php • SEB approval: NDS with reduced data package • SEB sponsor to show a “demonstrated similarity” between the SEB and a suitable reference biologic drug • Well characterized p ...
Hypertension
Hypertension

... • Thiazide-type diuretics should be used in drug treatment for most patients with uncomplicated hypertension, either alone or combined with drugs from other classes. • Certain high-risk conditions are compelling indications for the initial use of other antihypertensive drug classes (ACEI, beta-bloc ...
Shared care Guidelines for prescribing valproate in
Shared care Guidelines for prescribing valproate in

... Common dose-related side effects of valproate include gastrointestinal pain, benign hepatic transaminase elevations, tremor and sedation. Patients with past or current hepatic disease may be at increased risk for hepatotoxicity. Mild, asymptomatic leukopaenia and thrombocytopaenia occur less frequen ...
Outcomes: MDA-NINDS Workshop
Outcomes: MDA-NINDS Workshop

... • Natural history data critical—Tools: RDCRNs, R01s and PAGs • Define primary efficacy endpoint & biomarkers—Tools: CREATE requires TPP & enables target engagement marker development • Determine manufacturing process early—Tools: process development/scale-up is a CREATE Bio Discovery Track activity ...
Current Concepts in Antiretroviral Therapy Failure - IAS-USA
Current Concepts in Antiretroviral Therapy Failure - IAS-USA

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Intravenous anesthetic agents
Intravenous anesthetic agents

... Is used as a short acting opioid antagonist because of its short duration of action opioid terminated depression may return when effect of Nalaxone have terminated Nalaxone may precipitate the sympathetic drive of unrelieved pain (tachycardia, ...
Drugs and Alcohol 3 Lessons
Drugs and Alcohol 3 Lessons

... Why People Take Drugs • Just as there are many kinds of drugs available, there are as many reasons for trying them or starting to use them regularly. • People take drugs just for the pleasure they believe they can bring. • Often it's because someone tried to convince them that drugs would make them ...
Chapter 7: Extending Mendelian Genetics
Chapter 7: Extending Mendelian Genetics

... The inactive X chromosome is silenced by it being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin (silencing of genes) X-inactivation prevents them from having twice as many X chromosome gene products (RNA or proteins) as males, which only possess a s ...
Genes
Genes

... Hyman’s mother must carry two normal alleles, because she does not have M.S. Second, because Hyman’s father has M.S. it is very likely that Hyman inherited a defective fibrillin allele from him. The fact that her sister also had M.S. makes this virtually certain. Third, is M.S. inherited as a domina ...
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... Amplification of Allergic reaction ...
Commonly used drugs - British Kidney Patient Association
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... (Mycophenolic acid; ‘Myfortic’) should not to be confused with the similar-sounding drug mycophenolate sodium (mycophenolic acid, or ‘Myfortic’) which must not be prescribed in its stead. Very strong: ciclosporin (‘Neoral’) or tacrolimus (‘Prograf’) or sirolimus Note: all these tablets have side eff ...
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Study Problems for Quiz 1

... a) You conclude that the Piggy phenotype results from a combination of mutations in two different genes (that assort independently). You also propose that a worm homozygous for a recessive mutation in only one of these genes has a wild-type phenotype. Why did you propose that two genes were involved ...
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... technology to create particle-based ocular therapeutics that can deliver both small and large molecules in multiple formats. Envisia’s lead product, ENV515, is a marketed prostaglandin analogue that uses a proprietary, fully biodegradable PRINT particle formulation to provide sustained intraocular p ...
Lecture 4 pdf
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Chapter 5 Over the counter drugs[1].
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... sedative. Its use as an OTC drug for the treatment of respiratory illness is extremely overated and can have debilating side effects. ...
fentanyl citrate lollipop, Fentora
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... sources and development of bronchodilators that were more effective. Heliox resurfaced in the early 1980s when asthma deaths began to rise despite advances in medicine ...
Morphine
Morphine

... opiates and exhibit withdrawal symptoms if opioids are not administered. Only a small percentage of morphine crosses the blood-brain barrier, because of its low lipophilicity. Morphine is metabolized in the liver and excreted in the urine. Fate: Morphine is conjugated in the liver to glucuronic acid ...
5.5 Illicit drug use—current and future issues
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... showed that in 2011–12, the total number of pharmaceuticals detected at Australian borders (imported illegally) increased by 10 per cent, from around 1,200 in 2010–11 to 1,300 in 2011–12, the highest reported in the last decade. The majority (97%) of these detections were benzodiazepines. The total ...
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IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)

... the drug, while the animals in the control group were physically active. The exact biochemical mechanism responsible for the decrease in the physical activity, feed and water intake is a recommendation for further study. Hence, it may be attributed to the chemical constituents of the drug administer ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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