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Emerging options for the management of scorpion stings
Emerging options for the management of scorpion stings

... syndrome, the latter occurring mostly in children during viral infections treated by salicylates.37 The incidence of Reye’s syndrome, the symptoms of which can be confused with worsening of envenoming, is low at about 0.8 cases per million children,38 but is often fatal. Therefore, it is necessary t ...
Biowaiver extension potential to BCS Class III high solubility
Biowaiver extension potential to BCS Class III high solubility

... Thus, it is evident that if the formulation of metformin IR product is rapid dissolving, dissolution will not affect availability of metformin. Using the rationale of the BCS, it can be argued that biowaivers can be granted for metformin IR products on the basis of in vitro dissolution profiles. The ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... Classroom Response Question Which statement does the nurse include when teaching a patient about disulfiram (Antabuse) therapy? A. “Disulfiram (Antabuse) will cure your alcoholism if you take it as directed.” B. “If you drink alcohol after taking disulfiram (Antabuse), your blood pressure will get ...
Waddington`s Legacy in Development and
Waddington`s Legacy in Development and

... especially ammonites which he collected and studied with a passion. Known as "Con" to his relatives and friends, he established at an early age what was known as Con's museum; a collection of biological, geological and archaeological specimens. An avid interest and ability in natural C. H. WADDINGTO ...
Mykofenolatmofetil Actavis film
Mykofenolatmofetil Actavis film

... Mykofenolatmofetil Actavis. Physicians should ensure that women and men taking mycophenolate understand the risk of harm to the baby, the need for effective contraception, and the need to immediately consult their physician if there is a possibility of pregnancy. Contraception (see section 4.6) Beca ...
NAUSEA What`s the Problem, and How Do You Diagnose It
NAUSEA What`s the Problem, and How Do You Diagnose It

... Natural anti-nausea substances. In addition to all the anti-nausea medications discussed below, there are several natural substances that are very often effective. Since they have no side effects, are inexpensive, and are commonly available, they might be the best place to start in seeking help for ...
Lidoderm (Lidocaine Patch 5%)
Lidoderm (Lidocaine Patch 5%)

... Excessive dosing by applying LIDODERM to larger areas or for longer than the recommended wearing time could result in increased absorption of lidocaine and high blood concentrations, leading to serious adverse effects (see ADVERSE REACTIONS, Systemic Reactions). Lidocaine toxicity could be expected ...
psychiatric aspects of marihuana intoxication
psychiatric aspects of marihuana intoxication

... Marihuana has been known as a passport to euphoria since ancient times. It has fascinated men of imagination, and descriptions of its effects upon the mind and body have been given in popular and scientific literature countless times. The literature has been adequately considered by Walton (1) and b ...
Codeine and its Alternates for Pain and Cough Relief
Codeine and its Alternates for Pain and Cough Relief

... (1953) and Bucher (1958). Experiments of Friebel & Hahn (1966) in conscious guinea-pigs gave evidence of a remarkable ability of the cough centre to store the afferent impulses. The animals reacted with an explosive expulsion of air, on the average 2.8 seconds after an appropriate electrical stimula ...
Management of b-Adrenergic Blocker and Calcium Channel Antagonist Toxicity
Management of b-Adrenergic Blocker and Calcium Channel Antagonist Toxicity

... compromise, many will have abrupt central nervous system depression with loss of airway protective reflexes and require intubation and mechanical ventilation. For patients that present with hallmark bradycardia and hypotension, atropine and normal saline fluid bolus are reasonable initial therapies. I ...
PART I B SUMMARY OF PRODUCT CHARACTERISTICS
PART I B SUMMARY OF PRODUCT CHARACTERISTICS

... section 4.5). Clarithromycin must not be used in patients with congenital or documented acquired QT prolongation or history of ventricular arrhythmia (see section 4.3). Pneumonia: In view of the emerging resistance of Streptococcus pneumoniae to macrolides, it is important that sensitivity testing b ...
Cephalosporins
Cephalosporins

... Ceftriaxone may be associated with a decrease in prothrombin activity (prothrombin time and partial thromboplastin time), leading to an increased risk of bleeding. Patients at risk include those with renal impairment, liver disease, or impaired vitamin K synthesis or storage. Hypersensitivity reacti ...
A View of Life
A View of Life

... Inheritance of Blood Type ...
TCCC Change Prop 1403 Ondansetron 150403 JSOM
TCCC Change Prop 1403 Ondansetron 150403 JSOM

... pricing of generic ondansetron, its potential benefits versus the risks of promethazine make this a good time to re-evaluate the preferred medication for nausea and vomiting in combat casualties. The Case for ondansetron Ondansetron is used as an antiemetic with the FDA indications for treatment of ...
Neurochemical Enhancement of Conscious Error Awareness
Neurochemical Enhancement of Conscious Error Awareness

... arose if the same word was presented on two consecutive trials (“repeat no-go”) and the second if the word and its font color matched (“color no-go”) rather than the typical word and color incongruency (for examples, see Fig. 1). By having two competing types of response inhibition, we aimed to vary ...
sodium lactate - Pfizer Injectables
sodium lactate - Pfizer Injectables

... limited use has been inadequate to fully define proper dosage and limitations for use. Geriatric Use An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should ...
MATCH - Kansas Healthcare Collaborative
MATCH - Kansas Healthcare Collaborative

... noted that 36 percent of patients had errors in their admission medication orders with the majority of these occurring during the medication history gathering phase.4 A study utilized 12 years of administrative records of all hospitalizations and outpatient prescriptions for almost 400,000 patients ...
Medication Handling in NSW Public Health Facilities
Medication Handling in NSW Public Health Facilities

... This policy consolidates best practice principles on medication procurement, possession, storage, prescribing, dispensing, supplying, administering and recording at NSW public health facilities with the requirements of the NSW Poisons and Therapeutic Goods Act 1966 and the Poisons and Therapeutic Go ...
H alfLytely and B isacodyl Tablet B ow el P rep K it M e d ica tio n G
H alfLytely and B isacodyl Tablet B ow el P rep K it M e d ica tio n G

... The recommended HalfLytely and Bisacodyl Tablet Bowel Prep Kit oral dosage regimen for adults on the day prior to colonoscopy is as follows: • No solid food or milk (clear liquids only) should be consumed on the day of the preparation. • Take one 5 mg bisacodyl delayed-release tablet with water. Do ...
sodium lactate
sodium lactate

... limited use has been inadequate to fully define proper dosage and limitations for use. Geriatric Use An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should ...
August  II,2000 VIA  Fax:  301.8275562 and  Fed-Ex Attention:
August II,2000 VIA Fax: 301.8275562 and Fed-Ex Attention:

... concentration, five breaths are administered by a nebulizer that permits intermittent delivery time of 0.6 seconds by a breath-actuated timing device (dosimeter). At each of five inhalations of a serial concentration, the subject begins at functional residual capacity (FRC) and slowly and completely ...
Implementing array comparative genomic hybridization in male
Implementing array comparative genomic hybridization in male

... Some work has been done to identify additional candidate genes via animal model approaches, but there have been several limitations to identify novel genes associated with male infertility. These limitations include inappropriate controls, single gene analysis, lack of family pedigrees to corroborat ...
Substance Abuse: Cocaine This course expires on June 26, 2016.
Substance Abuse: Cocaine This course expires on June 26, 2016.

... and physical assessment. Kim graduated with a nursing diploma from Foothills Hospital School of Nursing in Calgary, Alberta in 1989. She achieved her Bachelor in Nursing through Athabasca University, Alberta in 2000, and her Master of Science in Nursing through University of Phoenix in 2005. Kim is ...
03_Intravenous infusion and Laplace
03_Intravenous infusion and Laplace

... concentration of a drug with one compartment PK resulting from the administration of an IV infusion (K0= Css∙Cl ) and a loading bolus (LD= Css∙Vd) that was given at the start of the infusion ...
Type 2 Diabetes
Type 2 Diabetes

...  Nephropathy  End-stage kidney disease  Increased risk of death from cardiovascular disease ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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