• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Medical Complications of Cocaine Addiction
Medical Complications of Cocaine Addiction

... Normally, ischemia occurs within minutes to 36 hours after cocaine use (Jaffe, Rawson, & Ling, 2005, Stein, 1999). Most cocaine users with myocardial ischemia or infarction present with chest pain within one-hour post use, at which time drug serum levels are at a peak. In some cases vasoconstriction ...
Digoxin and mortality in atrial fibrillation: a prospective cohort study
Digoxin and mortality in atrial fibrillation: a prospective cohort study

... included after selection by a stepwise procedure using the Akaike information criteria (AIC) for inclusion/exclusion. All included variables and interactions are shown in Table 1. When analyzing possible sex-based differences, sex was excluded from the propensity score. The propensity score was then ...
Effects of Commonly Used Benzodiazepines - E
Effects of Commonly Used Benzodiazepines - E

... The approximate half-life ranges are long, 48 hours or more; intermediate to long, 24 to 48 hours; short to intermediate, 10 to 24 hours; and short, 10 hours or less. The U.S. Food and Drug Administration (FDA) has devised a system of pregnancy categories based on the degree to which available infor ...
Table of Contents
Table of Contents

... adults.  Superficial Basal Cell Carcinoma: Imiquimod Cream is indicated for the topical treatment of biopsy-confirmed, primary superficial basal cell carcinoma (sBCC) in immunocompetent adults, with a maximum tumor diameter of 2.0 cm, located on the trunk (excluding anogenital skin), neck, or extre ...
Print this article - Hospital Chronicles
Print this article - Hospital Chronicles

... the systemic vascular resistance by 20% and by 40% from baseline resting values. Methods: Three studies were identified in the literature which reported epinephrine, dopamine, and sodium nitroprusside infusion doses with corresponding SVR responses. Infusion doses were normalized to mcg/kg/min and S ...
EES Granules - Arbor Pharmaceuticals
EES Granules - Arbor Pharmaceuticals

... stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Drug Interactions Theophylline   Erythromycin use in patients who are receiving high doses of theophylline may ...
Fibromyalgia treatment update Daniel S. Rooks Introduction
Fibromyalgia treatment update Daniel S. Rooks Introduction

... and pain in women with fibromyalgia compared to a group that did no exercise. After detraining, strength and quality of life improvements were maintained, whereas pain severity was not. Strength training, particularly in older adults, has become an expanding area of research due to its many health a ...
Public Summary Document (PSD) March 2016 PBAC Meeting
Public Summary Document (PSD) March 2016 PBAC Meeting

... nominated the eligible population as those for whom treatment with VEGF inhibitors is not the preferred treatment option. Therefore, the proposed population contains patients who would otherwise be treated with a VEGF inhibitor in the absence of an alternative, as well as those who have a contraindi ...
"Marijuana - Not Just Blowing Smoke"
"Marijuana - Not Just Blowing Smoke"

... Marijuana: Not Just Blowing Smoke Global Research and Development ...
PDF - Innovare Academic Sciences
PDF - Innovare Academic Sciences

... Successful oral delivery of drugs has always remained a challenge to the drug delivery field, since approximately 40% of the new drug candidates have poor water solubility, and thus oral delivery is frequently associated with implications of low bioavailability. Today, a large percent of the new che ...
establishing similarity between multisource betahistine
establishing similarity between multisource betahistine

... is approved in more than 80 countries and since its first approval in 1968 more than 130 million patients used BHD (5). Pharmacodynamic studies have shown that betahistine acts as a neurotransmitter modulator of the complex histaminergic receptor ...
Practice Guidelines for Sedation and Analgesia by Non
Practice Guidelines for Sedation and Analgesia by Non

... likelihood of adverse outcomes such as cardiac arrest and death. The Task Force agrees that hypoxemia during sedation and analgesia is more likely to be detected by oximetry than by clinical assessment alone. Hemodynamics: Although there is insufficient published data to reach a conclusion, it is th ...
Solubility enhancement technique for an anti-malarial
Solubility enhancement technique for an anti-malarial

... dihydro orotate dehydrogenase (DHODH). Atovaquone is a unique naphthoquinone with broad-spectrum of antiprotozoal activity. It is effective for the treatment and prevention of malaria. Atovaquone is currently used as a fixed-dose combination with proguanil (Malarone) for treating children and adults ...
Quinine Sulphate Tablets 200mg [jeb]
Quinine Sulphate Tablets 200mg [jeb]

... inadequately controlled malarial infection may precipitate an attack of blackwater fever. However, in some cases deficiency of glucose-6-phosphate dehydrogenase may have been involved. Glucose-6phosphate dehydrogenase deficient patients with malaria or taking quinine to treat leg cramps may be at an ...
Neuropathic Pain: Treatment Options Report November 2006
Neuropathic Pain: Treatment Options Report November 2006

... perceived safety. Unfortunately, the antidepressants and antiepileptics may require a long titration period to reach effective therapeutic levels; therefore, other medications, such as opioid analgesics, tramadol, and the lidocaine 5% transdermal patch, may be more convenient to use initially. Prega ...
product monograph serc
product monograph serc

... SERC® is highly metabolized primarily by the liver. No pharmacokinetic data are available in patients with hepatic impairment. Caution is advised with use of SERC® in this population. Recommended Dose and Dosage Adjustment The usual daily dosage range is 24 to 48 mg administered orally in divided do ...
The Magic Mint - Stephanie Nichole Halbleib
The Magic Mint - Stephanie Nichole Halbleib

... • Activated endogenous by peptides (like endorphins), or exogenously by alkaloid opiates (such as morphine) • Signal transduction is theorized as follows: – Activation is coupled to the G protein which increases phosphodiesterase activity – Breaks down cAMP, producing an inhibitory effect in neurons ...
Mosaic Isodicentric Y Chromosome in a Patient with Mixed Gonadal
Mosaic Isodicentric Y Chromosome in a Patient with Mixed Gonadal

... chromosome Y probe revealed that the derivative chromosome is a Y chromosome, without translocation a heterochromatic region on Yq was not observed by CBG banding. FISH examination by probes for the SRY region and whole chromosome Y revealed that the derivative chromosome is a Y chromosome, and one ...
E20
E20

... 1). It was suggested that plant height segregation of the DH population fit normal distribution for most stages in both locations and was suitable for QTL analysis. Transgressive segregants taller than the tall parent Azucena or lower than the short parent IR64 were observed at all stages. QTL for p ...
digoxin - DavisPlus
digoxin - DavisPlus

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A
Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A

... modulation of the activity, i.e., inhibition or induction, of cytochrome P450 (CYP) enzymes and transporters. Clinicians, prescribing the drug and pharmacists—often involved in medication review, therapeutic drug monitoring (TDM), or consultation on drug choice or dose—should be aware of clinically ...
How appropriate is antibacterial use in the community?
How appropriate is antibacterial use in the community?

...  proportion of visits to GPs for acute upper respiratory tract infections where antibacterials were prescribed increased from 29.6% in 200910 to 32.8% in 201112 and decreased to 29.0% in 201314. In residential aged-care facilities, the acNAPS data showed that about one in five prescriptions (21. ...
View/Open
View/Open

... multiple antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. In response, Artemisinin based Combination Therapies (ACTs) have been implemented in almost all malaria endemic areas in an attempt to reduce emergence of resistance. For instance, a combination of ...
Review of application by Expert Committee Member
Review of application by Expert Committee Member

... culture blunting the drop in temperature during the study period or antibiotherapy intake before the drug administration, these previous factors changing the antipyretic efficacy were not always taken into account in the studies. Moreover, the evidence suggests that the effect on pyrexia is equal fo ...
Evolution of medical treatment for endometriosis: back to the roots?
Evolution of medical treatment for endometriosis: back to the roots?

... Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and painalleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of ...
< 1 ... 74 75 76 77 78 79 80 81 82 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report