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gene mapping, marker gene mapping, marker-assisted
gene mapping, marker gene mapping, marker-assisted

... The research goal is to provide necessary scientific and technological information for improving the catfish broodstocks by MAS, introgression of important QTLs from channel catfish and blue catfish and genetic engineering using beneficial genes. To reach this goal, initial steps are to construct ge ...
this PDF file
this PDF file

... used for the treatment of prostate cancer (2,3). Although there has been significant scientific, as well as, commercial progress in this area, the understanding of this technology remains limited to a few global companies. This is primarily because of the complexities involved in the polymer chemist ...
full document
full document

... The first study with a PID controller-based automatic drug delivery system for propofol anesthesia in children is presented. It is shown that a robustly tuned PID controller is capable of delivering safe and adequate anesthesia. The design process of the control system is reviewed. Results are discu ...
Neuroscience Letters Withdrawal-like behavior
Neuroscience Letters Withdrawal-like behavior

... withdrawal from opioids, cannabinoids, stimulants and benzodiazepines. This suggests that planarians display a withdrawal-like behavior that can be quantified as a reduction in locomotor activity. Because withdrawal-like behavior in previous studies has been quantified only following the cessation of ...
Imitrex - GlaxoSmithKline
Imitrex - GlaxoSmithKline

... diagnosed as migraineurs, and in migraineurs who present with atypical symptoms, care should be taken to exclude other potentially serious neurological conditions. If a patient does not respond to the first dose, the opportunity should be taken to review the diagnosis before a second dose is given. ...
Diagnosis and Treatment of Common Headache Syndromes:A
Diagnosis and Treatment of Common Headache Syndromes:A

... and urinary retention [11]. Because these drugs must cross the blood brain barrier to exert their therapeutic effects, patients being started on the antidepressant compounds should be informed that although their sleep patterns may begin to improve in a few days, headache relief generally takes 3-4 ...
Full Text Article
Full Text Article

... ADRs may not manifest during the trials and are thus missed out. Once the drug is marketed, its safety is not completely identified and is used by clinicians in different ways and in varied populations on large number of patients. Thus many newer ADRs may be reported all of which need to be document ...
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THE RELATIONSHIP BETWEEN METHYLATION AND GENES

... A thesis submitted in partial fulfilment of the requirements of Bournemouth University for the degree of Doctor of Philosophy ...
Gene Mapping, Marker-Assisted Selection, Gene Cloning, Genetic
Gene Mapping, Marker-Assisted Selection, Gene Cloning, Genetic

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Importance of NMDA Receptor Activation During Initial
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EASL Recommendations on Treatment of Hepatitis C 2015
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mandated use of state prescription drug monitoring programs
mandated use of state prescription drug monitoring programs

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Dow Corning Silicones in Pharmaceutical Applications
Dow Corning Silicones in Pharmaceutical Applications

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Sedation and anesthesia in GI endoscopy
Sedation and anesthesia in GI endoscopy

... However, most endoscopists favor midazolam for its fast onset of action, short duration of action, and high amnestic properties.3 Opioids, such as meperidine and fentanyl administered intravenously, provide both analgesia and sedation. Fentanyl has a more rapid onset of action and clearance and has ...
Bone density vs bone quality - Cleveland Clinic Center for
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... armodafinil, amantadine and L-carnitine should be further examined. Consensus is needed regarding fatigue outcome parameters for clinical trials. ...
DP-Anastrozole
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Actinic prurigo - British Association of Dermatologists
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PPT File
PPT File

... a good prognosis) 2. When HSCT is not urgent and clinically can be postponed by at least 9 to 12 months 3. If not available locally or nationally  collaboration with another center (IHR & RGI: Established clinical collaborations with >100 different centers worldwide) ...
SPS Primer on Pediatric Sedation
SPS Primer on Pediatric Sedation

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Chapter 2. Left in the Genes - SciTech Connect
Chapter 2. Left in the Genes - SciTech Connect

... that found in families where the parents are both right-handed. Adopted children and their adopted parents do not show the resemblance patterns seen in biologically related pairs. This combined evidence bolsters a search for a handedness gene. However, the majority of children of all parental pairin ...
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... established. However, diminished rates of conception and of survival at weaning were observed in rats, in a dose related manner. Studies in dogs suggest that this may be due to diminished seminal secretion, which is evident at high doses of Glycopyrronium bromide. The significance of this for man is ...
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Development of nanovectors for the targeted drug delivery of antimalarials Patricia Urbán
Development of nanovectors for the targeted drug delivery of antimalarials Patricia Urbán

... hypoglycaemia, renal failure, acute pulmonary oedema and multi-organ system failure. If not treated, severe malaria is fatal in the majority of cases, and pregnant women are at high risk of dying from complications of this form of the disease. Malaria is also a cause of spontaneous abortion, prematu ...
Neuropharmacological Dissection of Placebo
Neuropharmacological Dissection of Placebo

... Drug administration. All drugs used in the present study were administered through an intravenous line. Before starting the experimental procedure, a needle was inserted into a vein of the dominant forearm. The needle was connected to a line, 1 m long, through which a slow inf usion of 5% glucose so ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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