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Methadone-Associated Mortality
Methadone-Associated Mortality

... when misused, the articles often did not balance that negative perspective with positive information about how the drugs provide vital relief to persons suffering from serious pain and, in the case of methadone, opioid addiction. The articles tended to perpetuate long-standing myths and misconceptio ...
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Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
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... Decongestants may cause hypertension, palpitations, and CNS stimulation—avoid in patients with these conditions Patients on medication therapy for hypertension should check with their prescriber before taking over-the-counter decongestants Assess for drug allergies ...
Chemotherapy-Induced Nausea and Vomiting
Chemotherapy-Induced Nausea and Vomiting

... In the past 20 years, one of the most important advances in research on chemotherapy-induced nausea and vomiting has been the recognition of the critical role played by 5-HT. Of the multiple 5-HT receptors identified to date, the 5-HT3 receptor appears to be most important in the acute phase of chem ...
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Document

Oxycodone and Acetaminophen Tablets USP 5
Oxycodone and Acetaminophen Tablets USP 5

... Agonist/antagonist analgesics (i.e., pentazocine, nalbuphine, and butorphanol) should be administered with caution to a patient who has received or is receiving a course of therapy with a pure opioid agonist analgesic such as oxycodone. In this situation, mixed agonist/antagonist analgesics may redu ...
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Pharmaceutical Administration and Regulations in Japan (2015)

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A Guide to Aerosol Delivery Devices for Respiratory Therapists
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Thyroxine Sodium - Therapeutic Goods Administration
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PRODUCT MONOGRAPH METADOL
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PrKETOTIFEN OPHTHALMIC SOLUTION
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state of oklahoma
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Fixed Combinations of Glaucoma Medications
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... There have been a number of concerns about the use of multiple bottles of glaucoma medications, such as increased toxicity of ophthalmic preservatives in multiple drugs, compliance, costs and washout effects [7, 8]. Complex dosing regimens have been clearly associated with nonadherence to medical th ...
Pharmacokinetic interactions related to the chemical structures of
Pharmacokinetic interactions related to the chemical structures of

... were also reported to increase plasma or serum theophylline concentrations, although no marked clinical symptoms were noted. A weak interaction with theophylline, without accompanying clinical effects, was also found for both ofloxacin and norfloxacin (Niki et al., 1987), yet no significant interact ...
Relanio inhalation 50_250 microgram 50_500 microgram per dose
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The following table lists plants and herbal remedies proven or
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Review of Anticoagulation Therapies in Atrial Fibrillation
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... education programs should be developed. In addition a campaign aimed at improving the awareness of AF should be developed for both health professionals and consumers. The most common antithrombotic medicines that are used for the reduction of stroke risk at the present time are the anticoagulant war ...
Partitioning Genetic Variance
Partitioning Genetic Variance

... necessarily lead to a statistical interaction3. Classic examples of epistasis for behavior can be seen in many rare genetic disorders. A Tay-Sachs genotype, for example, interacts with those loci that contribute to individual differences in normal cognitive development during infancy. If an infant h ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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