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My Big Data Experience - Getting my Feet Wet in the PUddle and Still Treading Water 2 Years Later
My Big Data Experience - Getting my Feet Wet in the PUddle and Still Treading Water 2 Years Later

... Truven MarketScan® [US] – (>140m patient lives) The above two data sources are very similar. There is a distinct start and stop date to each patient’s periods of enrolment in the health insurance plan (including what type of coverage they have e.g for drugs, mental health, etc.) which can be used to ...
iCup 10 Panel Drug Screening Kit Insert
iCup 10 Panel Drug Screening Kit Insert

... Phencyclidine is used in powder, capsule, and tablet form. The powder is either snorted or smoked after mixing it with marijuana or vegetable matter. Phencyclidine is most commonly administered by inhalation but can be used intravenously, intra-nasally, and orally. After low doses, the user thinks a ...
Hitchhiking to Speciation
Hitchhiking to Speciation

... these cases, the genetic basis of speciation is, effectively, the genetics of adaptation. But hybrid sterility and lethality have historically posed two special problems. Darwin [4] devoted an entire chapter of his Origin of Species to the first problem: as the sterility or lethality of hybrids prov ...
Aspects of successful drug discovery and
Aspects of successful drug discovery and

... safe metabolism, distribution, excretion, etc.) prove to be insurmountable. Projects can also be halted for quite different reasons such as poor patent protection, unexpected strong competition, lack of differentiation or innovation compared to other internal or external products in development, man ...
You Light Up My Life
You Light Up My Life

... A more or less continuous range of small differences in a given trait among individuals The greater the number of genes and environmental factors that affect a trait, the more continuous the variation in versions of that trait ...
Chapter 14: Mendel and the Gene Idea
Chapter 14: Mendel and the Gene Idea

... • Mendel developed a hypothesis to explain the 3:1 inheritance pattern he observed in F2 offspring • Four related concepts make up this model • These concepts can be related to what we now know about genes and chromosomes • The first concept is that ___________________________ of genes account for v ...
Chapter 23: The Evolution of a Population
Chapter 23: The Evolution of a Population

... • Average heterozygosity= average percent of loci that are heterozygous in a population • Fixed loci= all individuals in a population have same allele – Nucleotide variability • Measured by comparing the DNA sequences of pairs of individuals ...
56 Management of Hypertension – Role of Combination Therapy
56 Management of Hypertension – Role of Combination Therapy

... This combination can be suggested for the treatment of hypertensive patients with nephropathy, CHD or established atherosclerosis. The combination displays pronounced antihypertensive activity. Ca-antagonists are known to have anti-ischemic activity in CHD. ACE-inhibitors are proved to be renoprotec ...
EP FELLOWSHIP CORE CURRICULUM Introduction Basic
EP FELLOWSHIP CORE CURRICULUM Introduction Basic

... Objectives: To learn the pathogenesis of the full gamut of arrhythmias, related symptom complexes and syndromes, and neurocardiac diseases and to understand the technique, application, indications, limitation, sensitivity and specificity of the various non-invasive and invasive diagnostic tests. The ...
Selected examination methods in toxicology
Selected examination methods in toxicology

... biological material by means of several criteria, each of which enables classification of the detected drug or metabolite to certain group. An advantage of TLC screening is detection of a fairly wide range of substances and their metabolites and also ability to resolve the particular components in a ...
CHB_Prescribe_012_ EPR clinical checking and supply requests
CHB_Prescribe_012_ EPR clinical checking and supply requests

RTC ANTIBIOTICS CEPHALOSPORINS AND PENICILLINS
RTC ANTIBIOTICS CEPHALOSPORINS AND PENICILLINS

... • Bioavailability - percentage of an administered dose that reaches the circulation • Half-life – time required for halving of blood concentration – Function of clearance and volume of distribution ...
One Step Drug Test
One Step Drug Test

... after mixing it with marijuana or vegetable matter. Phencyclidine is most commonly administered by inhalation but can be used intravenously, intra-nasally, and orally. After low doses, the user thinks and acts swiftly and experiences mood swings from euphoria to depression. Self-injurious behavior i ...
17.Ramdas T. Dolas, Dr. Avinash Hosmani and Sachin B. Somwanshi
17.Ramdas T. Dolas, Dr. Avinash Hosmani and Sachin B. Somwanshi

... Raft forming systems incorporate alginate gels. These have a carbonate components and upon reaction with gastric acid, bubbles form in gel, enabling the floating. The raft floats because of the buoyancy created by carbon dioxide formation. The mechanism involves the formation of cohesive gel in cont ...
CONVULSIVE TAILS
CONVULSIVE TAILS

... Takes 30 minutes to administer Requires a syringe driver Requires a large IV (NOT central) line Requires cardiac monitoring for potential cardiac toxicity  Can only be given by IV route  Cannot be repeated  It not as effective as phenobarbitone DeToledo & Ramsay; Drug Saf 2000 Trieman et al; NEJM ...
GENITAL HERPES, GONOCOCCAL, AND CHLAMYDIAL
GENITAL HERPES, GONOCOCCAL, AND CHLAMYDIAL

... to a 7-day regimen was good. In populations with poor compliance or minimal follow-up, azithromycin may be more effective because it provides single dose, directly observed therapy. Azithromycin is a first-line agent recommended for the treatment of chlamydial infections in pregnancy. Azithromycin i ...
Safety of Chinese Herbal Medicine
Safety of Chinese Herbal Medicine

... practitioners for two reasons. First and foremost, because, as practitioners, we must strive to give patients the best possible care and minimize possible side-effects and adverse reactions; secondly, we need to be seen to practise in a professional and responsible manner that ensures the maximum sa ...
A Dubious Diagnosis - Children's Mercy Kansas City
A Dubious Diagnosis - Children's Mercy Kansas City

... control households, the rate was 12.6%. Among households with attention-disordered children older than 8, the comparable rates were 15.3% for children with ADHD, 10.7% for controls. Wymbs, Pelham et al. J Cons Clin Psychol. 2008. ...
here - Student Services - Touro University California
here - Student Services - Touro University California

... lowered self‐control often leads to the aggressive behavior associated with those who drink.  Alcohol use  can also quickly cause dehydration, coordination problems, and blurred vision.  ...
Sub-Therapeutic Doses in the Treatment of Depression: The
Sub-Therapeutic Doses in the Treatment of Depression: The

... based on either literature averages with the caveat, “which may have beneficial effects for some patients” or based on response in individual patients, adhering to the literal nature of the term. Seven participants highlighted the difficulties in predicting patient sensitivity to a new prescription. ...
Generic Name - UHN Research
Generic Name - UHN Research

... qualified medical practitioner knowledgeable about Cardiovascular illness and the treatments in question. Due to the rapidly changing nature of cardiovascular treatments and therapies, users are advised to recheck the information contained herein with the original source before applying it to patien ...
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES AND
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES AND

... resides in the organ of reticuloendothelial system (RES). The commonly prescribed drugs are antimonials, which are related to arsenic, and at high concentration they damage the heart, liver and kidney. ...
Warfarin Initiation Guidelines
Warfarin Initiation Guidelines

... Initiation strategies using 10 mg warfarin doses have been tested in randomized trials and are supported in published guidelines. Practitioners experienced in anticoagulation initiation may choose to use a 10mg initiation protocol in appropriately selected patients. The 10 mg initiation should only ...
document - South West London and St George`s Mental Health NHS
document - South West London and St George`s Mental Health NHS

... Treatment of Alzheimer’s disease (including mixed Alzheimer’s dementia) with acetylcholinesterase inhibitors (AChEIs) for mild to moderate severity, or memantine for moderate severity (where AChEIs cannot be used) or in severe disease. Additionally, the use of rivastigmine for Parkinson’s disease De ...
Side effects
Side effects

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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