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document - South West London and St George`s Mental Health NHS
document - South West London and St George`s Mental Health NHS

... Treatment of Alzheimer’s disease (including mixed Alzheimer’s dementia) with acetylcholinesterase inhibitors (AChEIs) for mild to moderate severity, or memantine for moderate severity (where AChEIs cannot be used) or in severe disease. Additionally, the use of rivastigmine for Parkinson’s disease De ...
Antibiotic Use in Agriculture: Background and Legislation CRS Report for Congress
Antibiotic Use in Agriculture: Background and Legislation CRS Report for Congress

... Notes: With regard to human medicine importance, FDA ranks antibiotics as “critically important” (“critical” in the above table), “highly important” (“high” in the table), or “important.” The ranking is based on five criteria from the most important (it is used in treating pathogens that cause foodb ...
Side effects
Side effects

Review sheet – Chapter 9
Review sheet – Chapter 9

... Cc; c x c = cc; C x c = Cc, and c x c = cc) See examples from your slides for this… Be able to explain why inbreeding increases the risk of genetic disorders in offspring produced by such pairings Understand that Huntington’s disease is caused by a dominant allele Understand what incomplete dominanc ...
T - Sites
T - Sites

... 1) Use the same letter for dominant & recessive genes: _____________ Tt not tT 2) If Heterozygous: The dominant (Capitol ) letter comes first.Bb ___________ ...
Genetic Metabolic Diseases I
Genetic Metabolic Diseases I

... 3. Postnatal Testing – Women who are pregnant are essentially housing a parasite – a parasite that is not only “sucking the life out of them” but is also sending cells from the placenta into their circulation. Most of the time, there isn’t any harm as a result though. Peripheral blood can be drawn f ...
prescribing information
prescribing information

... Adverse reactions to corticosteroids may be produced by too rapid withdrawal or by continued use of large doses. To avoid drug induced adrenal insufficiency, supportive dosage may be required in times of stress (such as trauma, surgery, or severe illness) both during treatment with fludrocortisone a ...
Lambda, J.K., et al. 2002. Genetic contribution to variable human
Lambda, J.K., et al. 2002. Genetic contribution to variable human

... variable homeostatic control mechanisms, disease states that alter homeostasis, up- or down-regulation by environmental stimuli (such as smoking, drug intake, or diet), and genetic mutations. This review summarizes the current understanding and implications of genetic variation in the CYP3A enzymes. ...
PrVISANNE
PrVISANNE

... During treatment, patients are advised to use non-hormonal methods of contraception (eg, barrier method) if contraception is required. Hormonal methods of contraception should not be used in combination with VISANNE. As VISANNE is a progestin-only therapy, it can be assumed that special warnings and ...
Catabasis Pharmaceuticals Announces Top
Catabasis Pharmaceuticals Announces Top

a to z guide of illicit and licit drugs
a to z guide of illicit and licit drugs

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GASTROINTESTINAL DRUGS
GASTROINTESTINAL DRUGS

... oPPI + Tetracycline + Metronidazole + CBS ...
Syva EMIT II Plus 6-Acetylmorphine Assay
Syva EMIT II Plus 6-Acetylmorphine Assay

... System and examined precision, linearity, accuracy, crossreactivity with structurally related opioids, and potential interference from endogenous substances and structurally unrelated drugs.5 In the semi-quantitative mode, the authors reported repeatability and withinlab precision of < 4% CV. Testin ...
Nonsteroidal Anti-inflammatory Drugs
Nonsteroidal Anti-inflammatory Drugs

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Avapro - Sanofi Canada
Avapro - Sanofi Canada

... and an increase in AER of ≥ 30% from baseline). In addition, after 1 and 2 years of treatment, the effect of irbesartan on the change in overnight AER and the change in 24-hour creatinine clearance was assessed. The most important exclusion criteria were: onset of type II diabetes mellitus at < 20 y ...
DIAZEPAM Oral Solution 5 mg per 5 mL DIAZEPAM
DIAZEPAM Oral Solution 5 mg per 5 mL DIAZEPAM

... As with other agents which have anticonvulsant activity, when diazepam is used as an adjunct in treating convulsive disorders, the possibility of an increase in the frequency and/or severity of grand mal seizures may require an increase in the dos­age of standard anticonvulsant medication. Abrupt wi ...
Modecate® Concentrate - Bristol
Modecate® Concentrate - Bristol

... The management of NMS should include 1) immediate discontinuation of all antipsychotic drugs including MODECATE* CONCENTRATE and other drugs not essential to therapy; 2), intensive symptomatic treatment and medical monitoring; and 3) treatment of any concomitant serious medical problems for which sp ...
Exploring Mendelian Genetics
Exploring Mendelian Genetics

... a. The inheritance of biological characteristics is determined by genes that are passed from parents to their offspring. b. Two or more forms of the gene for a single trait can never exist. c. The copies of genes are segregated from each other when gametes are formed. d. The alleles for different ge ...
Psychotropics in Psychiatric Patient – Bipolar disorders
Psychotropics in Psychiatric Patient – Bipolar disorders

... internal organ involvement A serious idiosyncratic, non- dose related adverse reaction caused by aromatic anticonvulsants (phenytoin, phenobarbital, primidone, carbamazepine and lamotrigine) ...
Lab. 11 Deviation of Mendel`s second law “Dihybrid” Part 2
Lab. 11 Deviation of Mendel`s second law “Dihybrid” Part 2

... The genes responsible for expression of the trait in the phenotype. In the case of simple Mendelian inheritance each gene is responsible for the expression of only one phenotypic trait. But, in reality the situation is more complicated. For example, the same gene may act on the expression of multipl ...
Case 1 - Coalition for Supportive Care of Kidney Patients
Case 1 - Coalition for Supportive Care of Kidney Patients

... severe pain all over her body, especially in her joints. She has nephrogenic fibrosing dermopathy. Her current pain medicine is extended-release morphine 200mg po q8h. Despite this dose, she is still in pain. She also complains of increasingly severe jerking. It is so bad that her body jumps six inc ...
Monohybrid and Dihybrid Crosses
Monohybrid and Dihybrid Crosses

... • Used a microscope to examine gametes • found “animalcules” in semen and decided they were preformed embryo’s • Female contribution was only the influence of the uterus during embryo development ...
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Can Topical and Oral NSAIDs Be Combined for

... NSAIDs inhibit COX enzymes involved in prostaglandin synthesis to reduce inflammation. COX-1 inhibition by nonselective NSAIDs increases the risk for gastrointestinal bleeding and ulceration. NSAIDs with specific affinity for the COX-2 enzyme, such as celecoxib, have been developed to reduce the ris ...
Combination Treatment With Curcumin and Quercetin of Adenomas
Combination Treatment With Curcumin and Quercetin of Adenomas

... ies with sulindac4 and with celecoxib, a selective inhibitor of cyclooxygenase 2.5 Although effective in adenoma regression, cyclooxygenase 1 and 2 inhibitors possess side effects that limit the use of these drugs as true chemopreventive agents. Curcumin is the major yellow pigment extracted from tu ...
PowerPoint - Palliative.info
PowerPoint - Palliative.info

... 1. ⬇︎current dose 10 - 30% while beginning new opioid at opioidnaïve dose or at the lowest available dose for the formulation. 2. Slowly ⬇︎ original total daily opioid dose by about 10 - 25% per week while ⬆︎ new daily opioid dose by about 10 - 20% based on clinical need and safety. In most instanc ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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