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KPGA Formulary Update August 2012
KPGA Formulary Update August 2012

... Recommendations: The new FDA information on QT prolongation does not change any of the oral dosing regimens for ondansetron. • The use of a single 32 mg IV dose of ondansetron should be avoided and no single IV dose of ondansetron should exceed 16 mg. • Patients who may be at particular risk for Q ...
DRUG CARDS A-list Paramedic rev0807 117KB Jan 14 2015
DRUG CARDS A-list Paramedic rev0807 117KB Jan 14 2015

... EMT-PARAMEDIC –Drug Cards Pharmacology Please note  Many drugs have nausea, vomiting, dizziness as side effects  All drugs are metabolized/eliminated by the liver and kidneys and should be given cautiously to patients with diseases in these body systems  You should never give any drug to a patien ...
Prescribing Information - Mallinckrodt Pharmaceuticals
Prescribing Information - Mallinckrodt Pharmaceuticals

... The mechanism of action of imipramine is not definitely known. However, it does not act primarily by stimulation of the central nervous system. The clinical effect is hypothesized as being due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings. INDICATIONS A ...
ENGLISH VERSION (Eng)
ENGLISH VERSION (Eng)

... animals [12]. As “Grünenthal” records were destroyed, we will never know how thalidomide’s safety was studied [13]. It is known that the Food and Drug Administration (USA) experts considered data given by the manufacturer on the drug’s safety obtained in experiments on animals insufficient and uncon ...
Alterations in Cardiovascular Function:
Alterations in Cardiovascular Function:

... •Antiotensin II is a very powerful vasoconstrictor •Also, angiotension stimulates release of aldosterone and ADH resulting in increase blood volume (CO) ...
genetic analysis in inherited metabolic disorders from diagnosis to
genetic analysis in inherited metabolic disorders from diagnosis to

... Inherited metabolic disorders, also referred to as inborn errors of metabolism (IEM), are a group of congenital disorders caused by mutation in genomic or mitochondrial DNA. IEM are mostly rare disorders with incidence ranging from 1/50 000-1/150 000), however in total IEM may affect even 1/1000 peo ...
Antitubercular Agents
Antitubercular Agents

... Dose- 150 mg OD (2-5 mg/ kg ) ,used in combined tablet with INH ...
271 KB - International Medical Press
271 KB - International Medical Press

... driver for the adverse event. With increasing interest in nucleoside-sparing regimens, knowledge of clinically significant adverse events such as this is important for HIV clinicians when selecting regimens for patients with highly resistant virus or drug tolerability issues. ...
Computational Drug Design and Molecular Dynamic Studies
Computational Drug Design and Molecular Dynamic Studies

... ISSN: 2090-4924 ...
Patterns of Inheritance
Patterns of Inheritance

... – histogram shows normal distribution ...
supplementary material
supplementary material

... For eQTL mapping, the combined results from PC-, cis- and trans-mapping detected most eQTLs found in SPA and many more. Methods which utilize multiple correlated etraits in some form (PC- and trans-mapping) exhibited a strong increase in the power of eQTL detection over SPA. For PC-mapping, 24% of ...
Prescribing Information
Prescribing Information

... observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. Safety data for OPSUMIT were obtained primarily from one placebo-controlled clinical study in 742 patients with PAH (SERAPHIN ...
AP Biology Unit 5 Packet-- Classical Genetics/Heredity
AP Biology Unit 5 Packet-- Classical Genetics/Heredity

... Geneticists can determine which genes will be expressed in offspring by tracking inheritance patterns and using Punnett squares. (a) Explain the role of alleles in determining the genotype and phenotype of offspring. (b) Discuss the purpose of a “test cross.” Create a sample Punnett square for the t ...
ECX Regimen - Cancer Care Ontario
ECX Regimen - Cancer Care Ontario

... syndrome in patients receiving capecitabine. • Supportive care should be provided, including loperamide for diarrhea. Also refer to CCO Antiemetic Summary back to top ...
Basic Considerations Of Sedating Children In The
Basic Considerations Of Sedating Children In The

... Poor impulse control or aggressive behavior (more common in young children) ...
Congenital hyperinsulinism caused by a de novo mutation in the
Congenital hyperinsulinism caused by a de novo mutation in the

... therapy the blood glucose could be maintaned at 2.1-2.3 mmol/l. Insulin was 4.5 mU/L, C-peptide was 0.76 ng/mL (Table 1). Genetic testing was initiated. After starting octreotide therapy his blood glucose begun to improve. Subcucatenously introduced octreotide was successfully replaced ...
Solution Overview - EMC Certified Solution Catalog
Solution Overview - EMC Certified Solution Catalog

... EMC Corporation is a global leader in enabling businesses and service providers to transform their operations and deliver IT as a service. Fundamental to this transformation is cloud computing. Through innovative products and services, EMC accelerates the journey to cloud computing, helping IT depar ...
Mystery of Heredity
Mystery of Heredity

... – histogram shows normal distribution ...
The Art and Science of Traditional Medicine Part 2: Multidisciplinary
The Art and Science of Traditional Medicine Part 2: Multidisciplinary

... used around the world for the prevention and treatment of diseases as well as the sources of numerous prescription and over-the-counter therapeutics (1). In many cases, these TMs have been used for thousands of years and are still largely harvested from the wild. However, the quality control for the ...
analg_opioide_Engl_2013
analg_opioide_Engl_2013

...  Hypothrombinaemia : occurs with large doses ie >5g/day ...
Pain Management Guide Card
Pain Management Guide Card

... •Pain intensity, location, onset, duration, relieving or exacerbating factors, quality (sharp, dull throbbing ) •If the patient is unable to communicate, assess pain based on behavioral cues. Such as facial grimacing, guarding an area of the body, crying, moaning, decrease in social interaction, agg ...
Treatment Outcomes in Patients Receiving Combination
Treatment Outcomes in Patients Receiving Combination

... 6 months. At 12 months, the probability of individuals still in care was 0.76 and the median CD4 gain was 165 cells per mµL. Of several indicators measuring adherence, selfreported poor adherence (< 80%) in the past 4 days was the best predictor of detectable viral load [8]. Recent studies demonstra ...
EPB PHC 6000 EPIDEMIOLOGY FALL, 1997
EPB PHC 6000 EPIDEMIOLOGY FALL, 1997

... 1) Examine links between genetic markers and specific disorders or traits. 2) Genetic markers are a measurable human trait controlled by a single gene with known chromosomal location. Must be polymorphic with at least two alleles having a gene frequency of at least 1 percent. ...
neuropathic pain
neuropathic pain

... Traditionally carbamazepine is the first choice but it ...
Phenylketonuria case
Phenylketonuria case

... PKU can be caused by an intron mutation that leads to aberrant splicing. (A) Normal primary transcript and mRNA. (B) Mutation of G to A in intron 12 results in the skipping of exon 12. Most mutations causing PKU occur in coding regions. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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