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Switching to Generic - CUA Law Scholarship Repository
Switching to Generic - CUA Law Scholarship Repository

... 11, 2008) [hereinafter Forum of America's Ideas] (stating "[a]pproximately 3.2 million Americans suffer from Epilepsy, including 40% who are women of childbearing age."). ...
Clofibric acid
Clofibric acid

... Appliances: Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits antiinflammatory, analgesic, and antipyretic activities. The mechanism of action of mefenamic acid, like that of other NSAIDs, is not completely understood. Dosage and administration (http://www.rxlist.com/cgi/ ...
Analgesia and Asthma
Analgesia and Asthma

... Zyflo CR will be given BID instead of QID. But patients will still need liver function tests every month for the first 3 months...then every 2 to 3 months for the rest of the first year. – 2007 ...
Pharmacogenetics of warfarin: current status and future
Pharmacogenetics of warfarin: current status and future

... allele on warfarin therapy.2,41 The role of other CYP2C isoforms has not been adequately evaluated, but would be predicted to be small. Furthermore, the coumarin hydroxylase variant CYP2A6*2 has been suspected to cause warfarin sensitivity.35,42 However, these reports from one laboratory have not be ...
Bioassays
Bioassays

... • Microbiological assays ...
Population Genetics
Population Genetics

... ¾ Over the long run, genetic drift will lead to allele fixation or loss. ¾ When a new mutation occurs within a population, genetic drift is more likely g y to cause the loss of the new allele rather than the fixation of the new allele. ¾ Genetic drift promotes genetic diversity between ...
inhibits protein synthesis
inhibits protein synthesis

... Aminoglycosides are mostly used against Gramnegative enteric bacteria, especially when the isolate may be drug-resistant and when there is suspicion of sepsis. They are almost always used in combination with a β-lactam antibiotic to extend coverage to include potential Grampositive pathogens and to ...
- Centers for Pain Management
- Centers for Pain Management

Sedative-Hypnotics/Alcohol Withdrawal
Sedative-Hypnotics/Alcohol Withdrawal

... BZDs which are oxidatively metabolized (chlordiazepoxide, diazepam, clorazepate, triazolam, prazepam, alprazolam, and midazolam) may undergo a reduced rate of metabolism in patients with liver failure resulting in prolonged oversedation. ...
Aripiprazole LAI Prescribing Guidelines
Aripiprazole LAI Prescribing Guidelines

... i.e. once per calendar month, (not 4-weekly) by deep intramuscular (IM) injection into the gluteal muscle (no sooner than 26 days after the previous injection). 6. Oral aripiprazole at 10mg-20mg per day must continue for two weeks after the first injection to maintain therapeutic aripiprazole concen ...
AEROSOLIZED ANTI-INFECTIVE AGENTS
AEROSOLIZED ANTI-INFECTIVE AGENTS

... viruses, the viruses responsible for the "flu." Neuraminidase is an enzyme that is required by the influenza viruses to spread from infected cells to healthy cells. Zanamivir blocks the action of neuraminidase thereby reducing the spread of influenza. Since the spread of the viruses is prevented, th ...
James R. Ginder, MS,NREMT,PI,CHES,NCEE
James R. Ginder, MS,NREMT,PI,CHES,NCEE

... Myanmar and other areas of Southeast Asia. o Kratom has been described as producing both stimulant and sedative. o Traditionally, Kratom was mostly used as a stimulant by Thai and Malaysian laborers and farmers to overcome the burdens of hard work. o Kratom is used in the treatment of morphine and h ...
pregabalin 25mg 50mg 75mg 100mg 150mg 200mg and 300mg
pregabalin 25mg 50mg 75mg 100mg 150mg 200mg and 300mg

... The evidence is cost utility analysis based on a Markov model. The model compares pregabalin with gabapentin for treatment of post herpetic neuralgia and diabetic neuropathy. The model uses indirect comparison based on data from placebo controlled trials. The model suggests that both pregabalin and ...
Title: Bayes` Theorem in the Twenty-First Century
Title: Bayes` Theorem in the Twenty-First Century

... learned, from sonograms, that they were due to be parents of twin boys. “What is the probability our twins will be Identical rather than Fraternal?” was their question. There are two pieces of relevant evidence: only one-third of twins are Identical; on the other hand, Identicals are twice as likely ...
Preview the test
Preview the test

... 6) Similar to other types of stimulants, cocaine produces its effects by increasing levels of a) serotonin b) dopamine c) acetylcholine d) epinephrine 7) An illegal drug that is part stimulant and part hallucinogen is methylenedioxymethamphetamine (MDMA), is also called a) Acid b) Angel Dust c) Ice ...
NEUROLOGICAL ADVERSE DRUG REACTIONS AND STATIN THERAPY Research Article
NEUROLOGICAL ADVERSE DRUG REACTIONS AND STATIN THERAPY Research Article

... about 2.5% to 91.7% of dyslipidemic patients use statin3. In US at least one third of all patients use statins, while 90% in Canada and 85% in Australia1,4 used these medications. In Malaysia, about 90% of cardiac patients use statin5. Although the benefits significantly associated to statin therapy ...
No Slide Title
No Slide Title

... 3. Anxiogenic-like responses in the plus maze and defensive burying tests 4. Escalation in drug self-administration with prolonged access ...
1 - Cloudfront.net
1 - Cloudfront.net

... • Gathered a huge amount of numerical data • Discovered the frequency of how traits are inherited • Established basic principles of Genetics ...
Quantitative Rationalization of Gemfibrozil Drug Interactions
Quantitative Rationalization of Gemfibrozil Drug Interactions

... and Barradell, 1996). Gemfibrozil is thus a highly prescribed and well-tolerated drug; however, its concomitant use with repaglinide is contraindicated because of documented drug interactions (Niemi et al., 2003b). As a perpetrator drug, gemfibrozil presents a complex profile involving inhibition of ...
Olive Leaf - Pure Encapsulations
Olive Leaf - Pure Encapsulations

... Uses For Olive Leaf Microbial Defense: The active nutrient in the olive leaf is oleuropein, a phenolic glucoside (structurally classified as an iridoid). The olive leaf also contains the bioflavonoids rutin, luteolin, and hesperidin, which work synergistically with oleuropein to enhance its natural ...
Oxymorphone ER Formulations
Oxymorphone ER Formulations

... A dose form where active drug is released slowly over a prolonged period of time thereby allowing for less frequent administration throughout the day Also known as long-acting formulation Immediate release formulation: A dose form where active drug is released quickly over a short period of time and ...
Takeda Takes Global Hematide Rights in $535m Affymax Deal
Takeda Takes Global Hematide Rights in $535m Affymax Deal

... to enter a pivotal Phase 3 study in kidney disease in the second quarter of 2007. That trial would be followed by a study in cancer patients, a program that is about 9 to 12 months behind kidney disease. ESA therapy has reduced the need for blood transfusions and the frequency and severity of anemia ...
History of Cannabis as a Medicine By Lester Grinspoon, M.D.
History of Cannabis as a Medicine By Lester Grinspoon, M.D.

... in hand, came forward to prevent the classification of pentazocine, or at least ensure that it was placed in one of the less restrictive schedules. They succeeded in part; it became a Schedule IV drug, available by prescription with minor restrictions. In the testimony on cannabis, the next drug to ...
Managing Drug Interactions
Managing Drug Interactions

... • Antifungals of the imidazole class are metabolized with varying affinities for the cyp enzymes. Fluconazole turns out to be one of the more benign medications whereas ketoconazole is a very potent inhibitor of cyp3A4. Mnemonic: “keto>itra>flu” ...
Punnet Quiz Study Guide
Punnet Quiz Study Guide

... Know the textbook definition for the following vocabulary terms: 1. Trait 2. Genetics 3. Gene 4. Alleles 5. Dominant allele 6. Recessive allele 7. Phenotype 8. Genotype 9. Homozygous 10. Heterozygous 1. What is the difference between genotype and phenotype? ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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