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Antidepressants - Dr BL Lim Centre for Psychological Wellness
Antidepressants - Dr BL Lim Centre for Psychological Wellness

... • Setraline most commonly used, level in breast milk very low ...
Data Sheet
Data Sheet

... Serious dermatological reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome) and erythema multiforme, have been reported very rarely in association with the use of Trileptal. Patients with serious dermatological reactions may require hospitalization, as these c ...
Newsletter - Beth Israel Deaconess Medical Center
Newsletter - Beth Israel Deaconess Medical Center

... however, it may be much longer than this in some patients (range 5-30 days.) When rapid parenteral administration of phenytoin is required, IV phenytoin is available. Caution is required with IV phenytoin due to potential cardiac toxicities associated with rapid IV administration including: hypotens ...
“Right to Try” Laws and Pre-Approval/Compassionate/Expanded
“Right to Try” Laws and Pre-Approval/Compassionate/Expanded

... cases over the last four decades—were due to severe, avoidable harms stemming from administration of a drug. The FDA has reviewed this matter and will be releasing a peerreviewed article about it. The FDA has stated repeatedly that it will be reasonable in dealing with adverse events that occur in t ...
Pea In Your Genes
Pea In Your Genes

... Genotype & Phenotype • Genotype – “code” for a trait. Letters we use. Ex. Yy • Phenotype – what you actually see. • Yellow peas – Use Y to represent Yellow • Green peas – Use y to represent Green ...
YAZ® and YASMIN - James A. Simon, MD
YAZ® and YASMIN - James A. Simon, MD

... pulmonary embolism, or heart attack. The venous thrombosis risk increases from 3.01 in 10,000 women per year in non-users of combination contraceptives, to 6.29 in 10,000 women per year in current users of combination oral contraceptives i . In other words, using combination birth control pills “dou ...
2nd T. 5th L. Updated
2nd T. 5th L. Updated

... ulcer disease is a contraindication to indomethacin use  The most frequent CNS effect is severe frontal headache. Caution is advised when administering indomethacin to elderly patients or to those with underlying epilepsy, psychiatric disorders, or Parkinson's disease, because they are at greater r ...
Pharmacy Policy Bulletin - Independence Blue Cross
Pharmacy Policy Bulletin - Independence Blue Cross

... technology at the time the document was developed. Since that time, new information relating to drug efficacy, interactions, contraindications, dosage, administration routes, safety, or FDA approval may have changed. This Pharmacy Policy will be regularly updated as scientific and medical literature ...
Drugs Combinations in the Treatment of Obesity
Drugs Combinations in the Treatment of Obesity

... as type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease, obstructive sleep apnea, musculoskeletal diseases and neoplasias [2]. Studies have shown that even small weight losses of 5– 10% of body weight, independently of how they were achieved, are associated with an improvement of th ...
BAHAGIAN PERKHIDMATAN FARMASI
BAHAGIAN PERKHIDMATAN FARMASI

... valganciclovir and that of aciclovir and valaciclovir, a cross-hypersensitivity reaction between these drugs is possible. Interaction Drug interaction studies with valganciclovir have not been performed, but since it undergoes rapid conversion to ganciclovir, interactions are likely to be the same a ...
Management of Neuropathic Pain
Management of Neuropathic Pain

... • Analgesia vs. function • Differential response on the several pain mechanisms found in a single individual – Allodynia – Burning C fiber pain – Spontaneous pain Baron 2006 Farrar 2001 ...
SUDEP
SUDEP

... Epilepsy Initiative Group, Royal Free London NHS Foundation Trust ...
Biomarkers and surrogate endpoints: How and when might they
Biomarkers and surrogate endpoints: How and when might they

... To increase the efficiency and quality of clinical development, pharmaceutical companies seek to improve their screening processes for NMEs by making critical go/no go decisions early in drug development. If the NME does not demonstrate the proof-of-concept in an appropriatedly designed early clinic ...
The Antihypertensive and Lipid-Lowering Treatment to Prevent
The Antihypertensive and Lipid-Lowering Treatment to Prevent

... 1.32 to 1.26), and these differences remained statistically significant. The discrepancy is particularly obvious in black patients for stroke, as the data suggested a staggering 40% higher risk of stroke in black patients, while only 13–16% of such risk was predicted using an external standard of po ...
Full Prescribing Information (Micardis)
Full Prescribing Information (Micardis)

... varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. Some a ...
Guide To Fibromyalgia Management
Guide To Fibromyalgia Management

... of appetite in chemotherapy patients and for lack of appetite in AIDS patients. It has shown some promise in the treatment of pain, sleep problems, and anxiety in fibromyalgia.8 Xyrem: Although not yet approved by the FDA for the treatment of fibromyalgia, the central nervous system depressant known ...
Chapter 4 - Wolters Kluwer Health
Chapter 4 - Wolters Kluwer Health

... • Harmful side effects, or adverse reactions, may occur when medications are taken • May: – Be mild, severe, or even life threatening – Happen after the first dose, after several doses, or after many doses – Happen in a predictable way or without warning ...
Sedation, Analgesia and Paralysis in ICU
Sedation, Analgesia and Paralysis in ICU

... ICU Sedation • ICU sedation is a complex clinical problem • Current therapeutic approaches all have potential adverse side effects • Agitated patients are often hypertensive, increase stress hormones, and require more intensive nursing care ...
Adenosine Pharmacology
Adenosine Pharmacology

... Guidelines and precautions: Do not confuse this drug with adenosine phosphate, which is used as adjunctive therapy in the treatment of complications associated with varicose veins. Due to the rapid metabolism it is imperative to administer the dose rapidly over 2 to 3 seconds. If given at a slower r ...
designer drugs - Alger County Courthouse.
designer drugs - Alger County Courthouse.

... health code, is responsible for the assignment of substances to one of five schedules; once so scheduled, substances are by definition controlled substances and different statutes address their manufacture, possession, use and distribution. The controlled substances article informs us that the admin ...
Attention-Deficit Hyperactivity Disorder (ADHD) Drug
Attention-Deficit Hyperactivity Disorder (ADHD) Drug

... Š↓ dose &/or titrate dose slowly Šoptimal sleep hygiene; give doses earlier in the day avoid stimulant after 2 pm if possible, change to shorter-acting meds Š↓ noon or afternoon stimulant dose Šconsider clonidine, trazodone, an antihistamine, or melatonin 36 mg ½-1 hr pre-HS; (others: benzos, TCAs, ...
Overview - ETSU.edu
Overview - ETSU.edu

... • Anxiolysis begins in 30-60 minutes after oral or parenteral administration • Safe and effective for short-term use; maintenance requires evaluation of risks vs. benefits • Avoid in patients with history of substance or alcohol abuse • Most commonly used in combination with SSRI/SNRI during first f ...
Which should be the first-line drug for newly diagnosed epilepsy
Which should be the first-line drug for newly diagnosed epilepsy

... tolerability of the two drugs in the very early period of therapy. If anything, carbamazepine in terms of efficacy performed rather better than lamotrigine 7) a surprisingly high number of patients developed a rash on carbamazepine, a figure higher than would be expected from previous studies 8) l ...
KPGA Formulary Update August 2012
KPGA Formulary Update August 2012

... Recommendations: The new FDA information on QT prolongation does not change any of the oral dosing regimens for ondansetron. • The use of a single 32 mg IV dose of ondansetron should be avoided and no single IV dose of ondansetron should exceed 16 mg. • Patients who may be at particular risk for Q ...
Supplementary Data Files Transcriptome Analysis on Monocytes
Supplementary Data Files Transcriptome Analysis on Monocytes

... Supplementary Material: The following supplementary material is available with the online version of this paper. Supplementary Figures and Legends Figure S1: ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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