• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
DEVELOPMENT AND INVITRO EVALUATION OF GASTRORETENTIVE VERAPAMIL HCl FLOATING TABLETS  Research Article
DEVELOPMENT AND INVITRO EVALUATION OF GASTRORETENTIVE VERAPAMIL HCl FLOATING TABLETS Research Article

... The purpose of the present work is to prepare gastro retentive tablets of verapamil HCl by using different polymers like HPMC K4M, HPMC K100M and Gum Kondagogu. Sodium bicarbonate is used as gas generating agent. Initially, preformulation studies were carried out which ruled out any incompatibility ...
Punnet Quiz Study Guide
Punnet Quiz Study Guide

... Know the textbook definition for the following vocabulary terms: 1. Trait 2. Genetics 3. Gene 4. Alleles 5. Dominant allele 6. Recessive allele 7. Phenotype 8. Genotype 9. Homozygous 10. Heterozygous 1. What is the difference between genotype and phenotype? ...
Basic genetics - Informatics: Indiana University
Basic genetics - Informatics: Indiana University

... One member of the gene pair segregates into a gamete, thus each gamete only carries one member of the gene pair. Gametes unite at random and irrespective of the other gene pairs involved. ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
HIGHLIGHTS OF PRESCRIBING INFORMATION These

... the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In the Systolic Heart failure treatment with the If inhibitor ivabradine Trial (SHIFT), safety was evaluated in 3260 patients treated with Cor ...
Lesson 3
Lesson 3

... of having a child with a genetically related disease. • They also can guide families of children with genetic disorders about possible treatment options. ...
Chapter 19 Lesson 3 heredity and genetics
Chapter 19 Lesson 3 heredity and genetics

... of having a child with a genetically related disease. • They also can guide families of children with genetic disorders about possible treatment options. ...
Oral anticoagulation in atrial fibrillation – Balancing the risk of stroke
Oral anticoagulation in atrial fibrillation – Balancing the risk of stroke

... monitoring and follow-up.3 A HAS-BLED score of 3 or more indicates the patient is at an increased risk of a major bleed.4 However, the effects of stroke are considerable, with up to 70% being either fatal or resulting in severe residual deficit.3 Major bleeding is less often fatal and is less likely ...
Sitagliptin Phosphate
Sitagliptin Phosphate

... No overall differences in safety or effectiveness were observed between subjects 65 years and over and younger subjects. While this and other reported clinical experience have not identified differences in responses between the elderly and younger patients, greater sensitivity of some older individu ...
Toxicity
Toxicity

... • Metabolized by Glutathione-S- transferase • Good CSF penetration • High dose used for myeloablation in BMT conditioning regimens ...
PACKAGE INSERT TEMPLATE FOR ACETYLSALICYLIC ACID
PACKAGE INSERT TEMPLATE FOR ACETYLSALICYLIC ACID

... Impaired liver and kidney function. Before surgery (including minor surgery such as dental extractions); the bleeding time can be prolonged. Habitual use of analgesics can lead to permanent kidney damage with the risk of kidney failure .The risk is particularly great when several different analgesic ...
book chapter
book chapter

... is wrong with this scenario? This question has been raised time and again. A change in strategy in drug discovery is not only necessary; it is crucial to the advancement of the pharmaceutical industry. Since the beginning of modern medicine, single molecules have been developed as drugs. For example ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Chronic stable angina, a condition that impairs quality of life is associated with decreased life expectancy (1) Several new investigational drugs are being tested for the t reatment of chronic angina. Ranolazine was approved on January 27, 2006, by U.S FDA for use in patients with chronic angina wh ...
High Dose Colistimethate Sodium (Colistin)
High Dose Colistimethate Sodium (Colistin)

... infections caused by pathogens with minimum inhibitory concentration (MIC) higher than 0·5 mg/L. Recent studies have shown that high dose regimens are more effective with limited increase in irreversible nephrotoxicity.1 Many patients do experience nephrotoxicity but the majority recover renal funct ...
Oral Fluid Drug Screen Device
Oral Fluid Drug Screen Device

... compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and i ...
Herbert Barry III by Thomas A. Ban
Herbert Barry III by Thomas A. Ban

... neurological effects of alcohol, on alcohol metabolism, and on interactions of alcohol with other drugs. I wrote the chapters on voluntary consumption of alcohol and on behavioral studies on laboratory animals. I also wrote a chapter on alcoholism, which was the first of my series of papers on alcoh ...
Companion Diagnostics: Development, Regulation
Companion Diagnostics: Development, Regulation

Place Header Here and Here in Initial Caps
Place Header Here and Here in Initial Caps

... In 2005 an estimated 2 million people in the United States were behind bars while another 4 million were on probation. Of those involved in our criminal justice system, it is estimated that 75 percent have diagnosable alcohol and drug disorders. Despite the large population behind bars in need of he ...
Sublingual drug delivery system List of contents
Sublingual drug delivery system List of contents

... Thin film drug delivery is a process of delivering drugs to the systemic circulation via a thin film that dissolves when in contact with liquid, often referred to as a dissolving film or strip. thin film strips are typically designed for oral administration, with the user placing the strip on or und ...
Acute Pain and Opioids: Through the Ages
Acute Pain and Opioids: Through the Ages

... The 1950s were also marked by significant innovations – this time in research methodology – innovations that would help significantly in the understanding of opioids. These included the mouse hot-plate method that would complement the tail-flick procedure developed in 1942, two procedures that have ...
Slide 1
Slide 1

... Metformin is well absorbed  from small intestine, stable, does not bind to plasma proteins, excreted unchanged in urine. Half life of Metformin is 1.5 -  4.5 hours, taken in three doses with meals ...
Biology Lesson Plan - Penn Arts and Sciences
Biology Lesson Plan - Penn Arts and Sciences

... and twenty-from the father, is produced. These chromosomes contain genes that provide the ‘blueprint’ for the developing embryo. The embryo has a pair of genes, one from each parent, which is responsible for specific characteristics. Each gene may contain different alleles, alternative versions of ...
Document
Document

... enzyme that dictates structure of a glycolipid on blood cells • Two alleles (IA and IB) are codominant when paired • Third allele (i) is recessive to others ...
The Genome Project and Pandora`s Box - S
The Genome Project and Pandora`s Box - S

... still very limited, so our expectations and hopes about the genome project, can be overly optimistic. We think it right to restrain scientific arrogance so it is important to keep a balance between scientific realism and individual optimism. It's not necessary to hold back the intellectual curiosity ...
Basic Genetics
Basic Genetics

... expressed as long as one dominant allele is present (R) ▪ Recessive – trait is only expressed when there are two copies of the recessive allele (r) ...
CetacaineSpray.Insert
CetacaineSpray.Insert

... caused by local anesthetics is contact dermatitis characterized by erythema and pruritus that may progress to vesiculation and oozing. This occurs most commonly in patients following prolonged self-medication, which is contraindicated. If rash, urticaria, edema, or other manifestations of allergy de ...
< 1 ... 581 582 583 584 585 586 587 588 589 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report