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finalist preview
finalist preview

... year post its IPO in March 2014 to firmly establish it as a world-leading translational genomics company. The firm has transitioned from a newly listed AIM company with 80 employees located in a single facility in Cambridge, to an international life science group employing approaching 250 employees ...
Human Genetic Disorders
Human Genetic Disorders

... People with sickle cell suffer from lack of oxygen in the blood and experience pain and weakness The allele that carries sickle cell is codominant with the normal allele. There is no cure but there are medications to lesson the pain and other symtoms. ...
Title
Title

... One MCQ phase test (40%) and an end of module MCQ exam (60%). The pass mark for each component is 50%. ...
factors modifying drug action
factors modifying drug action

... 2. Thiopentone sodium when mixed with succinylcholine or morphine. 3. Heparin when mixed with penicillin/ gentamicin/hydrocortisone. 4. Noradrenaline when added to sodium bicarbonate solution. • In general, it is advisable to avoid mixing of any two or more parenteral drugs before injecting. ...
infomedbaseproducts
infomedbaseproducts

... (5/2014) - one of the most comprehensive drug interaction databases in the market • SFINX gives a warning on the potential clinical problem with a specific drug interaction taking into account the formulation of the drug • SFINX provides medical expert recommendations on circumventing or controlling ...
PHARMACOLOGY Pharmacology is an experimental science
PHARMACOLOGY Pharmacology is an experimental science

... Pharmacology is an experimental science dealing with properties of drugs and their effects on living systems. If the substances have medical properties, they are considered pharmaceuticals. Drugs may be used to improve health and quality of life, to treat and prevent diseases, or as a research tool ...
Definitions to Know
Definitions to Know

... Indigestion - Discomforted caused from excessive acid production; caused by overeating, alcohol, smoking, anxiety, and eating certain types of foods in some individuals Lethal dose - The dose required to kill fifty percent of the animal population, known as the LD 50 Mild analgesic - Reduces sufferi ...
to - Salford GP Learning Hub
to - Salford GP Learning Hub

... cannabis. Opiates 5K B C. Alcohol 10k BC Holistic care. Crime/criminal behaviour/employment/mental health /physical health/family therapy/alternate medicine/ 3rd sector /housing/finance ...
FDA Labeling - American College of Rheumatology
FDA Labeling - American College of Rheumatology

... January 2006 (Code of Federal Regulations Title 21). These rules do not limit the use of labeled products to indications described in the label. Indeed, current FDA guidance explicitly directs physicians to use “legally available drugs, biologics and devices according to their best knowledge and jud ...
2 How do physicians decide when to prescribe a medication?
2 How do physicians decide when to prescribe a medication?

... Two additional factors that influence physicians’ prescribing habits are patients’ desires and the cost of a particular medication. What is the patient’s role? Patients should participate in the decision to treat. They need to know as much as possible about a medication’s benefits and potential adv ...
TBD - Tel Aviv University
TBD - Tel Aviv University

... Drug Metabolism The chemical modification of drugs with the overall goal of getting rid of the drug Enzymes are typically involved in metabolism Drug ...
A: There are only a small number of drugs that have unique side
A: There are only a small number of drugs that have unique side

... including some anesthetics, that are diffused throughout the body’s tissues when given and are particularly concentrated in muscles. If a polio survivor has a significantly decreased proportion of total body tissue as muscle, then the usual doses of medications may have a greater than expected effec ...
module description - University of Brighton
module description - University of Brighton

... inflammatory mediators; anti-inflammatory drugs; other drugs for the relief of inflammatory conditions.  Applied pharmacology: basic pharmacokinetics; individual variation in drug effects; drug interactions; the placebo response. The content of this module will be delivered by way of distance learn ...
Lithium Monitoring Protocol
Lithium Monitoring Protocol

... of prescriptions this should be easily attainable. 2. Recording of the lithium concentration at least once in the previous 4 months. This maybe compromised by non-attendance or patients being in hospital for considerable periods. 3. Maintenance of the concentration within therapeutic range of 0.4-1. ...
How to Dispose of Unused Medicines I
How to Dispose of Unused Medicines I

... Despite the safety reasons for flushing drugs, some people are questioning the practice because of concerns about trace levels of drug residues found in surface water, such as rivers and lakes, and in some community drinking water supplies. However, the main way drug residues enter water systems is ...
minutes
minutes

... begun to work on with Andrea Gaedigk. The propose 5 topics for CYP2D6 gene information: what phenotype is predicted for alleles, allele frequency by ethnicity, which alleles should be tested for, how genotype/phenotype relationships may be modified by other factors, and scoring systems to translate ...
Option D IB Chemistry Definitions SL
Option D IB Chemistry Definitions SL

Mass Spectrometry-Toxicology
Mass Spectrometry-Toxicology

... •D3 (cholecalciferol) is synthesized in the skin from sunlight and is also consumed via the intake of animalbased foods. •Both forms are commercially synthesized and found in dietary supplements or fortified foods. The normal range for Vitamin D is 30-60 ng/dL. •Vitamin D has been proven to be impor ...
Slide 1
Slide 1

... powerful: bring together the insight and creativity of the academic world with the drug discovery expertise of GlaxoSmithKline (GSK). We are a dedicated team of experienced drug discovery scientists – internal champions for your project and a gateway to the global resources of GSK. Our goal is to es ...
rights of correct drug administration
rights of correct drug administration

... • Free environment of allergens (if possible) • Corticosteroids • Short-term relief of symptoms with antihistamines • Long-term desensitization programs ...
FDA
FDA

... The FDA Route • The results of the testing program are codified in an FDA-approved public document that is called the product label, package insert or Full Prescribing Information. • The prescribing information is widely available on the web, from the FDA drug manufacturers, and frequently inserted ...
What are gene polymorphisms and how can we use them in
What are gene polymorphisms and how can we use them in

... (a) particularly sensitive individuals may avoid serious adverse reactions. (b) can avoid giving drugs to patients who cannot benefit from them. ...
amitriptyline - DavisPlus
amitriptyline - DavisPlus

... possible unless almost time for next dose; if regimen is a single dose at bedtime, do not take in the morning because of side effects. Advise patient that drug effects may not be noticed for at least 2 wk. Abrupt discontinuation may cause nausea, vomiting, diarrhea, headache, trouble sleeping with v ...
PY 440 Psychopharmacology Basics
PY 440 Psychopharmacology Basics

... treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely. • Phase IV studies are done after the drug or treatment has been mar ...
Overview of Draft Pharmacovigilance Protocol
Overview of Draft Pharmacovigilance Protocol

... Why Monitor ALL drugs? • Create an awareness of safety issues and drugs • To encourage health professionals to share concerns about drugs • To determine the concerns health professionals have over drugs and their best use – Including interactions ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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