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Cardio-Oncology and stem cell transplant
Cardio-Oncology and stem cell transplant

... (HF), and a 7.0–15.9-fold increased risk of CVD risk factors such as hypertension, diabetes, and dyslipidemia (Baker et al., 2007, 2012; Chow et al., 2011; Tichelli et al., 2008a; Armenian et al., 2012, 2011a,b, 2010; Griffith et al., 2010). This excess CVD risk (Speck et al., 2010; Baker et al., 201 ...
Systematic and comparative morphologies of the extrinsic cardiac
Systematic and comparative morphologies of the extrinsic cardiac

... Great veins: The inferior caval vein (IVC) is present only on the right side, whereas the superior caval vein is present on both sides (9/9 specimens, 100%): the main right superior caval vein (RSVC) and the persistent left superior caval vein (LSVC). 3.2. Positions of the cervical and upper thoraci ...
Acute Respiratory Acidosis Decreases Left Ventricular Contractility
Acute Respiratory Acidosis Decreases Left Ventricular Contractility

... increase venous return (equals cardiac output) in the face of decreased left ventricular contractility. The j-adrenergic response to respiratory acidosis substantially ameliorated the increase in end-systolic volume and supported the increase in venous return but did not alter the associated tachyca ...
Effect of Parameter Variations on the Hemodynamic
Effect of Parameter Variations on the Hemodynamic

... delivery to tissues and organs in the body. Advancement in the field of cardiac assist device technology has resulted in implantable rotary blood pumps (IRBPs) becoming widely used in these patients. Furthermore, with evidence showing successful experience for prolonged periods of implantation in pa ...
Left Ventricular Endocardial Longitudinal and - AJP
Left Ventricular Endocardial Longitudinal and - AJP

... the left ventricle (LV). During IVC, he observed a rapid increase in LV pressure, a fast expansion of the LV external circumference, and rapid shortening of its internal length. His conclusions were drawn from two experiments where he could successfully place internal distance gauges. All other dogs ...
Abnormal heart rate recovery after exercise predicts coronary artery
Abnormal heart rate recovery after exercise predicts coronary artery

... to 74 (mean 53) years. Patients who had an ischemic response during symptom-limited exercise testing underwent selective coronary angiography. The value for HRR was defined as the decrease in heart rate from peak exercise to one minute after the exercise ceased. Eighteen beats per minute was defined ...
PDF file - Via Medica Journals
PDF file - Via Medica Journals

... to 74 (mean 53) years. Patients who had an ischemic response during symptom-limited exercise testing underwent selective coronary angiography. The value for HRR was defined as the decrease in heart rate from peak exercise to one minute after the exercise ceased. Eighteen beats per minute was defined ...
Cardiac Rhythms
Cardiac Rhythms

... • usually between 0.36 and 0.44 second • varies greatly according to age, gender ,heart rate, and whether the patient is asleep • should be less than 1/2 the distance between two consecutive R waves (R-R interval) when the rhythm is regular Prolonged QT interval: Repolarization means that the muscle ...
Incidence, predictors and prognostic implications of
Incidence, predictors and prognostic implications of

... syndromes (ACS), coupled with the use of invasive procedures, has considerably reduced rates of recurrent ischemic events and death. However, the uses of multiple antiplatelet agents and anticoagulants have increased the risk of bleeding complications. Rates of bleeding in ACS and primary percutaneo ...
File
File

... or greater • May be confused with atrial fibrillation • Observed in patients with advanced chronic obstructive pulmonary disease, digoxin toxicity, and electrolyte imbalances. ...
The uses and limitations of end-systolic indexes of left
The uses and limitations of end-systolic indexes of left

... and narrow pulse pressure (e.g., in severe heart failure) are present. In such situations, substitutions of peak systolic pressure for end-systolic pressure might not be justified. Marsh et al. have described a method whereby a noninvasively determined carotid pulse tracing can be calibrated to the ...
Pulmonary Hypertension and Right Heart Failure in Chronic
Pulmonary Hypertension and Right Heart Failure in Chronic

... Renal salt and water retention may be aggravated by hypercapnia, which directly increases proximal tubular reabsorption of sodium, but also activates the sympathetic nervous system and the renin-angiotensin-aldosterone system, which causes additional distal tubular sodium reabsorption through amilor ...
Difficult Weaning Hanaa - Moodle
Difficult Weaning Hanaa - Moodle

... VALLVERDU et al 1995 reported that weaning failure occurred in as many as 61% of COPD patients, in 41% of neurological patients and in 38% of hypoxaemic patients ...
Heart rhythms - British Heart Foundation
Heart rhythms - British Heart Foundation

... The term ‘palpitations’ is often used to describe the sensation of feeling your own heart beating. Some people say that having palpitations feels like a fluttering in their chest, or their heart pounding. Others describe it as feeling like a thud or movement in their chest. Some say they feel their ...
Automatic Real-Time Embedded QRS Complex
Automatic Real-Time Embedded QRS Complex

... 0.67 Hz and 40 Hz. Modified from [3]. ...
Approach to narrow QRS tachycardias
Approach to narrow QRS tachycardias

... The most common form of paroxysmal SVT is AV node reentrant tachycardia (AVNRT), which accounts for greater than 60% of cases referred to an electrophysiology laboratory. Patients typically present in their 30s or 40s, with greater than 70% being women .Although the mechanism for AVNRT is reentry in ...
MRI in the assessment of ischaemic heart disease
MRI in the assessment of ischaemic heart disease

... coronary angiography is identified, representing a diagnostic and clinical dilemma.27 28 These patients are thought to have a better prognosis, therefore they do not always receive secondary prevention medications.29 However, a recent study suggests an overall all-cause mortality of 4.7% at 12 months ...
The Long Journey to Interatrial Block Discovery
The Long Journey to Interatrial Block Discovery

... of the Bachmann zone, the activation of the left atrium would take place retrogradely, originating a long P wave (≥ 120ms) together with a ± morphology in II, III and VF. However, there are many aspects that are not well explained or discussed in these publications, as outlined below. 1. In no publi ...
Predictors for Regression of Large Secundum Atrial Septal Defects
Predictors for Regression of Large Secundum Atrial Septal Defects

... sizes and patient age in earlier studies.1,2,9,10 Small ASDs were defined as those with a diameter of 3-5 mm because of stable hemodynamics with small left-to-right shunting. Small ASDs had a high spontaneous rate of closure (87%) in infancy.2 ASDs with diameters between 5 and 8 mm were defined as a ...
View - OhioLINK Electronic Theses and Dissertations Center
View - OhioLINK Electronic Theses and Dissertations Center

... bpm, and 201 bpm, respectively (P < 0.05; Schober et al, unpublished data). A study done with 56 cats with HCM found heart rate to be a prognostic indicator with a medium survival time after diagnosis of 1,830 days if heart rate was < 200 bpm and a median survival time of 152 days if heart rate was ...
Standards for Physical Activity and Exercise In the Cardiac
Standards for Physical Activity and Exercise In the Cardiac

... averaging 3 days per week that mainly focused on improving aerobic fitness. More recently similar systematic reviews have highlighted benefits to individuals with chronic heart failure (CHF), demonstrating evidence of decreased mortality, enhancement of quality of life (QOL) and that exercise is saf ...
Cardiovascular Consequences of Obese and Nonobese Obstructive
Cardiovascular Consequences of Obese and Nonobese Obstructive

... that OSA is one of the causative factors in systemic hypertension. Large prospective longitudinal studies help us understand the link between OSA and hypertension (HTN). The Wisconsin Sleep Cohort Study is a population-based longitudinal study that was initiated in the 1980s, and looked at the natur ...
Detection and Imaging of Cardiac Allograft Vasculopathy
Detection and Imaging of Cardiac Allograft Vasculopathy

... diagnosis of CAV. Intravascular imaging. The initial manifestations of CAV are confined to the arterial wall, so the ability of intravascular ultrasound to define the intimal and medial layers of the coronary arteries makes it particularly useful in the assessment of early-stage disease (Fig. 4). On ...
Cardiac Catheterization
Cardiac Catheterization

... a particular clinical scenario. The development of skills necessary to assist with interventions and comprehensive therapeutic procedures. Senior fellows who express a desire to pursue cardiac catheterization as a sub-specialty field will be given a higher level of exposure and responsibility. Fello ...
Left ventricular systolic performance during prolonged strenuous
Left ventricular systolic performance during prolonged strenuous

... In the present investigation, fractional area change increased during exercise and did not decline below pre-exercise baseline values. The heightened systolic performance appears to be secondary to an increase in myocardial contractility (i.e., increased systolic blood pressure – end-systolic cavity ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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