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Precordial and Carotid Pulse Palpation
Precordial and Carotid Pulse Palpation

... Figure 1. Normal and abnormal locations of precordial impulses. A = normal location of the left ventricular impulse in the left midclavicular line in the fifth intercostal space (approximately 1.5 cm in diameter); D = location of left ventricular impulse in dilated cardiomyopathy (in comparison with ...
Relationship between Sympathetic Overactivity and Left Ventricular
Relationship between Sympathetic Overactivity and Left Ventricular

... in this patient group. In addition, our RH/LVH(+) group had greater sympathetic activity, so it can be postulated that this patient group was able to gain more benefit from renal denervation. In this group of patients, renal denervation was able to both reduce BP levels and regress LV mass effective ...
June - North American - Congenital Cardiology Today
June - North American - Congenital Cardiology Today

... more effective than medical therapy, to date, it has not been shown to positively impact survival and in fact, may result in significant long-term sequelae.15-16 Several recent large studies have suggested that ligation is independently associated with the development of chronic lung disease and neu ...
Product Information – Australia APO
Product Information – Australia APO

... was accompanied by adverse effects on the eye (xerophthalmia and/or keratoconjunctivitis) of varying severity. This condition is called the oculomucocutaneous syndrome or practolol syndrome. On a few rare occasions, serious otitis media, sclerosing peritonitis, pericarditis and pleurisy have been re ...
Retrieval of a transcatheter pacemaker in sheep after a mid
Retrieval of a transcatheter pacemaker in sheep after a mid

... rare situations, the TPS may need to be removed. Although the TPS and delivery system were designed for acute TPS recovery and repositioning, to date no technical recommendations are available to approach chronically implanted devices. Some may argue that the most common time for retrieval/ extracti ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthc ...
Kainox VCS
Kainox VCS

... proper function. Lithotripsy - Lithotripsy treatment should be avoided, since electrical and/or mechanical interference with the ICD is possible and may damage the ICD. If this procedure must be used, the greatest possible distance from the point of electrical and mechanical strain should be chosen ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthc ...
Morphology and cardiac physiology are differentially affected by
Morphology and cardiac physiology are differentially affected by

... Finally, a third challenge is modelling the shape of the ventricle in a manner that most accurately reflects this complex structure (Perrichon et al., submitted). During the early developmental phase, the heart of mahi is somewhat irregularly shaped. As noted in the Methods, the ventricle is relativ ...
Non-coronary sinus of Valsalva aneurysm diagnosed after a road
Non-coronary sinus of Valsalva aneurysm diagnosed after a road

... recently developed aortic insuYciency, despite the rare asymptomatic acute aortic regurgitation. Nevertheless, the aneurysm and aortic insufficiency could have been congenital, with mild and asymptomatic regurgitation which had recently worsened and resulted in the heart murmur detected after the ac ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthc ...
Upregulation of eNOS and unchanged energy metabolism in
Upregulation of eNOS and unchanged energy metabolism in

... 3 U/l insulin, 0.2 mM pyruvate, and 0.8 mM lactate for 24 min before switching to 1.2 mM palmitate (11 rats/group) during 32 min low-flow (0.5 ml·min⫺1·g wet wt⫺1) ischemia. Next, flow was restored with 0.4 mM palmitate buffer for 32 min. A subset of hearts from each group (n ⫽ 8 for control and n ⫽ ...
2015 ESC Guidelines for the management of
2015 ESC Guidelines for the management of

... the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthc ...
2015 ESC Guidelines for the management of patients with
2015 ESC Guidelines for the management of patients with

... the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthc ...
Full Text  - Archives of Cardiovascular Imaging
Full Text - Archives of Cardiovascular Imaging

... Background: Abnormalities in the velocity and pattern of myocardial shortening on tissue Doppler imaging (TDI) have been proposed to aid in the noninvasive diagnosis of coronary artery disease (CAD). Objectives: We investigated the diagnostic value of post-systolic shortening (PSS), a delayed ejecti ...
digoxin delusions - UCSF | Department of Medicine
digoxin delusions - UCSF | Department of Medicine

... • Here’s a pearl: digoxin slows the SA node and the AV node but speeds up everything in between. Classic dig-associated arrhythmias include atrial tachycardia or junctional tachycardia associated with AV block. • Here’s another pearl: digoxin can cause pretty much arrhythmia! What were the results o ...
Uncertainty in Patients Newly Diagnosed with Atrial Fibrillation
Uncertainty in Patients Newly Diagnosed with Atrial Fibrillation

... subjects for this study. The criteria for inclusion in the study and their rationale are as follows: first, the subject must have been newly diagnosed with atrial fibrillation within 6 months prior to data collection. The reason for including only patients with acute atrial fibrillation was that the ...
Atrial Autonomic Innervation
Atrial Autonomic Innervation

... the maintenance of AF. Studies in lone AF patients and in animal models of intermittent rapid atrial pacing and congestive heart failure have indicated that AF onset is associated with simultaneous sympathovagal activation rather than with an increase in vagal or sympathetic drive alone (24–28). In ...
Reoperation for Tricuspid Regurgitation after Total Correction of
Reoperation for Tricuspid Regurgitation after Total Correction of

... Surgical criteria for tricuspid valve surgery after correction of TOF are controversial.10) Patients with congestive heart failure and correctable residual lesions generally are considered good candidates. The most common causes of tricuspid regurgitation are intraoperative injury to the tricuspid v ...
Tetralogy of fallot - The department of cardiology, Calicut medical
Tetralogy of fallot - The department of cardiology, Calicut medical

... - Perloff ‘s text book of congenital heart diseases - Moss and Adams ‘s text book of congenital cardiology - Rudolph text book of pediatric cardiology - Freedom’s natural and modified natural history of cong.heart diseases - Andreson text book of congenital heart disease - Figenbaum’ text book of ec ...
Development of the Pacemaker Tissues of the Heart
Development of the Pacemaker Tissues of the Heart

... embryonic myocytes will form the sinus node and the atrioventricular node and bundle. Recent efforts have revealed that the development of these nodal regions is achieved by highly localized suppression of working muscle differentiation, and have identified transcriptional repressors that mediate th ...
Right Heart Percutaneous Valve Therapies
Right Heart Percutaneous Valve Therapies

... during RVOT conduit stenting or valve placement, depending on the postsurgical anatomic relationship between the more anteriorly placed RV-PA conduit and the coronaries. Often, it is not possible to predict the risk of coronary compression with noninvasive testing; therefore, the risk of coronary co ...
University of Groningen Pathophysiology of thoracic
University of Groningen Pathophysiology of thoracic

... the risk of potentially lethal radiation-induced lung toxicity (RILT). In a clinical situation, RILT manifests as respiratory distress and changes on thorax X-ray/computed tomography 1. Several treatment-related factors such as the radiation dose and amount of irradiated lung tissue correlate with t ...
Optical mapping of activation patterns in an animal - AJP
Optical mapping of activation patterns in an animal - AJP

... photodiode array with 4-[-[2-(di-n-butylamino)-6-naphthyl]vinyl]pyridinium. Optical APs were recorded to simultaneously image activation patterns from the RA and RV. Perfusion of positive IgG (800–1,200 ␮g/ml) resulted in sinus bradycardia and varying degrees of heart block. Activation maps revealed ...
The Morphogenesis of Transposition of the Great Vessels
The Morphogenesis of Transposition of the Great Vessels

... the energy source responsible for the anomaly, such a theory does not identify the growth abnormality that takes place. Furthermore, as we shall see, the architectural changes in transposition are much more constant and systematic from case to case than one would expect from the vagaries of blood fl ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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