Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil
... ABSTRACT: Pulmonary arterial hypertension (PAH) still cannot be cured, warranting the search for novel treatments. Fasudil (a Rho kinase inhibitor) was compared with bosentan (an endothelin receptor blocker) and sildenafil (a phosphodiesterase 5 inhibitor), with emphasis on right ventricular (RV) fu ...
... ABSTRACT: Pulmonary arterial hypertension (PAH) still cannot be cured, warranting the search for novel treatments. Fasudil (a Rho kinase inhibitor) was compared with bosentan (an endothelin receptor blocker) and sildenafil (a phosphodiesterase 5 inhibitor), with emphasis on right ventricular (RV) fu ...
Distribution of late gadolinium enhancement in various types of
... spread diffusely into any areas of LV[11,37,38]. A previous study showed that more than 55% of HCM patients have some LGE, most commonly at the anterior and posterior RV insertion points. Gene-positive patients are more likely to have LGE and may even precede hypertrophy[39,40]. LGE in HCM usually r ...
... spread diffusely into any areas of LV[11,37,38]. A previous study showed that more than 55% of HCM patients have some LGE, most commonly at the anterior and posterior RV insertion points. Gene-positive patients are more likely to have LGE and may even precede hypertrophy[39,40]. LGE in HCM usually r ...
New Advances in the Diagnosis and Management of Cardioembolic
... new need for hemodialysis. Also, the amount of contrast agent used in those with stroke was significantly higher and was independently associated with this complication. The editorial comment from Bittl and Caplan 26 suggested it is self-evident and well known that thrombolytics and heparin increase ...
... new need for hemodialysis. Also, the amount of contrast agent used in those with stroke was significantly higher and was independently associated with this complication. The editorial comment from Bittl and Caplan 26 suggested it is self-evident and well known that thrombolytics and heparin increase ...
The Relationship Between the Right€Ventricle and its Load
... In pulmonary hypertension, the right ventricle adapts to the increasing vascular load by enhancing contractility (“coupling”) to maintain flow. Ventriculoarterial coupling implies that stroke volume changes little while preserving ventricular efficiency. Ultimately, a phase develops where ventricular ...
... In pulmonary hypertension, the right ventricle adapts to the increasing vascular load by enhancing contractility (“coupling”) to maintain flow. Ventriculoarterial coupling implies that stroke volume changes little while preserving ventricular efficiency. Ultimately, a phase develops where ventricular ...
Ghsy4y\y45y45y5
... also modelling work of Bernus et al., 2005). The fact that the 2:2 zone is so narrow in our simulations (~0.04 mM wide in Fig. 7B) implies that during ischemia the duration of the phase of primary alternans would be exceedingly brief indeed almost certainly ephemeral – before secondary alternans ...
... also modelling work of Bernus et al., 2005). The fact that the 2:2 zone is so narrow in our simulations (~0.04 mM wide in Fig. 7B) implies that during ischemia the duration of the phase of primary alternans would be exceedingly brief indeed almost certainly ephemeral – before secondary alternans ...
- Korean Circulation Journal
... study. Patients who were <19 years of age, were diagnosed with an infectious disease, had experienced allograft rejection or heart failure symptoms, were not in the normal sinus rhythm, or had a pacemaker, were excluded from the study. The study consisted of two series. The first series was a post-H ...
... study. Patients who were <19 years of age, were diagnosed with an infectious disease, had experienced allograft rejection or heart failure symptoms, were not in the normal sinus rhythm, or had a pacemaker, were excluded from the study. The study consisted of two series. The first series was a post-H ...
Timely Pulmonary Valve Replacement May Allow Preservation of
... (2), and LV circumferential and longitudinal strain have been associated with death or sustained ventricular tachycardia in TOF patients (3). The indication for treatment by pulmonary valve replacement (PVR) is subject to much discussion currently, as both surgical and transcatheter PVR are being ev ...
... (2), and LV circumferential and longitudinal strain have been associated with death or sustained ventricular tachycardia in TOF patients (3). The indication for treatment by pulmonary valve replacement (PVR) is subject to much discussion currently, as both surgical and transcatheter PVR are being ev ...
1 - American College of Radiology
... 2. Technical aspects of velocity and flow quantification Velocity and flow quantification with MRI are achieved using phase contrast imaging [9,10]. Phase contrast MRI (PC-MRI) exploits the fact that moving tissue (i.e. blood) acquires a phase shift in the presence of velocity encoding gradients. Th ...
... 2. Technical aspects of velocity and flow quantification Velocity and flow quantification with MRI are achieved using phase contrast imaging [9,10]. Phase contrast MRI (PC-MRI) exploits the fact that moving tissue (i.e. blood) acquires a phase shift in the presence of velocity encoding gradients. Th ...
Document
... normal values were obtained from healthy volunteers Baroreflex function, HR variability and blood pressure variability in patients early after coronary surgery ...
... normal values were obtained from healthy volunteers Baroreflex function, HR variability and blood pressure variability in patients early after coronary surgery ...
Fulltext - Jultika
... of various cardiovascular and/or pulmonary diseases. Failure will present with gradually decreasing cardiac performance accompanied with increases in pulmonary vascular pressure and its concurrent development of pulmonary dysfunction. Right heart failure may have various etiologies, the more common ...
... of various cardiovascular and/or pulmonary diseases. Failure will present with gradually decreasing cardiac performance accompanied with increases in pulmonary vascular pressure and its concurrent development of pulmonary dysfunction. Right heart failure may have various etiologies, the more common ...
Cardiac Function in Heart Failure: The Role of Calcium
... [32]. Structural changes in troponin C affect its calcium sensitivity [32]. Ca2+ binding affinity controls contractile force and changes in many types of diseases. Troponin C is part of a troponin complex that together with tropomyosin affects the interaction between actin and myosin leading to the ...
... [32]. Structural changes in troponin C affect its calcium sensitivity [32]. Ca2+ binding affinity controls contractile force and changes in many types of diseases. Troponin C is part of a troponin complex that together with tropomyosin affects the interaction between actin and myosin leading to the ...
High Time-Resolved Cardiac Functional Imaging - MIP :: Lab
... ability to assess whole heart volume. With robust estimation of myocardial contraction, MRI is considered as the gold standard for cardiac function assessment [2], [3]. In a context where cardiovascular diseases are still the leading cause of mortality worldwide [4], small animal cardiac MR imaging ...
... ability to assess whole heart volume. With robust estimation of myocardial contraction, MRI is considered as the gold standard for cardiac function assessment [2], [3]. In a context where cardiovascular diseases are still the leading cause of mortality worldwide [4], small animal cardiac MR imaging ...
Patent ductus arteriosus in a lamb: A case report
... evidences of a large PDA with left-sided heart failure. These signs are not specific for PDA and can be present with any congenital cardiac anomaly that result in a left-to-right shunt. No consistent electrocardiographic pattern has been identified with PDA. Echocardiographic evidence of a PDA is pr ...
... evidences of a large PDA with left-sided heart failure. These signs are not specific for PDA and can be present with any congenital cardiac anomaly that result in a left-to-right shunt. No consistent electrocardiographic pattern has been identified with PDA. Echocardiographic evidence of a PDA is pr ...
Heart Valves Structural Heart and Endograft Technologies
... any new programs will affect the health care changes already underway. While we wait and speculate, there is information that we do know and we hope to provide a small bit to you in this report. We do know the hospital inpatient reimbursement schedule for 2017. We do know that suppliers continue to ...
... any new programs will affect the health care changes already underway. While we wait and speculate, there is information that we do know and we hope to provide a small bit to you in this report. We do know the hospital inpatient reimbursement schedule for 2017. We do know that suppliers continue to ...
Cardiac Function in Heart Failure: The Role of Calcium Cycling
... [32]. Structural changes in troponin C affect its calcium sensitivity [32]. Ca2+ binding affinity controls contractile force and changes in many types of diseases. Troponin C is part of a troponin complex that together with tropomyosin affects the interaction between actin and myosin leading to the ...
... [32]. Structural changes in troponin C affect its calcium sensitivity [32]. Ca2+ binding affinity controls contractile force and changes in many types of diseases. Troponin C is part of a troponin complex that together with tropomyosin affects the interaction between actin and myosin leading to the ...
Association between Normal Aging and Phasic Left Atrial Volume as
... volume, compared with traditional M-mode and 2D methods. In this study, we used RT3DE to evaluate phasic LA volumes and functions among different age groups of healthy Taiwanese subjects. Methods: Sixty-eight healthy volunteers were divided into three groups according to age. Group 1: under 40 years ...
... volume, compared with traditional M-mode and 2D methods. In this study, we used RT3DE to evaluate phasic LA volumes and functions among different age groups of healthy Taiwanese subjects. Methods: Sixty-eight healthy volunteers were divided into three groups according to age. Group 1: under 40 years ...
Arrhythmia Risk and Obesity
... suffer from a cardiovascular disorder (substrate related), which may have an additive effect on the perpetuation of the arrhythmia [22,26], but there are some patients with “lone” atrial fibrillation, without an underlying cardiovascular disorder [28]. Patients with lone atrial fibrillation have nor ...
... suffer from a cardiovascular disorder (substrate related), which may have an additive effect on the perpetuation of the arrhythmia [22,26], but there are some patients with “lone” atrial fibrillation, without an underlying cardiovascular disorder [28]. Patients with lone atrial fibrillation have nor ...
Computed Tomography Imaging in Patients with Congenital Heart
... described for safe injection as well, although hand injection is commonly used with these access types. Umbilical catheters can be safely used but may result in suboptimal contrast enhancement due to reflux of contrast into the liver. Due to the high incidence of intra-cardiac shunting in patients wi ...
... described for safe injection as well, although hand injection is commonly used with these access types. Umbilical catheters can be safely used but may result in suboptimal contrast enhancement due to reflux of contrast into the liver. Due to the high incidence of intra-cardiac shunting in patients wi ...
Myocardial strain imaging: how useful is it in clinical
... myocardium.14 Importantly, a segment which is entirely passive during the first few hours after coronary occlusion, may yet not be irreversibly injured and may recover with reperfusion.15 In the chronic phase after an infarct, however, an entirely passive strain curve is most likely a sign of scarri ...
... myocardium.14 Importantly, a segment which is entirely passive during the first few hours after coronary occlusion, may yet not be irreversibly injured and may recover with reperfusion.15 In the chronic phase after an infarct, however, an entirely passive strain curve is most likely a sign of scarri ...
Cardiac phase-dependent time normalization reduces - VU-dare
... show that isochrones and also the ESPVR are generally nonlinear and that the degree of nonlinearity depends on the contractile state. In addition, studies investigating the length-tension relationship of mammalian papillary muscle showed that the time-course of isometric and isotonic contraction var ...
... show that isochrones and also the ESPVR are generally nonlinear and that the degree of nonlinearity depends on the contractile state. In addition, studies investigating the length-tension relationship of mammalian papillary muscle showed that the time-course of isometric and isotonic contraction var ...
Extracorporeal Membrane Oxygenation in Cardiopulmonary
... single-center study reported a comparably high rate of success with the use of conventional mechanical ventilation alone in patients with similar degrees of hypoxemia (28). Such discrepancies highlight the need for a prospective, randomized controlled trial evaluating the effect of ECMO on survival ...
... single-center study reported a comparably high rate of success with the use of conventional mechanical ventilation alone in patients with similar degrees of hypoxemia (28). Such discrepancies highlight the need for a prospective, randomized controlled trial evaluating the effect of ECMO on survival ...
Precordial and Carotid Pulse Palpation
... Figure 1. Normal and abnormal locations of precordial impulses. A = normal location of the left ventricular impulse in the left midclavicular line in the fifth intercostal space (approximately 1.5 cm in diameter); D = location of left ventricular impulse in dilated cardiomyopathy (in comparison with ...
... Figure 1. Normal and abnormal locations of precordial impulses. A = normal location of the left ventricular impulse in the left midclavicular line in the fifth intercostal space (approximately 1.5 cm in diameter); D = location of left ventricular impulse in dilated cardiomyopathy (in comparison with ...
Atrioventricular Node: Presence of New Functionally and
... background. The sino-atrial node potential could also be important for preservation of pacemaker activity in order to generate reentrant atrial. There is a ventricular pacemaker which takes over as the main pacemaker if the AV node fails. After the depolarization of the ventricles, a transient perio ...
... background. The sino-atrial node potential could also be important for preservation of pacemaker activity in order to generate reentrant atrial. There is a ventricular pacemaker which takes over as the main pacemaker if the AV node fails. After the depolarization of the ventricles, a transient perio ...
Massive pericardial effusion: two rare
... [4]. There is no consensus about the duration of antimicrobial therapy in salmonella pericarditis. However, most authors propose a minimum of three weeks [8]. During follow-up, no stool cultures were obtained. Thus it remains unknown, if the patient was a chronic carrier of salmonella. Pericardial t ...
... [4]. There is no consensus about the duration of antimicrobial therapy in salmonella pericarditis. However, most authors propose a minimum of three weeks [8]. During follow-up, no stool cultures were obtained. Thus it remains unknown, if the patient was a chronic carrier of salmonella. Pericardial t ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.