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Increases Left-to-Right Ventricular Systolic Interaction
Increases Left-to-Right Ventricular Systolic Interaction

... in the free walls, and the pericardium. It is useful to further subdivide anatomic mechanical interactions into those occurring during diastole and systole. Systolic ventricular interaction is especially important as a determinant of right heart function since it is known that a substantial portion ...
Advances in Parasympathetic Control of Heart Rate
Advances in Parasympathetic Control of Heart Rate

... In each respiratory cycle the heart beats more rapidly in inspiration and slows during postinspiration and expiration, often referred to as respiratory sinus arrhythmia. Respiratory sinus arrhythmia is present in healthy fetuses, newborns, and mature animals and humans. However, respiratory sinus ar ...
Myoglobin facilitates oxygen diffusion
Myoglobin facilitates oxygen diffusion

... of the MbCO signal at –2.3 ppm, whereas the MbO2 signal at – 2.8 ppm was no longer detectable (Fig. 1), which demonstrated complete inhibition of the oxygen binding capacity of Mb. Both Mb signals were absent in myo-/- hearts. As is apparent from Table 1, neither WT nor myo-/- hearts displayed a fun ...
Early glycoprotein IIb–IIIa inhibitors in primary - Heart
Early glycoprotein IIb–IIIa inhibitors in primary - Heart

... except for abciximab, whereas the rate of complete STsegment resolution was significantly higher with early Gp IIb–IIIa inhibitors. Mortality was not significantly different between groups, although early abciximab demonstrated improved survival compared with late administration, even after adjustme ...
Stenotic Semilunar Valve in Persistent Truncus Arteriosus
Stenotic Semilunar Valve in Persistent Truncus Arteriosus

... from 12 babies less than six months of age, seven of whom had deformed and incompetent truncal valves. In these latter seven, refractory cardiac failure had been present. Van Praagh and Van Praagh reported the pathologic findings in one case with probable truncal valvular stenosis. Victorica and ass ...
Acute and long-term results of radiofrequency ablation of common
Acute and long-term results of radiofrequency ablation of common

... population-based study have suggested that the overall incidence of AFL is 88/100 000 personyears or 200 000 new cases in the US population annually.3 AFL is highly symptomatic in the majority of patients4 and is associated with morbid events such as tachycardic cardiomyopathy,5 thromboembolism,6–8 ...
Soluble TNF Receptors Are Associated with Elevation Myocardial Infarction
Soluble TNF Receptors Are Associated with Elevation Myocardial Infarction

... Correlations between sTNFR1, sTNFR2, sFAS and sFASL and Measures of Infarct Size The infarct size, defined as the late gadolinium enhancement zone (LGE zone) on CMR examination, was assessed at five days and four months after STEMI and primary PCI. All study participants were included in the day fiv ...
Pregnancy-Related Spontaneous Coronary Artery
Pregnancy-Related Spontaneous Coronary Artery

... flow and salvaging ischemic myocardium acutely. In these instances, the surgical intervention (often with hemodynamic support) enabled shortterm survival of these patients and myocardial preservation. Mechanical support with intra-aortic balloon pump is often required for hemodynamically unstable pa ...
Cardiovascular magnetic resonance for the
Cardiovascular magnetic resonance for the

... Patients with ischaemic, but viable myocardium who are successfully revascularized have more than a four-fold decrease in annual mortality when compared to those treated medically8. Furthermore, medically treated viable myocardium is the harbinger of further non-fatal ischaemic events and significan ...
Left Ventricular Hypertrophy in Obese Hypertensives: Is It Really
Left Ventricular Hypertrophy in Obese Hypertensives: Is It Really

... males aged 53.11± 12.55 years (mean ± SD) and 61 females aged 48.18± 14.63 years. Corresponding values for the whole group were 50.83± 13.2 years. Almost all age groups were included. The youngest patient was 17 and the eldest 90 years old, median value was 50 years. All the patients were supposed t ...
Clinical characteristics, aetiological factors and
Clinical characteristics, aetiological factors and

... an acute myocardial infarction with absolutely normal epicardial coronary arteries at the post-myocardial infarction coronary angiogram. The aetiological and prognostic factors in this population were also analysed. Background Few data exist concerning the outcome, and aetiological and prognostic fa ...
Relationship between Anemia and Diastolic Dysfunction of the Heart
Relationship between Anemia and Diastolic Dysfunction of the Heart

... controversial. Recently ‘‘HF with preserved EF’’ has become the more accepted term used by the American Heart Association and the American College of Cardiology rather than ‘‘diastolic HF’’.[6] LV volume, geometry, and function differ substantially in these two conditions.[7] Even brain natriuretic ...
Electrocardiogram in an MRI Environment: Clinical Needs
Electrocardiogram in an MRI Environment: Clinical Needs

... Patient preparation such as skin preparation, electrode and lead positioning are of profound importance for any successful ECG monitoring in an MRI environment. Careful skin preparation includes (i) removal of chest hair by shaving, if applicable, (ii) cleaning of the skin with special abrasive skin ...
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)

... is interrupted or altered, and can cause life-threatening arrhythmias (abnormal heart rhythms) and in some cases sudden cardiac death. ...
The relationship between B-type natriuretic peptide levels and
The relationship between B-type natriuretic peptide levels and

... symptoms may vary substantially during the course of the disease process and may not correlate with changes in underlying cardiac function. Although HF is progressive and often fatal, patients can be stabilized, and myocardial dysfunction and remodeling may improve, either spontaneously or as a cons ...
Effects of prolonged anoxia on electrical activity of the heart in
Effects of prolonged anoxia on electrical activity of the heart in

... following conditions: initial denaturation at +98°C for 1 min followed with 35 cycles at +98°C for 10 s, +60°C for 30 s and +72°C for 40 s and final extension at +72°C for 2 min. The PCR products were run on an agarose gel, desired products were extracted from the gel by GeneJet Gel extraction kit ( ...
Yoga in cardiac health (A Review)
Yoga in cardiac health (A Review)

... This review studies the efficacy of yoga in the primary and secondary prevention of ischaemic heart disease and postmyocardial infarction patient rehabilitation. Yoga is an unconventional form of physical exercise that has been practised over a long period of time in the Indian sub-continent. It has ...
Specific Findings of the Standard 12-Lead ECG in
Specific Findings of the Standard 12-Lead ECG in

... ‘Takotsubo’ cardiomyopathy resembles anterior AMI in terms of chest symptoms and the ECG changes in the precordial leads. Therefore, emergency CAG is usually performed to distinguish ‘Takotsubo’ cardiomyopathy from anterior AMI during the acute phase. This is the first study to evaluate the usefulne ...
Recommendations for chamber quantification
Recommendations for chamber quantification

... there is a systemic tendency for higher measurements of LV wall thickness and mass and smaller measurements of internal dimensions and volumes.3,4 When analyzing serial studies on a given patient, differences in chamber dimension potentially attributable to imaging changes from the fundamental to th ...
Exercise and physical activity in relation to kinesiophobia
Exercise and physical activity in relation to kinesiophobia

... evidence, I am convinced that patients with coronary artery disease (CAD) will benefit greatly from exercise-based cardiac rehabilitation. In this thesis, secondary prevention and cardiac rehabilitation are seen from a physiotherapeutic perspective and physical activity and exercise therefore run li ...
Atrial fibrillation - Giornale Italiano di Cardiologia
Atrial fibrillation - Giornale Italiano di Cardiologia

... procedural endpoint is the total disconnection or dissociation of the PV. Additional ostial applications to eliminate all ostial PV potentials, notably between the PVs and at their posterior wall, reduce the risk of recurrence due to ostial foci. While the use of a circumferential mapping catheter p ...
Downstream clinical consequences of stress cardiovascular
Downstream clinical consequences of stress cardiovascular

... consensus and have not been systematically assessed for CMR. The aim of this study was to determine the rates of abnormal stress-CMR and subsequent downstream utilization of angiography and revascularization procedures based on the most recent AUC. Methods: 300 consecutive patients referred for CMR- ...
Increased IGF1 levels in relation to heart
Increased IGF1 levels in relation to heart

... number of studies have shown that IGF-1 is related to CV disease, but the mechanisms involved are still not clear (1-3). Both low and high levels of circulating IGF-1 have been reported to be associated with increased mortality (4-6) as well as with cardiac failure (7). Protective (1, 8, 9) as well ...
Amiodarone Supplants Lidocaine in ACLS and CPR Protocols
Amiodarone Supplants Lidocaine in ACLS and CPR Protocols

... Thyroxine and amiodarone have similar structures. Due to the iodine content of the agent, abnormalities in thyroid function are common. Both underactivity and overactivity of the thyroid may occur while on amiodarone treatment. Measurement of free thyroxine (FT4) alone may be unreliable in detecting ...
Living With Your CRT-D
Living With Your CRT-D

... are not delivered fast enough to the body. This condition is called heart failure. What is congestive heart failure? Fluid can also back up in the lungs and elsewhere in the body, causing congestion similar to a traffic jam. This fluid back up can lead to a serious condition called congestive heart ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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