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Triumph of the trials
Triumph of the trials

... Randomized 4060 patients to rate control therapy or to rhythm control therapy All patients enrolled in the trial were able to tolerate either rate or rhythm control ...
The Heart
The Heart

... after it leaves the left ventricle. The first branch represents the coronary arteries, which nourish the heart muscle itself. Blood from these arteries flows into capillaries, then into the coronary veins, which empty directly into the right atrium at the coronary sinus. Ascending branches of the ao ...
Three-dimensional alignment of the aggregated myocytes in the
Three-dimensional alignment of the aggregated myocytes in the

... using force probes suggest that these intruding myocytes working in conjunction with the fibrous matrix, have an impact on myocardial mechanics (16, 17). When assessing the mechanisms producing myocardial function, therefore, it is important to take note of the intruding angulation of the myocytes a ...
Combined angiotensin receptor blocker and ACE inhibitor on
Combined angiotensin receptor blocker and ACE inhibitor on

... fibrosis and left ventricular (LV) stiffness in animals with pathways in the heart for generating ANG II as well as ACE. A model of pacing-induced congestive heart failure (CHF) was used to test the central hypothesis that ARB ⫹ ACEI prevents myocardial fibrosis and decreases LV stiffness to a great ...
Sudden cardiac death in young athletes: what is the role
Sudden cardiac death in young athletes: what is the role

... Committee (IOC), and Federation Internationale de Futbol Association (FIFA) that cardiovascular screening in athletes should be undertaken [22–25]. The sudden death of a young athlete is a catastrophic event resulting in the loss of a substantial number of quality life-years [26]. Indeed, a working ...
Transcatheter valve interventions: mitral valve is the next quest
Transcatheter valve interventions: mitral valve is the next quest

... LVID: Left ventricular internal dimension. Adapted with permission from [10] . ...
Case report: Persistent truncus arteriosus with intact ventricular
Case report: Persistent truncus arteriosus with intact ventricular

... Genetic factors and familial occurrence have been reported in keeshond dogs. A genetic study suggested that specific mutations in oligenic genes including CFA2, CFA9 and CFA15 may be responsible for conotruncal heart malformations. These mutations might be spontaneous or induced by teratogens [27]. ...
document
document

... weeks and tapering over 3 months – Retrospective study compared prednisone 1mg/kg/day to 0.2-0.5mg/kg/day • Patients with recurrent pericarditis who are intolerant to or failed on NSAIDs • Baseline characteristics: more females and older in high dose group • Higher recurrence rate in 1mg/kg/day grou ...
Slideset - European Society of Cardiology
Slideset - European Society of Cardiology

... • CMR with late gadolinium enhancement (LGE) can detect myocardial ...
Gated blood pool SPECT improves reproducibility of right and left
Gated blood pool SPECT improves reproducibility of right and left

... WD. Quantitative gated blood pool SPECT: Analysis of 3dimensional models for the assessment of regional myocardial wall mot ...
Atrial pacing for the prevention of atrial fibrillation after
Atrial pacing for the prevention of atrial fibrillation after

... Conventional treatment strategies. Atrial fibrillation is the most common postoperative complication following cardiac surgery (2). Although it usually does not result in long-term sequelae, it does add significantly to morbidity, utilization of hospital resources and the length of hospitalization ( ...
imaging three-dimensional cardiac function
imaging three-dimensional cardiac function

... feedback, portability, and widespread availability. Echocardiographic imaging is based on the partial reflection of acoustic waves at tissue boundaries and echocardiographic image contrast is governed by the difference in acoustic properties between adjacent tissues. A pencil-shaped beam (M-mode) is ...
Aortic Valve
Aortic Valve

...  Catheter insertion site  Retroperitoneal o Surgical valvotomy  Monitor for hypertension  LV function usually preserved  Often hyperdynamic due to long standing stenosis and high afterload results in hypertension  Low cardiac output syndrome (LCOS)  May be prolonged due to the hypertrophied L ...
Cardiac Monitoring & ADHD - Scioto County Medical Society
Cardiac Monitoring & ADHD - Scioto County Medical Society

... and specificity of the ECG as a general screening test (AAP, Pediatrics statement) • There does not seem to be compelling findings of a medication- specific risk necessitating changes in our stimulant treatment of children and adolescents with ADHD (AAP, Pediatrics statement) ...
Ibutilide Pretreatment to Facilitate Cardioversion of Refractory Atrial
Ibutilide Pretreatment to Facilitate Cardioversion of Refractory Atrial

... second dose of the same strength can be given to patients in whom cardioversion is not achieved after the first dose. There are no specific dosing recommendations for patients who are obese. Furthermore, the optimal dose of ibutilide in the setting of facilitated cardioversion is not known. The grea ...
SUDDEN DEATH IN YOUNG ATHLETES
SUDDEN DEATH IN YOUNG ATHLETES

... influenced by the unavoidable limitations in patient selection because of retrospective analysis. Moreover, in other large studies, the autopsies were usually performed by different examiners, including local pathologists and medical examiners [10]. In the Italian study, to obtain a higher level of ...
Time-course changes in left ventricular myocardial deformation in
Time-course changes in left ventricular myocardial deformation in

... structure occurred early in diabetic rabbits with normal LV ejection fraction (EF), FS, and E/A. VVI could be used to evaluate subtle cardiac dysfunction in the early phase of DM. Key words: DM; myocardial deformation; VVI; STZ-induced rabbits Diabetes mellitus is among the most common chronic disea ...
Machine Learning for Cardiac Ultrasound Time Series Data
Machine Learning for Cardiac Ultrasound Time Series Data

... specialists. Although this is the gold standard method for identifying heart abnormalities, cost, time and geographic constraints necessitate research into automatic detection of key markers that signal heart dysfunction. Of central importance to the automation problem is the selection of frames cor ...
The right ventricle in pulmonary arterial hypertension
The right ventricle in pulmonary arterial hypertension

... Campus CP 640, 808 Route de Lennik, B-1070 Brussels, Belgium. E-mail: [email protected] ...
Ch. 20
Ch. 20

... • Cardiac muscle relies on aerobic cellular respiration for ATP production. • Cardiac muscle also produces some ATP from creatine phosphate • The presence of creatine kinase (CK) in the blood indicates injury of cardiac muscle usually caused by a myocardial infarction. ...
Ventricular Assist Device
Ventricular Assist Device

... The ventricular assist device is a mechanical device to assist or support the failing ventricle  It can be used as a bridge to recovery in acute reversible cardiac failure or as a bridge to transplant in chronic terminal heart failure ...
The Impact of ST Elevation on Athletic Screening
The Impact of ST Elevation on Athletic Screening

... single-lead criteria compared with the adjacent-lead criteria, so the following figures will only show the results for the singlelead criteria. As shown, the prevalence of STE decreases with age, is more prevalent in athletes compared with age-matched outpatients, and is 2 to 10 times more prevalent ...
DOI: 10.1161/CIRCULATIONAHA.106.172860 published online Jan
DOI: 10.1161/CIRCULATIONAHA.106.172860 published online Jan

... heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imply that the recommendation is weak. Many important clinical questions addressed in the guidelines do not lend themselves to clinical trials. Even though randomized trials are not available, there may be ...
A case with pyopericardium and cardiac tamponade
A case with pyopericardium and cardiac tamponade

... perforated the ventricular wall and subsequently migrated into the pericardial cavity. In both of these cases, gradual erosion of the atrial or ventricular wall caused by the distal tip of the VA shunt was one of the main sources of the cardiac tamponade. However, to our knowledge, there are no prev ...
Chapter 3
Chapter 3

... • Cardiac muscle relies on aerobic cellular respiration for ATP production. • Cardiac muscle also produces some ATP from creatine phosphate • The presence of creatine kinase (CK) in the blood indicates injury of cardiac muscle usually caused by a myocardial infarction. ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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