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Congenital heart diseases Simple complement 1. The most
Congenital heart diseases Simple complement 1. The most

... 2. The characteristic clinical signs in the interventricular septal defect with large shunt are: A. Dyspnea B. Difficulties of alimentation C. Diastolic murmur D. Nutritional deficit E. Recurrent respiratory infections 3. Which type of CHD are considering vascular malformations? A. Ebstein anomaly B ...
Acute viral myocarditis
Acute viral myocarditis

... getting their heart affected, only a selected few develop clinical symptoms. The exact incidence of myocarditis remains unclear, partly due to the insensitivity of diagnostic tools used in previous studies. This may cause an underestimation of its true incidence. The prevalence of myocarditis has be ...
Losartan Mylan film-coated tablet ENG SmPC
Losartan Mylan film-coated tablet ENG SmPC

... 6 months – less than 6 years The safety and efficacy of children aged 6 months to less than 6 years has not been established. Currently available data are described in sections 5.1 and 5.2 but no recommendation on posology can be made. Losartan is not recommended for use in children under 6 years ol ...
Biomarkers of Acute Coronary Syndrome and Heart Failure
Biomarkers of Acute Coronary Syndrome and Heart Failure

... Analytical Issues of ACS Biomarkers; Chapter 3: Clinical Utilization of Biomarkers of Heart Failure; Chapter 4: Analytical Issues of Heart Failure Biomarkers; Chapter 5: Point of Care Testing and Logistics; and Chapter 6: Cardiac Biomarkers and Other Etiologies. Each chapter was spearheaded by a wri ...
Guideline d
Guideline d

... Usually not necessary, but indicated • in complex cases • in undefined coronary anatomy • in case of late presentation and unclear hemodynamics ...
cardiac rhythm and atrial transport function after surgical ablation of
cardiac rhythm and atrial transport function after surgical ablation of

... AF occurs in up to 45% of patients with heart failure6. Its prevalence depends on the severity of heart failure, and rises approximately from 5% in the NYHA I functional class up to 50% in NYHA IV class7. Up to 50% of patients undergoing mitral valve surgery are diagnosed with AF prior to the surger ...
Ch26_Disorders of Cardiac Fxn - University of Perpetual Help
Ch26_Disorders of Cardiac Fxn - University of Perpetual Help

... In summary, the pericardium is a two-layered membranous sac that isolates the heart from other thoracic structures, maintains its position in the thorax, and prevents it from overfilling. The mechanisms that control the movement of fluid between the capillaries and the space that separates the two lay ...
2014 AHA/ACC/HRS Guideline for the€Management of Patients
2014 AHA/ACC/HRS Guideline for the€Management of Patients

... Experts in the subject under consideration are selected ...
Repaired tetralogy of Fallot: the roles of cardiovascular magnetic
Repaired tetralogy of Fallot: the roles of cardiovascular magnetic

... unique opportunity to examine the long-term effects of severe chronic PR without the confounding effects of cyanosis, ventricular septal defect, pulmonary stenosis, or the sequelae of cardiac surgery. In a review of 72 such cases reported in the literature [31], Shimazaki et al. found that that the ...
Acute myocardial infarction: pre-hospital and in
Acute myocardial infarction: pre-hospital and in

... undergone major changes in recent years. Good practice can now be based on sound evidence derived from well-conducted clinical trials. Because of this, the European Society of Cardiology decided that it was opportune to provide guidelines and appointed a Task Force to formulate these. It must be rec ...
coronary hemodynamic and angiographic determinants
coronary hemodynamic and angiographic determinants

... artery stenosis. Third, in no patient was there clinical evidence of variant angina, and the resting electrocardiogram showed no important Q waves or ST elevation or depression of 1 mm or greater. Fourth, left ventricular wall motion was preserved (ejection fraction .45%), and anterior wall motion w ...
14 Cardiovascular Physiology
14 Cardiovascular Physiology

... l­ ow-oxygen blood can impart a bluish color to certain areas of the skin, such as around the mouth and under the fingernails. This condition, known as cyanosis {kyanos, dark blue}, is the reason blue is used in drawings to indicate blood with lower oxygen content. From the right atrium, blood flows ...
Catheter Ablation in New Zealand
Catheter Ablation in New Zealand

... Catheter ablation is a minimally invasive procedure performed by Cardiac electrophysiology subspecialised Cardiologists for the treatment of many cardiac arrhythmias. It is a mature but continually evolving technology with clear indications for use as first-line treatment in certain defined populati ...
Echocardiographic Evaluation ofLeft Ventricular Size
Echocardiographic Evaluation ofLeft Ventricular Size

... 39 ± 5%,p < 0.001) and Vd (1.15 ± 0.15 vs 1.28 0.19 sec-',p < 0.001). Handgrip exercise at 15% of maximum grip produced similar but less marked changes in the 27 subjects, and acute pressure loading with phenylephrine caused similar but more marked changes in 10 of the subjects. In the 20 subjects w ...
Clinical Guideline
Clinical Guideline

... in patients with known or suspected IHD and a prior myocardial infarction, pathologic Q waves, symptoms or signs suggestive of heart failure, complex ventricular arrhythmias, or an undiagnosed heart murmur (Grade: strong recommendation; moderate-quality evidence). Recommendation 12: The organization ...
Final Protocol - Department of Health
Final Protocol - Department of Health

... technologies it is likely that the frequency of this intervention will gradually increase and more will be closed in this way replacing surgical treatment. However, the total number of VSDs which require closure either by surgical, hybrid or transcatheter technique should remain constant and it is a ...
Right ventricular function
Right ventricular function

... that encircle the normal left and right ventricle. Furthermore, in some forms of congenital heart disease the deeper layers or the right and left ventricle may be contiguous within the interventricular septum (28). The function of the two ventricles is therefore inextricably linked, in both the stru ...
Original file was main.tex
Original file was main.tex

... identified by an increased LV wall thickness, usually quantified by echocardiography or magnetic resonance imaging (MRI). The distribution of the hypertrophy may take many forms and vary greatly among patients but it is usually most prominent in the ventricular septum. In addition, the absolute thic ...
JEPonline Physiological Responses to Dangling and Standing in
JEPonline Physiological Responses to Dangling and Standing in

... with the legs hanging over the edge of the bed (35). It is a common nursing intervention used to assess and promote a patient’s physiologic tolerance to getting out of the bed (22,28,33). The patient may dangle or more typically, stand, pivot, and sit in a chair. Despite nurses' routine use of dangl ...
Atrial Fibrillation Management: 2005
Atrial Fibrillation Management: 2005

... Ganglionic Plexi ...
2014 AHA/ACC/HRS Guideline for the€Management of
2014 AHA/ACC/HRS Guideline for the€Management of

... Experts in the subject under consideration are selected ...
Preview the material
Preview the material

... and spectrum of arrhythmias change with age. As a consequence, treating arrhythmias in children has its unique challenges. While abnormal heart rates in children are often not a cause of concern, children with an abnormal heart rhythm, including consideration of the child’s age, age of onset of arrh ...
Almanac 2011: Valvular Heart Disease. The National Society
Almanac 2011: Valvular Heart Disease. The National Society

... Based on the aortic jet velocity and the B-type natriuretic peptide (BNP) level, a risk score predicting outcome in patients with moderate-to-severe asymptomatic AS was derived and validated in an independent cohort: score=(peak velocity (m/s)×2)+(ln of BNP×1.5)+1.5 (if female sex). Event-free survi ...
Transcatheter Mitral Valve Repair
Transcatheter Mitral Valve Repair

... For Medicare Advantage TMVR for MR is considered medically necessary under Coverage with Evidence Development (CED), with the following conditions (not an inclusive list): Treatment of significant symptomatic degenerative MR when furnished according to an FDA-approved indication and when all of the ...
Atrial Fibrillation After Lung Transplantation
Atrial Fibrillation After Lung Transplantation

... The mean age (±SD) of the population was 55 ± 11 years and 52% were male. A total of 48 patients (28%) developed AF in the postoperative period. Predictors of postoperative AF in multivariate analysis included: age (per decade) Odds Ratio (OR): 1.61, 95% confidence interval (CI) 1.10-2.34, p=0.01, p ...
< 1 ... 65 66 67 68 69 70 71 72 73 ... 680 >

Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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