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Correlation of Atrial Natriuretic Peptide and Cyclic
Correlation of Atrial Natriuretic Peptide and Cyclic

... transplantation were included in this study. All patients were examined only after their dismissal from the acute care facility and while they were in a stable chronic stage of their disease during rehabilitation. Beta-blocking drugs were withdrawn three days, and all other cardiac-active and vasodi ...
- Wiley Online Library
- Wiley Online Library

... Activation of the renin-angiotensin-aldosterone system (RAAS) occurs in people and in cats with HCM.11–13a In 1 study, myocardial aldosterone concentration was increased 4.5-fold in human patients with HCM, but plasma aldosterone concentration remained normal.11 Approximately 50% of Maine Coon cats ...
Resistant Hypertension: A Comprehensive Overview
Resistant Hypertension: A Comprehensive Overview

... patients whose BP is controlled on ≥ 4 AHDs but excludes patients whose BP is uncontrolled on a suboptimal AHD regimen or <3 AHDs [4]. Recent studies suggest that the prevalence of resistant HTN may be increasing over time [5]. Predictors of inadequately-controlled BP that characterize resistant HTN ...
Permanent Pacemaker
Permanent Pacemaker

... signal is sensed. If there is no intrinsic signal, the pacemaker delivers output.  Triggered mode will provide output from the pacemaker after a programmed time interval from a sensed event. This is an uncommon setting and mostly used during testing.  Dual mode is dependent on what chambers are se ...
Materials and Methods - AJP
Materials and Methods - AJP

... activation time maps for LV pacing with AV-delay from 0 to 150ms and for RA pacing. All ventricular pacing maps (A-E) are plotted using the LV pacing stimulus as the temporal reference while the RA pacing map (F) is plotted using the RA pacing stimulus as the reference. In Fig 3A, AV-delay is set to ...
Imaging cellular signals in the heart in vivo: Cardiac expression of
Imaging cellular signals in the heart in vivo: Cardiac expression of

... expression was detected by 2 weeks and robust functional signals were recorded beginning 4 weeks after withdrawal (see below). We confirmed that expression of GCaMP2 does not itself alter excitation–contraction coupling characteristics of heart cells by transiently loading control and transgenic hea ...
The visceral pericardium: macromolecular structure and - AJP
The visceral pericardium: macromolecular structure and - AJP

... photographing the opening angle was ⬍30 min. Microscopic examination and optical characterization. For twophoton excitation microscopy, small fresh tissue samples (⬍1 cm3) were collected from LV slices by dissection. Micrograph images were typically collected as a series of x-y planes as a function ...
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the

... jointly produced guidelines in the area of cardiovascular disease since 1980. The ACCF/AHA Task Force on Practice Guidelines (Task Force), charged with developing, updating, and revising practice guidelines for cardiovascular diseases and procedures, directs and oversees this effort. Writing committ ...
Management of stable angina pectoris
Management of stable angina pectoris

... Class III ‘Marked limitation of ordinary physical activity’ — walking one or two blocks on the level and climbing one flight of stairs in normal conditions and at normal pace. Class IV ‘Inability to carry on any physical activity without discomfort’ — anginal syndrome may be present at rest. The Can ...
Fig. 2
Fig. 2

... normalized by respective for glyceraldehyde-phospate dehydrogenase values. Each PCR reaction was performed at least twice, and four to five hearts were used for each experimental group. Drugs. Polyclonal rabbit anti-rat TNF-␣ Ab was purchased from R&D Systems (Minneapolis, Minnesota). Specific activ ...
The visceral pericardium: macromolecular structure and contribution
The visceral pericardium: macromolecular structure and contribution

... photographing the opening angle was ⬍30 min. Microscopic examination and optical characterization. For twophoton excitation microscopy, small fresh tissue samples (⬍1 cm3) were collected from LV slices by dissection. Micrograph images were typically collected as a series of x-y planes as a function ...
Atrial Fibrillation : Present Treatment Protocols by Drugs and Interventions Abstract
Atrial Fibrillation : Present Treatment Protocols by Drugs and Interventions Abstract

... An issue for concern about calcium channel blockers and beta blockers when used for initial ventricular rate control is their cardio-depressive effects, particularly in patients with heart failure. However, as a common practice – though not appropriately supported by data, one should feel comfortabl ...
Flecainide: Current status and perspectives in arrhythmia
Flecainide: Current status and perspectives in arrhythmia

... sinoatrial conduction time have been reported[25,26]. Finally, patients with implanted cardiac rhythm devices (pacemakers or internal cardiac defibrillators) and concomitant flecainide treatment may experience an increase in the pacing thresholds[25]. All the above mentioned electrophysiological pro ...
Impaired Myocardial Oxygenation Response to Stress in Patients
Impaired Myocardial Oxygenation Response to Stress in Patients

... Methods and Results-—Fifty-three subjects (23 subjects with CKD, 10 RT recipients, 10 hypertensive (HT) controls, and 10 normal controls without known coronary artery disease) underwent CMR scanning. All groups had cine and BOLD CMR at 3 T. The RT and HT groups also had late gadolinium CMR to assess ...
CHAPTER 13 Electrocardiography
CHAPTER 13 Electrocardiography

... boundary under study, and K is a constant reflecting differences in conductivity. This equation suggests that the recorded potential equals the product of two factors. First, the solid angle reflects spatial parameters, such as the size of the boundary of the region under study and the distance from ...
Full Text
Full Text

... jointly produced guidelines in the area of cardiovascular disease since 1980. The ACCF/AHA Task Force on Practice Guidelines (Task Force), charged with developing, updating, and revising practice guidelines for cardiovascular diseases and procedures, directs and oversees this effort. Writing committ ...
Left Atrial Size
Left Atrial Size

... onward (42). Indeed, age-related LA enlargement is a reflection of the pathophysiologic perturbations that often accompany advancing age rather than a consequence of chronologic aging (9). The relation of LA size to race or ethnicity has not been sufficiently studied. Atrial structural remodeling. M ...
Surgery for Atrial Fibrillation
Surgery for Atrial Fibrillation

... the sudden onset of the tachyarrhythmia. Surgical treatment should be considered in these patients. There is a subset of patients who are not indicated for surgery. Those include patients with a severely dilated left atrium, increased cardio-thoracic ratio, decreased amplitude of the f-waves in the ...
2008 Slide Set - American College of Cardiology
2008 Slide Set - American College of Cardiology

... Data derived from a single randomized trial or nonrandomized studies Limited populations evaluated ...
Thrombus aspiration in acute myocardial infarction
Thrombus aspiration in acute myocardial infarction

... The AngioJet thrombectomy system consists of a hollow catheter through which saline is infused under pressure and forced to exit retrogradely just before the catheter tip. These jets create a future science group ...
Slide 1
Slide 1

... Data derived from a single randomized trial or nonrandomized studies Limited populations evaluated ...
I IIa IIb III - Northside Heart and Lung
I IIa IIb III - Northside Heart and Lung

... Data derived from a single randomized trial or nonrandomized studies Limited populations evaluated ...
Theme: «CARDIAC INSUFFICIENCY»
Theme: «CARDIAC INSUFFICIENCY»

... E Intensification of RNA generation 2. In course of a preventive examination of a miner a doctor revealed changes of cardiovascular fitness which was indicative of cardiac insufficiency at the compensation stage. What is the main proof of cardiac compensation? A Myocardium hypertrophy B Tachycardia ...
A review of guidelines for cardiac rehabilitation exercise programmes
A review of guidelines for cardiac rehabilitation exercise programmes

... angina pectoris,7,10 myocardial infarction (MI)7,10,12 and coronary revascularisation.7,10 Cardiac rehabilitation is also recommended for patients who have undergone heart transplant13 or valvular surgery,14 in addition to those suffering chronic heart failure.15 Meta-analyses have shown significant r ...
ACC/AHA 2008 Guidelines for the Management of Adults With
ACC/AHA 2008 Guidelines for the Management of Adults With

... Data derived from a single randomized trial or nonrandomized studies Limited populations evaluated ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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