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SIHD_Slide_Set
SIHD_Slide_Set

... • Patients presenting with angina should be categorized as stable vs. unstable. Those at moderate or high risk should be treated emergently for acute coronary syndrome. • A standard exercise test is the first choice to diagnose IHD for patients with an interpretable ECG and able to exercise, especia ...
Left ventricular hypertrophy in athletes
Left ventricular hypertrophy in athletes

... Athletic training is associated with statistically significant increases in cardiac dimensions compared with sedentary individuals. A meta-analysis of almost 1000 M-mode echocardiographic studies in highly trained male athletes showed that athletes exhibited a 15–20% increase in septal and left vent ...
The effect of exercise training on transverse tubules in normal
The effect of exercise training on transverse tubules in normal

... The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts that associate with detubulation, by confocal l ...
Prevention and Treatment of Microvascular Obstruction
Prevention and Treatment of Microvascular Obstruction

... PCI and followed by oral treatment improved myocardial perfusion and regional left ventricular wall motion in treated patients when compared to a control group (10). Intracoronary adenosine and verapamil administered following primary PCI achieved equivalent improvement of myocardial perfusion, whic ...
Echocardiographic findings in pulmonary embolism: An important
Echocardiographic findings in pulmonary embolism: An important

... heparin should be given to patients with a moderate to high clinical probability of pulmonary embolism or deep vein thrombosis until all diagnostic results are available. LMWH is preferred to unfractionated heparin. LMWH can be given subcutaneously once or twice a day, and laboratory monitoring may ...
The Coronary Venous Anatomy
The Coronary Venous Anatomy

Radiofrequency ablation on veno-arterial extracorporeal life support
Radiofrequency ablation on veno-arterial extracorporeal life support

... drugs that were effective in controlling the tachyarrhythmia also caused heart rate slowing to 70/min, which was inadequate to provide sufficient cardiac output for the child to be weaned off extracorporeal support. Certain alterations to ablation technique were necessary because of the extracorpore ...
b-type natriuretic peptide/ (bnp)
b-type natriuretic peptide/ (bnp)

... should be used together.16 Studies also indicate that BNP also has a burgeoning role in the prognostic assessment of patients with heart failure.17 BNP is a powerful prognostic indicator for patients with CHF at all stages of the disease and seems to be a better predictor of survival than many tradi ...
Effect of Bipolar Electrode Spacing on Phrenic Nerve Stimulation
Effect of Bipolar Electrode Spacing on Phrenic Nerve Stimulation

... after the chest was closed (Figure 1B). During pacing, PNS was detected using tactile feel by placing a hand directly on the chest, and the presence of PNS was verified (ie, PNS threshold <2 V at 0.5 ms in unipolar configuration). Once the phrenic nerve was repositioned, unipolar electric measuremen ...
Electrical Cardioversion
Electrical Cardioversion

... action is restored and may result in an ischemic stroke or transient ischemic attack (TIA) usually within the first 10 days following cardioversion. Depending on the time elapsed between the onset of an AF episode and the cardioversion procedure it is also possible that clots may form in the LAA an ...
How€to€Report€a€Coronary€CT€Angiography
How€to€Report€a€Coronary€CT€Angiography

... CT Angiography of the coronaries with and without contrast was performed using a 16/32/40/64/128/256-detector CT scanner. Axial images were obtained from the level of the subclavian artery/aortic arch/ascending aorta through to the diaphragm at 0.6 collimation mm section thickness during breath hold ...
Importance of the Conal Branch of the Right Coronary Artery
Importance of the Conal Branch of the Right Coronary Artery

... coronary circulation, James (22) noted that the LAD might supply varying degrees of the right ventricular free wall. He also noted that the right paraseptal region was supplied by the first big septal branches of the LAD alone or together with the conal branch of the right coronary artery (RCA) (the ...
19 Congenital Heart Disease in Children and Adults
19 Congenital Heart Disease in Children and Adults

... In contrast to the normal postnatal circulation, in the fetus the systemic and pulmonary circulations exist in parallel (Fig. 19.2). Prenatal survival is possible with even major structural cardiovascular malformations, provided that either the right or left ventricle is able to pump blood derived f ...
Percutaneous Left Atrial Appendage Closure Devices for Stroke
Percutaneous Left Atrial Appendage Closure Devices for Stroke

... Although the Watchman device and other LAA closure devices would ideally represent an alternative to oral anticoagulation for the prevention of stroke in patients with AF, during the postimplantation period, the device may be associated with increased thrombogenicity and, therefore, anticoagulation ...
MRI Anatomy and Positioning Series
MRI Anatomy and Positioning Series

... types of carditis. We will briefly review some of the treatments available for cardiovascular disease, such as balloon and stent angioplasty, CABG, ablation, pacemakers, valve replacement, ICD and VAD, and medications. Our discussion of cardiac MRI will focus on the types of sequences that result in ...
Catheter ablation for AF
Catheter ablation for AF

... additional ablation strategies described above, except to state that, in most cases, additional ablation other than PV isolation will be necessary in patients with the persistent form of AFib. Therefore, in this group of patients, this will currently consist of performing ablation lines or targeting ...
Head Up Tilt Testing: An Appraisal of Its Current Role in the
Head Up Tilt Testing: An Appraisal of Its Current Role in the

... EBefore describing the different available protocols, some terms have to be defined. In previous studies, the use of “sensitivity” and “positivity” brought up some confusion because of the absence of a gold-standard test to diagnose vasovagal syndrome. When considering the clinical diagnosis as the ...
Cardiac Mapping Systems
Cardiac Mapping Systems

Researches on the struture and function of the mammalian heart.
Researches on the struture and function of the mammalian heart.

... of the viscera'. It is further well known that the fibres of which the various chambers are built up whilst having many characters in common, yet differ to a certain extent, and a regular series can be recognised, the fibres taken from the auricles presenting characters intermediate between those of ...
- The Annals of Thoracic Surgery
- The Annals of Thoracic Surgery

... subgroup analyses, both low transfusion (adjusted HR 0.81, 95% CI: 0.65 to 1.00, p ⴝ 0.05) and high transfusion (adjusted HR 0.65, 95% CI: 0.49 to 0.87, p ⴝ 0.004) in the biventricular group but not in the single ventricle group was associated with increased LOS. Conclusions. Blood transfusion is as ...
ACLS Pharmacology Review
ACLS Pharmacology Review

... angina, and increased myocardial oxygen demand – Do not mix or give with alkaline solutions – Higher doses have not improved outcome & may cause myocardial dysfunction Pulseless Electrical Activity ...
ACLS Pharmacology Review
ACLS Pharmacology Review

... angina, and increased myocardial oxygen demand – Do not mix or give with alkaline solutions – Higher doses have not improved outcome & may cause myocardial dysfunction Pulseless Electrical Activity ...
full articles - pdf - People`s Journal Of Scientific Research
full articles - pdf - People`s Journal Of Scientific Research

... diverticulum of the ventricle are the most commonly encountered heart lesions (Amato et al, 1995; Leca et al, 1989). The severity and the complexity of the intracardiac defect contribute largely to the poor prognosis associated with this malformation(Amato et al, 1995). It has been also observed tha ...
Guidelines ARVD New Criteria Circ 2010
Guidelines ARVD New Criteria Circ 2010

... ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation of the frequently nonspecific clinical features of ARVC/D. This enabled confirmatory clinical diagnosis in index cases through exclusion of phenocopies and provided a standard on which clinical research and ...
Effect of Caloric Restriction or Aerobic Exercise
Effect of Caloric Restriction or Aerobic Exercise

... exercise intolerance, the primary symptom and major contributor to reduced quality of life (QOL) in patients with chronic HFPEF, is significantly correlated with increased body adiposity and skeletal muscle adipose infiltration.6,10 In obese older individuals without heart failure, weight loss via d ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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