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The Wenckebach Phenomenon: A Salute and Comment on the
The Wenckebach Phenomenon: A Salute and Comment on the

... him to decipher the rhythm disturbance that became known as Wenckebach periodicity (1). “A forty-year-old lady with nervous temperament” consulted Wenckebach about an irregular pulse. “She had noticed for a long time that her pulse was irregular. Her only heart trouble was a mild dilatation. Nevert ...
Pericardial Disease - Society of Cardiovascular Anesthesiologists
Pericardial Disease - Society of Cardiovascular Anesthesiologists

... (Table 2). One small observational study (n=10) reviewing this disorder found that paroxysmal stabbing chest pain that mimicked coronary ischemia was the most common clinical presentation8. Individuals with congenital absence of the pericardium are at increased risk for additional congenital abnorma ...
A 40-year-old Woman with Chest Pain, ST Elevation, Elevated
A 40-year-old Woman with Chest Pain, ST Elevation, Elevated

... in identifying a presumptive source but will usually not alter treatment. The mainstay of therapy is supportive care and a heart failure regimen should be initiated at the earliest time possible. If medical therapy fails, mechanical circulatory support can be considered. Some patients may eventually ...
Antithrombotic Therapy in Valvular Heart Disease—Native and
Antithrombotic Therapy in Valvular Heart Disease—Native and

... form of valvular heart disease. While surgery and the frequent use of long-term anticoagulant therapy have altered the natural history of this disease during the past 40 years, Wood2 cited a prevalence of systemic emboli of 9 to 14% in several large early series of mitral stenosis; in 1961, Ellis a ...
- St George`s, University of London
- St George`s, University of London

... profile athletes, has gained huge attention. Such catastrophes have generated considerable scientific interest and triggered debates relating to controversial issues such as the magnitude and the actual causes of such events. At present, however, despite the impressive number of reports of SCA/SCD i ...
Resynchronisation Cardiaque: Type d`appareil à utiliser
Resynchronisation Cardiaque: Type d`appareil à utiliser

... • Validation of the different methods • Optimization at rest but also during exercise • Optimization of AV and VV timings is time and persons consuming and not adequate with the decrease of medical demography in many countries • Device based algorithms are very attractive at least because of the spe ...
PDF
PDF

... nerve stimulation, to the same range under control conditions without nerve stimulation. These observations suggest that increased heterogeneity may be a very important atrial proarrhythmic vagal mechanism. This idea is compatible with both experimental and computer models of AF which indicate that ...
Modelling and robust estimation of AV node function during AF
Modelling and robust estimation of AV node function during AF

Echo-Doppler assessment of diastole: flow, function and
Echo-Doppler assessment of diastole: flow, function and

... However, while Doppler velocities and time intervals reflect filling pressures at the time of the examination, LA volume often reflects the cumulative effects of filling pressures over time. An LA volume of ≥34 ml/m2 is an independent predictor of cardiovascular complications.2 13 Confounding conditions ...
Giant left atrial appendage aneurysm compressing the left anterior
Giant left atrial appendage aneurysm compressing the left anterior

... Cardiology Department, Aswan Heart Centre, Magdi Yacoub Foundation, Aswan, Egypt. Email: [email protected] ...
TASER® Electronic Control Devices Review of Safety Literature
TASER® Electronic Control Devices Review of Safety Literature

... Mark W. Kroll, PhD, FACC, FHRS University of Minnesota Biomedical Engineering [email protected] 25 August 2008 ...
Relationship of epicardial adipose tissue thickness with cardiac output.
Relationship of epicardial adipose tissue thickness with cardiac output.

... 1. Heart rate:- After the initial anticipatory response, heart rate increases in direct proportional to exercise intensity until a maximum heart rate is reached. 2. Stroke volume:- Stroke volume (SV) increases proportionally with exercise intensity. In untrained individuals SV at rest averages 50-70 ...
A Matter of the Heart: The African Clawed Frog Xenopus as a Model
A Matter of the Heart: The African Clawed Frog Xenopus as a Model

... currently the main tools in Xenopus research (see next section). With respect to MO based strategies and novel genome editing approaches, it is noteworthy to mention that Xenopus laevis is tetraploid whereas the related Xenopus tropicalis is diploid. 2. Tool Kit for Studying Heart Development and Di ...
Regional ventricular wall thickening reflects changes in - AJP
Regional ventricular wall thickening reflects changes in - AJP

... systolic wall thickening. However, the destructive nature of conventional histological analysis employed in such meticulous studies complicates direct evaluation of any changes in myocardial fiber and sheet structure that accompany cardiac contraction. Recently, diffusion tensor MRI (DTMRI) has been ...
Definition of terms related to cardiac rhythm
Definition of terms related to cardiac rhythm

... A period in the cardiac cycle during which there is absence of conduction, whereas conduction occurs with impulses of greater and lesser prematurity. Gap in conduction is usually seen during AV or VA transmission, but it probably also occurs in other parts of the heart. Incomplete (partial) block an ...
Regional ventricular wall thickening reflects changes in cardiac fiber
Regional ventricular wall thickening reflects changes in cardiac fiber

... systolic wall thickening. However, the destructive nature of conventional histological analysis employed in such meticulous studies complicates direct evaluation of any changes in myocardial fiber and sheet structure that accompany cardiac contraction. Recently, diffusion tensor MRI (DTMRI) has been ...
Closure of atrial septal defect in the adult. Cardiac remodeling is an
Closure of atrial septal defect in the adult. Cardiac remodeling is an

... occasion to another. The right ventricular – right atrium pressure gradient that had fallen markedly (p<0.001) the day, or week for surgical cases, after closure did not significantly change later on. The temporal pattern of the left ventricular changes, although going in an opposite direction, foll ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... reported by Bhatia. 14 Dwivedi et al 15 have reported that PGE- like activity is enhanced in ischaemic rabbit aorta. The enhancement of PGE- like activity by Terminalia arjuna may account to some extent for the observed rise in coronary flow. So, it is evident from the study that Terminalia arjuna ( ...
The contribution of mitral annular excursion and shape - AJP
The contribution of mitral annular excursion and shape - AJP

... encompasses a volume that is part of the total LV volume change during both filling and emptying. Our objective was to evaluate the contribution of MA excursion and shape variation to total LV volume change. Nine healthy subjects aged 56±11 (mean±SD) years underwent transesophageal echocardiography ...
The right ventricle, outflow tract, and ventricular
The right ventricle, outflow tract, and ventricular

... marked by the activity of the mef2c-AHF-Cre transgene. In addition, the studies presented here demonstrate that cells marked by the mef2c-AHF-Cre transgene contribute to the endocardium of the right ventricle. We also show that within the outflow tract, the myocardium and endothelium are marked by t ...
Chapter 03 - Sinus Mechanisms ECGs made Easy, Ch 3 Quiz
Chapter 03 - Sinus Mechanisms ECGs made Easy, Ch 3 Quiz

... Usually normal but varies because of the pause Irregular due to the pause(s) caused by the SA block — the pause is the same as (or an exact multiple of) the distance between two other P-P intervals Positive (upright) in lead II, P waves look alike. When present, one precedes each QRS complex. 0.12–0 ...
Acute Liver Failure - The Medical University of South Carolina
Acute Liver Failure - The Medical University of South Carolina

... common in patients with acute liver failure and are often multifactorial in origin. The effective blood volume may initially be low owing to poor oral intake and fluid losses through vomiting and the development of vasodilatation, leading to a condition consistent primarily with hypovolemic shock. A ...
In Vivo Measurements of Atrial Repolarization Alternans
In Vivo Measurements of Atrial Repolarization Alternans

... rapid pacing mimicking pulmonary vein tachycardia did not lower Re-ALT threshold but increased the range of CL during which Re-ALT took place. This may facilitate alternation of atrial repolarization and wavebreaks over a wider range of heart rates as during the remodeling process of patients suffer ...
Flow Characteristics of the Medtronic CoreValve: Difficulties
Flow Characteristics of the Medtronic CoreValve: Difficulties

... less-invasive alternative for patients with severe symptomatic aortic stenosis who are at high-risk for surgical AVR2,3. Survival after TAVI is higher compared to medical therapy alone4, and is comparable with surgical AVR at 1-year5. The need for accurate follow-up assessment of TAVI devices is the ...
0474 ch 14(281-305).
0474 ch 14(281-305).

... Although the heart’s right and left sides are separated from each other, they work together. Blood is squeezed through the chambers by a heart muscle contraction that begins in the thin-walled upper chambers, the atria, and is followed by a contraction of the thick muscle of the lower chambers, the ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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