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Prognostic value of heart rate and systemic systolic blood pressure
Prognostic value of heart rate and systemic systolic blood pressure

... mortality and hospitalization. The predictive value of vital signs at the first follow-up visit was similar to the predictive value of enrollment vital signs, which we have previously presented.3 Thus, the presence of hypotension and or tachycardia at any time predicts a worse clinical outcome. • H ...
Angiotensin-Converting Enzyme Inhibitors in Patients
Angiotensin-Converting Enzyme Inhibitors in Patients

... were searched manually, particularly for the references cited in reviews, commentaries, and other selected publications. National and international colleagues were contacted to limit the risk for selection bias. We searched presentations at scientific meetings (American Heart Association, American C ...
Atrial Fibrillation and Heart Failure: A Review of the
Atrial Fibrillation and Heart Failure: A Review of the

... AF and heart failure: a vicious pathophysiological cycle. LA indicates left atrial; MR, mitral regurgitation; and TR, tricuspid regurgitation. ...
IMPACT OF PEM ON HEART STRUCTURE  Original Article AMAL S. AL-SAMERRAEE
IMPACT OF PEM ON HEART STRUCTURE Original Article AMAL S. AL-SAMERRAEE

... L. Olivares study results. Olivares stated that, children with primary third-degree malnutrition not only have cardiac wasting, but also have inherent ventricular dysfunction. LVEd, LVEs, LVm, Lvmi and cardiac output are all lower in malnourished children than in controls of our study; and there is ...
Vascular Endothelial Dysfunction and Mortality Risk in
Vascular Endothelial Dysfunction and Mortality Risk in

... NO increases in response to exercise in the healthy human and is thought to play an important role in the normal regulation of smooth muscle tone in pulmonary airways and blood vessels.11,30 –33 Experimental and clinical studies have demonstrated that NO may be derived from endothelial, epithelial, ...
Limited usefulness of intermittent nitroglycerin patches in
Limited usefulness of intermittent nitroglycerin patches in

... 36 patients did not experience angina during exercise; however, all but 1 patient still developed ST depression. Spontaneous angina1 attacks, as assessed by patient diary, occurred infrequently and were not significantly reduced by active treatment. Previous studies. The intermittent application of ...
Understanding your child`s heart Atrial septal defect
Understanding your child`s heart Atrial septal defect

... pulmonary artery (the blood vessel that takes blood to the lungs). The left ventricle pumps blood – red in the illustration – into the aorta (the blood vessel that takes blood to the rest of the body). Blood flows from the right side of the heart, through the pulmonary valve into the pulmonary arter ...
Techniques of Permanent Pacemaker Implantation
Techniques of Permanent Pacemaker Implantation

... catheterization laboratory, or operating room [1]. Pacemaker implantation by interventional electrophysiologist in EP lab or catheterization laboratory resulted in a significant reduction in medical cost and hospital stay [2]. Minimum required personnel for pacemaker implantation consist of implanti ...
Ventricular arrhythmia in coronary artery disease
Ventricular arrhythmia in coronary artery disease

... previous studies exploring the mechanistic pathways leading to SCD were necropsy studies. To our knowledge, no unselected large study integrated clinical characteristics and angiographic findings to distinguish the patterns of life-threatening ventricular arrhythmias in CAD. In particular, most stud ...
Advances in Natural and Applied Sciences
Advances in Natural and Applied Sciences

... changes in sodium levels were significantly different in the two groups. However, there was no significant difference in terms of potassium. Studied variables showed the importance of renal function in the surgery. The factors that increase the risk of renal failure should be avoided as much as poss ...
62 KB
62 KB

... apart from the usual, traditional CVD risk factors (age, diabetes, smoking, arterial hypertension, positive family history), the importance is also attached to additional risk factors typical for uremic syndrome (anemia, arteriovenous fistula, permanent changes in blood volume, acquired valvular dis ...
Catheter Ablation for Cardiac Arrhythmias Other Than Atrial Fibrillation
Catheter Ablation for Cardiac Arrhythmias Other Than Atrial Fibrillation

... Without the ventricles pumping blood to the body, sudden cardiac arrest and death can occur within a few minutes. V-Fib is a medical emergency that must be treated with cardiopulmonary resuscitation (CPR) and defibrillation as soon as possible. Ventricular Tachycardia (VT): VT is a rapid heart rhyth ...
To Article - BSP - Biological Signal Processing Ltd.
To Article - BSP - Biological Signal Processing Ltd.

... ratio for each lead was calculated at rest condition as the ratio between HFQRS intensity (within QRS onset and offset) to noise measured after the J point. Leads with rest sound-tonose ratio less than 3 were excluded from further analysis. In each lead, the maximal HFQRS intensity from rest to peak ...
Mathematical Modeling of the Cardiovascular System
Mathematical Modeling of the Cardiovascular System

... Mathematical modeling of physiological systems is an interdisciplinary field that applies fundamental laws in biology, mathematics, physics, chemistry, and engineering to characterize the interactions among physiological subsystems. Developing these models is beneficial to many different application ...
cardiac cycle - The department of cardiology, Calicut medical college
cardiac cycle - The department of cardiology, Calicut medical college

... scared and abandoned the effort by the time the catheter reached the axilla. Forssmann completed the task himself with radiographer holding the mirror infront of screen. Forssmann catheterize his heart safely nine times till he had no more peripheral veins left to try. But this was not enough to con ...
Transcripts/4_10 10-12 (pt.3) (McNicholas)
Transcripts/4_10 10-12 (pt.3) (McNicholas)

... g. QRS duration: duration of ventricular muscle depolarization h. PR segment: The period of time between the P wave and the QRS complex. i. Due to conduction through the AV node. ii. If you slow the conduction, you increase the PR segment. i. QT interval: duration of ventricular depolarization and r ...
electrophysiology study and radiofrequency ablation
electrophysiology study and radiofrequency ablation

... procedures, one after the other, while you are in the EP lab. This possibility will be discussed with you prior to the study. Catheter ablation is a non-surgical technique that heats parts of the abnormal electrical pathway that is causing your rapid heart rhythm. During catheter ablation, doctors i ...
A Technique for Aortic Valve Replacement on the Beating Heart
A Technique for Aortic Valve Replacement on the Beating Heart

... clamped aorta, if the patient was in sinus rhythm before operation. In patients with atrial fibrillation before operation, the same but irregular frequency (50 to 80 beats per minute) can be observed. We have not observed any serious ventricular arrhythmias (ventricular fibrillation, ventricular tac ...
Successful closure of ventricular septal defect in a patient with
Successful closure of ventricular septal defect in a patient with

... the complaint of heart failure. Noncompaction primarily affects the left ventricle, but the right ventricle may also be involved.[4,8,9] Asymptomatic cases have normal systolic function and increased left ventricular enddiastolic pressure, mimicking restrictive cardiomyopathy. Most patients are init ...
АНТИАНГІНАЛЬНІ (КОРОНАРОАКТИВНІ) ЗАСОБИ
АНТИАНГІНАЛЬНІ (КОРОНАРОАКТИВНІ) ЗАСОБИ

... muscle tension, improvement of metabolic processes, increasing of ATP synthesis • in case of acute myocardium infarction – increasing of blood supply of ischemic areas of heart, decreasing of size of infarction seat, prevention of development of cardiac ...
2 Cirie` (Turin), Italy 1National Institute of Cardiology
2 Cirie` (Turin), Italy 1National Institute of Cardiology

... sudden arrhythmic death and adequate ICD discharge was 55%. Conclusions: Surgical resection of postinfarction VT is not at all a risky treatment and should be seriously considered in cases with repairable left ventricular aneurysm and recurrent VT/VF.This surgery causes a better survival than that o ...
Infective Endocarditis: The Anesthesiologist`s
Infective Endocarditis: The Anesthesiologist`s

... valve prolapse than normal individuals.7 The 1997 AHA guidelines on IE recommended antibiotic prophylaxis to all high and moderate risk cardiac patients. But as time passed, the validity of the evidence behind the recommendation came under increasing scrutiny. In the 2007 guidelines, the committee t ...
Ablation of the Epicardial Substrate in the Right Ventricular Outflow
Ablation of the Epicardial Substrate in the Right Ventricular Outflow

... ajmaline test performed with the previously described protocol and the ECG placed at high precordial leads at 18 months after ablation (Fig. 1). His resting ECG showed a type II pattern, which did not change after administration of ajmaline, thus ablation prevented this response. Brugada syndrome is ...
Heart Failure with Preserved Ejection Fraction
Heart Failure with Preserved Ejection Fraction

... or eject blood. Heart failure has a high incidence, with an estimated 550,000 new cases diagnosed annually in the United States, and high mortality, with one-half of these patients likely to die within 5 years. Substantial increases in the incidence and costs associated with this disease have occurr ...
Plastination of the heart: preparation for the study of the cardiac valves
Plastination of the heart: preparation for the study of the cardiac valves

... Visualize the coronary arteries and/or myocardium. To study the cardiac valves, the dissection is performed in a way that permits Visualization of the valves and their relationship to each other and adjacent structures. In either case, it is difficult to make permanent specimens, free of fixatives f ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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