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phys chapter 10 [12-11
phys chapter 10 [12-11

... Rapid Transmission in Ventricular Purkinje System  Purkinje fibers lead from AV node through AV bundle into ventricles - except for initial portion of these fibers where they penetrate AV fibrous barrier, they are very large fibers (even larger than normal ventricular muscle fibers), and they trans ...
Risk for Clinically Relevant Adverse Cardiac Events in Patients With
Risk for Clinically Relevant Adverse Cardiac Events in Patients With

... for patients with chest pain; however, this assumption remains untested. The potential for this benefit depends largely on the rate of treatable or avoidable adverse events during hospitalization. Previous studies have examined primarily rates of cardiac events rates at 30 days or longer, including ...
Guide For Arrhythmia Recognition
Guide For Arrhythmia Recognition

... is measured from the beginning of the QRS complex to the end of the T wave.  To determine if the QT is WNL: measure between R-R waves. If the QT interval is less than ½ the R-R interval it is considered ...
biographical sketch - Cardiovascular Research Training Program
biographical sketch - Cardiovascular Research Training Program

... The major research focus undertaken in my lab is to determine the molecular signaling pathways involved in the ventricular wall growth, maturation, and function in normal and various disease conditions using mouse genetic manipulation. Oure current work evolves largely from our original discovery an ...
Spironolactone Preserves Cardiac Norepinephrine Reuptake in Salt
Spironolactone Preserves Cardiac Norepinephrine Reuptake in Salt

... determine how MR antagonism improves survival. Aldosterone, the endogenous MR agonist, is known to not only regulate renal electrolyte and body fluid balance, but also promote cardiac and vascular fibrosis, baroreceptor dysfunction, parasympathetic inhibition, and sympathetic activation (5, 8). Howe ...
Questions for test-control on the theme: “Cardiac arrhythmias”: What
Questions for test-control on the theme: “Cardiac arrhythmias”: What

... 2. Increasing K+ in cardiomyocytes 3. Increasing Ca2+ in cardiomyocytes 4. Increasing extracellular K+ in myocardium 5. Decreased pH in cardiomyocytes 9. Cardiac arrhythmias can result from disturbance of: ...
A Closer Look Connecting DF-4 and IS-4 Leads
A Closer Look Connecting DF-4 and IS-4 Leads

... generator Tachy Mode to Off during implant, explant or postmortem procedures. Always have external defibrillator protection available during implant and electrophysiologic testing. Ensure that an external defibrillator and medical personnel skilled in CPR are present during post-implant device testi ...
Simultaneous 4-Chamber Strain - Circulation: Cardiovascular Imaging
Simultaneous 4-Chamber Strain - Circulation: Cardiovascular Imaging

... found, again lower than currently recommended normal values from (−29±4.5%).1 Given the smooth appearance of the strain curves, postprocessing may have contributed to underestimation, which re-emphasizes that strain values are dependent on underlying software and hardware. A puzzling detail of the l ...
Implantable Cardioverter Defibrillators
Implantable Cardioverter Defibrillators

... Insertion or replacement of permanent implantable defibrillator system, with transvenous lead(s), single or dual chamber Removal of implantable defibrillator pulse generator with replacement of implantable defibrillator pulse generator; single lead system Removal of implantable defibrillator pulse g ...
Senile cardiac amyloid deposit
Senile cardiac amyloid deposit

... angiotensin II and others, induce the secretion of BNP in the early phase of AMI. On the other hand, the mechanisms for the formation of the second peak are considered to be caused by infarct expansion and subsequent ventricular remodeling. The accumulating evidence raises the possibility that the p ...
Prevalence of Cardiac Arrhythmia Disorders in Patients with
Prevalence of Cardiac Arrhythmia Disorders in Patients with

... the involvement sites of the MI with patients' age (F=0.793, p=0.577). Kruskal - Wallis test showed a significant correlation between the cardiac infarction and arrhythmias (p=0.002, χ2=14.4). In all age ranges; most site of infarction was in the lower part of heart which its rates in people under 6 ...
nnp 2 2010:Neurologia 1-2006.qxd.qxd
nnp 2 2010:Neurologia 1-2006.qxd.qxd

... vimentin (Fig. 3, part F). The proliferative activity, evaluated by the Ki67 positivity of the metastasis, was estimated between 5% and 10% (Fig. 3, part E). Histopathological workup of local recurrence of the primary cardiac spindle cell sarcoma showed S100 negativity (Fig. 4, part A) and CD31 nega ...
diastolic dysfunction and heart failure physiology, historical features
diastolic dysfunction and heart failure physiology, historical features

... PROGNOSIS OF DIASTOLIC DYSFUNCTION NOMAL CORONARY ARTERIES ...
Impact of completeness of revascularization by coronary intervention
Impact of completeness of revascularization by coronary intervention

... meaningful clinical benefit [19]. Since our CEPT results also suggest that CR does not significantly improve CEPT parameters, we believe it is reasonable to recommend that multivessel revascularization should be only used in patients with instability or very high clinical risk, and that intervention ...
Acute Care Problems Case Studies 1 and 2
Acute Care Problems Case Studies 1 and 2

... function tests, thyroid function tests, and anti-phospholipid antibodies such as a lupus anticoagulant are also recommended (Barst et al., 2004; Galie et al., 2009). A brain natriuretic peptide (BNP) level is drawn to evaluate right and left ventricle wall stress (Barst et al., 2004; Galie et al., 2 ...
Downloaded
Downloaded

... ventricular ejection fraction; EDD, end-diastolic diameter; NYHA, New York Heart Association. a Date of publication. ...
Laboratory 1: Anatomy of the Heart
Laboratory 1: Anatomy of the Heart

... (lab) = 1. You must register for lecture and lab if this is the first time you are taking the course. If you are registering for the evening sections you must register for both the evening lecture and lab sections. Course Description: A continuation of Biology 2010. Surveys the cardiovascular, lymph ...
Cardiovascular Damage Resulting from Chronic
Cardiovascular Damage Resulting from Chronic

... aortic stiffness and atrial pulse wave reflections have been established as independent predictors of CV risk.47 functional adaptation to chronic ET. LV mass, as ...
MED-TEXT 1 Question #41 http://www
MED-TEXT 1 Question #41 http://www

... amyloidosis. The cause is unknown. It may result in enlargement of the heart, heart failure, arrhythmias, and embolism. There is often no specific treatment but patient improve following the control of heart failure and arrhythmias (Martin, 1987:92). c) Any disease that affects the structure and fun ...
Cardiomyopathy Australia - Cardiomyopathy Association of Australia
Cardiomyopathy Australia - Cardiomyopathy Association of Australia

... Have you heard that a few people have died from a broken heart? It is called stress cardiomyopathy and has the same symptoms as a heart attack. Sufferers typically have had a severe shock to the system resulting from the death or illness of a loved one, (hence broken heart) anger, terror, accident, ...
Basic Cardiovascular System and Pathological Abnormalities
Basic Cardiovascular System and Pathological Abnormalities

... • Palpate liver • +/- rales and CXR to evaluate for CHF • Reverse dehydration  Reverse acidosis ...
A Patient`s Guide to the Non-surgical Closure of an Atrial Septal Defect
A Patient`s Guide to the Non-surgical Closure of an Atrial Septal Defect

... Though some patients worry about airport security systems, there is really no need for concern. The metal parts in AMPLATZER occlusion devices are very small and usually do not trigger metal detector alarms. However, the sensitivity setting of the metal detector and other factors may affect how the ...
Acute Responses to Intermittent and Continuous Exercise in Heart
Acute Responses to Intermittent and Continuous Exercise in Heart

... Supplementary Material (section B).9,14,16,22-24 MICE isocaloric session This exercise session was performed on the ergocycle (Ergoline 800S) at an intensity of 60% PPO and consistent with current exercise training recommendations in patients with HFREF.1 Exercise duration was 22 minutes and matched ...
Pericardial Effusion
Pericardial Effusion

... done by inserting a catheter through the chest wall and into the pericardial sac and then aspirating the fluid that is present. There is some risk in performing this procedure, but this is minimized by utilizing ultrasound guidance and monitoring the patient’s ECG. The fluid removed is frequently su ...
Early Reperfusion Therapy Affects Inducibility, Cycle Length, and
Early Reperfusion Therapy Affects Inducibility, Cycle Length, and

... Background—This study aimed to evaluate the impact of early reperfusion during acute myocardial infarction (MI) on ventricular tachycardia (VT) inducibility, inducible VT cycle length (CL), and occurrence of spontaneous VT late after MI. Methods and Results—Five hundred six patients (440 men; age, 6 ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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