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Trying to succeed when the right ventricle fails
Trying to succeed when the right ventricle fails

... of pulmonary hypertension. Emerging data indicate a possible hemodynamic, functional and quality of life benefit in patients with chronic thromboembolic pulmonary hypertension [39], idiopathic pulmonary fibrosis [40] and left-sided heart failure [41,42]. Early studies [43,44] of sildenafil in hear ...
ACHA Q and A: Transposition of the Great Arteries after Mustard
ACHA Q and A: Transposition of the Great Arteries after Mustard

... area. If a stent cannot fix the problem, surgery may be needed. Baffles can also leak over time. The baffle sutures may come loose and holes can develop. Sometimes these leaks do not need treatment. If they are large, they can cause problems with blood clots and strokes. Doctors often can use a cove ...
Training in Cardiothoracic Anaesthesia and Critical Care
Training in Cardiothoracic Anaesthesia and Critical Care

... cardiac critical care would seem relevant. Similarly as echocardiography has become ...
Effects of the Purkinje system and cardiac geometry on
Effects of the Purkinje system and cardiac geometry on

... 08018 Barcelona, Spain. Electronic mail: [email protected] ...
Linköping University Post Print A metabolic protective strategy could improve
Linköping University Post Print A metabolic protective strategy could improve

... regard to short-term and long-term results is also given. Based on our results and the overview we will provide an argument for the principles of our strategy and the need for adequately powered randomized clinical trials to determine the role of metabolic interventions in cardiac surgery. ...
Life Stress and Cardiovascular Disorders
Life Stress and Cardiovascular Disorders

... A striking example of the nonfixity of the effort syndrome is afforded by a patient described by L. F. Bishop.5 The patient, a farmer, was examined under Army auspices on the occasions of his being called to military duty during both World War I and II. Although an interval of 25 years separated the ...
Cardiac Rehabilitation and Secondary Prevention
Cardiac Rehabilitation and Secondary Prevention

... rates of CHD patients. Meta-analyses based on studies performed in the 1970s and 1980s and reviewed in the 1994 AHA scientific statement on cardiac rehabilitation programs1 and the Agency for Health Care Policy and Research guidelines5 revealed a statistically significant reduction in both cardiac a ...
Significance of systemic vascular resistance in determining the
Significance of systemic vascular resistance in determining the

... with a control SVR of 20 U m2 or higher, and group lb (n = 8), consisting of those with a lower SVR. Group II consisted of three patients with lower pulmonary arterial pressures. Intravenous injection of hydralazine (0.3 mg/kg) reduced SVR in all but two patients. The magnitude of reduction correlat ...
Part b
Part b

... (c) Second-degree heart block. (d) Ventricular fibrillation. These chaotic, grossly irregular ECG Some P waves are not conducted deflections are seen in acute through the AV node; hence more heart attack and electrical shock. P than QRS waves are seen. In this tracing, the ratio of P waves to QRS wa ...
Ventricular Assist Devices and Total Artificial Hearts
Ventricular Assist Devices and Total Artificial Hearts

Left ventricle
Left ventricle

... 3 Repolarization is due to Ca2+ channels inactivating and K+ channels opening. This allows K+ efflux, which brings the membrane potential back to its most negative voltage. ...
Clinical research priorities in adult congenital heart disease
Clinical research priorities in adult congenital heart disease

... and general topics to ensure comprehensive consideration of all lesions. Distinct and specific research questions were generated for each, rather than general issues. Questions were circulated and revised over several iterations during a 12-month period. Overlapping questions were consolidated. From ...
The effect of thrombolytic therapy on QT dispersion in acute
The effect of thrombolytic therapy on QT dispersion in acute

... frequency of 3.7‑6.6%. Following MI, VF has been shown to have a frequency of 2.3‑5.3% in day 1 and 2.5‑15% within the first 2 weeks.[2,3,28,30] In our study, none of the patients demonstrated VF within the 1st day; only one patient (5%) demonstrated VF within the 1st week after MI. In those studies ...
Roderick Tung, Noel G. Boyle and Kalyanam Shivkumar 2011;123:2284-2288 doi: 10.1161/CIRCULATIONAHA.110.989079
Roderick Tung, Noel G. Boyle and Kalyanam Shivkumar 2011;123:2284-2288 doi: 10.1161/CIRCULATIONAHA.110.989079

... the patient presented 3 weeks later with lightheadedness; device interrogation showed 35 episodes of VT at a rate of 140 bpm, which were terminated with antitachycardia pacing over the prior 10 days. The patient was referred for catheter ablation. A basal inferolateral scar was confirmed by contrast ...
SCA Know The Difference A4 Sheet.indd
SCA Know The Difference A4 Sheet.indd

... An AED is a portable device that can automatically shock a heart back into rhythm before the emergency services arrive. Once activated, the AED guides the user through each step of the defibrillation process by using voice and visual prompts. Who can use an AED? Anyone! Using an AED is easy and can ...
DOC
DOC

... recorded). In general, use medical record documents related to that hospitalization as the first reference; however, records included by the abstractor that pre-date the hospitalization can be used to answer these items if there are no current related documents for that hospitalization. 3a. A dilate ...
Post Operative Arrhythmias
Post Operative Arrhythmias

... – V6 trace their axis center out from right to left respectively, so that V1 represents right of the interventricular septum, V2 and V3 the interventricular septum (anterior wall), V4 the apex (anterolateral), V5 and V6 the lateral ventricular wall. Any current flowing towards the lead causes a posi ...
Influence of pneumoperitoneum on left ventricular filling pressures
Influence of pneumoperitoneum on left ventricular filling pressures

... groups, but approximating the baseline values after 12 hours (T5). These changes are more evident in those patients with diastolic dysfunction. According to our findings an augmented intraabdominal pressure significantly affects the filling pressures of the left ventricle in hypertensive women. More ...
Cardiac PET and PET/CT Imaging Practice Guidelines
Cardiac PET and PET/CT Imaging Practice Guidelines

... 1. FDG PET with PET MPI compares the regional distribution of myocardial glucose use to regional myocardial perfusion. Two sets of images are recorded. The first is with 18F-FDG administered under conditions of glucose loading to determine the regional myocardial use of glucose, and the second is r ...
Heart Rate Turbulence in Patients after Percutaneous Coronary
Heart Rate Turbulence in Patients after Percutaneous Coronary

... version 12. p value < 0.05 was considered as statistically significant. RESULTS Of the 20 eligible patients who underwent revascularization only 13 patient met our study criteria. Five patients ...
Name of presentation
Name of presentation

... onset of clinical signs and/or murmur – FS has to fall <15% to cause CHF ...
question
question

... Enter 98 if beta-blockers were prescribed, and the patient did not refuse at the time of prescription, but the patient did not take the medication, stopped it on his own, or took it only occasionally. Enter 99 if the patient was discharged from a private sector hospital and records are not available ...
Cardiac Overexpression of the Norepinephrine Transporter Uptake
Cardiac Overexpression of the Norepinephrine Transporter Uptake

... an animal model of heart failure. Heart failure was induced in rabbits by rapid ventricular pacing. Adenoviral gene transfer was used to overexpress uptake-1 in the myocardium. Uptake-1 overexpression led to increased NE uptake capacity into the myocardium. In contrast, systemic plasma NE levels in ...
Early history of the pre
Early history of the pre

... causing a short P-R interval and a delta wave. Sodi-Palares offered a similar mechanism in which electrotonus from the depolarized atrium triggers a ventricular impulse [20]. Further, according to Prinzmetal et al., a short P-R interval and a delta wave could be due to an accelerated atrial impulse ...
Assessment of systolic and diastolic cycle duration from
Assessment of systolic and diastolic cycle duration from

... In an electrocardiogram electrical systole of the ventricles begins at the beginning of the QRS complex. Cardiac Diastole is the period of time when the heart relaxes after contraction in preparation for refilling with circulating blood. Ventricular diastole is when the ventricles are relaxing, whil ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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