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Method for puncturing the pericardial membrane by synchronizing
Method for puncturing the pericardial membrane by synchronizing

... muscle with oxygen and nutrients), which can cause a heart ...
Transcatheter Aortic Valve Replacement
Transcatheter Aortic Valve Replacement

... The risks associated with surgery depend on how healthy or sick a patient is. Based on their health, some patients may be considered intermediate-risk for surgery. If you are at intermediate-risk for surgery, these clinical data may resemble what you can expect. As part of the PARTNER II Trial, the ...
Contemporary Pacemakers - CCM, University of Pittsburgh
Contemporary Pacemakers - CCM, University of Pittsburgh

... approach to the treatment of bradyarrhythmias. During the past several decades, major advances in technology and in our understanding of cardiac pathophysiology have led to the development of new pacing techniques for the treatment of heart failure in the absence of bradycardia. Left ventricular or ...
Effects of glycyl-glutamine dipeptide supplementation on myocardial
Effects of glycyl-glutamine dipeptide supplementation on myocardial

... Recent studies have shown that several special amino acids, such as glutamine, glycine, arginine and taurine, exhibit cytoprotective effect on the cardiocyte [4-7], and have established the cardioprotective properties of glutamine [8, 9]. Glutamine is one of the principal free intracellular amino ac ...
Robert Kloner, M.D., Ph.D.
Robert Kloner, M.D., Ph.D.

... infarction: a randomised trial  333 patients with first AMI randomized to primary PCI with or without remote ...
IOSR Journal of Electronics and Communication Engineering (IOSR-JECE)
IOSR Journal of Electronics and Communication Engineering (IOSR-JECE)

... Portable ECG is a hand-handled device that helps to monitor heart stroke rehabilitation patients, postheart surgery patients or patients with critical heart disorder. Post heart surgery or post heart attack patients are kept under walking or aerobic exercise rehab. It is proven that this rehab reduc ...
Basic ECG Rhythm Interpretation
Basic ECG Rhythm Interpretation

... chambers, an atrium and a ventricle. The thick walled ventricles are the larger pumping chambers that expel blood from the heart with each beat (contraction or systole.) The relatively thin-walled atria function as collecting and loading chambers. The atria hold blood being returned to the heart dur ...
Electrocardiography, Blood Pressure
Electrocardiography, Blood Pressure

... increases blood pressure to a maximum, which is the systolic pressure. In this lab activity you will record the ECG and heart sounds from a subject and, with the aid of a stethoscope, hear those characteristic sounds of the heartbeat, typically described as a "lubdub." These sounds are produced by t ...
Myocardial deletion of Smad4 using a novel α skeletal muscle actin
Myocardial deletion of Smad4 using a novel α skeletal muscle actin

... developmental defects, including valvuloseptal septal defects [10-20]. These malformations are consistent with myocardial TGFβ2 and BMP2/4 acting on the overlying cushion to promote an epithelial to mesenchymal transition of a distinct group of endocardial cells [21,22]. The TGFβs and BMPs are membe ...
Atrial Natriuretic Peptide in Chronic Heart Failure in the Rat: A
Atrial Natriuretic Peptide in Chronic Heart Failure in the Rat: A

... heart failure, and concomitant therapy. In the present study, a model of chronic ischemic heart failure in the rat1718 has been used to study the relation between ANP and ventricular dysfunction. Furthermore, the concentrations of both atrial and plasma IR-ANP have been measured simultaneously. Mate ...
Atrial Flutter
Atrial Flutter

... involves a long slow path with an excitable gap, forming a circuit within the right atrium. Slowly conducting reentrant circuit is located in the low right atrial isthmus. The isthmus of tissue is between the inferior vena cava and tricuspid annulus. ...
Image Quality of Cardiac Magnetic Resonance Imaging in Patients
Image Quality of Cardiac Magnetic Resonance Imaging in Patients

... postimplant visit and were sent to a core laboratory (German Red Cross Hospital, Neuwied, Germany, led by T.S.). The assessment of cardiac image quality was originally done by evaluating the SSFP and FGE sequences by an experienced CMR reader and was redone independently by a second reader. Acquisit ...
Safety of Minimally Invasive Mitral Valve Surgery Without
Safety of Minimally Invasive Mitral Valve Surgery Without

... Results. Thirty-day mortality was 3% (6 of 195). Duration of fibrillatory arrest, cardiopulmonary bypass, and “skin to skin” surgery were 88 ⴞ 32, 118 ⴞ 52, and 280 ⴞ 78 minutes, respectively. Ten patients (5%) underwent reexploration for bleeding and 44% did not receive any blood transfusions. Six ...
Management of the postoperative Fontan patient
Management of the postoperative Fontan patient

... procedure, but reoperation may be necessary if obstruction progresses over time. Both enlargement of BVF and the DKS procedure have been reported to be successful in this regard w14,15x. Significant pulmonary hypertension is an absolute contraindication to Fontan palliation. However, mild pulmonary ...
Utility of the surface electrocardiogram for confirming right
Utility of the surface electrocardiogram for confirming right

... risk of damage to the left anterior descending artery.8 Surface electrocardiogram (ECG) criteria of the paced QRS complex (e.g. a negative QRS complex in lead I) have been proposed to confirm an RVOT septal position.5,9 – 11 However, the ECG criteria in these studies have not been properly validated ...
Philips HeartStart FR2+ Defibrillator
Philips HeartStart FR2+ Defibrillator

... shockable. Research shows that for some patients, especially those in long-duration cardiac arrest, CPR prior to defibrillation may provide more benefit.1, 2, 3 At the discretion of the medical director, the defibrillator's SMART CPR algorithm can be configured to look at characteristics of a shocka ...
Left Atrial Enlargement and Reduced Physical Function During Aging
Left Atrial Enlargement and Reduced Physical Function During Aging

... S. Michal Jazwinski, and David A. Welsh Diastolic dysfunction, often seen with increasing age, is associated with reduced exercise capacity and increased mortality. Mortality rates in older individuals are linked to the development of disability, which may be preceded by functional limitations. The ...
ECG Interpretation
ECG Interpretation

... depolarised and remain inactive. If this occurs due to hyperkalaemia, the impulses are conducted from the SA node by internodal pathways to the AV node, thus there is a sinoventricular rhythm. If this occurs due to myocardial disease, the internodal pathways are also diseased and thus a nodal (or ju ...
Congenital absence of pericardium revisited
Congenital absence of pericardium revisited

... left ventricle was found to be displaced to the left axilla. Although actual pericardium cannot be visualized, the abnormal position of the heart raised the suspicion of absent pericardium. Subsequent MRI confirmed the diagnosis. Retrospective analysis of the chest radiograph reveals slight rotation ...
Read More - Ebstein`s Anomaly Foundation
Read More - Ebstein`s Anomaly Foundation

... true tricuspid annulus and the proper subvalvular apparatus are left in place (Figure 1, B). Then the free edge of the posterior leaflet is rotated clockwise and sutured to the anterior leaflet septal edge, forming a new TV resembling a cone (Figure 1, C). An important technical consideration is man ...
T-Vector Direction Differentiates Postpacing From Ischemic T
T-Vector Direction Differentiates Postpacing From Ischemic T

T-Vector Direction Differentiates Postpacing From Ischemic T
T-Vector Direction Differentiates Postpacing From Ischemic T

... activation, such as ventricular pacing,5 transient left bundle-branch block, ventricular arrhythmias, or WolfParkinson-White syndrome.6,7 Pacing-induced TWI, the most common clinical example of CM, is usually localized to precordial and inferior leads.6,8 Postpacing CM often produces striking precor ...
The Canadian Syncope Risk Score to Identify Patients at Risk for
The Canadian Syncope Risk Score to Identify Patients at Risk for

... 11 ED vitals: 6 BPs, 3 pulse rates, triage respiratory rate  and O2 saturation  4 Lab tests: Hemoglobin, hematocrit, BUN, and  creatinine 3 ECG: QRS axis, QRS duration and cQT interval ...
Echo Features of Posteromedial Papillary Muscle Rupture without
Echo Features of Posteromedial Papillary Muscle Rupture without

... Figure 1. (A) End-systolic parasternal long-axis imaging reveals prolapse of the posterior mitral valve leaflet. AV = aortic valve; LA = left atrium; LV = left ventricle; RV = right ventricle. (B) Systolic apical four-chamber frame demonstrates “extra” chaotic echoes (arrow) within the cavity of the ...
Transposition of the great arteries associated with a - Heart
Transposition of the great arteries associated with a - Heart

... ventricular outflow tract? Applying the embryological interpretation of Goor and Lillehei (1975), rotation of the ostium bulbi occurred in our case to account for the posterior position of the aortic outflow tract and coronal plane of the infundibular septum. However, failure of truncal inversion le ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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