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A guide to Automated External Defibrillators (AEDs)
A guide to Automated External Defibrillators (AEDs)

... The automated external defibrillator (AED) has been described as the single most important development in the treatment of SCA. These devices are now widely available and increasingly used by people, often with little or no training, to re-start the heart of a victim of SCA. Under ideal circumstance ...
A guide to Automated External Defibrillators (AEDs)
A guide to Automated External Defibrillators (AEDs)

... The automated external defibrillator (AED) has been described as the single most important development in the treatment of SCA. These devices are now widely available and increasingly used by people, often with little or no training, to re-start the heart of a victim of SCA. Under ideal circumstance ...
A guide to Automated External Defibrillators (AEDs)
A guide to Automated External Defibrillators (AEDs)

... The automated external defibrillator (AED) has been described as the single most important development in the treatment of SCA. These devices are now widely available and increasingly used by people, often with little or no training, to re-start the heart of a victim of SCA. Under ideal circumstance ...
Mechanical Interactions between Four Heart Chambers with and
Mechanical Interactions between Four Heart Chambers with and

... intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) the right ventricle and left ventricles, (3) the atrium and one ven ...
PRODUCT MONOGRAPH HYDRALAZINE
PRODUCT MONOGRAPH HYDRALAZINE

... Evacuate gastric contents by induction of emesis or gastric lavage, taking adequate precautions against aspiration and for protection of the airway. If general conditions permit, administer activated charcoal slurry and possibly an osmotic cathartic. These procedures may have to be omitted or carrie ...
Crawford Current Cardiology Edition 2
Crawford Current Cardiology Edition 2

... Anginal pain usually has a substernal location but may extend to the left or right chest, the shoulders, the neck, jaw, arms, epigastrium and, occasionally, the upper back. The pain is deep, visceral, and intense; it makes the patient pay attention but is not excruciating. Many patients describe it ...
Normal Sinus Rhythm
Normal Sinus Rhythm

... • Etiology: Recent theories suggest that it is due to multiple re-entrant wavelets conducted between the R & L atria. Either way, impulses are formed in a totally unpredictable fashion. The AV node allows some of the impulses to pass through at variable intervals (so rhythm is irregularly irregular) ...
MECANISMES FISIOPATOLÒGICS DE LA MIOCARDIOPATIA ALCOHÒLICA: CANALS DE CALCI, APOPTOSI I ESTRÈS OXIDATIU.
MECANISMES FISIOPATOLÒGICS DE LA MIOCARDIOPATIA ALCOHÒLICA: CANALS DE CALCI, APOPTOSI I ESTRÈS OXIDATIU.

... documentat en la literatura (10-12). L’exposició aguda a la ingesta alcohòlica pot generar arítmies, principalment de tipus supraventricular, com el flutter, sent la fibril·lació auricular la que ha estat objecte de més estudis (13-17). Degut als costums socials actuals, que suposen una ingesta supe ...
Heart rate variability and baroreflex sensitivity in subjects without
Heart rate variability and baroreflex sensitivity in subjects without

... cardiovascular risk factors. Short-term HRV was analyzed from 15-minute periods of standardized recording in supine and upright positions using time and frequency domain measures, and BRS was calculated using the Valsalva maneuver in an original randomly selected population of 600 hypertensive and 6 ...
Digoxin Immune Fab (DigiFab®) Management of Digoxin Toxicity
Digoxin Immune Fab (DigiFab®) Management of Digoxin Toxicity

... Prescribing is restricted to Cardiology, Intensive Care, and Emergency Attending physicians. Physician must be available during administration. NOTE: The following are criteria for use, but should not preclude use if, in the opinion of the clinician, it is medically indicated. All cases should be re ...
Subclinical Atrial Fibrillation and the Risk of Stroke
Subclinical Atrial Fibrillation and the Risk of Stroke

... An implanted atrial lead that is in position over the long term, with the analytic software of the modern pacemaker, allows the continuous detection and characterization of individual episodes of rapid atrial rate over long periods.12 Studies have indicated that, depending on the programming of the ...
Systemic venous drainage: can we help Newton? - Area-c54
Systemic venous drainage: can we help Newton? - Area-c54

... correlated with the morphological and functional characteristics of the patient. The most important morphological elements to be considered are the body weight and the body surface area. The size of the right atrium and, therefore, the blood volume ready available for the venous drainage is importan ...
Print - Circulation Research
Print - Circulation Research

... induce VT were used to deliver STSs at various sites on the endocardium or epicardium. To deliver STS, the settings on the stimulator were changed to deliver a 2- to 5-second train of impulses with a CL of 25 to 50 milliseconds, a duration of 0.5 to 25 milliseconds, and a voltage of 0.5 x to 0.8 x t ...
The role of altered fatty acid metabolism in cardiomyopathy and
The role of altered fatty acid metabolism in cardiomyopathy and

... availability of substrates in the blood may still modulate substrate metabolism in the failing heart. For example, in the presence of high levels of FA, the failing heart exhibits more FAO, while when the concentration of ketone bodies is increased, FAO is usually suppressed (22). Moreover, comorbid ...
Module 2: Abnormal ECGs
Module 2: Abnormal ECGs

... 2. in V1, the S wave is greater than the R wave 3. in V5 or 6, the R wave is < 2.5 mV (25 mm) 4. left ventricle leads (V5 or 6) may show Q waves, but these are < 1 mm across and < 2 mm deep. The QRS is abnormally wide when electrical conduction and depolarisation of the ventricles do not follow t ...
Glasgow 12-lead ECG Analysis Program
Glasgow 12-lead ECG Analysis Program

... analysis and all leads require to have been acquired simultaneously. A 50 or 60 Hz notch filter is applied to the ECG data before sending it to the Glasgow program to remove any AC interference. The first stage of the analysis is to compute leads III, aVR, aVL, and aVF from the provided leads I and ...
Echocardiography in the Management of Patients with Left
Echocardiography in the Management of Patients with Left

... first-line imaging modality used to screen LVAD candidates for structural and/or functional abnormalities that represent absolute or relative contraindications to device implantation. In some cases, patients require urgent or emergent surgical LVAD placement. In these acute situations, adequate TTE ...
Study of the cholinergic system in the heart and its potential
Study of the cholinergic system in the heart and its potential

... The heart is one of the most frequently studied tissues. While at first sight its function seems simple, in deeper view it is a complicated and still relatively undiscovered organ. Moreover, cardiovascular diseases are one of the most often causes of death in human in middle age. Thus, new informati ...
Endogenous Endothelin-1 Depresses Left Ventricular Systolic and
Endogenous Endothelin-1 Depresses Left Ventricular Systolic and

... L-754,142, we measured cardiovascular responses during ET-1 infusion with and without pretreatment of L-754,142. Data were initially recorded with the animals lying quietly on their sides without medication to obtain baseline values. Three sets of variably loaded P-V loops were generated by sudden t ...
Myocardial ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury

... infarct-related coronary artery, there is still no effective therapy for preventing myocardial reperfusion injury. In this respect, myocardial reperfusion injury remains a neglected therapeutic target for cardioprotection in PPCI patients. In this article, the pathophysiology of myocardial lRI and t ...
Functional Comparison of Cardiac Troponin C from
Functional Comparison of Cardiac Troponin C from

... the vertebrate heart, and how these regulatory mechanisms have changed over evolutionary time. The evolution of the cardio-pulmonary system within the vertebrate lineage, along with the emergence of endothermy is one of the central points. This is because the function of proteins, and indeed of most ...
Risk scores: a guide in clinical practice? Application of risk scores in
Risk scores: a guide in clinical practice? Application of risk scores in

... (PCI) or Coronary Artery Bypass Grafting surgery (CABG), as they will benefit most from these treatments. Lower risk patients can be safely treated with pharmacological therapy [2,3]. This leaves the attending physician with the difficult and complex task to distinguish high risk patients from lower ...
Prospective and Retrospective ECG Gating for Thoracic CT
Prospective and Retrospective ECG Gating for Thoracic CT

... Fig. 1—Diagrams show injection/acquisition technique retrospective and prospective gating for thoracic CT angiography. Cephalocaudad coverage is 25 cm. A, Schematic diagram illustrates injection acquisition technique for thoracic CT angiography using retrospective gating. Time in seconds is indicate ...
ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of
ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of

... update the guidelines published by the American Society of Anesthesiologists and the Society of Cardiovascular Anesthesiologists (SCA). There are extensive revisions especially of the sections on ischemic heart disease; congestive heart failure, cardiomyopathy, and assessment of left ventricular fun ...
Guidelines - Lettre de l`UFCV N°58
Guidelines - Lettre de l`UFCV N°58

... revise practice guidelines for important cardiovascular diseases and procedures, directs this effort. The Task Force is pleased to have this guideline developed in conjunction with the European Society of Cardiology (ESC). Writing committees are charged with the task of performing an assessment of t ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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