Quantitative Imaging of Diastolic Function using Cardiac Magnetic
... pressure gradients. Mitral blood velocity and flow were found to have distinct time-courses that become more similar with increasing severity of diastolic dysfunction. Velocity propagation, a wave-like pressure wave phenomenon, was observed in the left atrium during systole, early filling and atrial ...
... pressure gradients. Mitral blood velocity and flow were found to have distinct time-courses that become more similar with increasing severity of diastolic dysfunction. Velocity propagation, a wave-like pressure wave phenomenon, was observed in the left atrium during systole, early filling and atrial ...
Brief Review Determinants of Left Ventricular Filling and of the
... between the volume and equilibrium volume, Vo, is increased. As a result of this increased strain, diastolic wall stress and end-diastolic pressure increase. Over time, cardiac myocytes respond by elongating and thickening in a way that effectively increases Vo with little or no increase in wall thi ...
... between the volume and equilibrium volume, Vo, is increased. As a result of this increased strain, diastolic wall stress and end-diastolic pressure increase. Over time, cardiac myocytes respond by elongating and thickening in a way that effectively increases Vo with little or no increase in wall thi ...
Potential Role of QT Interval Prolongation in Sudden
... to alter the QT interval. Furthermore, no subject had evidence of cardiovascular abnormalities known to alter the QT interval such as conduction defect, left ventricular hypertrophy, congestive heart failure, myocardial or valvular disease, pericarditis, cor pulmonale, cerebral disorder, or previous ...
... to alter the QT interval. Furthermore, no subject had evidence of cardiovascular abnormalities known to alter the QT interval such as conduction defect, left ventricular hypertrophy, congestive heart failure, myocardial or valvular disease, pericarditis, cor pulmonale, cerebral disorder, or previous ...
Sample Chapter 36 from Runge: Netter`s Cardiology, 2nd Edition
... replacement can correct the mitral regurgitation and improve long-term prognosis. When the valve leaks because the ventricle is dysfunctional and dilated, mitral repair or replacement may have little or no effect on symptoms or prognosis. With mitral regurgitation, blood is discharged during systole ...
... replacement can correct the mitral regurgitation and improve long-term prognosis. When the valve leaks because the ventricle is dysfunctional and dilated, mitral repair or replacement may have little or no effect on symptoms or prognosis. With mitral regurgitation, blood is discharged during systole ...
Severe paediatric pulmonary hypertension: new management strategies REVIEW A Rashid, D Ivy
... As the most successful strategy in the treatment of pulmonary hypertension is to treat the underlying cause, the workup of pulmonary hypertension involves a complete history and examination (box 2) and extensive evaluation (box 3), aiming to exclude all known aetiologies of pulmonary hypertension (b ...
... As the most successful strategy in the treatment of pulmonary hypertension is to treat the underlying cause, the workup of pulmonary hypertension involves a complete history and examination (box 2) and extensive evaluation (box 3), aiming to exclude all known aetiologies of pulmonary hypertension (b ...
Print - Circulation
... a 2.2% to 2.5% risk of arrhythmic death without concomitant antiarrhythmic therapy6'7 and 5% in patients treated with antiarrhythmic agents.6 It is therefore apparent that cardioversion of atrial fibrillation to sinus rhythm is of significant importance and that all efforts must be expended to minim ...
... a 2.2% to 2.5% risk of arrhythmic death without concomitant antiarrhythmic therapy6'7 and 5% in patients treated with antiarrhythmic agents.6 It is therefore apparent that cardioversion of atrial fibrillation to sinus rhythm is of significant importance and that all efforts must be expended to minim ...
EACVI position paper:multimodality imaging in pericardial disease
... Pericardial disease represents a wide spectrum of processes involving or damaging the pericardium. Imaging is essential for an appropriate diagnosis of pericardial disease and its complications and plays an important role in its management. In addition to chest radiography, three main non-invasive i ...
... Pericardial disease represents a wide spectrum of processes involving or damaging the pericardium. Imaging is essential for an appropriate diagnosis of pericardial disease and its complications and plays an important role in its management. In addition to chest radiography, three main non-invasive i ...
2013 ESH/ESC Guidelines for the management of arterial
... These guidelines also appear in the Journal of Hypertension, doi: 10.1097/01.hjh.0000431740.32696.cc and in Blood Pressure, doi: 10.3109/08037051.2013.812549. With special thanks to Mrs Clara Sincich and Mrs Donatella Mihalich for their contribution. Other ESC entities having participated in the dev ...
... These guidelines also appear in the Journal of Hypertension, doi: 10.1097/01.hjh.0000431740.32696.cc and in Blood Pressure, doi: 10.3109/08037051.2013.812549. With special thanks to Mrs Clara Sincich and Mrs Donatella Mihalich for their contribution. Other ESC entities having participated in the dev ...
EARLY POSTNATAL CARDIAC DEVELOPMENT IN ATRIAL NATRIURETIC PEPTIDE GENE-DISRUPTED MICE
... vasculature revealed striking structural differences between ANP+/+ and ANP-/- mice. Quantitative stereological analysis of LM images indicated a greater vessel volume in ANP-/- compared to ANP+/+ mice. This study demonstrates that alterations in early molecular events, such as changes in NPS expres ...
... vasculature revealed striking structural differences between ANP+/+ and ANP-/- mice. Quantitative stereological analysis of LM images indicated a greater vessel volume in ANP-/- compared to ANP+/+ mice. This study demonstrates that alterations in early molecular events, such as changes in NPS expres ...
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the
... The writing committee gratefully acknowledges the memory of James T. Dove, MD, who died during the development of this document but contributed immensely to our understanding of stable ischemic heart disease. This document was approved by the American College of Cardiology Foundation Board of Truste ...
... The writing committee gratefully acknowledges the memory of James T. Dove, MD, who died during the development of this document but contributed immensely to our understanding of stable ischemic heart disease. This document was approved by the American College of Cardiology Foundation Board of Truste ...
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the
... diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography ...
... diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography ...
Why, When and How Should Atrial Septal Defects Be
... five, stroke in four and miscellaneous complications in three. In addition, more than half of the patients had dyspnea at follow-up evaluation. Predictors of complications were analyzed and age at presentation, elevated pulmonary artery pressures and O2 saturation less than 80% were found to be asso ...
... five, stroke in four and miscellaneous complications in three. In addition, more than half of the patients had dyspnea at follow-up evaluation. Predictors of complications were analyzed and age at presentation, elevated pulmonary artery pressures and O2 saturation less than 80% were found to be asso ...
CardiologyClinicalOutcomesReport BASED ON 2009 DATA
... elite group of hospitals in the nation to develop hypothermia protocols for comatose survivors of cardiac arrest. Arctic Sun® is an advanced, non-invasive technique that circulates chilled water in external cooling pads to lower a patient's body temperature to between 32 and 34°C, inducing mild hypo ...
... elite group of hospitals in the nation to develop hypothermia protocols for comatose survivors of cardiac arrest. Arctic Sun® is an advanced, non-invasive technique that circulates chilled water in external cooling pads to lower a patient's body temperature to between 32 and 34°C, inducing mild hypo ...
Mitochondrial Membrane Permeability Inhibitors in Acute Myocardial
... PILOT PHASE II CLINICAL TRIALS OF C S A These studies provided not only a better understanding but also insight into potential therapeutic targets. The hypothesis that a drug given at a specific time during reperfusion could reduce infarct size and improve on the benefit of reperfusion became the sear ...
... PILOT PHASE II CLINICAL TRIALS OF C S A These studies provided not only a better understanding but also insight into potential therapeutic targets. The hypothesis that a drug given at a specific time during reperfusion could reduce infarct size and improve on the benefit of reperfusion became the sear ...
Coronary Artery Spasm is a Nightmare: a Rare Case of Multi Vessel
... ECMO can provide full circulatory support. In addition, ECMO will improve oxygenation, decompress the heart and reduce myocardial oxygen consumption, therefore reducing any on-going ischemia. Once stabilized on ECMO, the patient can be safely transported to the catheterization laboratory for further ...
... ECMO can provide full circulatory support. In addition, ECMO will improve oxygenation, decompress the heart and reduce myocardial oxygen consumption, therefore reducing any on-going ischemia. Once stabilized on ECMO, the patient can be safely transported to the catheterization laboratory for further ...
Lead aVR – The Neglected Lead - Journal of the Association of
... aberrancy. In the presence of QS complexes in inferior leads, the lead aVR helps to differentiate between inferior wall MI (IWMI) and left anterior fascicular block (LAFB). Initial R in aVR is suggestive of IWMI and terminal R is suggestive of LAFB. In pericarditis, lead aVR is most often the only l ...
... aberrancy. In the presence of QS complexes in inferior leads, the lead aVR helps to differentiate between inferior wall MI (IWMI) and left anterior fascicular block (LAFB). Initial R in aVR is suggestive of IWMI and terminal R is suggestive of LAFB. In pericarditis, lead aVR is most often the only l ...
Cardiac Thyrotropin-Releasing Hormone Mediates
... significantly lower compared to those of the Con-iRNA– treated SHR. These normal ratios found in the animals with the inhibition of the LV TRH were not caused by normalization of blood pressure or changes in the body weight, as we measured both variables weekly during the entire experiment, and we d ...
... significantly lower compared to those of the Con-iRNA– treated SHR. These normal ratios found in the animals with the inhibition of the LV TRH were not caused by normalization of blood pressure or changes in the body weight, as we measured both variables weekly during the entire experiment, and we d ...
3D Echocardiography: A Review of the Current Status and Future
... and techniques offer superior image quality, greater accuracy, and expanding capabilities. As a result, more and improved imaging modalities are available for evaluating cardiac anatomy, ventricular function, blood flow velocity, and valvular diseases. Threedimensional (3D) echocardiography offers t ...
... and techniques offer superior image quality, greater accuracy, and expanding capabilities. As a result, more and improved imaging modalities are available for evaluating cardiac anatomy, ventricular function, blood flow velocity, and valvular diseases. Threedimensional (3D) echocardiography offers t ...
Three-dimensional transmural organization of perimysial collagen in
... 29) have disputed the existence of any ordered laminar arrangement of ventricular myocytes. However, consistent transmural distributions of ventricular myolaminae have been reported for various species in fresh and processed myocardial tissue with different microscopic techniques (10, 19, 53) and al ...
... 29) have disputed the existence of any ordered laminar arrangement of ventricular myocytes. However, consistent transmural distributions of ventricular myolaminae have been reported for various species in fresh and processed myocardial tissue with different microscopic techniques (10, 19, 53) and al ...
Molecular distinction between physiological and pathological
... Pathological and physiological hypertrophy has classically been subdivided as concentric or eccentric. These classifications are based on changes in shape, which is dependent on the initiating stimulus (Grossman et al., 1975; Pluim et al., 2000) (Fig. 3). Concentric hypertrophy refers to an increase ...
... Pathological and physiological hypertrophy has classically been subdivided as concentric or eccentric. These classifications are based on changes in shape, which is dependent on the initiating stimulus (Grossman et al., 1975; Pluim et al., 2000) (Fig. 3). Concentric hypertrophy refers to an increase ...
A modified version of
... conducts to the ventricles and a regular ventricular rate is produced, but the PR interval exceeds 0.20 second in adults less than 75 years or exceeds 0.24 second in persons 75 years or older. Second degree type I (Wenckebach) block is characterised (Wenckebach) by progressive prolongation of the PR ...
... conducts to the ventricles and a regular ventricular rate is produced, but the PR interval exceeds 0.20 second in adults less than 75 years or exceeds 0.24 second in persons 75 years or older. Second degree type I (Wenckebach) block is characterised (Wenckebach) by progressive prolongation of the PR ...
Innocent Cardiac Murmur in Puppies: Prevalence, Correlation with
... Background: The aims of this study were to establish the prevalence of innocent cardiac murmurs in clinically healthy puppies, to investigate a possible correlation between the presence of an innocent murmur and hematocrit, and to describe the auscultation characteristics of innocent murmurs. Hypoth ...
... Background: The aims of this study were to establish the prevalence of innocent cardiac murmurs in clinically healthy puppies, to investigate a possible correlation between the presence of an innocent murmur and hematocrit, and to describe the auscultation characteristics of innocent murmurs. Hypoth ...
Curriculum Vitae - The Royal Children`s Hospital
... cardiopulmonary bypass surgery for congenital heart disease does not shorten time to chest closure or reduce blood loss and need for transfusions: a randomized, double-blind, parallel group, placebocontrolled study of rFVIIa and standard haemostatic replacement therapy versus standard haemostatic ...
... cardiopulmonary bypass surgery for congenital heart disease does not shorten time to chest closure or reduce blood loss and need for transfusions: a randomized, double-blind, parallel group, placebocontrolled study of rFVIIa and standard haemostatic replacement therapy versus standard haemostatic ...
Practical diastology André Y Denault, Pierre Couture CITATION
... These studies have shown a clear relationship between the presence and severity of LV diastolic dysfunction and their primary end-point which could have been difficult separation from cardiopulmonary bypass (CPB)[4,5] or survival[2]. Baseline assessment of LV diastolic function is relevant because i ...
... These studies have shown a clear relationship between the presence and severity of LV diastolic dysfunction and their primary end-point which could have been difficult separation from cardiopulmonary bypass (CPB)[4,5] or survival[2]. Baseline assessment of LV diastolic function is relevant because i ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.