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Treatment-Specific Approaches for Analysis and Control of
Treatment-Specific Approaches for Analysis and Control of

... A Left Ventricular Assist Device (LVAD) is a mechanical pump that helps patients with heart failure conditions. This rotary pump works in parallel to the ailing heart and provides an alternative path for blood flow from the weak left ventricle to the aorta. The LVAD is controlled by the power suppli ...
Pseudo-postpacing interval of diastolic potential after entrainment
Pseudo-postpacing interval of diastolic potential after entrainment

... heart was performed. The heart weighed 590 g. The left ventricle was open across the anterior aneurysm and the apex (Fig. 4c), along the same plane as the right oblique fluoroscopic view shown in Fig. 4b, exposing the abla- ...
Catheter Ablation as Treatment for Atrial Fibrillation
Catheter Ablation as Treatment for Atrial Fibrillation

... Treatment strategies can be broadly subdivided into rate control, in which only the ventricular rate is controlled and the atria are allowed to fibrillate, or rhythm control, in which there is an attempt to re-establish and maintain normal sinus rhythm. Rhythm control has long been considered an imp ...
the PDF - Heart Rhythm Society
the PDF - Heart Rhythm Society

... by each of them so that the reader can select it as the primary dictionary for use in interpreting all or some ECGs. We are also hopeful that the vendors will collaborate among themselves to align diagnostic criteria for this specific lexicon. This would not interfere with continued development of e ...
Factors affecting tolerance to digitalis
Factors affecting tolerance to digitalis

... symptoms. The latter frequently resemble symptoms of underlying heart disease or those of other systems. The long list of toxic digitalis effects includes such nonspecific manifestations as increasing severity of congestive heart failure, acute hemorrhage and necrosis of the intestines, fatigue, hea ...
An Emerging Antiarrhythmic Target: Late Sodium Current
An Emerging Antiarrhythmic Target: Late Sodium Current

... Cardiac arrhythmias are one of the primary causes of death and a major public health problem. However, anti-arrhythmic drug therapies using ion channel blockers led to conflicting results. Many seemingly promising drugs turned out to be proarrhythmic. Clinical experiences by many physicians sum up t ...
QTc interval and survival in 75-year
QTc interval and survival in 75-year

... Aims The study concerns the relationship of the corrected QT (QTc) interval to 6.4 years of survival and to measures of cardiac function, such as echocardiographic variables and plasma levels of brain natriuretic peptide (BNP), in 75-year-old people. Methods and results QTc was measured in a 12-lead ...
Management strategies for patients with pulmonary hypertension Continuing Medical Education Article
Management strategies for patients with pulmonary hypertension Continuing Medical Education Article

... dopamine, dobutamine, phenylephrine, isoproterenol, and vasopressin. Both human and animal studies related to pulmonary hypertension were reviewed. Conclusions: Pulmonary hypertension presents a particular challenge in critically ill patients, because typical therapies such as volume resuscitation a ...
Antithrombotic Therapy for Coronary Artery Disease
Antithrombotic Therapy for Coronary Artery Disease

... 123S–131S). Among the key recommendations in this chapter are the following: for patients with non–ST-segment elevation (NSTE)-acute coronary syndrome (ACS) we recommend daily oral aspirin (75–100 mg) [Grade 1A]. For patients with an aspirin allergy, we recommend clopidogrel, 75 mg/d (Grade 1A). For ...
Management strategies for patients with pulmonary hypertension in
Management strategies for patients with pulmonary hypertension in

... dopamine, dobutamine, phenylephrine, isoproterenol, and vasopressin. Both human and animal studies related to pulmonary hypertension were reviewed. Conclusions: Pulmonary hypertension presents a particular challenge in critically ill patients, because typical therapies such as volume resuscitation a ...
Cardiac Sympathetic Innervation Via the Middle Cervical and
Cardiac Sympathetic Innervation Via the Middle Cervical and

... ganglia (2) electrophysiological and anti-arrhythmic effects of CSD, including VT inducibility, ...
Transcatheter pulmonary valve replacement
Transcatheter pulmonary valve replacement

... preferred route of delivery; however, the procedure can also be performed via the internal jugular vein. A small sheath (7 Fr) is used initially in the vein to perform right heart catheterization and angiography, and is later upsized to a larger sheath, depending on the size of the valve chosen. In ...
Left atrial systolic and diastolic function accompanying chronic rapid
Left atrial systolic and diastolic function accompanying chronic rapid

... underwent hemodynamic study. The remaining six dogs had the pacing lead and pulse generator (set at 30 beats/min) implanted and served as controls. Sham dogs were studied after a minimum of 2 wk after surgery. Long-acting diltiazem (Cardizem 300 mg) was given daily to slow the ventricular response ( ...
American Society of Echocardiography Recommendations for
American Society of Echocardiography Recommendations for

... patients with normal dobutamine stress echocardiography results, the subgroup in whom target heart rate is not achieved has a higher cardiac event rate.22 Achievement of target rate is an important goal of testing and consideration should be given to holding beta-blocker therapy on the day of testin ...
Review Article Frequency Analysis Of Atrial Fibrillation
Review Article Frequency Analysis Of Atrial Fibrillation

... A direct comparison between endocardially recorded electrograms and body surface recordings clearly evidences the validity of fibrillatory rate obtained from surface ECG as an index of the average atrial fibrillatory cycle and subsequently atrial refractoriness. Fibrillatory rates calculated from le ...
THE EFFECT OF EXERCISE TRAINING ON THE AUTONOMIC
THE EFFECT OF EXERCISE TRAINING ON THE AUTONOMIC

... Lastly this research has shown that regular, controlled exercise for RA patients with controlled disease can decrease joint stiffness and improve joint mobility, strength and aerobic capacity without exacerbating pain or disease activity. Also, if one observes the decline in the sedentary group for ...
Original Article
Original Article

... CVD. First, the original discovery of the pathway began with an unbiased metabolomics study of plasma from subjects undergoing elective cardiac evaluations, revealing a striking association between plasma levels of choline, TMAO, and betaine with cardiovascular risks among subjects (n=1876).2 Examin ...
Cardiac Effects of Cupping: Myocardial Infarction, Arrhythmias, Heart
Cardiac Effects of Cupping: Myocardial Infarction, Arrhythmias, Heart

... of the abdomen (6) per se protect against both ischemia and reperfusion arrhythmias (2, 3). Although we did not evaluate NE release following cupping, it appears that cupping, as in any stress, increases NE release from cardiac sympathetic nerves. In general, signalling from one tissue to another ma ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... Clinical studies have consistently shown the superiority of radiofrequency catheter ablation compared with standard medical therapy in controlling recurrent VT.3,4 However, even after an acutely successful ablation, the long-term freedom from recurrent VT remains suboptimal, especially in patients w ...
2014 AHA/ACC Guideline for the Management of Patients With Non
2014 AHA/ACC Guideline for the Management of Patients With Non

... Non–ST-Elevation Acute Coronary Syndromes, Journal of the American College of Cardiology (2014), doi: 10.1016/j.jacc.2014.09.017. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. ...
as a PDF - Lettre de l`UFCV N°58
as a PDF - Lettre de l`UFCV N°58

... of the ESC Scientific and Clinical Initiatives Committee, who helped initiate this joint effort. Experts in the subject under consideration have been selected from all three organizations to examine subject-specific data and write guidelines. The process includes additional representatives from other ...
The Effect of Right Ventricular Filling on the Pressure
The Effect of Right Ventricular Filling on the Pressure

... loops were recorded. An example of one set of four loops is shown in Figure 2. With the right ventricle totally empty, the first set of four left ventricular pressure-volume loops was obtained by adjusting the amount of air above the left ventricular volumetric cylinder. Loops were recorded after a ...
ACC/AHA Guidelines for the Management of Patients With Unstable
ACC/AHA Guidelines for the Management of Patients With Unstable

... in the production of such guidelines in the area of cardiovascular disease since 1980. This effort is directed by the ACC/AHA Task Force on Practice Guidelines, whose charge is to develop and revise practice guidelines for important cardiovascular diseases and procedures. Experts in the subject unde ...
101 Anatomical Particularities of the Papillary Muscles, Tendonous
101 Anatomical Particularities of the Papillary Muscles, Tendonous

... compared anatomy of the cardiac particular parts. It involved a number of 12 dissected pig hearts where there were some anatomical aspects worth mentioning on the valve, muscular and papillary forms, and also on the tendinous cordages of the left ventricle. Compared to the classical descriptions, es ...
MITRAL REGURGITATION IN LEFT VENTRICULAR
MITRAL REGURGITATION IN LEFT VENTRICULAR

... The heart pumps blood around the body. Its most important component is the left ventricle (LV) because it pumps freshly oxygenated blood out to the entire body. Heart failure is when a diseased heart cannot provide the body with enough blood flow. One treatment option for heart failure is the Left V ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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