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ACC/AHA/ESC Guidelines for the Management of
ACC/AHA/ESC Guidelines for the Management of

... chair of the ESC Scientific and Clinical Initiatives Committee, who helped initiate this joint effort. Experts in the subject under consideration have been selected from all 3 organizations to examine subject-specific data and write guidelines. The process includes additional representatives from ot ...
acc/aha/esc practice guidelines—full text
acc/aha/esc practice guidelines—full text

... chair of the ESC Scientific and Clinical Initiatives Committee, who helped initiate this joint effort. Experts in the subject under consideration have been selected from all 3 organizations to examine subject-specific data and write guidelines. The process includes additional representatives from ot ...
Acute Right Atrial and Ventricular Infarction
Acute Right Atrial and Ventricular Infarction

... Acute coronary syndromes involving the right side of the heart are associated with increased mortality, a complex clinical course, and lengthy hospitalization, as well as with frequent mechanical and electrical complications. It is important that the signs and symptoms associated with the spread of ...
PowerPoint - Cardiovascular Radiology
PowerPoint - Cardiovascular Radiology

... Thoracic Rads - Normal Normal cats change with age • Long axis of the heart is more horizontal in old cats (40%) • Aortic bulge develops (30%) – Not due to hypertension or hyperthyroidism – At the aortic isthmus – Cardiac measurements in young & old cats are the same, despite these conformational c ...
Cardiac Action Potential
Cardiac Action Potential

... channels, nitric oxide levels, and autonomic nervous system Varying degree of external compression due to myocardial contraction/relaxation (most coronary blood flow occurs during diastole) ...
Myocardial Extracellular Volume Fraction From T1 Measurements in
Myocardial Extracellular Volume Fraction From T1 Measurements in

... underestimation of both the presence and extent of diffuse fibrosis (5 7). The LGE technique relies on relative enhancement of an abnormal region of myocardium compared with a normal reference. In conditions such as hypertension, sleep apnea, valvular disease, diabetes, obesity, and nonischemic cardi ...
Vagal nerve stimulation activates vagal afferent fibers - AJP
Vagal nerve stimulation activates vagal afferent fibers - AJP

... provides important cardiomotor efferent fibers to the heart, ⬎80% of the fibers within the vagal nerve are afferent neural fibers, transducing information from visceral organs, including the heart, to the central nervous system (14, 32, 49). VNS likely leads to activation of both afferent and effere ...
ENDOCARDIAL SCLEROSIS IN INFANTS AND CHILDREN* We
ENDOCARDIAL SCLEROSIS IN INFANTS AND CHILDREN* We

... rheumatic carditis of the healed type was often mentioned. The next period apparently started with Fischer8 who was one of the first to stress the microscopic changes found. Fischer discarded most of the cases reported previous to his time because of the lack of histologic descriptions. The microsco ...
Xanthine Derivatives in the Heart: Blessed or Cursed?
Xanthine Derivatives in the Heart: Blessed or Cursed?

... cardiac myocytes. It was suggested that this can be an additional mechanism by which caffeine and theophylline may contribute to generation of cardiac arrhythmias. It is important to take into account that these changes occur in a concentration range of 1 to 20 mM of methylxanthines. This range is w ...
How to Distinguish Between Innocent and Pathologic Murmurs in
How to Distinguish Between Innocent and Pathologic Murmurs in

Guidelines on the Diagnosis and Management of Pericardial Diseases
Guidelines on the Diagnosis and Management of Pericardial Diseases

... Table 3 Patterns of pericardial changes, their visualization and interpretation in chest X-ray, computer tomography (CT) and ...
Atrial Fibrillation in the Wolff-Parkinson-White Syndrome
Atrial Fibrillation in the Wolff-Parkinson-White Syndrome

... study the patient presented two spontaneous episodes of AF initiated by PVC conducted to the atria through the AP. After successful catheter ablation of the AP the patient did not present arrhythmia recurrences, although he had multiple PVCs recorded in a 24 Hs Holter monitoring. 15 It may be argued ...
Guidelines on the Diagnosis and Management of Pericardial Diseases
Guidelines on the Diagnosis and Management of Pericardial Diseases

... Table 3 Patterns of pericardial changes, their visualization and interpretation in chest X-ray, computer tomography (CT) and ...
State of the Art: Degenerative Mitral Valve Disease
State of the Art: Degenerative Mitral Valve Disease

... relatively independent of haemodynamic status. Preoperative left ventricular end systolic diameter is an independent predictor of post-operative left ventricular function: a left ventricular end systolic diameter of 45 mm represents the value above which patients are highly likely to have abnormal p ...
Adult Heart Murmurs - American Academy of Family Physicians
Adult Heart Murmurs - American Academy of Family Physicians

... and explain the pathology of heart murmurs to patients. 3. Evaluate diagnostic factors in patients with suspected heart murmurs using cost-effective cardiac testing. 4. Coordinate referral and follow-up to a cardiologist for patients with a pathologic cardiac examination, or who has cardiac symptoms ...
insight review articles
insight review articles

... arrhythmia generators (Fig. 2a,b). Figure 2a illustrates the mechanism of ‘automaticity’, which is the basis of cardiac pacemaker function. Various areas of the heart can show automaticity, but cardiac rhythmicity is normally controlled by the sinus node, which is intrinsically the fastest pacemaker ...
2001 The European Society of Cardiology
2001 The European Society of Cardiology

... of the ESC Scientific and Clinical Initiatives Committee, who helped initiate this joint effort. Experts in the subject under consideration have been selected from all three organizations to examine subject-specific data and write guidelines. The process includes additional representatives from other ...
Exercise training prevents the exaggerated exercise pressor reflex
Exercise training prevents the exaggerated exercise pressor reflex

... were prepared in the same manner, but did not undergo coronary artery ligation. All of the rats (n ⫽ 27) survived from the sham surgery. However, ⬃70% of rats (i.e., 28 of total 41 rats) survived from coronary artery ligation surgery. In this study, the cardiac function in all experimental animals w ...
Pulmonary atresia with intact ventricular septum
Pulmonary atresia with intact ventricular septum

... TCPC was described by de Leval et al. in 1988. The connection between the inferior caval vein and the pulmonary artery has been achieved using different techniques, for exampel. with an intracardiac tunnel consisting of pericardium or Gore-Tex®. This technique is still developing; and the extracardi ...
Extracorporeal membrane oxygenation and sepsis
Extracorporeal membrane oxygenation and sepsis

... extracorporeal circuit have evolved considerably over the past 30 years and are now safer and more effective than those used in that first trial. At around the same time, some centres were applying ECMO to neonates with respiratory failure with considerably more success.1 Persistent pulmonary hypert ...
Common Pulmonary Vein Atresia
Common Pulmonary Vein Atresia

... and establish that the left heart chambers and aorta are normally developed. Our cases, as well as the only two previously reported in whom cardiac catheterization was carried out, showed right-to-left shunting through the ductus. In all infants the ductus arteriosus was widely patent at autopsy. A ...
Overexpression of microRNA-1 impairs cardiac
Overexpression of microRNA-1 impairs cardiac

... moter were generated and identified by real-time reverse-transcription polymerase chain reaction with left ventricular samples. We found an age-dependent decrease in the heart function in Tg mice by pressure –volume loop analysis. Histological analysis and electron microscopy displayed short sarcome ...
Alternative Lead Systems for Diagnostic Electrocardiography
Alternative Lead Systems for Diagnostic Electrocardiography

... positions. Manuscript. ...
Full version (PDF file)
Full version (PDF file)

... papillary muscle contraction force at 0.1 mmol/l. Propofol did not affect action potential duration at any concentration studied. Our study suggests that mechanisms contributing to the impaired myocardial contraction during propofol anesthesia might include ...
Treatment-Specific Approaches for Analysis and Control of
Treatment-Specific Approaches for Analysis and Control of

... A Left Ventricular Assist Device (LVAD) is a mechanical pump that helps patients with heart failure conditions. This rotary pump works in parallel to the ailing heart and provides an alternative path for blood flow from the weak left ventricle to the aorta. The LVAD is controlled by the power suppli ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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