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Copyright Information of the Article Published Online TITLE Renal
Copyright Information of the Article Published Online TITLE Renal

... 10 patients with mainly non-ischemic cardiomyopathies reveals a dramatic drop in arrhythmia burden after RDN[36]. Nonetheless, further prospective, randomized trials are needed to confirm this scope of application for RDN. Hemodynamics and volume changes: Since the effects of RDN on renal water/sodi ...
The extents of mitral leaflet opening and closure are - Heart
The extents of mitral leaflet opening and closure are - Heart

... been demonstrated that this phenomenon occurs in nonischaemic LV dysfunction as well.11 13 15 It has been shown that when papillary muscle function is kept normal (by perfusing it selectively with blood), the degree of IMLC correlates with the degree of LV systolic dysfunction.15 The main role of th ...
150 Practice ECGs: Interpretation and Review
150 Practice ECGs: Interpretation and Review

... It measures the small amount of voltage generated by depolarization of heart muscle. The vertical, or y axis, on the ECG is voltage, with each millimeter (mm) of paper equal to 0.1 millivolt (mV) (Fig 1.1). For practical purposes, we often refer to the amplitude, or height, of an ECG complex in mill ...
MEANS ECG Physicians` Manual
MEANS ECG Physicians` Manual

... The diagnostic logic operates on the parameters and produces both a rhythm classification and a contour or morphology classification. The criteria used by the computer may differ from the criteria used in the ECG textbooks. The basic reason is that a human observer is inaccurate but flexible and cre ...
English
English

... pulmonary artery or Bland- Garland-White syndrome is a rare anomaly, whose incidence is estimated as 1:300,000 live births, accounting for 0.24% of congenital heart diseases 1. Usually, it manifests as an isolated defect, but, in 5% of cases, it may be associated with other heart anomalies, such as ...
65 ECHOCARDIOGRAPHIC CHARACTERISTIC OF LEFT
65 ECHOCARDIOGRAPHIC CHARACTERISTIC OF LEFT

... left ventricular hypertrophy (eccentric and concentric). Training volume and cycling sporting discipline were significantly associated with eccentric left ventricular hypertrophy. Introduction Long-term physical load is associated with remodeling of cardiac geometry referred as physiological left ve ...
Genetics - Circulation
Genetics - Circulation

... Small studies have demonstrated the effect of the background strain on cardiac phenotypes related to embryonic viability and myocardial, valvar, or ventricular septal morphology in Tbx5, Gata4, and Hey2 mutations.14 –16 The extent to which genetic modifiers contribute to incomplete penetrance and ph ...
Using a human cardiovascular-respiratory model to characterize
Using a human cardiovascular-respiratory model to characterize

... Pericardial effusion leads to increased chamber interaction. A parallel interaction occurs whereby expansion of the RV during inspiration compresses the LV; likewise, a smaller RV volume during expiration allows more blood to be drawn into the LV [6-10]. The septum and pericardium are involved in th ...
Ventricular septal defect - Orphanet Journal of Rare Diseases
Ventricular septal defect - Orphanet Journal of Rare Diseases

... not all defects are anatomically the same. The phenotypic differences are important, not only when determining the optimal approach to correction, but also for subsequent genetic counseling. This is because the morphogenesis of the various types is fundamentally different [9]. In terms of phenotypic ...
Feasibility and effect of para-right bundle branch pacing in patients
Feasibility and effect of para-right bundle branch pacing in patients

... with pacing from RVA, pacing from para-RBB is more physiological and could obtain more clinical advantage. To our knowledge, it is the first time up to now to report the new physiological pacing site of para-RBB. The traditional RVA pacing allows easy endocardial implantation of pacing leads while p ...
Y.Q. Zhou, F.S. Foster, R. Parkes, S.L. Adamson. Developmental
Y.Q. Zhou, F.S. Foster, R. Parkes, S.L. Adamson. Developmental

... cardiomyopathy, ventricular diastolic dysfunction, relative to systolic dysfunction, is associated with a significantly higher risk of perinatal mortality (32). Genetically engineered mice have been used to model human cardiac diseases. As in humans, diastolic dysfunction occurs in association with ...
Unilateral and Multilateral Congenital Coronary-Pulmonary
Unilateral and Multilateral Congenital Coronary-Pulmonary

... Background: Congenital coronary-pulmonary fistulas (CPFs) are commonly unilateral, but bilateral and multilateral fistulas may occur. In multilateral CPFs, the value of a multidetector computed tomography (MDCT) imaging technique as an adjuvant to coronary angiography (CAG) is eminent. The purpose of ...
Lead aVR: The Neglected Lead - The Association of Physicians of
Lead aVR: The Neglected Lead - The Association of Physicians of

... INTRODUCTION Lead aVR, one of the 12 electrocardiographic leads, is frequently ignored in clinical medicine. In fact, many clinicians refer to the 12-lead electrocardiogram (ECG) as the 11-lead ECG, noting the commonly held belief that lead aVR rarely offers clinically useful information.1 The augme ...
Role of ST2 in Non–ST-Elevation Acute Coronary Syndrome in the
Role of ST2 in Non–ST-Elevation Acute Coronary Syndrome in the

... With adjustment for relevant clinical factors, the risks related to high ST2 were significant, including the risk of CVD or HF, which persisted when clinically established biomarkers (cTnI and BNP) were added to the model (adjusted HR 1.67, 95% CI 1.32–2.11, P ⬍ 0.0001) (Table 3). Adjusted HRs are s ...
ACC/AHA 2002 Guideline Update for the
ACC/AHA 2002 Guideline Update for the

... These statements are reviewed by the parent task force, reported orally to all members of the writing panel at the first meeting, and updated as changes occur. These practice guidelines are intended to assist physicians in clinical decision making by describing a range of generally acceptable approa ...
2013 ESC guidelines on the management of stable coronary artery
2013 ESC guidelines on the management of stable coronary artery

... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
Action Potential Dynamics Explain Arrhythmic Vulnerability in
Action Potential Dynamics Explain Arrhythmic Vulnerability in

... time of APD at 90% repolarization (APD90), and for phase II (defined as the first half of this interval) and phase III (second half). We did not study phase I alternans because upstroke velocity is slower in MAPs than in single cell APs ...
consensus statement
consensus statement

... with PPH are often the same as those in adult patients with PPH, the clinical presentation, natural history, and factors influencing survival may differ. These ...
2013 ESC guidelines on the management of stable
2013 ESC guidelines on the management of stable

... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
Consensus statement on the management of pulmonary
Consensus statement on the management of pulmonary

... consensus statement which updates the ‘‘Recommendations on the management of pulmonary hypertension in clinical practice’’ of 2001. The consensus statement reflects contemporary practice in the management of this uncommon, deadly but now treatable condition in the pulmonary hypertension designated c ...
Protecting the acute ischemic myocardium on top of reperfusion
Protecting the acute ischemic myocardium on top of reperfusion

... diminished cell necrosis.34 These observations strongly suggested that cooling during the ...
Translating Novel Imaging Technologies Into Clinical Applications
Translating Novel Imaging Technologies Into Clinical Applications

... In response to the narrowed valve, left ventricular hypertrophy is initially adaptive to restore wall stress and cardiac performance. Ultimately, adverse events, such as symptoms, heart failure, and death, occur as the left ventricle decompensates. This transition from adaptation to decompensation i ...
2013 ESC guidelines on the management of stable coronary artery
2013 ESC guidelines on the management of stable coronary artery

... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
2013 ESC guidelines on the management of stable coronary artery
2013 ESC guidelines on the management of stable coronary artery

... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
ACC/AHA 2002 Guideline Update for the Management Elevation Myocardial Infarction
ACC/AHA 2002 Guideline Update for the Management Elevation Myocardial Infarction

... These statements are reviewed by the parent task force, reported orally to all members of the writing panel at the first meeting, and updated as changes occur. These practice guidelines are intended to assist physicians in clinical decision making by describing a range of generally acceptable approa ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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