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Ephedrine Hydrochloride Injection
Ephedrine Hydrochloride Injection

Recommendations for Cardiac Chamber Quantification by
Recommendations for Cardiac Chamber Quantification by

... mild, moderate, and severe abnormalities on the basis of SDs above or below the reference limit derived from a group of healthy people. The advantage of this method is that these data readily exist for most echocardiographic parameters. However, this approach is fundamentally flawed. First, not all ...
Recommendations for Cardiac Chamber Quantification by
Recommendations for Cardiac Chamber Quantification by

... mild, moderate, and severe abnormalities on the basis of SDs above or below the reference limit derived from a group of healthy people. The advantage of this method is that these data readily exist for most echocardiographic parameters. However, this approach is fundamentally flawed. First, not all ...
CRT-D - Boston Scientific
CRT-D - Boston Scientific

... Over time, the heart muscle weakens and becomes enlarged (Figure 3). The ventricles are unable to contract with the same strength or coordination as before. As a result, the flow of blood and oxygen to the body is poor. This failure of the heart to pump efficiently and meet the body’s need for blood ...
Impact of exercise training on myostatin expression in the
Impact of exercise training on myostatin expression in the

... kinase with anti-apoptotic effect. In a rat model of volume overload heart failure, myocardial myostatin mRNA and protein expression were upregulated.13 It is known that exercise training has anti-inflammatory effects, with the potential to reduce local cytokine expression and increase anti-apoptoti ...
valve and supravalvar mitral ring - Heart
valve and supravalvar mitral ring - Heart

REGULATION OF CARDIAC VOLTAGE GATED POTASSIUM
REGULATION OF CARDIAC VOLTAGE GATED POTASSIUM

... the electrophysiologic reverse remodeling after cardiac resynchronization therapy. Chapter 6 focuses on atrial ionic remodeling in chronic heart failure. The results suggest that duration of heart failure is a very important predictor of persistence of atrial fibrillation in heart failure. In addit ...
ACC/AHA Guidelines for the Management of Patients With Acute
ACC/AHA Guidelines for the Management of Patients With Acute

... jointly engaged in the preparation of such guidelines in the area of cardiovascular disease since 1980. This effort is directed by the ACC/AHA Task Force on Practice Guidelines, which is charged with developing and revising practice guidelines for important cardiovascular diseases and procedures. Ex ...
Dissecting the Role of the Extracellular Matrix in Heart Disease
Dissecting the Role of the Extracellular Matrix in Heart Disease

... the heart that are linked to numerous cardiac diseases present in mice, dogs, pigs, and humans [4–8]. In this review, we shall illustrate how insights into gene function from the Drosophila model are relevant to our understanding of the basis of mammalian disorders. 2. ECM Regulation and Cardiac Dys ...
Cortisol and Testosterone in Hair as Biological Markers of Systolic
Cortisol and Testosterone in Hair as Biological Markers of Systolic

... assessed using serum and saliva as matrices, which are only point measurements and do not provide long-term information. Scalp hair is a novel matrix that allows for measurement of hormones over a period of several months. We aimed to evaluate whether levels of cortisol and testosterone and their ra ...
Alternate Patterns of Premature Ventricular Excitation
Alternate Patterns of Premature Ventricular Excitation

... premature ventricular excitation have been observed during induced atrial bigeminy in 18 subjects, including five normal volunteers. Each study was performed in the cardiac catheterization suite where a transvenous catheter electrode was positioned in the right atrium. Coupled or paired stimuli were ...
Print - Circulation
Print - Circulation

... catenins.17–19 ␣-E-catenin is ubiquitously expressed in tissues, mainly in epithelial cells, but also at high levels in the heart.1,20 On the other hand, ␣-N-catenin expression is restricted to neural tissues,18 whereas ␣-T-catenin expression is restricted to testis, muscle, and brain.20 ␣-E-catenin ...
the postmortem rigor of the mammalian heart and the influence of an
the postmortem rigor of the mammalian heart and the influence of an

... by connecting them with a manometer. The main object of the investigations of Brouardel as well as of Strassman seems to have been to prove from a forensic point of view, that the heart after death passes into a state of rigorand this less than twenty years ago. Meirowsky,' 899, reports the experime ...
Echocardiographic parameters in healthy young adult Sphynx cats
Echocardiographic parameters in healthy young adult Sphynx cats

... Subjective comparisons of the left ventricle (LV), intraventricular septum (IVS) and right ventricle (RV) wall thicknesses to lumen size, as well as right heart to left heart structures were made. Specific parameters such as the hyperechogenicity of the papillary muscles, basal, septal to global hype ...
ST-segment depression and T-wave inversion
ST-segment depression and T-wave inversion

... wave is sharp, and the QT interval is often prolonged. These abnormalities are characteristically seen hours to days after the ischemic chest pain resolves. In fact, the ischemic episode is usually associated with transient ST-segment elevation or depression that progresses to the T-wave abnormality ...
Interventional cardiac catheterization
Interventional cardiac catheterization

... decisively impact patient management (82,134-136). Today, therapeutic catheterization techniques have replaced conventional surgery for many lesions. New methods, tested through research protocols in specialized centers, combined with continuous critical evaluation of established techniques continue ...
the left atrium in hypertension: a symbol of mortality and morbidity?
the left atrium in hypertension: a symbol of mortality and morbidity?

... though left atrial enlargement was significantly greater among patients with LVH in the study by Tedesco et al [31], this group was significantly older compared to the group without LVH. As the authors admit, relationship between the left ventricular diastolic dysfunction and left atrial dimensions ...
Chow Sample Chap 1
Chow Sample Chap 1

... atria and the ventricles. Electrical activation proceeds from the right atrium, through the AV node to the His-Purkinje system, and then to the ventricles. The His-Purkinje system comprises myocardial cells that are specialized for rapid conduction. Its anatomic components are (in order of activatio ...
Effect of Definition on Incidence of Postinfarction
Effect of Definition on Incidence of Postinfarction

... atypical T-wave evolution ("false-positives"). One explanation for this 2.5% incidence of false-positives is that those patients may have had painless and acoustically silent postinfarction pericarditis. If so, the actual incidence of postinfarction pericarditis would be 32.5% in patients not receiv ...
Final appraisal determination document
Final appraisal determination document

... with similar structures have been published previously, including the model submitted to NICE as part of the technology appraisal guidance on ivabradine for treating chronic heart failure. In the company’s primary base-case analysis, patients entered in the model in either the sacubitril valsartan o ...
ACC/AHA/ESC Guidelines for the Management of Patients
ACC/AHA/ESC Guidelines for the Management of Patients

... This document was peer reviewed by two official external reviewers representing the American College of Cardiology Foundation, two official external reviewers representing the American Heart Association, and two official external reviewers representing the European Society of Cardiology. The North A ...
Bassett, Kiah - Cardiff Metropolitan University
Bassett, Kiah - Cardiff Metropolitan University

... responses are dependent on the intensity, duration and frequency of exercise as well as the environmental conditions (Burton et al., 2004). During exercise the body requires increased oxygen and substrate delivery to the working muscles, dissipation of heat energy produced and the increased removal ...


... This document was peer reviewed by two official external reviewers representing the American College of Cardiology Foundation, two official external reviewers representing the American Heart Association, and two official external reviewers representing the European Society of Cardiology. The North A ...
Regulation of atrial natriuretic peptide
Regulation of atrial natriuretic peptide

... of β-adrenoceptors, raised sodium concentration, angiotensin-II and endothelin. ANP binds to three cell surface receptors called ANP receptors. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system. It has also been reported ...
ACC/AHA Guidelines for the Management of Patients With Acute
ACC/AHA Guidelines for the Management of Patients With Acute

... jointly engaged in the preparation of such guidelines in the area of cardiovascular disease since 1980. This effort is directed by the ACC/AHA Task Force on Practice Guidelines, which is charged with developing and revising practice guidelines for important cardiovascular diseases and procedures. Ex ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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