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How to Use An AED - Palm Beach State College
How to Use An AED - Palm Beach State College

... For both infants and children, conventional CPR is given at a rate of 30 compressions followed by 2 rescue breaths (100 compressions/minute). In all cases, conventional CPR starts with compressions first! Then the breathing. ...
Simplified Method for Vagal Effect Evaluation in Cardiac Ablation
Simplified Method for Vagal Effect Evaluation in Cardiac Ablation

... denervation at any time during the ablation procedure without autonomic residual effect. BACKGROUND Parasympathetic denervation has been increasingly applied in ablation procedures such as in vagalrelated atrial fibrillation and cardioneuroablation. This method proposes an easy way to study the vagal ...
Automated detection of effective left-ventricular
Automated detection of effective left-ventricular

... from the pacing cathode. The algorithm was based on a fundamental principle in electrophysiology—effective capture of tissue generates a QS or QS-r morphology on the unipolar electrogram measured from the pacing cathode to an indifferent electrode.10 The pacing cathode is any pacing pole of any comm ...
by Angiotensin II - Circulation Research
by Angiotensin II - Circulation Research

... Although the role of angiotensin II (Ang II) in the pathogenesis and progression of the failing heart is uncertain, previous reports have suggested that myocyte injury may be a component in this process. In this study, we investigated this possibility in more detail. Cardiotoxic effects of nonacutel ...
ACCF/AHA Pulmonary Hypertension
ACCF/AHA Pulmonary Hypertension

... and/or technologies that are widely available or new to the practice community. Topics chosen for coverage by expert consensus documents are so designed because the evidence base, the experience with technology, and/or the clinical practice are not considered sufficiently well developed to be evalua ...
The Cardioprotective Effects of Hydrogen Sulfide in Heart
The Cardioprotective Effects of Hydrogen Sulfide in Heart

... Hydrogen sulfide (H2S) has been thought to be just a toxic gas with a strong odor of rotten eggs for hundreds of years. However, with the advancement of scientific technology over the years, researchers have discovered that H2S takes part in a series of physiological and pathological processes in ma ...
Left atrial myxoma with aortic regurgitation - Heart
Left atrial myxoma with aortic regurgitation - Heart

... the coronary arteries, and the left atrial mass. Immediate surgery was advised and carried out and therefore further echocardiographic studies could not be undertaken. A left atrial myxoma was found. It had a greenish gelatinous appearance with an impression on it where part of it had been pushed in ...
and the role of cardiac resynchronization therapy
and the role of cardiac resynchronization therapy

... ventricular pacing have shown that asynchronous ventricular activation immediately deteriorates left ventricular (LV) function.7 Moreover, evidence is increasing that asynchronous ventricular activation is associated with structural changes in the long run. Animal studies have shown that long-term L ...
Grid Lead System
Grid Lead System

... Most clinical ECG leads determine cardiac currents from a few surface potential samples, without quantitating torso geometry and structure, by empirical-intuitive methods. The present report is part of a broader study asking whether the known limitations of ECG can be reduced by multi-electrode grid ...
visionist™, visionist™ x4, valitude™, valitude
visionist™, visionist™ x4, valitude™, valitude

... contraindications, and technical specifications. Read this material carefully for implant procedure instructions specific to the chosen lead configurations. Refer to the PRM system Operator's Manual or ZOOM Wireless Transmitter Reference Guide for specific information about the PRM or ZOOM Wireless ...
Relation of Ultrastructure to Function in the Intact Heart: Sarcomere
Relation of Ultrastructure to Function in the Intact Heart: Sarcomere

... dogs and 10 cats anesthetized with sodium pentobarbital (25 mg/kg) and sacrificed acutely. The mitral orifice of the hearts from dogs was sealed with a clamp, and the right ventricle was opened widely. A Gregg cannula was inserted into the left main coronary artery and the aorta was sealed around th ...
Appraisal consultation document
Appraisal consultation document

... with similar structures have been published previously, including the model submitted to NICE as part of its technology appraisal guidance on ivabradine for treating chronic heart failure. In its primary base-case analysis, patients entered in the model in either the sacubitril valsartan or the enal ...
Defective Ca2+ Handling Proteins Regulation During Heart Failure
Defective Ca2+ Handling Proteins Regulation During Heart Failure

... delicate balance between influx and efflux of Ca2+. Some reports suggest that the reduction of SR Ca2+ content has been attributed to depressed SERCA2a function and/or enhanced NCX activity during HF (Shannon et al. 2003). These changes are expected to facilitate Ca2+ removal from the cell at the ex ...
BAJ Reddi and RHS Carpenter
BAJ Reddi and RHS Carpenter

... where it limits the rate at which blood is permitted to enter the right atrium: atrial filling will then also depend on the heart rate. Both of these methods were used by Starling as a way of altering atrial input: either, as described earlier, raising and lowering the reservoir to create different ...
Pacing mode selection in patients with sick sinus syndrome
Pacing mode selection in patients with sick sinus syndrome

... Patients with SSS and concomitant atrioventricular (AV) block must be treated with a pacemaker system including a ventricular lead. The majority of patients with SSS have no additional atrioventricular (AV) block or bundle branch block. In those patients, the bradycardia-related symptoms can be succ ...
Venous excess: a new approach to cardiovascular control and its
Venous excess: a new approach to cardiovascular control and its

... where it limits the rate at which blood is permitted to enter the right atrium: atrial filling will then also depend on the heart rate. Both of these methods were used by Starling as a way of altering atrial input: either, as described earlier, raising and lowering the reservoir to create different ...
Catheter Ablation for Atrial Fibrillation: Predicting Recurrence
Catheter Ablation for Atrial Fibrillation: Predicting Recurrence

... isolate the foci within the PV from the atria, thereby preventing the chaotic electrical signals from interrupting the normal conduction of the left atrium.9 It has emerged as a treatment modality for symptomatic patients who have not responded to medication. 10, 11 Acute procedural success is indic ...
Electrical Activity During the PR Interval
Electrical Activity During the PR Interval

... from the specialized tissue. For the same reason, most records were obtained with contiguous bipolar electrodes. The effect of the filters on the bipolar electrogram can be seen in figure 3. In this tracing, the records on the second and third lines were obtained through the same set of close bipola ...
12 Lead ECGs: Ischemia, Injury, Infarction
12 Lead ECGs: Ischemia, Injury, Infarction

... the people who die from heart attacks, about half died within an hour of the first symptoms and before they reach a healthcare facility (National Heart, Lung and Blood Institute, 2015). Prognosis is based on variables including size and depth of MI, blood supply to residual non-infarcted myocardium ...
Augmented Unipolar Limb Leads
Augmented Unipolar Limb Leads

... upward. The 150 per cent slope, which corresponds to Goldberger's predicted augmentation over the Wilson leads, is indicated by a solid line. The figures show that the predicted slope agrees roughly with the general trend observed. However, the individual scatter is great. Theoretically, there is no ...
Catheter Ablation as a Treatment for Atrial Fibrillation
Catheter Ablation as a Treatment for Atrial Fibrillation

... fibrillation or to developing atrial flutter. In most of the published studies, success rates were based on having as many as 3 separate procedures, although these repeat procedures may be more limited than the initial procedure. Results of randomized controlled trials that compare radiofrequency ab ...
Results and conclusions: The perceived exertion differed
Results and conclusions: The perceived exertion differed

... Overall it is agreed that more may be learned about complex systems by trying to understand the important patterns of interaction and association across different elements and dimensions of such systems [89]. It appears that the stepping stone for the understanding the complex systems is to start to ...
3.3. Isolated heart perfusion
3.3. Isolated heart perfusion

nt-pro brain natriuretic peptide: new diagnostic tool for heart failure
nt-pro brain natriuretic peptide: new diagnostic tool for heart failure

... exudates who are treated with diuretics. Han et al (2) reported that 26 of the 28 misclassified heart-failure patients received diuretics before thoracentesis and had pleural fluid NT-proBNP levels of higher than 1,714 ...
Double Outlet Right Ventricle With Pulmonary Stenosis - Heart
Double Outlet Right Ventricle With Pulmonary Stenosis - Heart

... ventricular septal defect which lies near to the pulmonary artery and is relatively remote from the aortic orifice. Flow from the right ventricle is mainly into the aorta, and these patients are cyanotic from birth. Type 2b. Here there is a large supracristal ventricular septal defect related to bot ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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