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13421-45587-1
13421-45587-1

... tachyarrhythmia, such as torsades de pointes (Tdp). Many drugs, including antidepressants, were reported to induce the QTc prolongation. Compared with tricyclic antidepressants (TCAs), use of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine was less likely to cause severe cardiac a ...
Cardiac Resynchronization Therapy Defibrillator
Cardiac Resynchronization Therapy Defibrillator

... Your heart works as both a mechanical pump and an electrical organ. It is able to beat because it produces electrical signals. These signals travel through the electrical pathways of your heart (Figure 1), causing the muscle contraction that pumps blood throughout your body. Normally these signals c ...
anomalous pulmonary venous drainage - Heart
anomalous pulmonary venous drainage - Heart

... The electrocardiographic findings in the present series are similar to those in previous reports of atrial septal defect (Bedford et 1941; Routier et 1940; Barber et 1950) and anomalous it is venous drainage (Whitaker, 1954; Geraci, 1953; and Grishman et 1945), and their pulmonary of view in way: of ...
Progression of Aortic Stenosis
Progression of Aortic Stenosis

... actuarial survival was 31% and 22% at 2 and 5 years, respectively. They concluded that asymptomatic or minimally symptomatic patients with severe aortic stenosis are at low risk of death and that surgical ...
Missing a Sub-pulmonary Ventricle: The Fontan Circulation
Missing a Sub-pulmonary Ventricle: The Fontan Circulation

... capillary bed pools blood into another capillary bed through veins without passing through the heart, as for example in the hepatic portal system and the pituitary portal system. The Fontan neo-portal system dams off and pools the systemic venous blood. As a result, transit of blood through this neo ...
Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of
Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of

... Abbreviations: Ao, aorta; AV, aortic valve; LA, left atrium; LV, left ventricle; MV, mitral valve; PA, pulmonary artery; PV, pulmonic valve; RA, right atrium; RV, right ventricle; TV, tricuspid valve. Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography, © 2012. All right ...
Heart Guide - Center for Plain Language
Heart Guide - Center for Plain Language

... ƒƒ Coronary artery disease – This refers to conditions that block blood flow in the arteries that supply the heart. The most common cause of this blockage is a condition called atherosclerosis, when the arterial walls thicken and stiffen due to the buildup of fatty deposits inside the arteries. ƒƒ C ...
Experimental Demonstration of Concealed AV
Experimental Demonstration of Concealed AV

... junction. By driving the right atrium at a rate slower than that of the natural (sinus) pacemaker an atrial parasystole has been produced artificially. Of the five pacemaker stimuli that fall outside the refractory phase of the atria and elicit an atrial response (Pl) only the first, fourth, and fif ...
Guidelines for the diagnosis and treatment of pulmonary hypertension
Guidelines for the diagnosis and treatment of pulmonary hypertension

... Disclaimer. The ESC Guidelines represent the views of the ESC and were arrived at after careful consideration of the available evidence at the time they were written. Health professionals are encouraged to take them fully into account when exercising their clinical judgement. The guidelines do not, ...
Apical hypertrophic cardiomyopathy associated with multiple
Apical hypertrophic cardiomyopathy associated with multiple

... HCM and coronary fistulae is essentially medical. Thus, conservative management with continued follow-up seems appropriate when these conditions co-exist. Our patient was treated with nebivolol and a vitamin K antagonist and was discharged after the investigation was completed. She remained asymptom ...
Prevalence and characteristics of ectopic atrial tachycardia
Prevalence and characteristics of ectopic atrial tachycardia

... 1 Introduction Supraventricular tachycardias (SVTs) are common rhythm disturbances and were previously clustered together into one diagnostic category. Based on the knowledge gained from invasive electrophysiological studies, it has become possible to differentiate between the various SVT subtypes ...
Guidelines for the diagnosis and treatment of pulmonary hypertension
Guidelines for the diagnosis and treatment of pulmonary hypertension

... A great number of Guidelines and Expert Consensus Documents have been issued in recent years by the European Society of Cardiology (ESC) as well as by other societies and organizations. Because of the impact on clinical practice, quality criteria for development of guidelines have been established i ...
Heart rate variability - European Society of Cardiology
Heart rate variability - European Society of Cardiology

... short-term high frequency variations, as well as the lowest frequency components seen in a 24-h period. As the period of monitoring decreases, SDNN estimates shorter and shorter cycle lengths. It should also be noted that the total variance of HRV increases with the length of analysed recording[19]. ...
Guidelines for the diagnosis and treatment of pulmonary hypertension
Guidelines for the diagnosis and treatment of pulmonary hypertension

... A great number of Guidelines and Expert Consensus Documents have been issued in recent years by the European Society of Cardiology (ESC) as well as by other societies and organizations. Because of the impact on clinical practice, quality criteria for development of guidelines have been established i ...
Increased Phosphorylation of Ca2+ Handling Proteins as a - J
Increased Phosphorylation of Ca2+ Handling Proteins as a - J

... Methods and Results:  Myocarditis was induced by injection of 2 mg porcine cardiac myosin into the footpads of adult Lewis rats on days 1 and 8 (Myo, n=15) and the results compared with Control rats (Control, n=15). In an additional 15 rats, 6 mg/kg prednisolone was injected into the gluteus muscle ...
Effect of Altered Activation Sequence on Epicardial QRST Area and
Effect of Altered Activation Sequence on Epicardial QRST Area and

... distributed over the entire cardiac surface were recorded. Next, refractory periods at electrode sites near pacing electrodes were measured. Paired right ventricular/left ventricular (RV/LV) pacing data were obtained six or seven times in each sample. Although the QRST isoarea maps during the two ac ...
Egan`s Fundamentals of Respiratory Care
Egan`s Fundamentals of Respiratory Care

... Caused by a wide variety of disorders such as rheumatic heart disease, coronary heart disease, renal failure, stress, and hypoxemia ...
FAMILY  STUDY Cardiovascular Disease in American Indians (Phase IV)
FAMILY STUDY Cardiovascular Disease in American Indians (Phase IV)

... The general approach to surveillance at each center is to divide the total number of participants into twelfths from a listing of surviving Phase I participants, ordered by calendar time from least to most recent exam date. This would result in an approximately equal distribution of participants acr ...
Document
Document

... model described by Torrent-Guasp, cardiac muscular structures produce two simple loops that start at the pulmonary artery and end in the aorta. These components include a horizontal basal loop that surrounds the right and left ventricles, changes direction through a spinal fold in the ventricular my ...
Transvenous Lead Extraction: Heart Rhythm Society Expert
Transvenous Lead Extraction: Heart Rhythm Society Expert

... removal and, 4) use of laser extraction technique.47 Most of these data represented non-laser assisted extraction but also represented an earlier version of the laser hardware and the physician learning curve for laser use. The prospectively collected PLEXES and early laser reported results can be u ...
PEDMEANS Physicians Manual
PEDMEANS Physicians Manual

... This part deals with the analysis of the various waveforms. First of all the QRS complexes must be detected. No other waves or artifacts should be labeled as such. The intervals between QRS complexes are measured and stored. After all QRS complexes have been detected, they are typified, i.e., a comp ...
ACC/AHA Guideline
ACC/AHA Guideline

... ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Adults With Congenital Hea ...
development of interatrial and interventricular septum
development of interatrial and interventricular septum

... May be associated with other ASDs.  Multiple defects can be seen if the floor of the fossa ovalis (AKA valve of the foramen ovale) is fenestrated.  Ten to twenty percent have a functional mitral valve prolapse  May be related to changing LV geometry associated with RV volume ...
Influence of Paroxysmal Atrial Fibrillation Attack on Brain Natriuretic
Influence of Paroxysmal Atrial Fibrillation Attack on Brain Natriuretic

... recovery processes of cardiac function in patients with chronic Af after electrical defibrillation. The atrial contribution to left ventricular filling recovered within 1 week, and the left ventricular ejection fraction and maximum oxygen consumption continued to increase for 1 month after the defib ...
Systematization and clinical study of `dextroversion, mirror
Systematization and clinical study of `dextroversion, mirror

... the complexes in these leads being pre- our 4I cases of malposition were dextroverdominantly negative. It is important to know sions (29%). It has been described under the unipolar morphologies corresponding to different names: dextrorotation (Ayres and variations of potential peculiar to the ven- S ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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