SERIES ‘‘PULMONARY HYPERTENSION: BASIC CONCEPTS FOR PRACTICAL MANAGEMENT’’
... sleep and exacerbation. Pulmonary vascular remodelling in COPD is the main cause of increase in pulmonary artery pressure and is thought to result from the combined effects of hypoxia, inflammation and loss of capillaries in severe emphysema. A small proportion of COPD patients may present with ‘‘ou ...
... sleep and exacerbation. Pulmonary vascular remodelling in COPD is the main cause of increase in pulmonary artery pressure and is thought to result from the combined effects of hypoxia, inflammation and loss of capillaries in severe emphysema. A small proportion of COPD patients may present with ‘‘ou ...
Guidelines on the management of stable angina pectoris: full text
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
Materials and Methods - Frontiers in Bioscience
... Following 3 weeks of carnitine supplementation, serum FC increased (from 44.4+/-3.5 to 94.1+/-10.1 micromol/L, p value less than 0.001 and from 25.3+/-1.7 to 69.4+/-5.9 micromol/L, p value less than 0.001) in control and uraemic groups respectively. There was a smaller increase in control (from 51.7 ...
... Following 3 weeks of carnitine supplementation, serum FC increased (from 44.4+/-3.5 to 94.1+/-10.1 micromol/L, p value less than 0.001 and from 25.3+/-1.7 to 69.4+/-5.9 micromol/L, p value less than 0.001) in control and uraemic groups respectively. There was a smaller increase in control (from 51.7 ...
The Pathophysiology of Ischemic Mitral Regurgitation
... Some patients with ischemic MR have Type II dysfunction (excess leaflet motion), resulting from either an acute (ruptured papillary muscle) or chronic (fibrotic and elongated papillary muscle) myocardial ischemic event. It should be emphasized that the prior concept of ”acute ischemia with papillary ...
... Some patients with ischemic MR have Type II dysfunction (excess leaflet motion), resulting from either an acute (ruptured papillary muscle) or chronic (fibrotic and elongated papillary muscle) myocardial ischemic event. It should be emphasized that the prior concept of ”acute ischemia with papillary ...
Guidelines on the Management of Stable Angina Pectoris : Full Text
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
Atrial Fibrillation - George Washington University School of Medicine
... cause mechanical dysfunction of the atrium.27 Restoration of sinus rhythm is generally associated with the normalization of function over a period of two to four weeks.28 Possibly because of the delayed recovery of atrial mechanical function, the risk of thromboembolism posed by atrial fibrillation ...
... cause mechanical dysfunction of the atrium.27 Restoration of sinus rhythm is generally associated with the normalization of function over a period of two to four weeks.28 Possibly because of the delayed recovery of atrial mechanical function, the risk of thromboembolism posed by atrial fibrillation ...
S193687981401646X_mmc1
... regression analysis patients in non-US institutions were at higher risk for mortality. ...
... regression analysis patients in non-US institutions were at higher risk for mortality. ...
Techniques for Ventricular Repolarization Instability Assessment
... of cases of SCD are due to bradycardia. Three main factors have been identified to have a major role in the initiation and maintenance of arrhythmias: substrate, triggers, and modulators. A vulnerable myocardium is the substrate for arrhythmogenesis, meaning that when triggering factors appear, they ...
... of cases of SCD are due to bradycardia. Three main factors have been identified to have a major role in the initiation and maintenance of arrhythmias: substrate, triggers, and modulators. A vulnerable myocardium is the substrate for arrhythmogenesis, meaning that when triggering factors appear, they ...
a biphasic role for the voltage
... I’d also like to thank the members of my thesis committee, Al George, Charles Hong, Doug Mortlock, and the chair, Scott Baldwin. Their interest in my research and career are reflected heavily in my thesis. Leaving each committee meeting inspired and enthusiastic about my project was always encour ...
... I’d also like to thank the members of my thesis committee, Al George, Charles Hong, Doug Mortlock, and the chair, Scott Baldwin. Their interest in my research and career are reflected heavily in my thesis. Leaving each committee meeting inspired and enthusiastic about my project was always encour ...
Flecainide BNM
... From age 20 to 80, plasma flecainide levels are only slightly higher with advancing age. With usual doses the rate of flecainide elimination from plasma is somewhat slower in elderly than in younger subjects. This should be taken into consideration when making dose adjustments. In elderly patients t ...
... From age 20 to 80, plasma flecainide levels are only slightly higher with advancing age. With usual doses the rate of flecainide elimination from plasma is somewhat slower in elderly than in younger subjects. This should be taken into consideration when making dose adjustments. In elderly patients t ...
A manual for pacemaker patients
... The best source of information for your health questions is your physician, since every person is unique and many factors affect your overall health. It is our goal at BIOTRONIK to give you a good overview of pacemakers and share with you what we have found to be the general experiences of most pati ...
... The best source of information for your health questions is your physician, since every person is unique and many factors affect your overall health. It is our goal at BIOTRONIK to give you a good overview of pacemakers and share with you what we have found to be the general experiences of most pati ...
Wyrwoll_PNAS_forMegan - Edinburgh Research Explorer
... EC50 dose of U46619. L-NAME + indomethacin caused a further 25-50% transient contraction ...
... EC50 dose of U46619. L-NAME + indomethacin caused a further 25-50% transient contraction ...
Atrial fibrillation management
... The impact of atrial fibrillation AF is the most prevalent sustained cardiac arrhythmia. The Rotterdam Study showed that AF is found in 5.5% of the general population of 55 years or older.14 AF incidence increases with advancing age from 1.1 per 1000 person-years in age 55-59 years to 19.6 per 1000 ...
... The impact of atrial fibrillation AF is the most prevalent sustained cardiac arrhythmia. The Rotterdam Study showed that AF is found in 5.5% of the general population of 55 years or older.14 AF incidence increases with advancing age from 1.1 per 1000 person-years in age 55-59 years to 19.6 per 1000 ...
Quantification of Left Ventricular Function With Premature
... create variable symptoms and may cause a cardiomyopathy. Clinically, PVC-induced cardiomyopathy remains a diagnosis of exclusion and conventional imaging is often used to rule out underlying disease.1 Accurate assessments of left ventricular (LV) function using conventional multishot cardiovascular ...
... create variable symptoms and may cause a cardiomyopathy. Clinically, PVC-induced cardiomyopathy remains a diagnosis of exclusion and conventional imaging is often used to rule out underlying disease.1 Accurate assessments of left ventricular (LV) function using conventional multishot cardiovascular ...
Thesis, Emmanuel Moss 20110625 Final
... denervation, from 365±252 at baseline to 53±106mm2 following RAGP ablation (p<0.03). With retrograde denervation, chronotropic and repolarisation changes were suppressed following RAGP ablation in two canines, and following Ao/SVC ablation in three. Surface area of REPOL∆ diminished following RAGP a ...
... denervation, from 365±252 at baseline to 53±106mm2 following RAGP ablation (p<0.03). With retrograde denervation, chronotropic and repolarisation changes were suppressed following RAGP ablation in two canines, and following Ao/SVC ablation in three. Surface area of REPOL∆ diminished following RAGP a ...
Chronic Coronary Artery Constriction Leads to Moderate
... Sampling size. The magnitude of sampling utilized in this investigation was selected on the basis of previous work performed in our laboratory and the principle ofPoisson statistics (30). The latter can be used as a reasonable guideline for morphometric data collection since it provides a more conse ...
... Sampling size. The magnitude of sampling utilized in this investigation was selected on the basis of previous work performed in our laboratory and the principle ofPoisson statistics (30). The latter can be used as a reasonable guideline for morphometric data collection since it provides a more conse ...
The DDDR closed loop stimulation for the prevention of the
... INOS2 CLS pacemaker (BIOTRONIK, Germany) detects changes in myocardial contraction dynamics through intracardiac impedance measurement and transfers them into individual pacing rates[4] (Fig. 1). After initialization of the CLS pacing mode, the pacemaker system not only initiates the rate modulating ...
... INOS2 CLS pacemaker (BIOTRONIK, Germany) detects changes in myocardial contraction dynamics through intracardiac impedance measurement and transfers them into individual pacing rates[4] (Fig. 1). After initialization of the CLS pacing mode, the pacemaker system not only initiates the rate modulating ...
Case Report: Left bundle branch block: a rare ECG - SVIMS
... segment elevation simulating acute injury. This disappears with haemodialysis dialyzable current of injury. ...
... segment elevation simulating acute injury. This disappears with haemodialysis dialyzable current of injury. ...
Mitochondria in heart failure
... afterload, altered signal transduction pathways, abnormalities of calcium homeostasis, as well as neurohormonal dysregulation are major pathogenic factors for myocardial dysfunction in HF. Despite significant advances in therapy, particularly inhibition of the renin – angiotensin and sympathetic ner ...
... afterload, altered signal transduction pathways, abnormalities of calcium homeostasis, as well as neurohormonal dysregulation are major pathogenic factors for myocardial dysfunction in HF. Despite significant advances in therapy, particularly inhibition of the renin – angiotensin and sympathetic ner ...
CMR Imaging Assessing Viability in Patients With Chronic
... Baseline characteristics. Of the 24 studies, 11 studies (10,44 –53) enrolling 331 patients (mean age 64 years; 83% men) and analyzing 4,397 LV segments evaluated myocardial viability using DE CMR, 10 studies used cine-CMR for follow up, and only 1 used echocardiography. Nine studies (36,45,51,54 –59 ...
... Baseline characteristics. Of the 24 studies, 11 studies (10,44 –53) enrolling 331 patients (mean age 64 years; 83% men) and analyzing 4,397 LV segments evaluated myocardial viability using DE CMR, 10 studies used cine-CMR for follow up, and only 1 used echocardiography. Nine studies (36,45,51,54 –59 ...
Aortic Stenosis: Diagnosis and Treatment
... Aortic stenosis is the most important cardiac valve disease in developed countries, affecting 3 percent of persons older than 65 years. Although the survival rate in asymptomatic patients with aortic stenosis is comparable to that in age- and sex-matched control patients, the average overall surviva ...
... Aortic stenosis is the most important cardiac valve disease in developed countries, affecting 3 percent of persons older than 65 years. Although the survival rate in asymptomatic patients with aortic stenosis is comparable to that in age- and sex-matched control patients, the average overall surviva ...
The Role of Muscarinic K Channels in the Negative Chronotropic
... Concentration-Dependent Effect of Carbachol on the Sinus Rate of a Rabbit Heart.I first examined the concentration-dependent effect of CCh on the sinus rate in the Langendorff preparation of a rabbit heart by monitoring the ECG (Fig. 1). At the beginning of each experiment, a -adrenergic blocker pr ...
... Concentration-Dependent Effect of Carbachol on the Sinus Rate of a Rabbit Heart.I first examined the concentration-dependent effect of CCh on the sinus rate in the Langendorff preparation of a rabbit heart by monitoring the ECG (Fig. 1). At the beginning of each experiment, a -adrenergic blocker pr ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.