Circa- and ultradians in the occurrence of simple extrasystoles in
... to some other studies (e.g. 9, 13, 20, 22). In those studies were displayed also long pauses, multiform extrasystoles, bigeminy or ventricular tachycardia in very old persons. But no attempts to exclude silent myocardial ischaemia can be fully successful. Only a few publications can be compared with ...
... to some other studies (e.g. 9, 13, 20, 22). In those studies were displayed also long pauses, multiform extrasystoles, bigeminy or ventricular tachycardia in very old persons. But no attempts to exclude silent myocardial ischaemia can be fully successful. Only a few publications can be compared with ...
The Role of Muscarinic K Channels in the Negative Chronotropic
... Concentration-Dependent Effect of Carbachol on the Sinus Rate of a Rabbit Heart.I first examined the concentration-dependent effect of CCh on the sinus rate in the Langendorff preparation of a rabbit heart by monitoring the ECG (Fig. 1). At the beginning of each experiment, a -adrenergic blocker pr ...
... Concentration-Dependent Effect of Carbachol on the Sinus Rate of a Rabbit Heart.I first examined the concentration-dependent effect of CCh on the sinus rate in the Langendorff preparation of a rabbit heart by monitoring the ECG (Fig. 1). At the beginning of each experiment, a -adrenergic blocker pr ...
Therapeutic Hypothermia
... trials have provided conflicting results [50-55]. Although the early large multicenter randomized controlled trial (RCT) [53,56,57], did not demonstrate an overall benefit of hypothermia in severe TBI, subsequent clinical trial data have suggested that systemic methods of inducing hypothermia provid ...
... trials have provided conflicting results [50-55]. Although the early large multicenter randomized controlled trial (RCT) [53,56,57], did not demonstrate an overall benefit of hypothermia in severe TBI, subsequent clinical trial data have suggested that systemic methods of inducing hypothermia provid ...
Author`s final copy - Canada`s Michael Smith Genome Sciences
... phenotype [19]. The mesenchymal cells invade the ECM and populate the cardiac cushions [20,21]. The OFT, which will form the SL valves, develops similarly with the exception that neural crest cells migrate and contribute to the OFT cushions (reviewed in [22]). Following invasion into the cardiac cus ...
... phenotype [19]. The mesenchymal cells invade the ECM and populate the cardiac cushions [20,21]. The OFT, which will form the SL valves, develops similarly with the exception that neural crest cells migrate and contribute to the OFT cushions (reviewed in [22]). Following invasion into the cardiac cus ...
Observations on the Carotid Sinus Reflex
... observed and the actual duration of attacks induced by exercise had been repeatedly measured and found to be reproducible. In our previous studies13 13a, 131) the response to nitroglycerin was used to determine the likelihood of response to other forms of treatment and served to divide patients into ...
... observed and the actual duration of attacks induced by exercise had been repeatedly measured and found to be reproducible. In our previous studies13 13a, 131) the response to nitroglycerin was used to determine the likelihood of response to other forms of treatment and served to divide patients into ...
PATIENT EDUCATION TOOLS The following tools can be used to
... changes in the shape of the heart and result in an uncoordinated heartbeat, which is called an arrhythmia (this means a rhythm that is not normal). ...
... changes in the shape of the heart and result in an uncoordinated heartbeat, which is called an arrhythmia (this means a rhythm that is not normal). ...
Percutaneous Mitral Valve Therapy: The Next Decade
... Transcatheter aortic valve implantation (TAVI) is already yielding almost $700 million in revenues (in OUS markets) where some 50,000 patients have undergone the procedure to date. Market estimates place the size of the TAVI market at almost $2 billion by 2014, including only high risk patients not ...
... Transcatheter aortic valve implantation (TAVI) is already yielding almost $700 million in revenues (in OUS markets) where some 50,000 patients have undergone the procedure to date. Market estimates place the size of the TAVI market at almost $2 billion by 2014, including only high risk patients not ...
The Sequence of Retrograde Atrial Activation in the Canine Heart
... The present report describes a series of studies performed on the canine heart which correlate P-wave polarity and morphology with the origin and the time course of atrial epicardial and endocardial activation during ectopic atrial rhythms. Ectopic pacing sites were selected which produced either a ...
... The present report describes a series of studies performed on the canine heart which correlate P-wave polarity and morphology with the origin and the time course of atrial epicardial and endocardial activation during ectopic atrial rhythms. Ectopic pacing sites were selected which produced either a ...
Percutaneous PFO Closure - Virginia Commonwealth University
... o Underpowered for rigorous primary endpoint in patients at the severe end of the migraine spectrum o Follow-up too short? o Incorrect hypothesis – maybe closing PFO does not alter the course? ...
... o Underpowered for rigorous primary endpoint in patients at the severe end of the migraine spectrum o Follow-up too short? o Incorrect hypothesis – maybe closing PFO does not alter the course? ...
Pericardial heart disease
... Although pericardial disease has many causes, the morphologic reaction of the pericardia to injury is rather limited. The pericardium reacts to acute injury by exuding fluid, fibrin, or cells or combinations of these three. The type of fluid and/or cells exuded is determined by the cause of the peri ...
... Although pericardial disease has many causes, the morphologic reaction of the pericardia to injury is rather limited. The pericardium reacts to acute injury by exuding fluid, fibrin, or cells or combinations of these three. The type of fluid and/or cells exuded is determined by the cause of the peri ...
N-Dimensional Presentation State Use Cases Toshiba
... PET / CT Fusion – Added 15 Feb Input is a set of registered PET /CT exams, typically from a combined PET / CT scanner. A set of prior exams may also be loaded. ...
... PET / CT Fusion – Added 15 Feb Input is a set of registered PET /CT exams, typically from a combined PET / CT scanner. A set of prior exams may also be loaded. ...
morphological study of coronary sinus in human cadaveric
... arrhythmia ablation, biventricular pacing and implantation of cardiac pacemakers. The present study aims to study the formation and tributaries of coronary sinus and also the morphology of thebesian valve. Materials and Methods: 30 formalin fixed cadaveric hearts available in the department of Anato ...
... arrhythmia ablation, biventricular pacing and implantation of cardiac pacemakers. The present study aims to study the formation and tributaries of coronary sinus and also the morphology of thebesian valve. Materials and Methods: 30 formalin fixed cadaveric hearts available in the department of Anato ...
2013 STEMI Guideline - American Heart Association
... The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease. When properly applied, expert analysis of available data on the benefits and risks of these therapies and procedures can im ...
... The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease. When properly applied, expert analysis of available data on the benefits and risks of these therapies and procedures can im ...
ACC/AHA 2008 Performance Measures for Adults With ST
... task to comment, when appropriate, on the strengths and limitations of such external reporting for a particular cardiovascular disease state or patient population. Thus, the metrics contained within this document are categorized as either performance measures or test measures. Performance measures a ...
... task to comment, when appropriate, on the strengths and limitations of such external reporting for a particular cardiovascular disease state or patient population. Thus, the metrics contained within this document are categorized as either performance measures or test measures. Performance measures a ...
Review Article Epicardial Ablation For Ventricular Tachycardia
... ablation but, above all, when an endo-epicardial ablation must be performed as first choice. One cardiomyopathy in which the expression of the pathological processes may have in some cases a predominant expression not only adjacent to the valve annulus, deep in the endocardium but also in the epicar ...
... ablation but, above all, when an endo-epicardial ablation must be performed as first choice. One cardiomyopathy in which the expression of the pathological processes may have in some cases a predominant expression not only adjacent to the valve annulus, deep in the endocardium but also in the epicar ...
QT dispersion: time for an obituary?
... QT dispersion: time for an obituary? See page 1023 for the article to which this Editorial refers During the past decade, studies of QT dispersion[1] have become popular and numerous publications have reported some physiological and/or clinical value of QT dispersion measurement. Among others, incre ...
... QT dispersion: time for an obituary? See page 1023 for the article to which this Editorial refers During the past decade, studies of QT dispersion[1] have become popular and numerous publications have reported some physiological and/or clinical value of QT dispersion measurement. Among others, incre ...
Advances in Arrhythmia and Electrophysiology
... its surroundings. A small crescent-like edge is usually the only discernable margin of the flap valve of the oval fossa (or floor of the fossa) that is developed from the embryonic septum primum (Figure 5A). The rest of the flap valve blends into the paraseptal atrial wall. Thus, the extensive fossa ...
... its surroundings. A small crescent-like edge is usually the only discernable margin of the flap valve of the oval fossa (or floor of the fossa) that is developed from the embryonic septum primum (Figure 5A). The rest of the flap valve blends into the paraseptal atrial wall. Thus, the extensive fossa ...
Lead Extraction - Department of Mechanical Engineering
... rate or by coordinating the heart’s contraction for some heart failure patients.1 Implantable cardioverter defibrillators stop dangerous rapid heart rhythms by delivering an electric shock.2 As the range of applications widens, the number of patients with cardiac devices continues to increase. Appro ...
... rate or by coordinating the heart’s contraction for some heart failure patients.1 Implantable cardioverter defibrillators stop dangerous rapid heart rhythms by delivering an electric shock.2 As the range of applications widens, the number of patients with cardiac devices continues to increase. Appro ...
The University of Birmingham Na+/Ca2+ exchange and Na+/K+
... 1992) consistent with a state-dependent model, but the mechanism is elusive. One hypothesis is that the binding of Na+ to its transport site drives the exchanger into an inactivated state (Hilgemann et al. 1992). However, mutagenesis studies have shown that a region within the large cytoplasmic loop ...
... 1992) consistent with a state-dependent model, but the mechanism is elusive. One hypothesis is that the binding of Na+ to its transport site drives the exchanger into an inactivated state (Hilgemann et al. 1992). However, mutagenesis studies have shown that a region within the large cytoplasmic loop ...
Atrial Fibrillation: New Horizons
... for torsades de pointes and there are various other side effects of these drugs. Maintenance of the sinus rhythm is poor using pharmacotherapy alone, which is as low as 25% at the end of the first year. It is interesting to note that even on placebo, 37% of patients with recent onset AF of <8 hours ...
... for torsades de pointes and there are various other side effects of these drugs. Maintenance of the sinus rhythm is poor using pharmacotherapy alone, which is as low as 25% at the end of the first year. It is interesting to note that even on placebo, 37% of patients with recent onset AF of <8 hours ...
A neural explanation of fetal heart rate patterns: A test of the
... Heart period levels immediately before the decelerations were evaluated to determine if a significant heart rate acceleration (i.e., decrease in heart period) occurred. Significant accelerations were statistically defined according to the following steps. First, for each deceleration, the range of h ...
... Heart period levels immediately before the decelerations were evaluated to determine if a significant heart rate acceleration (i.e., decrease in heart period) occurred. Significant accelerations were statistically defined according to the following steps. First, for each deceleration, the range of h ...
Clinical predictors of the defibrillation threshold with the
... Defibrillation threshold testing. The defibrillation threshold of the unipolar system was determined before testing and implantation of a standard system that utilized two transvenous electrodes and a left infraclavicular subcutaneous patch. Standard antiarrhythmic medications were stopped at least ...
... Defibrillation threshold testing. The defibrillation threshold of the unipolar system was determined before testing and implantation of a standard system that utilized two transvenous electrodes and a left infraclavicular subcutaneous patch. Standard antiarrhythmic medications were stopped at least ...
PowerPoint Presentation - Hemodynamic Principles
... Sudden changes in pressure Deterioration in frequency response Catheter whip artifact End-pressure artifact Catheter impact artifact – Pressure transient produced by impact on the fluid-filled catheter by an adjacent structure (i.e. heart valve) – Any frequency component of this transient that coinc ...
... Sudden changes in pressure Deterioration in frequency response Catheter whip artifact End-pressure artifact Catheter impact artifact – Pressure transient produced by impact on the fluid-filled catheter by an adjacent structure (i.e. heart valve) – Any frequency component of this transient that coinc ...
Slide 1
... • 1. When the patient lying on his or her stomach, and propped up on the elbows. Also this position is useful to detect a pericardial friction rub. • 2. The patient standing, leaning forward with his/her hands on the wall. • The great majority of murmurs of aortic regurgitation are heard louder at t ...
... • 1. When the patient lying on his or her stomach, and propped up on the elbows. Also this position is useful to detect a pericardial friction rub. • 2. The patient standing, leaning forward with his/her hands on the wall. • The great majority of murmurs of aortic regurgitation are heard louder at t ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.