Glucocorticoid receptor alters isovolumetric contraction and restrains
... for life after birth. Hearts of foetal SMGRKO mice, which lack GR in cardiomyocytes and VSM, showed evidence of functional, structural and biochemical immaturity (RogZielinska et al. 2013). Consistent with this, glucocorticoid treatment of primary murine foetal cardiomyocytes, improved contractility ...
... for life after birth. Hearts of foetal SMGRKO mice, which lack GR in cardiomyocytes and VSM, showed evidence of functional, structural and biochemical immaturity (RogZielinska et al. 2013). Consistent with this, glucocorticoid treatment of primary murine foetal cardiomyocytes, improved contractility ...
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate
... Despite the simplicity of the structure, the genetic and molecular mechanisms that orchestrate heart formation are remarkably conserved between flies and vertebrates (Bodmer, 1995; Cripps and Olson, 2002). Moreover, recent studies using multiple functional assays revealed extensive conservation of ...
... Despite the simplicity of the structure, the genetic and molecular mechanisms that orchestrate heart formation are remarkably conserved between flies and vertebrates (Bodmer, 1995; Cripps and Olson, 2002). Moreover, recent studies using multiple functional assays revealed extensive conservation of ...
cellular update From syncitium to regulated pump: a cardiac muscle
... can represent findings that are decades old or more contemporary classic papers such as original experiments related to the discovery of Ca2⫹ sparks (3). This approach has allowed for the prioritization of necessary core concepts while assuring exposure to evolving information to expand currently ac ...
... can represent findings that are decades old or more contemporary classic papers such as original experiments related to the discovery of Ca2⫹ sparks (3). This approach has allowed for the prioritization of necessary core concepts while assuring exposure to evolving information to expand currently ac ...
The Right Ventricular Outflow Tract: The Road to Septal Pacing
... surprisingly difficult to attach to the wall as it may not lie in the trabeculated area to the right of the septomarginal trabeculation (Fig. 1). Although advancement of the lead into the pulmonary artery could be achieved using a conventional curve and then the prepared stylet inserted, this has th ...
... surprisingly difficult to attach to the wall as it may not lie in the trabeculated area to the right of the septomarginal trabeculation (Fig. 1). Although advancement of the lead into the pulmonary artery could be achieved using a conventional curve and then the prepared stylet inserted, this has th ...
Congenital Aneurysms of the Aortic Sinuses with
... all of whom demonstrated complete clinical recovery with disappearance of symptoms. The fact that this lesion is now susceptible to curative surgical correction argues for an analysis of the pathogenesis of the lesion and the clinical findings which may aid in its detection. Since Sawyer’s recent su ...
... all of whom demonstrated complete clinical recovery with disappearance of symptoms. The fact that this lesion is now susceptible to curative surgical correction argues for an analysis of the pathogenesis of the lesion and the clinical findings which may aid in its detection. Since Sawyer’s recent su ...
The CALF (Congenital Heart Disease in Adults Lower Extremity
... by clinical history. Inspection and palpation define physical findings to further classify CVI. CVI can be thereby identified and graded according to a well-established scale describing clinical, etiological, anatomical, and pathophysiological (CEAP) classifications (18,19). The objective of this st ...
... by clinical history. Inspection and palpation define physical findings to further classify CVI. CVI can be thereby identified and graded according to a well-established scale describing clinical, etiological, anatomical, and pathophysiological (CEAP) classifications (18,19). The objective of this st ...
ACC/AHA Clinical Practice Guideline
... 2014 perspective article.4 The latter recounts the history of the collaboration, changes over time, current policies, and planned initiatives to meet the needs of an evolving healthcare environment. Recommendations on value in proportion to resource utilization will be incorporated as high-quality c ...
... 2014 perspective article.4 The latter recounts the history of the collaboration, changes over time, current policies, and planned initiatives to meet the needs of an evolving healthcare environment. Recommendations on value in proportion to resource utilization will be incorporated as high-quality c ...
S0735109707014052_mmc2
... Waggoner AD, Ehler D, Adams D, Moos S, Rosenbloom J, Gresser C, Perez JE, Douglas PS. Guidelines for the cardiac sonographer in the performance of contrast echocardiography: Recommendations of the American Society of Echocardiography Council on Cardiac Sonography. J Am Soc Echocardiogr ...
... Waggoner AD, Ehler D, Adams D, Moos S, Rosenbloom J, Gresser C, Perez JE, Douglas PS. Guidelines for the cardiac sonographer in the performance of contrast echocardiography: Recommendations of the American Society of Echocardiography Council on Cardiac Sonography. J Am Soc Echocardiogr ...
Chapter 35 - Extras Springer
... perfusion of the anterolateral and inferolateral segments. Imaging in the parasternal long-axis (inferolateral wall) and the apical four- and apical long-axis views (inferolateral wall) augment the short-axis exam for visualization of the typical LCx infarction. In approximately 20% of patients, the ...
... perfusion of the anterolateral and inferolateral segments. Imaging in the parasternal long-axis (inferolateral wall) and the apical four- and apical long-axis views (inferolateral wall) augment the short-axis exam for visualization of the typical LCx infarction. In approximately 20% of patients, the ...
If Inhibition, Heart Rate, and Coronary Artery Disease
... heart failure and cardiac hypertrophy. The sinoatrial node is densely innervated by the adrenergic and cholinergic branches of the autonomic nervous system, which controls the chronotropic state of the heart. Sympathetic β-adrenergic stimulation accelerates the pacemaker, while parasympathetic choli ...
... heart failure and cardiac hypertrophy. The sinoatrial node is densely innervated by the adrenergic and cholinergic branches of the autonomic nervous system, which controls the chronotropic state of the heart. Sympathetic β-adrenergic stimulation accelerates the pacemaker, while parasympathetic choli ...
Public Summary Document - April 2015 - Word 274 KB
... Several devices are listed on the Australian Register of Therapeutic Goods for use in patients with symptomatic aortic stenosis (aortic valve area <0.8cm2) requiring aortic valve replacement who have high risk for operative mortality, or are "non-operable", as determined by an objectively predicted ...
... Several devices are listed on the Australian Register of Therapeutic Goods for use in patients with symptomatic aortic stenosis (aortic valve area <0.8cm2) requiring aortic valve replacement who have high risk for operative mortality, or are "non-operable", as determined by an objectively predicted ...
Clinical Perspective of Coronary Computed Tomographic - J
... extent, location, and distribution predicted the risk of allcause mortality independently in 1,127 patients undergoing CCTA by 16-detector row CCTA.33 In particular, the segment involvement score, which measures the total number of coronary segments with stenosis regardless of severity, was shown to ...
... extent, location, and distribution predicted the risk of allcause mortality independently in 1,127 patients undergoing CCTA by 16-detector row CCTA.33 In particular, the segment involvement score, which measures the total number of coronary segments with stenosis regardless of severity, was shown to ...
Congenital Diaphragmatic Hernia and Congenital Heart
... Congenital heart disease is present in up to 15% of infants with CDH. (Pober 2007) These lesions may co exist because formation of the fetal diaphragm and the development of the fetal heart occur at similar times embryologically. (Noimark, Sellwood et al. 2000) Although the available data estimates ...
... Congenital heart disease is present in up to 15% of infants with CDH. (Pober 2007) These lesions may co exist because formation of the fetal diaphragm and the development of the fetal heart occur at similar times embryologically. (Noimark, Sellwood et al. 2000) Although the available data estimates ...
UTILISATION OF CARDIAC MAGNETIC RESONANCE
... then progressed quickly to the contrasted study for myocardial viability and perfusion in the 1990s.1 From a 0.1 Tesla MRI in the early days, technology has now progressed such that the use of a 3.0 Tesla scanners and dedicated third party cardiac analysis software are not uncommonly encountered in ...
... then progressed quickly to the contrasted study for myocardial viability and perfusion in the 1990s.1 From a 0.1 Tesla MRI in the early days, technology has now progressed such that the use of a 3.0 Tesla scanners and dedicated third party cardiac analysis software are not uncommonly encountered in ...
Simvastatin Modulates Remodeling of Kv4.3 Expression in Rat
... Blood samples were collected and rats were sacrificed by cervical vertebrae dislocation. The hearts were removed and the left ventricles were dissected. The left ventricle was weighed and divided by body weight in order to calculate the LVWI. ...
... Blood samples were collected and rats were sacrificed by cervical vertebrae dislocation. The hearts were removed and the left ventricles were dissected. The left ventricle was weighed and divided by body weight in order to calculate the LVWI. ...
Transcatheter Aortic Valve Replacement: A Review Article Juan A
... only one patient required a pacemaker implantation due to heart block (24). However, further studies are required in order to evaluate the efficacy of the transaortic approach and compare it with other delivery modalities. In this regard, initial studies have yielded promising results for future the ...
... only one patient required a pacemaker implantation due to heart block (24). However, further studies are required in order to evaluate the efficacy of the transaortic approach and compare it with other delivery modalities. In this regard, initial studies have yielded promising results for future the ...
Aortic stenosis: Who should undergo surgery, transcatheter valve
... diseased, and leaflet opening is reduced by a failing ventricle. When cardiac output is low, the formulae used to calculate the aortic valve area become less accurate, so that patients with cardiomyopathy who have only mild or moderate aortic stenosis may appear to have severe stenosis. Patients w ...
... diseased, and leaflet opening is reduced by a failing ventricle. When cardiac output is low, the formulae used to calculate the aortic valve area become less accurate, so that patients with cardiomyopathy who have only mild or moderate aortic stenosis may appear to have severe stenosis. Patients w ...
Cardiogenesis in the bovine to 35 somites - K-REx
... were interpreted to be the vasofactive cells of the first aortic arch. The yolk sac contained numerous endothelial lined blood vessels in its wall, some of which extended as lines of vasofactive cells toward the ...
... were interpreted to be the vasofactive cells of the first aortic arch. The yolk sac contained numerous endothelial lined blood vessels in its wall, some of which extended as lines of vasofactive cells toward the ...
Avhandling 20130902 Ulla-Britt Diamant
... T-wave. There are also intra- and inter- individual differences in measurements of the QT interval (1), which further worsens the accuracy of manual measurements. The ECG is fundamental in determining the diagnosis and in the risk stratification of LQTS. Nonetheless, there is no consensus on how to ...
... T-wave. There are also intra- and inter- individual differences in measurements of the QT interval (1), which further worsens the accuracy of manual measurements. The ECG is fundamental in determining the diagnosis and in the risk stratification of LQTS. Nonetheless, there is no consensus on how to ...
Mutations in SCN10A Are Responsible for a Large Fraction
... diagnosis of ERS was on the basis of criteria suggested in our recent review of the J-wave syndromes (24). Informed consent was obtained from all patients upon referral to the Masonic Medical Research Laboratory for genetic testing, and patients were tracked anonymously. This study was approved by t ...
... diagnosis of ERS was on the basis of criteria suggested in our recent review of the J-wave syndromes (24). Informed consent was obtained from all patients upon referral to the Masonic Medical Research Laboratory for genetic testing, and patients were tracked anonymously. This study was approved by t ...
Factors Associated With Pericardial Effusion in Acute Q Wave
... increase in hydrostatic pressure is considered to be the factor associated with increased myocardial interstitial fluid volume. Therefore, although right atrial pressure was not selected as a variable in this study, our results from the multivariate analysis are in keeping with previous findings sug ...
... increase in hydrostatic pressure is considered to be the factor associated with increased myocardial interstitial fluid volume. Therefore, although right atrial pressure was not selected as a variable in this study, our results from the multivariate analysis are in keeping with previous findings sug ...
Chapter 14 Paroxysmal Supraventricular Tachycardias and the
... ranging from 16 to 65 years old and noted a low incidence of supraventricular arrhythmias.8,9 In contrast, recent longitudinal studies with telemetric monitoring and even implanted cardiac pacemakers document a very high incidence of asymptomatic and symptomatic atrial arrhythmias, particularly atri ...
... ranging from 16 to 65 years old and noted a low incidence of supraventricular arrhythmias.8,9 In contrast, recent longitudinal studies with telemetric monitoring and even implanted cardiac pacemakers document a very high incidence of asymptomatic and symptomatic atrial arrhythmias, particularly atri ...
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular
... Disclaimer. The ESC Guidelines represent the views of the ESC and EASD and were arrived at after careful consideration of the available evidence at the time they were written. Health professionals are encouraged to take them fully into account when exercising their clinical judgement. The guidelines ...
... Disclaimer. The ESC Guidelines represent the views of the ESC and EASD and were arrived at after careful consideration of the available evidence at the time they were written. Health professionals are encouraged to take them fully into account when exercising their clinical judgement. The guidelines ...
II. ICG Characterisitc Points
... Naidu et al. [31] reported an automatic technique for beat-tobeat detection of the characteristic points from ICG, using ECG R-peaks as a reference for cycle identification. The Rpeaks were detected using Pan-Tompkin algorithm [32] and the characteristic points were detected based on empirically def ...
... Naidu et al. [31] reported an automatic technique for beat-tobeat detection of the characteristic points from ICG, using ECG R-peaks as a reference for cycle identification. The Rpeaks were detected using Pan-Tompkin algorithm [32] and the characteristic points were detected based on empirically def ...
Pulmonary regurgitation in congenital heart disease
... left ventricular filling is diastolic bowing of the interventricular septum into the left ventricular cavity that is already compromised by right ventricular dilatation within the pericardial space. In Davlouros’ MRI study left and right ventricular ejection fraction were correlated (correlation co ...
... left ventricular filling is diastolic bowing of the interventricular septum into the left ventricular cavity that is already compromised by right ventricular dilatation within the pericardial space. In Davlouros’ MRI study left and right ventricular ejection fraction were correlated (correlation co ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.