Simultaneous assessment of cardiac metabolism and perfusion
... Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ...
... Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ...
Point mutations in murine Nkx2-5 phenocopy human
... highlighting the importance of this gene in adult life and long-term followup, especially given the aging cohort of patients carrying congenital heart disease (21). We have recently uncovered a NKX2-5 mutation in a family that showed septal malformations, left ventricular noncompaction, dilated card ...
... highlighting the importance of this gene in adult life and long-term followup, especially given the aging cohort of patients carrying congenital heart disease (21). We have recently uncovered a NKX2-5 mutation in a family that showed septal malformations, left ventricular noncompaction, dilated card ...
MOTETE_2013 - Durban University of Technology
... Echocardiography is important in the evaluation of patients suspected to have pericardial constriction (Little and Freeman, 2006). It usually demonstrates pericardial thickening. Restricted filling of both ventricles with a rapid deceleration of theearly diastolic mitral inflow velocity (E wave) and ...
... Echocardiography is important in the evaluation of patients suspected to have pericardial constriction (Little and Freeman, 2006). It usually demonstrates pericardial thickening. Restricted filling of both ventricles with a rapid deceleration of theearly diastolic mitral inflow velocity (E wave) and ...
The American Journal of Cardiology
... Shaun G. Goodman, Gordon FitzGerald, Jeanna Allegrone, and David Brieger, for the GRACE ...
... Shaun G. Goodman, Gordon FitzGerald, Jeanna Allegrone, and David Brieger, for the GRACE ...
Mathematical Modeling of Electrocardiograms: A Numerical Study
... (see e.g. Sect. 4.6 in Lines et al.,32 and Sundnes et al.51) have shown realistic 12-lead ECG simulations. The main ingredients of our mathematical ECG model are standard (see e.g. Lines et al.,32 Pullan et al.,44 Sundnes et al.51): bidomain equations and phenomenological cell model for the heart, a ...
... (see e.g. Sect. 4.6 in Lines et al.,32 and Sundnes et al.51) have shown realistic 12-lead ECG simulations. The main ingredients of our mathematical ECG model are standard (see e.g. Lines et al.,32 Pullan et al.,44 Sundnes et al.51): bidomain equations and phenomenological cell model for the heart, a ...
Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte
... cardiomyocytes. In left ventricular biopsies of heart failure (HF) patients, aortic stenosis (AS) patients, and controls (CON), we therefore related Fpassive of isolated cardiomyocytes to expression of titin isoforms and to phosphorylation of titin and titin isoforms. Biopsies were procured by trans ...
... cardiomyocytes. In left ventricular biopsies of heart failure (HF) patients, aortic stenosis (AS) patients, and controls (CON), we therefore related Fpassive of isolated cardiomyocytes to expression of titin isoforms and to phosphorylation of titin and titin isoforms. Biopsies were procured by trans ...
Ventricular structure, function, and mechanics at high altitude
... nerve activity, and pulmonary vasoconstriction (17, 30, 37), all of which have considerable impact on cardiac function and in time, could stimulate cardiac remodeling. Himalayan native Sherpa, who are of Tibetan lineage and have resided at HA for ⬃25,000 yr (2), are well adapted to life at HA, demon ...
... nerve activity, and pulmonary vasoconstriction (17, 30, 37), all of which have considerable impact on cardiac function and in time, could stimulate cardiac remodeling. Himalayan native Sherpa, who are of Tibetan lineage and have resided at HA for ⬃25,000 yr (2), are well adapted to life at HA, demon ...
Living anatomy of the atrioventricular junctions
... Figure 1 Schematic representation of the atrioventricular junctions in the left anterior oblique projection, showing the anatomically inaccurate nomenclature currently used for the locations of accessory pathways. The aortic valve is not shown. See Figs 2–4 for anatomical orientation and detail. Suc ...
... Figure 1 Schematic representation of the atrioventricular junctions in the left anterior oblique projection, showing the anatomically inaccurate nomenclature currently used for the locations of accessory pathways. The aortic valve is not shown. See Figs 2–4 for anatomical orientation and detail. Suc ...
36th Bethesda Conference - American College of Cardiology
... facilitate consideration of significant and timely issues regarding the practice of cardiovascular medicine and matters affecting patient care, research, and training for which absolute or hard data are incomplete. Appropriate organizations other than the American College of Cardiology Foundation (A ...
... facilitate consideration of significant and timely issues regarding the practice of cardiovascular medicine and matters affecting patient care, research, and training for which absolute or hard data are incomplete. Appropriate organizations other than the American College of Cardiology Foundation (A ...
View/Open
... than dobutamine, with a resultant increase in mechanical efficiency. Another study showed that Emax increased to the same extent with dobutamine, PDE III inhibitor and Ca sensitizing agent and that Ea was unchanged with dobutamine or Ca sensitizing agent, but decreased with PDE 1U inhibitor. Thus Ea ...
... than dobutamine, with a resultant increase in mechanical efficiency. Another study showed that Emax increased to the same extent with dobutamine, PDE III inhibitor and Ca sensitizing agent and that Ea was unchanged with dobutamine or Ca sensitizing agent, but decreased with PDE 1U inhibitor. Thus Ea ...
- Wiley Online Library
... NHLBI, NIH, Medtelligence, and SLACK Inc; and receiving unrestricted educational grants from AstraZeneca, AtCor Medical Inc, Daiichi Sankyo Inc, Eli Lilly, Pfizer Inc, SanofiAventis, and Schering-Plough. Drs. Winchester and Gong ...
... NHLBI, NIH, Medtelligence, and SLACK Inc; and receiving unrestricted educational grants from AstraZeneca, AtCor Medical Inc, Daiichi Sankyo Inc, Eli Lilly, Pfizer Inc, SanofiAventis, and Schering-Plough. Drs. Winchester and Gong ...
Document
... dramatically depolarizes (as seen between points B and C); that is, an action potential is produced. The downslope between points C and D represents repolarization. This cycle will repeat over and over for, let us hope, many, many years. ...
... dramatically depolarizes (as seen between points B and C); that is, an action potential is produced. The downslope between points C and D represents repolarization. This cycle will repeat over and over for, let us hope, many, many years. ...
Influence of Type 2 Diabetes and the Sex on the
... diseases [3], while diastolic dysfunction can be the first stage of diabetic cardiomyopathy, previously belonging to the systolic damages [4, 5], and the diastolic abnormalities at these can bring higher morbidity and mortality [1]. The subclinical left ventricular diastolic dysfunction is proven at ...
... diseases [3], while diastolic dysfunction can be the first stage of diabetic cardiomyopathy, previously belonging to the systolic damages [4, 5], and the diastolic abnormalities at these can bring higher morbidity and mortality [1]. The subclinical left ventricular diastolic dysfunction is proven at ...
Aortic Valve and Ascending Aorta Guidelines for Management and
... durability, with no difference in survival compared with other devices, but better than the untreated population. Clearly, there are few, if any, medical procedures that are as effective in relieving symptoms, improving quality of life, and also increasing long term survival as much as AVR for aorti ...
... durability, with no difference in survival compared with other devices, but better than the untreated population. Clearly, there are few, if any, medical procedures that are as effective in relieving symptoms, improving quality of life, and also increasing long term survival as much as AVR for aorti ...
Recommendations for the Evaluation of Left Ventricular Diastolic
... for the maximum time for LV filling. This theoretically optimal situation is approached by the cyclic interaction of myofilaments and assumes competent mitral and aortic valves. Diastole starts at aortic valve closure and includes LV pressure fall, rapid filling, diastasis (at slower heart rates), a ...
... for the maximum time for LV filling. This theoretically optimal situation is approached by the cyclic interaction of myofilaments and assumes competent mitral and aortic valves. Diastole starts at aortic valve closure and includes LV pressure fall, rapid filling, diastasis (at slower heart rates), a ...
TBX5 drives Scn5a expression to regulate cardiac conduction
... Cardiac conduction system (CCS) disease, which results in disrupted conduction and impaired cardiac rhythm, is common with significant morbidity and mortality. Current treatment options are limited, and rational efforts to develop cell-based and regenerative therapies require knowledge of the molecu ...
... Cardiac conduction system (CCS) disease, which results in disrupted conduction and impaired cardiac rhythm, is common with significant morbidity and mortality. Current treatment options are limited, and rational efforts to develop cell-based and regenerative therapies require knowledge of the molecu ...
Caffeine and Cardiac Arrhythmias: A Review of the Evidence
... periods of the right atrium, AV node, and right ventricle. Paradoxically, the effective refractory period of the left atrium increased with caffeine. Of note, there was an increase in sustained atrial arrhythmias in response to programmed atrial extrastimuli after ingestion of caffeine, an effect th ...
... periods of the right atrium, AV node, and right ventricle. Paradoxically, the effective refractory period of the left atrium increased with caffeine. Of note, there was an increase in sustained atrial arrhythmias in response to programmed atrial extrastimuli after ingestion of caffeine, an effect th ...
"MRS Studies of Creatine Kinase Metabolism in Human Heart" in
... healthy controls has doubled to over 110 studies of more than 1600 volunteers. The NMR field strength (B0 ) for human cardiac studies has been extended from 1.5 to 7 T (Figure 2).26–28 Protocols for quantifying absolute concentrations of the CK substrates, [PCr] and [ATP],29 the CK rate constant k1 ...
... healthy controls has doubled to over 110 studies of more than 1600 volunteers. The NMR field strength (B0 ) for human cardiac studies has been extended from 1.5 to 7 T (Figure 2).26–28 Protocols for quantifying absolute concentrations of the CK substrates, [PCr] and [ATP],29 the CK rate constant k1 ...
open the file... - Univera Healthcare
... in recurrent ischemic stroke for the PFO group and a 62% risk reduction [HR 0.38 (95% CI: 0.18, 0.79) Log-rank 2sided P-value: 0.007] from recurrent ischemic stroke of unkown mechanism. An additional sensitivity analysis of allcause stroke in patients under age 60 showed a 58% relative risk reductio ...
... in recurrent ischemic stroke for the PFO group and a 62% risk reduction [HR 0.38 (95% CI: 0.18, 0.79) Log-rank 2sided P-value: 0.007] from recurrent ischemic stroke of unkown mechanism. An additional sensitivity analysis of allcause stroke in patients under age 60 showed a 58% relative risk reductio ...
Transcatheter Closure Devices for Cardiac Defects
... in recurrent ischemic stroke for the PFO group and a 62% risk reduction [HR 0.38 (95% CI: 0.18, 0.79) Log-rank 2sided P-value: 0.007] from recurrent ischemic stroke of unkown mechanism. An additional sensitivity analysis of allcause stroke in patients under age 60 showed a 58% relative risk reductio ...
... in recurrent ischemic stroke for the PFO group and a 62% risk reduction [HR 0.38 (95% CI: 0.18, 0.79) Log-rank 2sided P-value: 0.007] from recurrent ischemic stroke of unkown mechanism. An additional sensitivity analysis of allcause stroke in patients under age 60 showed a 58% relative risk reductio ...
Management of acute myocardial infarction in patients presenting
... be focused on the detection of other cardiac or non-cardiac causes of the presenting symptoms. A working diagnosis of myocardial infarction must first be made. This is usually based on the history of severe chest pain lasting for 20 min or more, not responding to nitroglycerine. Important clues are ...
... be focused on the detection of other cardiac or non-cardiac causes of the presenting symptoms. A working diagnosis of myocardial infarction must first be made. This is usually based on the history of severe chest pain lasting for 20 min or more, not responding to nitroglycerine. Important clues are ...
CV - Division of Cardiology
... Physical Diagnostic Course Participant: Regular contributor to this annual effort since 1999. (6 sessions x medical students, annually) Physician Shadowing: Hosted countless premed and accelerated track WSU (MEDSTART) medical students as part of shadowing experience to expose trainees to the daily r ...
... Physical Diagnostic Course Participant: Regular contributor to this annual effort since 1999. (6 sessions x medical students, annually) Physician Shadowing: Hosted countless premed and accelerated track WSU (MEDSTART) medical students as part of shadowing experience to expose trainees to the daily r ...
Perioperative Assessment of Diastolic Dysfunction
... of patients presenting for cardiac and high-risk noncardiac surgery, and has been shown to be an independent predictor of adverse postoperative outcome. Normalcy of systolic function in 50% of patients with congestive heart failure implicates diastolic dysfunction as the probable etiology. Comprehen ...
... of patients presenting for cardiac and high-risk noncardiac surgery, and has been shown to be an independent predictor of adverse postoperative outcome. Normalcy of systolic function in 50% of patients with congestive heart failure implicates diastolic dysfunction as the probable etiology. Comprehen ...
American College of Cardiology - Hypertrophic Cardiomyopathy
... factors. Therefore, treatment strategies have necessarily evolved based on available data that have frequently been observational in design, sometimes obtained in relatively small patient groups, or derived from the accumulated clinical experience of individual investigators, and reasonable inferenc ...
... factors. Therefore, treatment strategies have necessarily evolved based on available data that have frequently been observational in design, sometimes obtained in relatively small patient groups, or derived from the accumulated clinical experience of individual investigators, and reasonable inferenc ...
2003 The European Society of Cardiology
... be focused on the detection of other cardiac or non-cardiac causes of the presenting symptoms. A working diagnosis of myocardial infarction must first be made. This is usually based on the history of severe chest pain lasting for 20 min or more, not responding to nitroglycerine. Important clues are ...
... be focused on the detection of other cardiac or non-cardiac causes of the presenting symptoms. A working diagnosis of myocardial infarction must first be made. This is usually based on the history of severe chest pain lasting for 20 min or more, not responding to nitroglycerine. Important clues are ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.