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NCD Watch August 2016
NCD Watch August 2016

... Ethnicity — Atrial fibrillation is more common in Whites than in other racial groups, such as Blacks and Asians.11, 15 For example, a U.S. study found that Whites had 32% increased risk of atrial fibrillation at age 50 compared with non-Whites.15 Cardiovascular diseases, such as hypertension, corona ...
Role of catheter-induced mechanical trauma in localization of target
Role of catheter-induced mechanical trauma in localization of target

... recorded by the distal pair of the exploring catheter electrodes, and the beginning of the P wave on the surface electrocardiogram (AP interval) during atrial tachycardia. The site characterized by the longest AP interval, with an AP interval ->30 ms, was considered as the ideal atrial ablation site ...
CHAPTER 28 Three-Dimensional Echocardiographic Guidance of
CHAPTER 28 Three-Dimensional Echocardiographic Guidance of

... scopy and 2D echocardiography (such as 2D TEE and ICE) have been used for many years to guide transseptal puncture with a good safety record,10 real time 3D TEE provides distinct advantages that may enhance both the safety of the puncture procedure and the success of the subsequent percutaneous inte ...
12-lead Electrocardiogram in Acute Coronary Syndrome
12-lead Electrocardiogram in Acute Coronary Syndrome

... 5.1.1 Biochemical changes during myocardial ischemia ...................................................................................................... 37 5.1.2 ST-segment depression in subendocardial ischemia ...................................................................................... ...
PI - BDI Pharma
PI - BDI Pharma

... Cardiotoxicity is a known risk of anthracycline treatment. Anthracycline-induced cardiotoxicity may be manifested by early (or acute) or late (delayed) events. Early cardiotoxicity of doxorubicin consists mainly of sinus tachycardia and/or electrocardiogram (ECG) abnormalities such as non-specific S ...
When Calcium Turns Arrhythmogenic: Intracellular Calcium
When Calcium Turns Arrhythmogenic: Intracellular Calcium

... Linking Intracellular Ca2+ Handling to Ventricular Tachyarrhythmias in Hypertrophy and Heart Failure While resting intracellular Ca2+ remains normal in non-failing hypertrophied myocardium (7,14,18), alterations in Ca2+ handling are unlikely to cause arrhythmias directly, unless Ca2+ handling is fur ...
MATERNAL CARDIOVASCULAR ADAPTATIONS IN RODENT MODELS OF PREGNANCY COMPLICATIONS
MATERNAL CARDIOVASCULAR ADAPTATIONS IN RODENT MODELS OF PREGNANCY COMPLICATIONS

... cardioprotective role of PGF during pregnancy. This altered maternal phenotype did not affect fetal blood flow but resulted in decreased fetal weights. Although congenital heart defects are the most common birth anomaly, their impact on postnatal adaptation to pregnancy is unknown. To investigate th ...
2014 ACC/AHA Guideline on Perioperative
2014 ACC/AHA Guideline on Perioperative

... weighing the strength and quality of evidence for or against particular tests, treatments, or procedures; and estimating expected health outcomes when data exist. In analyzing the data and developing CPGs, the GWC uses evidence-based methodologies developed by the Task Force (6). A key component of ...
Frequently Asked Questions About AEDs
Frequently Asked Questions About AEDs

... a sudden cardiac arrest? Lay rescuers are most often asked to call 911 and get the AED. The lay rescuer can assemble the pocket facemask and begin providing mouth-to-mask ventilations. Responders might provide CPR or continue defibrillation if a workplace defibrillator is used. Support and direction ...
Emergency echocardiography: the European Association of
Emergency echocardiography: the European Association of

... performance and interpretation of emergency echocardiography Performing an echocardiographic examination in a patient with suspected or known cardiovascular disease presenting as an emergency case may be challenging. Key decisions should be made quickly, in a stressful situation, characterized often ...
2017 ACC/AHA/HRS Guideline for the Evaluation and
2017 ACC/AHA/HRS Guideline for the Evaluation and

... Practice guidelines provide recommendations applicable to patients with or at risk of developing cardiovascular disease. The focus is on medical practice in the United States, but guidelines developed in collaboration with other organizations may have a global impact. Although guidelines may be used ...
ACC/AHA/ACP-ASIM Guidelines for the Management
ACC/AHA/ACP-ASIM Guidelines for the Management

... a major public health problem. Chronic stable angina is the initial manifestation of ischemic heart disease in approximately one half of patients (3,4). It is difficult to estimate the number of patients with chronic chest pain syndromes in the U.S. who fall within these guidelines, but clearly it i ...
ESC Guidelines on Diabetes, Pre-diabetes and Cardiovascular
ESC Guidelines on Diabetes, Pre-diabetes and Cardiovascular

Scintigraphic imaging of neuroadrenergic
Scintigraphic imaging of neuroadrenergic

... [1,2] as well as for assessing the functional status of the sympathetic nerve endings in the human heart and lungs [3, 4]. While there have been several publications dealing with the clinical applications of this tracer, less is known about the mechanisms underlying its uptake by noradrenergic nerve ...
Left Ventricular Papillary Muscles
Left Ventricular Papillary Muscles

... from each other in the same heart, considerable morphologic variation is observed in comparing either or both muscles from one heart with those of another. The A-L papillary muscle usually (75%) consists of a single major muscle group, whereas the P-M papillary muscle often (65%) consists of two or ...
Pulmonary Hypertension
Pulmonary Hypertension

... and signs of right heart failure, usually in the setting of marked hypoxemia. Pulmonary function tests and chest computed tomographic imaging are helpful in making a diagnosis in these patients. At cardiac catheterization, the level of the pulmonary hypertension typically is relatively mild. Indeed, ...
Emergency echocardiography - European Society of Cardiology
Emergency echocardiography - European Society of Cardiology

... performance and interpretation of emergency echocardiography Performing an echocardiographic examination in a patient with suspected or known cardiovascular disease presenting as an emergency case may be challenging. Key decisions should be made quickly, in a stressful situation, characterized often ...
Better Lesion Creation And Assessment During Catheter
Better Lesion Creation And Assessment During Catheter

... blood compared to myocardium and greater interface area between the electrode and blood. However, impedance varies at different sites in the heart, and the baseline impedance does not appear to be a reliable indicator of RF ablation lesion creation.48, 49 With RF application, tissue heating results ...
Success of Surgical Left Atrial Appendage Closure
Success of Surgical Left Atrial Appendage Closure

... persistent communication with the left atrium as demonstrated by persistent flow into the appendage. Currently, there are devices designed to percutaneously occlude the LAA: the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) device (Appriva Medical Inc., Sunnyvale, California) ( ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... primum ASD and subaortic VSD with normal biventricular function. Abdominal ultrasound confirmed transposition of abdominal viscera. Both babies were on breast feeding and kept on follow up, especially the second twin for any sign of congestive heart failure. ...
Venice Chart International Consensus Document on Ventricular
Venice Chart International Consensus Document on Ventricular

... causes of morbidity and sudden death (SD), especially in patients with structural heart disease. Therapeutic options for the treatment of these arrhythmias include antiarrhythmic drugs, implantable cardioverter-defibrillators (ICDs), and surgical and catheter ablation. Antiarrhythmic drugs have disa ...
File
File

... The American College of Cardiology (ACC) and the American Heart Association (AHA) are committed to the prevention and management of cardiovascular diseases through professional education and research for clinicians, providers, and patients. Since 1980, the ACC and AHA have shared a responsibility to ...
Atrial Fibrillation in Children
Atrial Fibrillation in Children

... however, one of the few areas under investigation that would give us a potential leap forward in both detecting and understanding fetal arrhythmias. Many different treatments have been attempted and recommended for fetal atrial flutter and fibrillation, and this condition may be the most accurate re ...
Analysis of intrinsic cardiac neuron activity in relation to
Analysis of intrinsic cardiac neuron activity in relation to

... Atrial fibrillation is the most frequent sustained rhythm disorder in humans and often leads to severe complications such as heart failure and stroke. A neurogenic mechanism of atrial fibrillation has been hypothesized. Tachyarrhythmia induction by mediastinal nerve stimulation has been proposed as ...
In 1869 Meyer (I) first observed differences
In 1869 Meyer (I) first observed differences

... while the left nerve was without effect on the rhythm in two cases. H e concluded that the right vagus controls the rate better than the left, though in some cases the reverse is true. T h e left nerve sometimes had no effect on the heart, or an effect only on its force. H e added, an observation u ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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