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Increased Connective Tissue Growth Factor Relative
Increased Connective Tissue Growth Factor Relative

... Key Words: extracellular matrix 䡲 hypertrophy 䡲 cardiac function 䡲 connective tissue growth factor 䡲 natriuretic peptide ...
ACC/AHA 2006 Guidelines for the Management of Patients with
ACC/AHA 2006 Guidelines for the Management of Patients with

... of Cardiology Foundation, Resource Center, at 9111 Old Georgetown Road, Bethesda, MD 20814-1699. To purchase additional reprints: up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 410-528-4121, fax 410-528-4264, or e-mail [email protected]. Per ...
ACC/AHA 2006 Guidelines for the Management of Patients
ACC/AHA 2006 Guidelines for the Management of Patients

... This document was approved by the American College of Cardiology Foundation Board of Trustees in May 2006 and by the American Heart Association Science Advisory and Coordinating Committee in May 2006. When this document is cited, the American Heart Association requests that the following citation fo ...
Atrial Electric Signal During Sinus Rhythm in Lone
Atrial Electric Signal During Sinus Rhythm in Lone

... left ventricle, left ventricular magnetocardiogram, magnetocardiography, magnetocardiographic premature atrial complex duration of filtered P wave pulmonary vein right atrium, right atrial root mean square; root mean square amplitude signal average electrocardiogram standard deviation sinus rhythm W ...
ACC/AHA 2006 Guidelines for the Management of Patients With
ACC/AHA 2006 Guidelines for the Management of Patients With

... Robert O. Bonow, MD, FACC, FAHA, Chair Bruce Whitney Lytle, MD, FACC Blase A. Carabello, MD, FACC, FAHA Rick A. Nishimura, MD, FACC, FAHA Kanu Chatterjee, MB, FACC Patrick T. O’Gara, MD, FACC, FAHA Antonio C. de Leon, JR, MD, FACC, FAHA David P. Faxon, MD, FACC, FAHA Robert A. O’Rourke, MD, MACC, FA ...
THESIS BIOMECHANICS OF TRANS APICAL MITRAL VALVE
THESIS BIOMECHANICS OF TRANS APICAL MITRAL VALVE

... BIOMECHANICS OF TRANS APICAL MITRAL VALVE IMPLANTATION ...


... Rick A. Nishimura, MD, FACC, FAHA Patrick T. O’Gara, MD, FACC, FAHA Robert A. O’Rourke, MD, MACC, FAHA Catherine M. Otto, MD, FACC, FAHA Pravin M. Shah, MD, MACC, FAHA Jack S. Shanewise, MD* *Society of Cardiovascular Anesthesiologists Representative ...
2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for... Management of Patients With Valvular Heart Disease: A Report of...
2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for... Management of Patients With Valvular Heart Disease: A Report of...

... in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Fu ...
O`Rourke, Catherine M. Otto, Pravin M. Shah and
O`Rourke, Catherine M. Otto, Pravin M. Shah and

... 3.6.6. Evaluation of Patients After Mitral Valve Replacement or Repair. . . . . . . . . . . . . . . . . . . . .e584 3.6.7. Special Considerations in the Elderly . . . . .e584 3.7. Multiple Valve Disease . . . . . . . . . . . . . . . . . . . . . . . . .e584 3.7.1. Introduction . . . . . . . . . . . . ...
Guidelines ESC EACTS 2014 Guidelines on myocardial
Guidelines ESC EACTS 2014 Guidelines on myocardial

... Councils: Council for Cardiology Practice, Council on Cardiovascular Primary Care, Council on Cardiovascular Nursing and Allied Professions. Disclaimer 2014: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and th ...
2014 ESC/EACTS Guidelines on myocardial revascularization
2014 ESC/EACTS Guidelines on myocardial revascularization

... Councils: Council for Cardiology Practice, Council on Cardiovascular Primary Care, Council on Cardiovascular Nursing and Allied Professions. Disclaimer 2014: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and th ...
2014 ESC/EACTS Guidelines on myocardial revascularization
2014 ESC/EACTS Guidelines on myocardial revascularization

2014 ESC/EACTS Guidelines on myocardial
2014 ESC/EACTS Guidelines on myocardial

... Councils: Council for Cardiology Practice, Council on Cardiovascular Primary Care, Council on Cardiovascular Nursing and Allied Professions. Disclaimer 2014: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and th ...
PDF Article
PDF Article

... The interstitium of the myocardium includes fibrillar connective tissue; various cells, such as fibroblasts and plasma cells, and a gel-like ground substance composed of glycosaminoglycans and glycoproteins. Cardiac nerves and the coronary vasculature also reside in the interstitium. Myocytes repres ...
The Wavelength of the Cardiac Impulse and Reentrant Arrhythmias
The Wavelength of the Cardiac Impulse and Reentrant Arrhythmias

... diastolic threshold) through two platinum plates ( 2 x 4 mm) embracing one end of the preparation. The distance between the two stimulating electrodes was such that the preparation could move freely between the two plates. Field stimulation was preferred above point stimulation because, in this way, ...
Get PDF - Wiley Online Library
Get PDF - Wiley Online Library

... The volume fractions of dispersed hydrogel and infarcted tissue within the hydrogel-treated region were obtained from morphometric analysis of histological micrographs from a previous study [32]. All institutional and national guidelines for the care and use of laboratory animals were followed for t ...
Sinus of Valsalva Aneurysm with Rupturing into the Right Atrium ¾ A
Sinus of Valsalva Aneurysm with Rupturing into the Right Atrium ¾ A

... sinus, usually over many years. Therefore, sinus of Valsalva aneurysm can remain subclinical for several years until it eventually ruptures between the 3rd and 4th decades of life. The commonest sites of aneurysm ruptures are cardiac chambers, interventricular septum,8 or pericardial space.9 Dilated ...
Modelling of the ventricular conduction system
Modelling of the ventricular conduction system

... Nowadays an important area in the study of cardiac arrhythmias is anatomically accurate modelling. The majority of current anatomical models have not included a description of the Purkinje network. As a consequence, these models cannot be used to study the important role of the Purkinje system in ar ...
receptor activation increases contractility in isolated perfused hearts
receptor activation increases contractility in isolated perfused hearts

Document
Document

... myocardial infarction • dilatation aneurysmal dissection ...
Coexpression of Cardiac titins
Coexpression of Cardiac titins

... the A band in N2B than N2BA titin (see Fig. 1 and DISCUSSION). Immunoelectron micrographs of cardiac sarcomeres from a range of species labeled with N2BC are shown in Fig. 2B. At a given SL, sarcomeres from myocardium that expresses predominately N2B titin contain a single epitope toward the A band ...
Management of Children with Cardiac Devices
Management of Children with Cardiac Devices

... for the placement of electrodes within the heart and can provide clinical advantages especially in pediatric population. • Approved by the Food & Drug Administration (FDA) in 2012 • Gained Category 1 CPT Codes in January 2015 • Shown to be highly effective. • We describe the initial experience of S- ...
Translational models of coronary artery disease, myocardial
Translational models of coronary artery disease, myocardial

... prolonged period of myocardial ischaemia leads to myocardial necrosis. Necrotic myocardium is replaced with scar tissue. Myocardial infarction results in various changes in cardiac structure and function over time that results in “adverse remodelling”. This remodelling may result in a progressive wo ...
On the innervation of the heart, with special reference to the heart of
On the innervation of the heart, with special reference to the heart of

... brings out certain differences between the frog and the tortoise. In the first place, the ventricle of the tortoise when isolated beats automatically with as great a certainty as the isolated auricle. The extra assistance in the shape of some constant chemical, mechanical or electrical stimulus whic ...
The spectrum and distribution of imaging findings at coronary
The spectrum and distribution of imaging findings at coronary

... had hypertension. Overall there were more patients with abnormal scans at 76% than the normal. Atherosclerotic coronary plaque lesions were the most commonly encountered abnormality accounting for 93.1%. The predominant plaque type was the non-calcified plaque seen in 50% of males and 61.5% of femal ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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