Na,K-ATPase in the Myocardium: Molecular Principles, Functional
... particularly about its possible presence in the heart still has to be elucidated. It may be concluded that when fulfilling its physiological role, Na,K-ATPase has to respond actively to numerous modulatory and regulatory signals of diverse origin, and some may only be transmitted via the β subunit of ...
... particularly about its possible presence in the heart still has to be elucidated. It may be concluded that when fulfilling its physiological role, Na,K-ATPase has to respond actively to numerous modulatory and regulatory signals of diverse origin, and some may only be transmitted via the β subunit of ...
Coexistence of Sick Sinus Rhythm and Atrial Flutter
... and positioned in the right atrium. Three standard ECG leads and intra-atrial electrograms, filtered at frequency settings of 40-500 Hz and time lines generated at 40, 200 and 1000 msec, were displayed on a multichannel oscilloscope (Electronics for Medicine VR 12) and recorded on a tape recorder (H ...
... and positioned in the right atrium. Three standard ECG leads and intra-atrial electrograms, filtered at frequency settings of 40-500 Hz and time lines generated at 40, 200 and 1000 msec, were displayed on a multichannel oscilloscope (Electronics for Medicine VR 12) and recorded on a tape recorder (H ...
M elatonin: a novel protective agent against oxidative injury of the
... reopening of the coronary artery, it highly significantly reduced both the PVC and VF. The arrhythmias in this study were defined in accordance with the guidelines of the Lamberth Conventions. The concentration of melatonin in the perfusate was either 1, 10 or 50 mM. Anticipating that melatonin’s ef ...
... reopening of the coronary artery, it highly significantly reduced both the PVC and VF. The arrhythmias in this study were defined in accordance with the guidelines of the Lamberth Conventions. The concentration of melatonin in the perfusate was either 1, 10 or 50 mM. Anticipating that melatonin’s ef ...
quantification of left ventricular myocardial collagen system in
... the wall of the left ventricle. Another possible mechanism for collagen accumulation with age could be an inhibition of collagen degradation25. In the present study, we have shown that there is an increase in collagen type I and a decrease in collagen type III with age. As mentioned above, it is pos ...
... the wall of the left ventricle. Another possible mechanism for collagen accumulation with age could be an inhibition of collagen degradation25. In the present study, we have shown that there is an increase in collagen type I and a decrease in collagen type III with age. As mentioned above, it is pos ...
Development of Heart Failure and Congenital Septal
... examined by light microscopy. To quantify the incidence of septal defects, neonatal hearts (36 eNOS⫺/⫺, 34 eNOS⫹/⫺ , and 41 eNOS⫹/⫹) were fixed in 10% buffered formalin, and a standard procedure for microdissection of the heart was applied according to methods described previously.18,19 Briefly, the ...
... examined by light microscopy. To quantify the incidence of septal defects, neonatal hearts (36 eNOS⫺/⫺, 34 eNOS⫹/⫺ , and 41 eNOS⫹/⫹) were fixed in 10% buffered formalin, and a standard procedure for microdissection of the heart was applied according to methods described previously.18,19 Briefly, the ...
Fulltext - Jultika
... oscillations of the heart rate (HR) calculated from the electrocardiogram (ECG). These oscillations are termed as heart rate variability (HRV). HRV is a physiological phenomenon driven mainly by the balance of the two branches of the autonomic nervous system, sympathetic and parasympathetic. Measure ...
... oscillations of the heart rate (HR) calculated from the electrocardiogram (ECG). These oscillations are termed as heart rate variability (HRV). HRV is a physiological phenomenon driven mainly by the balance of the two branches of the autonomic nervous system, sympathetic and parasympathetic. Measure ...
Endocardial mapping of atrial fibrillation in the human right atrium
... present in the right atrium for >50% of the time. (2) Type II atrial fibrillation—two independent wave fronts present in the right atrium for >50% of the time. (3) Type III atrial fibrillation—three or more wave fronts present in the right atrium for >50% of the time. Our definitions differed from th ...
... present in the right atrium for >50% of the time. (2) Type II atrial fibrillation—two independent wave fronts present in the right atrium for >50% of the time. (3) Type III atrial fibrillation—three or more wave fronts present in the right atrium for >50% of the time. Our definitions differed from th ...
A STUDY OF THE PATHOLOGY AND PATHOGENSIS OF MYOCARDIAL
... cases. In two sheep cardiac dilatation was associated with subendocardial pallor (fibrosis) and transmural myocardial mottling. Myofibre hypertrophy was recorded in all the sheep, myofibre necrosis and replacement fibrosis occurred in seven animals the latter being particularly evident in animals w ...
... cases. In two sheep cardiac dilatation was associated with subendocardial pallor (fibrosis) and transmural myocardial mottling. Myofibre hypertrophy was recorded in all the sheep, myofibre necrosis and replacement fibrosis occurred in seven animals the latter being particularly evident in animals w ...
2011 ACCF/AHA/HRS Focused Updates Incorporated Into the
... Alice K. Jacobs, MD, FACC, FAHA, Chair; Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect; Nancy Albert, PhD, CCNS, CCRN; Christopher E. Buller, MD, FACC#; Mark A. Creager, MD, FACC, FAHA; Steven M. Ettinger, MD, FACC; Robert A. Guyton, MD, FACC; Jonathan L. Halperin, MD, FACC, FAHA; Judith S. Hochma ...
... Alice K. Jacobs, MD, FACC, FAHA, Chair; Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect; Nancy Albert, PhD, CCNS, CCRN; Christopher E. Buller, MD, FACC#; Mark A. Creager, MD, FACC, FAHA; Steven M. Ettinger, MD, FACC; Robert A. Guyton, MD, FACC; Jonathan L. Halperin, MD, FACC, FAHA; Judith S. Hochma ...
TNF- and myocardial depression in endotoxemic rats
... through the right atrium, and serum was prepared by centrifugation and stored at 270°C. Hearts were excised, and coronary blood vessels were flushed with 10 ml of phosphatebuffered saline (pH 7.4, 4°C) by retrograde perfusion through the aortic root. After removal of the major vessels and atria, ven ...
... through the right atrium, and serum was prepared by centrifugation and stored at 270°C. Hearts were excised, and coronary blood vessels were flushed with 10 ml of phosphatebuffered saline (pH 7.4, 4°C) by retrograde perfusion through the aortic root. After removal of the major vessels and atria, ven ...
ACC - A Fib (Complete)
... ([email protected]), Journals Division, Oxford University Press, Great Clarendon Street, Oxford, OX2 6DP, UK. Phone ⫹44 (0) 1865 353827, Fax ⫹44 (0) 1865 353774, Work Mobile ⫹44 07841322925. Single copies of the executive summary and the full-text guidelines are also available by calli ...
... ([email protected]), Journals Division, Oxford University Press, Great Clarendon Street, Oxford, OX2 6DP, UK. Phone ⫹44 (0) 1865 353827, Fax ⫹44 (0) 1865 353774, Work Mobile ⫹44 07841322925. Single copies of the executive summary and the full-text guidelines are also available by calli ...
Professor Denis Noble CBE FRS FMedSci FRCP (Hon)
... Korean – good knowledge of written Korean (Hangul) and some knowledge of Chinese script (Hancha). Sufficient knowledge of spoken Korean to give a speech or introduction to a lecture. Denis Noble was a UK Government Advisor on Korea. Chinese – some reading knowledge (through Japanese and Korean chara ...
... Korean – good knowledge of written Korean (Hangul) and some knowledge of Chinese script (Hancha). Sufficient knowledge of spoken Korean to give a speech or introduction to a lecture. Denis Noble was a UK Government Advisor on Korea. Chinese – some reading knowledge (through Japanese and Korean chara ...
CARACTERIZACIÓN CLÍNICA Y ELECTROFISIOLÓGICA DE LAS ALTERACIONES RECÍPROCAS DEL ELECTROCARDIOGRAMA EN
... induces electric and metabolic changes in myocardial cells caused by the interruption of coronary blood flow. These changes are recorded in the conventional ECG as ST segment elevation in leads directly related to the ischemic region, and they allow to predict the location of the coronary artery occ ...
... induces electric and metabolic changes in myocardial cells caused by the interruption of coronary blood flow. These changes are recorded in the conventional ECG as ST segment elevation in leads directly related to the ischemic region, and they allow to predict the location of the coronary artery occ ...
Anatomy of the Atrioventricular Conduction System in
... the ostium of the coronary sinus. It measured 4 mm. in diameter. The more anterior defect was located under the area of the commissure between the anterior and septal leaflets of the tricuspid valve and between the tricuspid ring and the crista supraventrieularis. It measured 5 mm. in diameter. The ...
... the ostium of the coronary sinus. It measured 4 mm. in diameter. The more anterior defect was located under the area of the commissure between the anterior and septal leaflets of the tricuspid valve and between the tricuspid ring and the crista supraventrieularis. It measured 5 mm. in diameter. The ...
Conus Artery in Coronary CT Angiography
... the conus artery exists. Sankari et al. (8) examined 30 cadaveric hearts and 20 angiograms and showed that the most frequent occurrence was a single ostium from the right sinus of Valsalva/RCA (23.30%; 76.7%) and the double ostium, which indicated the RCA and the conus artery (5.30% ; 16.7%). In our ...
... the conus artery exists. Sankari et al. (8) examined 30 cadaveric hearts and 20 angiograms and showed that the most frequent occurrence was a single ostium from the right sinus of Valsalva/RCA (23.30%; 76.7%) and the double ostium, which indicated the RCA and the conus artery (5.30% ; 16.7%). In our ...
ACC/AHA/ESC Practice Guidelines
... unchanged recommendations has not been updated. It is important that the medical profession play a significant role in critically evaluating the use of diagnostic procedures and therapies as they are introduced and tested in the detection, management, or prevention of disease states. Rigorous and ex ...
... unchanged recommendations has not been updated. It is important that the medical profession play a significant role in critically evaluating the use of diagnostic procedures and therapies as they are introduced and tested in the detection, management, or prevention of disease states. Rigorous and ex ...
ACC/AHA/ESC 2006 guidelines for the management
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
ACC/AHA/ESC guidelines for the management of patients with atrial
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
Characterization of Atrial Repolarization Alternans and
... is a clear illustration of this fact. In the study that triggered it, elaborate experiments on an animal model yielded large amounts of data perturbed by unavoidable interferences, and the phenomenon of interest had an elusive nature. This thesis describes the physiological motivation for this study ...
... is a clear illustration of this fact. In the study that triggered it, elaborate experiments on an animal model yielded large amounts of data perturbed by unavoidable interferences, and the phenomenon of interest had an elusive nature. This thesis describes the physiological motivation for this study ...
ACC/AHA/ESC Practice Guidelines
... Preamble . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e260 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.1. Organization of Committee and Evidence Review. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.2. ...
... Preamble . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e260 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.1. Organization of Committee and Evidence Review. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.2. ...
Roberts-AM-2015-PhD-Thesis (3) - Spiral
... usage than those in controls (P=2.5x10-4) and these are estimated to have >93% probability of pathogenicity (likelihood ratio 14). Compared to TTNtv-ve DCM, TTNtv+ve patients had lower LVEF (P=0.02), thinner LV walls (P=0.02), and a higher incidence of sustained ventricular tachycardia (P=0.001). C- ...
... usage than those in controls (P=2.5x10-4) and these are estimated to have >93% probability of pathogenicity (likelihood ratio 14). Compared to TTNtv-ve DCM, TTNtv+ve patients had lower LVEF (P=0.02), thinner LV walls (P=0.02), and a higher incidence of sustained ventricular tachycardia (P=0.001). C- ...
ACC/AHA/ESC Practice Guidelines
... Preamble . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e260 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.1. Organization of Committee and Evidence Review. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.2. ...
... Preamble . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e260 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.1. Organization of Committee and Evidence Review. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e261 1.2. ...
ACC/AHA/ESC Practice Guidelines
... Special Sales ([email protected]), Journals Division, Oxford University Press, Great Clarendon Street, Oxford, OX2 6DP, UK. Phone ⫹44 (0) 1865 353827, Fax ⫹44 (0) 1865 353774, Work Mobile ⫹44 07841322925. Single copies of the executive summary and the full-text guidelines are also ava ...
... Special Sales ([email protected]), Journals Division, Oxford University Press, Great Clarendon Street, Oxford, OX2 6DP, UK. Phone ⫹44 (0) 1865 353827, Fax ⫹44 (0) 1865 353774, Work Mobile ⫹44 07841322925. Single copies of the executive summary and the full-text guidelines are also ava ...
Electrophysiology Products
... * EU Indication for Use: The Boston Scientific Cardiac Ablation System is indicated for interruption of accessory atrioventricular conduction pathways associated with tachycardia, for treatment of AV nodal reentrant tachycardia and for creation of complete AV block in patients with a rapid ventricul ...
... * EU Indication for Use: The Boston Scientific Cardiac Ablation System is indicated for interruption of accessory atrioventricular conduction pathways associated with tachycardia, for treatment of AV nodal reentrant tachycardia and for creation of complete AV block in patients with a rapid ventricul ...
Cardiac contractility modulation
Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.