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Tilburg University Improvement in diastolic function and left
Tilburg University Improvement in diastolic function and left

... performed before and 3 and 12 months after CRT. Tissue Doppler early diastolic annular (Em) and color M-mode–derived flow propagation (Vp) velocities were used to estimate LV filling pressures by E/Em and E/Vp ratios. Results After 12 months, LV reverse remodeling (end-systolic volume decrease N15%) ...
Epinephrine infusion in the evaluation of unexplained cardiac arrest
Epinephrine infusion in the evaluation of unexplained cardiac arrest

... presumed arrhythmic; and (4) syncope with documented polymorphic ventricular tachycardia (PMVT). Investigators and coordinators performed a consultation/assessment to determine whether reversible causes, including drug overdose or a proarrhythmic effect, were present or reviewed the medical record w ...
Syncope and The Older Patient
Syncope and The Older Patient

... Association with young and healthy men from southeast asia who present with sudden cardiac death Brugada sign may be asymptomatic High risk of sudden cardiac death in those who have syncope or family history of sudden death (Indication for AICD based upon observational data) ...
Paroxysmal stress-induced atrial tachycardia as an unusual cause
Paroxysmal stress-induced atrial tachycardia as an unusual cause

... right phrenic nerve (6), an 1 minute RF application was made (55oC, 50W), stopping the tachycardia. However, repeated burst pacing after another 4 mg intravenous bolus of isoprenaline re-induced AT but with a larger CL (375 ms). Re-mapping identified earliest atrial depolarization 1 mm inferior to t ...
Developmental anatomy of the heart
Developmental anatomy of the heart

... in the human and mouse are very similar (Fig. 1). Thus in both species the heart has four chambers; two atria, separated by an interatrial septum (IAS), and two ventricles, separated by an interventricular septum (IVS). In addition, located between the IAS and IVS there is a small “septal segment,” ...
Coronary artery-left ventricular microfistulae associated with apical
Coronary artery-left ventricular microfistulae associated with apical

... There were deep inverted T waves and ST segment depression at anterior precordial derivations. Coronary angiography revealed widespread coronary artery to left ventricular microfistulae arising from distal portions of both left and right coronary systems. Left ventriculography and transthoracic echo ...
Seven and one-half years` experience with the Medtronic
Seven and one-half years` experience with the Medtronic

... Aortography and autopsy evidence indicated that the flow through the minor orifice behind the disc in the existing valves was not satisfactory, and it was in this location and where the disc touches the valve ring in the open position that thrombosis was likely to occur. Our goal was therefore to de ...
Branches of Right Coronary Artery
Branches of Right Coronary Artery

...  Larger then Right coronary artery.  Arises from posterior aortic sinus of the Ascending Aorta.  Passes between pulmonary trunk and left auricle.  It enters in the atrioventricular groove and divides into an anterior interventricular branch and a circumflex branch.  Supply greater part of the l ...
Complex inheritance for susceptibility to sudden cardiac death
Complex inheritance for susceptibility to sudden cardiac death

... utes of occlusion also occurs in human, but it is considered likely to be with a retarded time course. It has been proposed that during phase 1a, two different mechanisms are involved in development of arrhythmias. A reentrant excitation causes VF and VT while a non-reentrant mechanism causes prema ...
Cardiac channelopathies: Genetic and molecular mechanisms
Cardiac channelopathies: Genetic and molecular mechanisms

... Cardiac channelopathies are a clinically and genetically heterogeneous group of diseases. Their electrocardiographic features are very different and highly specific but some of their basic clinical expressions are often similar. For example, spontaneous and exercise-triggered syncopes due to ventricu ...
Single-Beat Noninvasive Imaging of Cardiac
Single-Beat Noninvasive Imaging of Cardiac

... in the AV node). Therefore, the accessory pathway remained the only input for ventricular activation, whereas under baseline conditions there were 2 activation inputs for ventricular activation: 1) the accessory pathway, and 2) the AV node. The short half-life of adenosine (approximately 1.5 s) caus ...
A brief glossary of the most used cardiac acronyms and medical
A brief glossary of the most used cardiac acronyms and medical

... or more to dissipate from the body. Currently, the product is often being prescribed offlabel as a first-line anti-arrhythmic, and patients are being left on it longer than FDA approvals indicate is appropriate. Anemia – when there are an insufficient number of red blood cells to provide the body wi ...
Innovative devices for advanced heart failure
Innovative devices for advanced heart failure

... Novel device therapies for advanced heart failure continue to show promising clinical results. Randomized controlled trials are still needed to better evaluate their efficacy. Nevertheless, it can be anticipated that at least several of these devices will be among the armamentarium of treatment opti ...
changes in left atrial size and cardiac rhythm in patients after mitral
changes in left atrial size and cardiac rhythm in patients after mitral

... decrease the risk of embolic stroke. A meta-analysis of pooled results from several studies showed that warfarin, an antithrombotic agent, lowered the incidence of stroke in patients with atrial fibrillation by 65%, as compared to those receiving placebo (12). This implies that even patients on an e ...
Effects of exercise training on left ventricular volumes
Effects of exercise training on left ventricular volumes

... these studies, exercise programs are now a well-established component of the therapeutic regimen for patients with CHF.3,4 Early reservations about potential adverse effects of training on the myocardial remodeling process in postinfarction CHF5,6 have largely been allayed by recent studies with ech ...
Case Report Hemolysis and Pulmonary Insufficiency
Case Report Hemolysis and Pulmonary Insufficiency

... In those patients who qualify for cardiac transplantation, the primary indications for VAD implantation as bridge-totransplant therapy are refractory arrhythmia or worsening hemodynamics, in spite of maximal inotropic support [2]. The ultimate clinical goals of VAD therapy are to restore adequate bl ...
Echocardiographic Evaluation of Left Ventricular Diastolic Function
Echocardiographic Evaluation of Left Ventricular Diastolic Function

... pattern in healthy neonates. Aa velocity greater than Ea velocity is observed in fullterm fetuses (20,21). Sequential TDI of same fetuses has shown progressive increase in Ea velocity without change in Aa velocity (21). Pulsed Doppler study of diastolic filling patterns in fetuses has shown that E-w ...
JE Muller, PL Ludmer, SN Willich, GH Tofler, G Aylmer, I
JE Muller, PL Ludmer, SN Willich, GH Tofler, G Aylmer, I

... ALTHOUGH sudden cardiac death afflicts over 400,000 individuals each year in the United States alone and accounts for approximately 50% of all deaths from coronary artery disease,l1 the mechanisms triggering this common catastrophic event remain obscure. Attempts to identify precipitating mechanisms ...
3
3

... has never been reported for the RV though. However, for the left ventricle it is known that V 0 is smaller in patients with a normal ejection fraction, compared to patients with a lower ejection fraction28,29. Patients with a low ejection fraction did have larger end-diastolic and end-systolic volum ...
Left Ventricular Non-Compaction: Mid-myocardial
Left Ventricular Non-Compaction: Mid-myocardial

... affected by LVNC [6,11,12,14]. This may be explained by the normal compaction process that goes from base to apex, from epicardium to endocardium, and from the septal to the lateral wall. Different degrees of arrest in this normal embryologic process may explain the typical pattern of distribution o ...
Right Coronary Artery
Right Coronary Artery

...  Branches of the coronary arteries are functional end arteries  Anastomoses can occur in the following sites : - At the apex - In the posterior part of coronary sulcus - Along the interventricular septum ...
Transcatheter valve interventions: mitral valve is the next quest
Transcatheter valve interventions: mitral valve is the next quest

... imaging and the need for multiple devices, potentially to be used in combination. However, the unmet need for less-invasive treatments for mitral valve insufficiency is a great driver to innovate in this field. Technologies to treat mitral valve regurgitation include repair devices acting at the lea ...
EKG - Birdville High School
EKG - Birdville High School

... sodium, potassium and calcium channels, is the drive that causes contraction of the cardiac cells/muscle ▪ 6. Depolarization with corresponding contraction of myocardial muscle moves as a wave through the heart ▪ 7. Repolarization is the return of the ions to their previous resting state, which corr ...
Cardiac Perforation Associated with a Pacemaker or ICD Lead
Cardiac Perforation Associated with a Pacemaker or ICD Lead

... will be reduced in general. However, impedance will be variable because it depends on the tissue components such as muscle, blood, and air. In some asymptomatic patients with delayed perforation, pacemaker function and electrophysiological parameters appear normal (Hirschl et al., 2007). Therefore, ...
Edwards, Daniel - Cardiff Metropolitan University
Edwards, Daniel - Cardiff Metropolitan University

... The term ‘athlete’s heart’ is used in modern sport and exercise medicine to describe the hypertrophy of the myocardium in response to repeated bouts of exercise (Maron, 1986). This hypertrophy of the myocardium allows for increased maximal stroke volume (SV ) and cardiac output (Q), both of which in ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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