Mietzsch U, McKenna J 3rd, Reith RM, Way SW, Gambello MJ. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013 Nov. 521(16):3817-31.
... TSC2 (tuberin), are responsible for most cases. Hamartin and tuberin form a heterodimer that functions as a major cellular inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) kinase. Genotypephenotype studies suggest that TSC2 mutations are associated with a more severe neurologic phen ...
... TSC2 (tuberin), are responsible for most cases. Hamartin and tuberin form a heterodimer that functions as a major cellular inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) kinase. Genotypephenotype studies suggest that TSC2 mutations are associated with a more severe neurologic phen ...
Activity of Neurons in Anterior Inferior Temporal Cortex during a
... analysis of variance (ANOVA) and t tests, evaluated at the p < 0.05 level of significance. However, the fact that a response difference is statistically significant does not, in itself, indicate how potentially useful the difference is in discriminating among the stimuli. We were particularly intere ...
... analysis of variance (ANOVA) and t tests, evaluated at the p < 0.05 level of significance. However, the fact that a response difference is statistically significant does not, in itself, indicate how potentially useful the difference is in discriminating among the stimuli. We were particularly intere ...
Primate amygdala neurons evaluate the progress of self
... sequence ended with a spend choice). However, the relationship between spend probability and sequence progress varied between interest rate conditions, reflecting the animals’ preferences for different sequence lengths (Figure 1C). The animals typically preferred shorter sequences when interest was ...
... sequence ended with a spend choice). However, the relationship between spend probability and sequence progress varied between interest rate conditions, reflecting the animals’ preferences for different sequence lengths (Figure 1C). The animals typically preferred shorter sequences when interest was ...
Executive Control Over Cognition: Stronger and Earlier Rule
... Each trial, we presented first a sample stimulus followed after a delay by the category boundary (Fig. 1 A, B, sample– boundary sequence), or we presented the two stimuli in reverse order, first the category boundary followed by the sample stimulus (Fig. 1C, boundary–sample sequence). Presenting the ...
... Each trial, we presented first a sample stimulus followed after a delay by the category boundary (Fig. 1 A, B, sample– boundary sequence), or we presented the two stimuli in reverse order, first the category boundary followed by the sample stimulus (Fig. 1C, boundary–sample sequence). Presenting the ...
Effects of lithium and valproate on amphetamine
... Recent studies have consistently reported increased products of lipid peroxidation and alterations of the major antioxidant enzymes in people with bipolar disorder (BD).1–3 It has been widely demonstrated that the generation of reactive oxygen species (ROS) plays a critical role in the pathophysiolo ...
... Recent studies have consistently reported increased products of lipid peroxidation and alterations of the major antioxidant enzymes in people with bipolar disorder (BD).1–3 It has been widely demonstrated that the generation of reactive oxygen species (ROS) plays a critical role in the pathophysiolo ...
AP150 PATHWAYS ASSIGNMENT
... An action potential begins on a ___UPPER MOTOR_ neurons that leaves the __FRONTAL__ lobe of the brain and passes through the ____CEREBRAL PENDUNCLES__ of the midbrain and then the __PYRAMIDS__ of the medulla oblongata where it then decussates and travels down a __ANTERIOR OR LATTERAL __ column to th ...
... An action potential begins on a ___UPPER MOTOR_ neurons that leaves the __FRONTAL__ lobe of the brain and passes through the ____CEREBRAL PENDUNCLES__ of the midbrain and then the __PYRAMIDS__ of the medulla oblongata where it then decussates and travels down a __ANTERIOR OR LATTERAL __ column to th ...
Noise and Coupling Affect Signal Detection and Bursting in a
... between the neurons. When analyzed in the frequency domain, a sharp peak is produced as the system becomes more periodic, which can be used as a measure of synchrony. The synchrony follows a bell-shaped curve as noise intensity increases (Neiman et al. 1997). While SR in a single element has been ve ...
... between the neurons. When analyzed in the frequency domain, a sharp peak is produced as the system becomes more periodic, which can be used as a measure of synchrony. The synchrony follows a bell-shaped curve as noise intensity increases (Neiman et al. 1997). While SR in a single element has been ve ...
Selectivity for the Shape, Size, and Orientation of Objects for
... closely related to the handgrip than to the object shape. We found a similar selectivity for handgrip in motor-dominant neurons that did not show any visual response. With regard to the size of the objects, 16 of 26 object-type neurons tested were selective for both size and shape, whereas 9 object- ...
... closely related to the handgrip than to the object shape. We found a similar selectivity for handgrip in motor-dominant neurons that did not show any visual response. With regard to the size of the objects, 16 of 26 object-type neurons tested were selective for both size and shape, whereas 9 object- ...
14. Development and Plasticity
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
fMR-adaptation reveals separate processing regions for the
... participants attended to the surface properties of the same objects, activation was present in more medial and anterior regions in the collateral sulcus (CoS) and the inferior occipital gyrus (IOG). We went on to demonstrate that attending explicitly to texture activated regions in the IOG and the C ...
... participants attended to the surface properties of the same objects, activation was present in more medial and anterior regions in the collateral sulcus (CoS) and the inferior occipital gyrus (IOG). We went on to demonstrate that attending explicitly to texture activated regions in the IOG and the C ...
GABAergic neuron distribution in the pedunculopontine nucleus
... Indeed, recent studies have shown that there are also functional differences between the two portions of the PPN, which have been evaluated in terms of behavioral responses following excitotoxic lesions or electrical stimulation (Alderson et al., 2006, 2008; Andero et al., 2007). Taken together, the ...
... Indeed, recent studies have shown that there are also functional differences between the two portions of the PPN, which have been evaluated in terms of behavioral responses following excitotoxic lesions or electrical stimulation (Alderson et al., 2006, 2008; Andero et al., 2007). Taken together, the ...
14. Development and Plasticity
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
IOSR Journal Of Environmental Science, Toxicology And Food Technology (IOSR-JESTFT)
... Present study results revealed extensive neurodegeneration in the various brain areas exposed to fluoride. Ascorbic acid and Ginkgo biloba received animal brain showed less degeneration. Fluoride exposed brain showed histopathological changes suggesting necrosis/ apoptosis, and these changes are lin ...
... Present study results revealed extensive neurodegeneration in the various brain areas exposed to fluoride. Ascorbic acid and Ginkgo biloba received animal brain showed less degeneration. Fluoride exposed brain showed histopathological changes suggesting necrosis/ apoptosis, and these changes are lin ...
The neuronal structure of the medial geniculate body in the pig
... measure from 20 to 35 mm. These neurons have one or two dendritic trunks which arise from one pole of the cell body. The primary dendrites divide dichotomically next to the soma into secondary dendrites, which in term after a short distance bifurcate, making the dendrites form tufts. The tufted appe ...
... measure from 20 to 35 mm. These neurons have one or two dendritic trunks which arise from one pole of the cell body. The primary dendrites divide dichotomically next to the soma into secondary dendrites, which in term after a short distance bifurcate, making the dendrites form tufts. The tufted appe ...
Connection Patterns Distinguish 3 Regions of Human Parietal Cortex
... area Opt, and some transitional opercular regions in the most ventral part of the IPL are also recognized. Distinct functional and anatomical regions, MIP and PE, occupy the medial bank of the IPS and the superior parietal lobule (SPL). The functional specializations of these regions have been inves ...
... area Opt, and some transitional opercular regions in the most ventral part of the IPL are also recognized. Distinct functional and anatomical regions, MIP and PE, occupy the medial bank of the IPS and the superior parietal lobule (SPL). The functional specializations of these regions have been inves ...
MMNeuropharm2011
... cocaine exposure elicits long-lasting synaptic adaptations at excitatory synapses on VTA DA neurons. Furthermore, drug-evoked plasticity can be generalized to other addictive drugs. Additional experiments with amphetamine, morphine, ethanol, nicotine and benzodiazepines (Saal et al., 2003; Tan et al ...
... cocaine exposure elicits long-lasting synaptic adaptations at excitatory synapses on VTA DA neurons. Furthermore, drug-evoked plasticity can be generalized to other addictive drugs. Additional experiments with amphetamine, morphine, ethanol, nicotine and benzodiazepines (Saal et al., 2003; Tan et al ...
Gap Junctions in the Ventral Hippocampal-Medial
... Departments of 1Psychology and 2Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544 ...
... Departments of 1Psychology and 2Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544 ...
Acidic and Basic Fibroblast Growth Factors in the Nervous System
... are presently not well understood. Both aFGF and bFGF, for example, have similar effects in most of the in vitro test systems analyzed so far, with an interesting difference between the 2 FGFs being that the activity of aFGF is stimulated 1O-l OO-fold by addition of heparin, whereasthe activity ofbF ...
... are presently not well understood. Both aFGF and bFGF, for example, have similar effects in most of the in vitro test systems analyzed so far, with an interesting difference between the 2 FGFs being that the activity of aFGF is stimulated 1O-l OO-fold by addition of heparin, whereasthe activity ofbF ...
file
... first part of the thesis was on the basic characterisation of the maturation and trafficking of the CLN5 protein by in vitro studies. Thorough analyses presented proteolytical cleavage of a predicted CLN5 signal peptide in the ER, subsequent maturation/trimming of the proform followed by trafficking ...
... first part of the thesis was on the basic characterisation of the maturation and trafficking of the CLN5 protein by in vitro studies. Thorough analyses presented proteolytical cleavage of a predicted CLN5 signal peptide in the ER, subsequent maturation/trimming of the proform followed by trafficking ...
pre_print_Blunted_and_exaggerated_cardiac_stress_reactivity
... stability study in which cardiac reactions to a mental stress task, a 10-minute version of the paced auditory serial arithmetic test (PASAT; Gronwall, 1977), were measured using Doppler Echocardiography and electrocardiography on four separate occasions. A full description of the version of the PASA ...
... stability study in which cardiac reactions to a mental stress task, a 10-minute version of the paced auditory serial arithmetic test (PASAT; Gronwall, 1977), were measured using Doppler Echocardiography and electrocardiography on four separate occasions. A full description of the version of the PASA ...
slides
... – highly subjective to person experiencing it – pain of some type is the most frequent reason for physician consultation in the US, causing half of all Americans to seek medical care annually – pain that stops without treatment or responds to simple measures is called acute – pain is part of the bod ...
... – highly subjective to person experiencing it – pain of some type is the most frequent reason for physician consultation in the US, causing half of all Americans to seek medical care annually – pain that stops without treatment or responds to simple measures is called acute – pain is part of the bod ...
reciprocal inhibition in the motor nervous system of the nematode
... neurons. The DE21 neuron synapses onto the next three posterior VI neurons. A weak response of the VI:,, neuron was revealed by signal averaging techniques in two of five experiments. No interaction with the VI& was observed. The diagram on the left shows the array of commissures in the first three ...
... neurons. The DE21 neuron synapses onto the next three posterior VI neurons. A weak response of the VI:,, neuron was revealed by signal averaging techniques in two of five experiments. No interaction with the VI& was observed. The diagram on the left shows the array of commissures in the first three ...
How Do Short-Term Changes at Synapses Fine
... saline, while climbing fiber synapses onto Purkinje neurons always depress (Perkel et al., 1990). Remarkably, the synapses formed by a single cell onto different target neurons can show different plasticity. This phenomenon was discovered in cerebral cortex (Reyes et al., 1998) and is called “target ...
... saline, while climbing fiber synapses onto Purkinje neurons always depress (Perkel et al., 1990). Remarkably, the synapses formed by a single cell onto different target neurons can show different plasticity. This phenomenon was discovered in cerebral cortex (Reyes et al., 1998) and is called “target ...
Cytoarchitecture of the canine perirhinal and postrhinal cortex
... have shown that the perirhinal cortex has numerous reciprocal connections with a number of cortical areas in the temporal, parietal, occipital and frontal cortex, both sensory and associative in function. Thus, it is a site of polymodal convergence where particular sensory systems can be introduced ...
... have shown that the perirhinal cortex has numerous reciprocal connections with a number of cortical areas in the temporal, parietal, occipital and frontal cortex, both sensory and associative in function. Thus, it is a site of polymodal convergence where particular sensory systems can be introduced ...
Neural constraints on learning
... Learning, whether motor, sensory or cognitive, requires networks of neurons to generate new activity patterns. As some behaviours are easier to learn than others1,2, we asked if some neural activity patterns are easier to generate than others. Here we investigate whether an existing network constrai ...
... Learning, whether motor, sensory or cognitive, requires networks of neurons to generate new activity patterns. As some behaviours are easier to learn than others1,2, we asked if some neural activity patterns are easier to generate than others. Here we investigate whether an existing network constrai ...