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Impact of correlated inputs to neurons
Impact of correlated inputs to neurons

Three-dimensional organization of dendrites and local axon
Three-dimensional organization of dendrites and local axon

... arbors of MSN in the primate striatum along a rostral– dorsal–medial to caudal–ventral–lateral axis. These authors suggested that this orientation tends to parallel the preferred orientation of the striatal compartments, i.e., the striosomes, in the primate striatum. Thus, the geometry of striatal M ...
The Organization of Behavioral Repertoire in Motor Cortex
The Organization of Behavioral Repertoire in Motor Cortex

... representation. The method was then relatively neglected in the motor system until our stimulation studies in monkeys suggested a possible mapping of complex movements in the precentral gyrus (Cooke & Graziano 2004a; Graziano et al. 2002a, 2003, 2004, 2005). We found that short stimulation trains ev ...
Glycemic State Regulates Brain-Derived Neurotrophic Factor
Glycemic State Regulates Brain-Derived Neurotrophic Factor

... During a time when role models seem to become rarer and rarer, I‟ve had the privilege of learning from one of the best, Professor Alastair Ferguson. Thank you Al, not only for ironing out the rough edges of my research every step of the way, but also for teaching me the importance of balance in my l ...
The Switch of Subthalamic Neurons From an Irregular to a Bursting
The Switch of Subthalamic Neurons From an Irregular to a Bursting

... rates and discharge patterns, the significance level was set at p 0.05. All data are expressed as mean ± SEM. ...
The Diversity of Cortical Interneurons
The Diversity of Cortical Interneurons

... The cortex, although heterogeneous at the cellular level, has a well-organized topographic structure. The cortex can be divided into 6 layers along the radial axis and each layer consists of different neuronal cell types. A strong vertical organization (column) is also apparent and this column spans ...
This article was originally published in the
This article was originally published in the

... high-conflict tasks show the greatest increases in reaction time following trials with the greatest ERN. These observations are supported by several functional magnetic resonance imaging (fMRI) studies showing hemodynamic responses believed to reflect the same processes that generate the ERN. Howeve ...
Binding and Cytotoxic Effects of Clostdium botulinum Type A, C1
Binding and Cytotoxic Effects of Clostdium botulinum Type A, C1

... Many of the neuronal somas in the aggregates fluoresced when treated with anti-yy-enolase IgG. However, some of the cells in the aggregates reacted with anti-glial fibrillary protein IgG and anti-S-100 (PP) IgG, indicating that the aggregates contained glial cells as well as neurons. Anti-68K-neurof ...
Discrete coding of stimulus value, reward expectation, and reward
Discrete coding of stimulus value, reward expectation, and reward

... To investigate how the striatum integrates sensory information with reward information for ...
Bissonette Gregory B, Gentry Ronny N, Padmala Srikanth, Pessoa L
Bissonette Gregory B, Gentry Ronny N, Padmala Srikanth, Pessoa L

Uncovering the Forgotten Effect of Superior Cervical Ganglia on
Uncovering the Forgotten Effect of Superior Cervical Ganglia on

... Figure 2: A schematic drawing of cervical ganglia and related anatomical structures of a rabbit in the right upper corner (SSG: Superior cervical sympathetic ganglion, MSG: Middle cervical sympathetic ganglion, ISG: Inferior cervical sympathetic ganglion, STG: Stellate ganglion). At the base, histol ...
A transcription factor network controls cell migration
A transcription factor network controls cell migration

... post fertilization (hpf), resulting in large deficits in all subtypes of pineal cells (Masai et al., 1997); despite the loss of these cells, the parapineal organ can still form in Flh mutants (Snelson et al., 2008a). In contrast, parapineal development is dramatically affected in Tbx2b mutants, whic ...
Neural substrates for expectation-modulated fear learning in
Neural substrates for expectation-modulated fear learning in

... stores memories of the conditioned stimulus–unconditioned stimulus association, but the origin of UCS inputs to the amygdala is unknown. Theory and evidence suggest that instructive UCS inputs to the amygdala will be inhibited when the UCS is expected, but this has not been found during fear conditi ...
Behavioural Brain Research Learning processing in the basal ganglia
Behavioural Brain Research Learning processing in the basal ganglia

... At the first half of the last century, Parkinson’s and Huntington’s diseases were known by their motor disabilities. The discovery that these diseases are caused by the degeneration of components of the basal ganglia led to the theory that this system is exclusively involved in motor functions [13,55 ...
Role of the bed nucleus of the stria terminalis in the control
Role of the bed nucleus of the stria terminalis in the control

... 2. BST as a hub connecting hippocampus, prefrontal cortex and dopamine system The anterolateral group of the BST plays a critical role in anxiety and reward related behaviors (Forray and Gysling, 2004; Dumont et al., 2005). It is a complex structure that can be divided into anterolateral, subcommiss ...
Gating of Sensory Input by Spontaneous Cortical Activity
Gating of Sensory Input by Spontaneous Cortical Activity

... The ␮cc measure. To quantify the fine temporal relationship between a neuron and population activity, we assessed the asymmetry of the spiketriggered MUA using a previously described measure, ␮cc, defined as the mean spike time of spike-triggered MUA within a 100 ms time window, which is equivalent ...
Article
Article

... compared to the time scale of an action potential or synaptic transmission [6–8]. Moreover, the duration of each cycle can change according to the circumstances [9]. In general, CPG networks consist of interconnected interneurons that generate motor patterns underlying rhythmic behaviors. Since inte ...
Cilia development, morphogenesis, and
Cilia development, morphogenesis, and

... channel cilia are found in XS`, XSG, XSH, XSI, XSh, XSK, XDF, and XDL neurons. XDF and XDL possess two cilia each, while the other cells possess a single cilium. These cilia are exposed to the environment through the cuticle. The amphid wing neurons (XYX, XYB, XYC) have complex ciliary structures. T ...
Spatial tuning of reaching activity in the medial parieto
Spatial tuning of reaching activity in the medial parieto

A Dendritic Disinhibitory Circuit Mechanism for Pathway
A Dendritic Disinhibitory Circuit Mechanism for Pathway

... cally disinhibiting the branches targeted by this pathway (Fig. 1c), i.e. by a disinhibition pattern ...
Reaching beyond the classical receptive field of V1 neurons
Reaching beyond the classical receptive field of V1 neurons

... have used (especially CTB), relative to previously used tracers (e.g. biocytin) and even to a recently introduced tracing method (i.e. an adenovirus bearing the gene for enhanced green fluorescent protein––EGFP [95]. In the cat these connections are slightly more extensive, being on average 6–8 mm lo ...
A neurocomputational model of the mammalian fear
A neurocomputational model of the mammalian fear

... their functions [37]. It is a particularly interesting case study because of how well linked it is to learning and memory; fearful experiences have a strong effect on an animal’s future behaviour [37]. This link provides a potential avenue of investigation into how low-level reward and punishment sys ...
Full PDF
Full PDF

... system. J Appl Physiol 115: 954 –971, 2013. First published May 2, 2013; doi:10.1152/japplphysiol.00700.2012.—This article advances the theory that the hypocretinergic (orexinergic) system initiates, coordinates, and maintains survival behaviors and survival-related processes (i.e., the Unified Surv ...
Chapter 16 - MBFys Home Page
Chapter 16 - MBFys Home Page

... the lower motor neurons in the medial ventral horn, have axons that project to many spinal cord segments; indeed, some project to targets along the entire length of the cord. Moreover, many of these local circuit neurons also have axonal branches that cross the midline in the commissure of the spina ...
Assembly and Function of Spinal Circuits for Motor Control
Assembly and Function of Spinal Circuits for Motor Control

... family of transcription factors to regulate the expression profile of two classes of homeodomain (HD) transcription factors (Class I/Class II) in the ventral spinal cord (Shirasaki & Pfaff 2002). Shh induces expression of the more ventrally expressed Class II protein genes, whereas genes encoding Cl ...
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Mirror neuron

A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron ""mirrors"" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in primate species. Birds have been shown to have imitative resonance behaviors and neurological evidence suggests the presence of some form of mirroring system. In humans, brain activity consistent with that of mirror neurons has been found in the premotor cortex, the supplementary motor area, the primary somatosensory cortex and the inferior parietal cortex.The function of the mirror system is a subject of much speculation. Many researchers in cognitive neuroscience and cognitive psychology consider that this system provides the physiological mechanism for the perception/action coupling (see the common coding theory). They argue that mirror neurons may be important for understanding the actions of other people, and for learning new skills by imitation. Some researchers also speculate that mirror systems may simulate observed actions, and thus contribute to theory of mind skills, while others relate mirror neurons to language abilities. Neuroscientists such as Marco Iacoboni (UCLA) have argued that mirror neuron systems in the human brain help us understand the actions and intentions of other people. In a study published in March 2005 Iacoboni and his colleagues reported that mirror neurons could discern if another person who was picking up a cup of tea planned to drink from it or clear it from the table. In addition, Iacoboni has argued that mirror neurons are the neural basis of the human capacity for emotions such as empathy.It has also been proposed that problems with the mirror neuron system may underlie cognitive disorders, particularly autism. However the connection between mirror neuron dysfunction and autism is tentative and it remains to be seen how mirror neurons may be related to many of the important characteristics of autism.Despite the excitement generated by these findings, to date, no widely accepted neural or computational models have been put forward to describe how mirror neuron activity supports cognitive functions such as imitation. There are neuroscientists who caution that the claims being made for the role of mirror neurons are not supported by adequate research.
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