Theta Modulation in the Medial and the Lateral Entorhinal Cortices
... doi:10.1152/jn.01141.2009. Hippocampal neurons show a strong modulation by theta frequency oscillations. This modulation is thought to be important not only for temporal encoding and decoding of information in the hippocampal system, but also for temporal ordering of neuronal activities on timescale ...
... doi:10.1152/jn.01141.2009. Hippocampal neurons show a strong modulation by theta frequency oscillations. This modulation is thought to be important not only for temporal encoding and decoding of information in the hippocampal system, but also for temporal ordering of neuronal activities on timescale ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
... The neuronal ceroid lipofuscinoses (NCL) are progressive neurodegenerative disorders with onset from infancy to adulthood that are manifested by blindness, seizures, and dementia. In NCL, lysosomes accumulate autofluorescent proteolipid in the brain and other tissues. The mnd/mnd mutant mouse was fi ...
... The neuronal ceroid lipofuscinoses (NCL) are progressive neurodegenerative disorders with onset from infancy to adulthood that are manifested by blindness, seizures, and dementia. In NCL, lysosomes accumulate autofluorescent proteolipid in the brain and other tissues. The mnd/mnd mutant mouse was fi ...
Extracellular voltage threshold settings can be tuned for optimal
... crossingsʼ) can be counted, regardless of the waveform shape. Evidence is accumulating that there is information in such non-spike signals recorded from microelectrodes. In one example, Stark and Abeles (2007) used a multiunit activity signal, processed by computing the root mean square of the volta ...
... crossingsʼ) can be counted, regardless of the waveform shape. Evidence is accumulating that there is information in such non-spike signals recorded from microelectrodes. In one example, Stark and Abeles (2007) used a multiunit activity signal, processed by computing the root mean square of the volta ...
i BASAL GANGLIA PATHWAYS: BEYOND THE CLOSED
... Neuroscience Institute at the University of Pittsburgh. I would like to thank them for creating a great scientific environment for my graduate training. I am especially grateful to Richard Dum for his patience in teaching me the surgical and data analysis skills needed for this work and for his invo ...
... Neuroscience Institute at the University of Pittsburgh. I would like to thank them for creating a great scientific environment for my graduate training. I am especially grateful to Richard Dum for his patience in teaching me the surgical and data analysis skills needed for this work and for his invo ...
Local Field Potentials Related to Bimanual Movements in the
... 1998), and that the response properties of the LFP and single units may differ (Mitzdorf et al., 1994). In human motor cortex, studies have addressed the complex sequence of evoked EEG potentials preceding movement (Shibasaki, 1975;Lang et al., 1990;Cui and Deecke, 1999). However, animal research on ...
... 1998), and that the response properties of the LFP and single units may differ (Mitzdorf et al., 1994). In human motor cortex, studies have addressed the complex sequence of evoked EEG potentials preceding movement (Shibasaki, 1975;Lang et al., 1990;Cui and Deecke, 1999). However, animal research on ...
CURRICULUM VITAE - Test - University of South Florida
... Role: PI with T. E. Dick, Ph. D. Case Western Reserve University Medical School R01 NS46062-01 Lindsey (PI) 09/30/02 to 08/31/07 NIH/NINDS Computational Studies of the Respiratory Brainstem This collaborative project brings together researchers in five states to simulate populations of respiratory n ...
... Role: PI with T. E. Dick, Ph. D. Case Western Reserve University Medical School R01 NS46062-01 Lindsey (PI) 09/30/02 to 08/31/07 NIH/NINDS Computational Studies of the Respiratory Brainstem This collaborative project brings together researchers in five states to simulate populations of respiratory n ...
Topographic Organization of Connections Between the Hypothalamus and
... microscope. The number of labeled neurons within the enclosed area was calculated by an algorithm written for this purpose. Because many hypothalamic nuclei are small, it was necessary to match the rostrocaudal level of sections across cases as much as possible to ensure equivalent opportunity to sa ...
... microscope. The number of labeled neurons within the enclosed area was calculated by an algorithm written for this purpose. Because many hypothalamic nuclei are small, it was necessary to match the rostrocaudal level of sections across cases as much as possible to ensure equivalent opportunity to sa ...
Coordinate Roles for LIM Homeobox Genes in Directing the
... early lethality of Lim1tlz mutants, we generated ES cells in which both copies of the Lim1 gene carried the Lim1tlz insertion and used these ES cells to generate mutant ↔ wild-type chimeric embryos. ES cells contribute selectively to definitive embryonic tissues (Beddington and Robertson, 1989), and ...
... early lethality of Lim1tlz mutants, we generated ES cells in which both copies of the Lim1 gene carried the Lim1tlz insertion and used these ES cells to generate mutant ↔ wild-type chimeric embryos. ES cells contribute selectively to definitive embryonic tissues (Beddington and Robertson, 1989), and ...
Pallidal Discharge Related to the Kinematics of Reaching
... pulse-code-modulated VHS-based data storage system (Vetter 4000). Isolated action potentials were identified with a time/amplitude window discriminator (BAK DIS-1), and acceptance pulses were converted with custom electronics to an analog signal that reflected instantaneous firing frequency (1,000/i ...
... pulse-code-modulated VHS-based data storage system (Vetter 4000). Isolated action potentials were identified with a time/amplitude window discriminator (BAK DIS-1), and acceptance pulses were converted with custom electronics to an analog signal that reflected instantaneous firing frequency (1,000/i ...
Spike-based Winner-Take-All Computation in a Multi
... ”Biological information processing systems (’brains’) overwhelmingly outperform their artificial counterparts.”1 This citation from the Caviar project description underscores the fact that our current artificial computation systems, as powerful as they are when processing large data sets, still fail ...
... ”Biological information processing systems (’brains’) overwhelmingly outperform their artificial counterparts.”1 This citation from the Caviar project description underscores the fact that our current artificial computation systems, as powerful as they are when processing large data sets, still fail ...
Nicotine injections into the ventral tegmental area increase
... has attracted considerable scientific attention, the postsynaptic consequences of this presynaptic DA activation are less well characterized. One way to evaluate the effect of DA in postsynaptic neurons is to examine their expression of immediate early genes, such as c-jos, by means of in situ hybri ...
... has attracted considerable scientific attention, the postsynaptic consequences of this presynaptic DA activation are less well characterized. One way to evaluate the effect of DA in postsynaptic neurons is to examine their expression of immediate early genes, such as c-jos, by means of in situ hybri ...
PDF - Oxford Academic - Oxford University Press
... and to physically pull axons toward the dendrite. As the neuron matures, dendritic spines with characteristic morphologies are formed (Harris, 1999). Although these spines have classically been considered stable structures, recent imaging experiments clearly demonstrate that spines undergo rapid str ...
... and to physically pull axons toward the dendrite. As the neuron matures, dendritic spines with characteristic morphologies are formed (Harris, 1999). Although these spines have classically been considered stable structures, recent imaging experiments clearly demonstrate that spines undergo rapid str ...
Neurodynamical theory of decision confidence Andrea Insabato TESI DOCTORAL UPF / 2014
... that a double-layer attractor neural network can account for neural recordings and behavior of rats in a post-decision wagering experiment. In this model a decision-making layer takes the perceptual decision and a separate confidence layer monitors the activity of the decisionmaking layer and makes ...
... that a double-layer attractor neural network can account for neural recordings and behavior of rats in a post-decision wagering experiment. In this model a decision-making layer takes the perceptual decision and a separate confidence layer monitors the activity of the decisionmaking layer and makes ...
The Cellular Basis of a Corollary Discharge
... How do animals discriminate self-generated from external stimuli during behavior and prevent desensitization of their sensory pathways? A fundamental concept in neuroscience states that neural signals, termed corollary discharges or efference copies, are forwarded from motor to sensory areas. Neuron ...
... How do animals discriminate self-generated from external stimuli during behavior and prevent desensitization of their sensory pathways? A fundamental concept in neuroscience states that neural signals, termed corollary discharges or efference copies, are forwarded from motor to sensory areas. Neuron ...
Contact guidance of CNS neurites on grooved quartz: influence of
... (Harrison, 1914) yet surprisingly little is known about the cellular events of contact sensing and their transduction into directional growth, especially in neuronal growth cones. The aim of the present study was to describe the directional effects of substratum contours on the morphology of develop ...
... (Harrison, 1914) yet surprisingly little is known about the cellular events of contact sensing and their transduction into directional growth, especially in neuronal growth cones. The aim of the present study was to describe the directional effects of substratum contours on the morphology of develop ...
Neural mechanism of rapid eye movement sleep generation
... The noradrenergic (NA-ergic) rapid eye movement (REM)-OFF neurons in locus coeruleus (LC) and cholinergic REM-ON neurons in laterodorsal/pedunculopontine tegmentum show a reciprocal firing pattern. The REM-ON neurons fire during REM sleep whereas REM-OFF neurons stop firing during REM sleep. The ces ...
... The noradrenergic (NA-ergic) rapid eye movement (REM)-OFF neurons in locus coeruleus (LC) and cholinergic REM-ON neurons in laterodorsal/pedunculopontine tegmentum show a reciprocal firing pattern. The REM-ON neurons fire during REM sleep whereas REM-OFF neurons stop firing during REM sleep. The ces ...
Regulation of neurons in the dorsal motor nucleus of the vagus by
... application of 100 µM resveratrol the frequency of sEPSCs significantly increased to 4.2 ± 0.8 Hz (range from 0.8 to 8.2 Hz, n = 8, p < 0.05) (Figures 1A–C). The average amplitude of sEPSCs was 13.2 ± 1.4 pA (range from 7.5 to 19.2 pA) before and 10.3 ± 0.6 pA (range from 8.0 to 13.7 pA) after appli ...
... application of 100 µM resveratrol the frequency of sEPSCs significantly increased to 4.2 ± 0.8 Hz (range from 0.8 to 8.2 Hz, n = 8, p < 0.05) (Figures 1A–C). The average amplitude of sEPSCs was 13.2 ± 1.4 pA (range from 7.5 to 19.2 pA) before and 10.3 ± 0.6 pA (range from 8.0 to 13.7 pA) after appli ...
Circadian Organization in Hemimetabolous Insects
... Circadian clocks have been localized in several insect species. For locomotor rhythms, the optic lobe has been recognized as the locus of the principal clock in cockroaches (Nishiitsutsuji-Uwo and Pittendrigh, 1968a), crickets (Tomioka and Chiba, 1984; Abe et al., 1997) and New Zealand weta (Waddel ...
... Circadian clocks have been localized in several insect species. For locomotor rhythms, the optic lobe has been recognized as the locus of the principal clock in cockroaches (Nishiitsutsuji-Uwo and Pittendrigh, 1968a), crickets (Tomioka and Chiba, 1984; Abe et al., 1997) and New Zealand weta (Waddel ...
Prefrontal Cortex Activity during Flexible Categorization
... stimulus was always a “dog” or a “cat”). This was a necessary first step in establishing the basic neural phenomenon and its distribution in higher-level cortex. However, one of the remarkable features of primate cognition is our great flexibility. We can classify the same object into different cate ...
... stimulus was always a “dog” or a “cat”). This was a necessary first step in establishing the basic neural phenomenon and its distribution in higher-level cortex. However, one of the remarkable features of primate cognition is our great flexibility. We can classify the same object into different cate ...
Three-dimensional organization of dendrites and local axon
... inputs within the core. Although dendrites respect the shellcore and patch-matrix boundaries, recurrent axon collaterals may cross these boundaries. Finally, different degrees of overlap between dendritic and axonal arborizations of individual MSN were identified, suggesting various possibilities of ...
... inputs within the core. Although dendrites respect the shellcore and patch-matrix boundaries, recurrent axon collaterals may cross these boundaries. Finally, different degrees of overlap between dendritic and axonal arborizations of individual MSN were identified, suggesting various possibilities of ...
Chemical Transmitters and Modulation of Sleep
... Aithough evidence has suggested a dual role of the basal forebrain (BF) in arousai and sleep generation, the neurotransmitter identity and activity ofBF neurons serving these different functions have remained uncertain. Furthermore, few studies have been done to clarify how the wake vs. sleep promot ...
... Aithough evidence has suggested a dual role of the basal forebrain (BF) in arousai and sleep generation, the neurotransmitter identity and activity ofBF neurons serving these different functions have remained uncertain. Furthermore, few studies have been done to clarify how the wake vs. sleep promot ...
... preferentially to lateral prefrontal areas while its rostrally adjacent sectors projected to medial and orbitofrontal cortices. The diagonal band nuclei projected to orbitofrontal and medial prefrontal areas. Cortical and subcortical structures that are interconnected appear to have a similar patter ...
Mechanisms of Sleep Control - UCLA Integrative Center for
... activated state and a quiescent state. The activated state is characterized by high levels of muscle tone identical to those seen in active waking and by accelerated respiration and heart rate. The quiescent state is characterized by lower levels of muscle tone, resembling those seen in NREM sleep, ...
... activated state and a quiescent state. The activated state is characterized by high levels of muscle tone identical to those seen in active waking and by accelerated respiration and heart rate. The quiescent state is characterized by lower levels of muscle tone, resembling those seen in NREM sleep, ...
Postnatal Development of the Corticospinal Tract in the Reeler Mouse
... Corticospinal tract (CST) neurons are located in layer V of the motor cortex, and send their axons to the spinal motoneurons, directly (5, 23) or indirectly (2, 35). The CST forms the longest axonal projection in the mammalian central nervous system (CNS). The development of CST axons is the latest ...
... Corticospinal tract (CST) neurons are located in layer V of the motor cortex, and send their axons to the spinal motoneurons, directly (5, 23) or indirectly (2, 35). The CST forms the longest axonal projection in the mammalian central nervous system (CNS). The development of CST axons is the latest ...
Neural oscillation
Neural oscillation is rhythmic or repetitive neural activity in the central nervous system. Neural tissue can generate oscillatory activity in many ways, driven either by mechanisms within individual neurons or by interactions between neurons. In individual neurons, oscillations can appear either as oscillations in membrane potential or as rhythmic patterns of action potentials, which then produce oscillatory activation of post-synaptic neurons. At the level of neural ensembles, synchronized activity of large numbers of neurons can give rise to macroscopic oscillations, which can be observed in the electroencephalogram (EEG). Oscillatory activity in groups of neurons generally arises from feedback connections between the neurons that result in the synchronization of their firing patterns. The interaction between neurons can give rise to oscillations at a different frequency than the firing frequency of individual neurons. A well-known example of macroscopic neural oscillations is alpha activity.Neural oscillations were observed by researchers as early as 1924 (by Hans Berger). More than 50 years later, intrinsic oscillatory behavior was encountered in vertebrate neurons, but its functional role is still not fully understood. The possible roles of neural oscillations include feature binding, information transfer mechanisms and the generation of rhythmic motor output. Over the last decades more insight has been gained, especially with advances in brain imaging. A major area of research in neuroscience involves determining how oscillations are generated and what their roles are. Oscillatory activity in the brain is widely observed at different levels of observation and is thought to play a key role in processing neural information. Numerous experimental studies support a functional role of neural oscillations; a unified interpretation, however, is still lacking.